Malaria medicines to address drug resistance and support malaria elimination efforts

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

(2017) Feng Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Pyronaridine-Artesunate for Treatment of Uncomplicated Plasmodium falciparum Malaria in Western Cambodia

(2016) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial

(2016) Bronner P. Gonçalves et al.   BMC Medicine

Efficacy of OZ439 (artefenomel) against earlyPlasmodium falciparumblood-stage malaria infection in healthy volunteers

(2016) James S. McCarthy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial

(2016) Issaka Sagara et al.   LANCET INFECTIOUS DISEASES

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

(2016) Aung Pyae Phyo et al.   LANCET INFECTIOUS DISEASES

Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial

(2016) Alassane Dicko et al.   LANCET INFECTIOUS DISEASES

The Community As the Patient in Malaria-Endemic Areas: Preempting Drug Resistance with Multiple First-Line Therapies

(2016) Maciej F. Boni et al.   PLOS MEDICINE

The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial

(2016) Joseph Okebe et al.   EBioMedicine

Continued Sensitivity ofPlasmodium falciparumto Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles

(2016) Reyaud Rahman et al.   Open Forum Infectious Diseases

Antimalarial drug resistance in Africa: key lessons for the future

(2015) Shannon Takala-Harrison et al.   Annals of the New York Academy of Sciences

Malaria and the Millennium Development Goals

(2015) Stephen Owens   ARCHIVES OF DISEASE IN CHILDHOOD

Supporting malaria elimination with 21st century antimalarial agent drug discovery

(2015) Thierry T. Diagana   DRUG DISCOVERY TODAY

Independent Emergence of thePlasmodium falciparumKelch Propeller Domain Mutant Allele C580Y in Guyana

(2015) Stella M. Chenet et al.   JOURNAL OF INFECTIOUS DISEASES

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa

(2015) Ingrid Chen et al.   MALARIA JOURNAL

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

A Brief History of Qinghaosu

(2015) Nicholas J. White et al.   TRENDS IN PARASITOLOGY

Optimum population-level use of artemisinin combination therapies: a modelling study

(2015) Tran Dang Nguyen et al.   Lancet Global Health

Pharmacokinetic Interactions between Primaquine and Pyronaridine-Artesunate in Healthy Adult Thai Subjects

(2014) Podjanee Jittamala et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects

(2014) Borimas Hanboonkunupakarn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Were medicine quality and pharmaceutical management contributing factors in diminishing artemisinin efficacy in Guyana and Suriname?

(2014) Victor S Pribluda et al.   MALARIA JOURNAL

Primaquine: the risks and the benefits

(2014) Elizabeth A Ashley et al.   MALARIA JOURNAL

Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether

(2014) Stephen GS Vreden et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

The Origins of Antimalarial-Drug Resistance

(2014) Randall M. Packard   NEW ENGLAND JOURNAL OF MEDICINE

Spiroindolone KAE609 for Falciparum and Vivax Malaria

(2014) Nicholas J. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance

(2013) C. Wongsrichanalai et al.   CLINICAL MICROBIOLOGY AND INFECTION

Artemisinin resistance or artemisinin-based combination therapy resistance?

(2013) Chansuda Wongsrichanalai   LANCET INFECTIOUS DISEASES

Single low-dose primaquine to reduce malaria transmission

(2013) Richard W Steketee et al.   LANCET INFECTIOUS DISEASES

Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial

(2013) Alice C Eziefula et al.   LANCET INFECTIOUS DISEASES

Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials

(2013) Stephan Duparc et al.   MALARIA JOURNAL

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

From bark to weed: The history of artemisinin

(2013) C. Faurant   Parasite

Arterolane Maleate Plus Piperaquine Phosphate for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Comparative, Multicenter, Randomized Clinical Trial

(2012) N. Valecha et al.   CLINICAL INFECTIOUS DISEASES

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

(2012) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Policy options for deploying anti-malarial drugs in endemic countries: a population genetics approach

(2012) Tiago Antao et al.   MALARIA JOURNAL

Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial

(2012) Kassoum Kayentao et al.   MALARIA JOURNAL

Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

(2012) Ronnatrai Rueangweerayut et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

(2011) Tao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial

(2010) Antoinette K Tshefu et al.   LANCET

Changes in the burden of malaria in sub-Saharan Africa

(2010) Wendy Prudhomme O'Meara et al.   LANCET INFECTIOUS DISEASES

Prospective strategies to delay the evolution of anti-malarial drug resistance: weighing the uncertainty

(2010) David L Smith et al.   MALARIA JOURNAL

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fixed‐Dose Pyronaridine‐Artesunate Combination for Treatment of Uncomplicated Falciparum Malaria in Pediatric Patients in Gabon

(2008) Michael Ramharter et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benefits of using multiple first-line therapies against malaria

(2008) M. F. Boni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE