期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2017.00047
关键词
exocytosis; endocytosis; vesicle recycling; calmodulin; synaptotagmin; SNARE
资金
- National Natural Science Foundation of China [31400708, 81571235, 31670843]
- Natural Science Foundation of Heilongjiang Province of China [C201453]
- Natural Science Foundation of Shandong Province of China [ZR2016CM16]
- Scientific Research Fund of Heilongjiang Provincial Education Department [12531750, 12531746]
- start-up funding of Liaocheng University [318051525]
Neuronal communication and brain function mainly depend on the fundamental biological events of neurotransmission, including the exocytosis of presynaptic vesicles (SVs) for neurotransmitter release and the subsequent endocytosis for SV retrieval. Neurotransmitters are released through the Ca2+-and SNARE-dependent fusion of SVs with the presynaptic plasma membrane. Following exocytosis, endocytosis occurs immediately to retrieve SV membrane and fusion machinery for local recycling and thus maintain the homeostasis of synaptic structure and sustained neurotransmission. Apart from the general endocytic machinery, recent studies have also revealed the involvement of SNARE proteins (synaptobrevin, SNAP25 and syntaxin), synaptophysin, Ca2+/ calmodulin, and members of the synaptotagmin protein family (Syt1, Syt4, Syt7 and Syt11) in the balance and tight coupling of exo-endocytosis in neurons. Here, we provide an overview of recent progress in understanding how these neuronspecific adaptors coordinate to ensure precise and efficient endocytosis during neurotransmission.
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