Article
Cardiac & Cardiovascular Systems
David Montero, Frederic Dutheil, Guillaume Walther, Antonia Perez-Martin, Laura Soto-Esclapez, Agnes Vinet, Enrique Roche
Summary: The study analyzed the complete lipoprotein profile of severely obese adolescents and found that low levels of large high-density lipoprotein subfractions could be considered as candidate predictors for future cardiovascular disease. Therefore, diet and exercise are key tools to fight against this pathology.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biology
Carlo Maria Barbagallo, Angelo Baldassare Cefalu, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi
Summary: Chronic kidney disease is an important risk factor for cardiovascular disease, with dyslipidemia often present in patients with CKD. Various lipoprotein abnormalities occur due to impaired enzymes pathways and proteins involved in lipoprotein metabolism in CKD patients. Hypolipidemic treatments may alter the progression of CVD in CKD patients.
Article
Biochemistry & Molecular Biology
Anna E. Engell, Henrik L. Jorgensen, Bent S. Lind, Anton Pottegard, Christen L. Andersen, John S. Andersen, Margit Kriegbaum, Mia K. Grand, Lise Bathum
Summary: Lipid levels in blood have decreased significantly in the general population due to the use of statins. This trend was observed in primary health care patients who were not using statins from 2001 to 2018, with substantial decreases in total cholesterol and low-density lipoprotein cholesterol levels, especially in the elderly population.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Endocrinology & Metabolism
Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and storage, facilitated by lipoprotein lipase (LPL) which acts as a gatekeeper for fatty acid uptake. LPL activity is regulated by extracellular proteins including members of the angiopoietin-like family of proteins. This review delves into how ANGPTL3, ANGPTL4, and ANGPTL8 regulate LPL activity and coordinate triglyceride metabolism and fat partitioning.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Jennifer A. Fleming, Penny M. Kris-Etherton, Kristina S. Petersen, David J. Baer
Summary: Incorporating lean beef into a Mediterranean-style diet does not attenuate the reduction in lipid and lipoprotein concentrations as compared to an average American diet.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Hyungjong Park, Yoonkyung Chang, Heajung Lee, Iksun Hong, Tae-Jin Song
Summary: The study investigates the association between total cholesterol (TC) variability and the occurrence of venous thromboembolism (VTE) using a Korean database. The results show a positive correlation between higher TC variability and the occurrence of VTE, emphasizing the importance of maintaining stable TC levels to prevent VTE.
Review
Hematology
Cheng-Chieh Hsu, Jenny E. Kanter, Vishal Kothari, Karin E. . Bornfeldt
Summary: APOA1 and APOB are structural proteins of different types of lipoproteins, regulating the levels of triglyceride and cholesterol. Among the smaller APOCs, APOC3 has been studied extensively and is associated with cardiovascular and kidney diseases in type 1 diabetes. Insulin deficiency and resistance are related to elevated APOC3 levels. APOC3 slows down the clearance of triglyceride-rich lipoproteins, leading to the accumulation of atherogenic remnants in atherosclerosis lesions. Little is known about the roles of APOC1, APOC2, and APOC4 in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Adina Stanciulescu, Alexandru Scafa-Udriste, Maria Dorobantu
Summary: Cardiovascular disease (CVD) is a leading cause of death worldwide, with atherosclerosis being the most common form of manifestation. Recent studies have shown that small, dense low-density lipoproteins (LDLs) are more frequently associated with a higher risk for developing atherosclerotic CVD. This review aims to comprehensively evaluate the association between LDL subfractions and the risk of major adverse cardiovascular events, by assessing their genetic and clinical features, physiopathological characteristics, and ability to predict long-term cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maureen Sampson, Rami A. Ballout, Daniel Soffer, Anna Wolska, Sierra Wilson, Jeff Meeusen, Leslie J. Donato, Erica Fatica, James D. Otvos, Eliot A. Brinton, Robert S. Rosenson, Peter Wilson, Marcelo Amar, Robert Shamburek, Sotirios K. Karathanasis, Alan T. Remaley
Summary: This study developed a new algorithm for classifying lipoprotein disorders based on the standard lipid panel, categorizing patients into classical Fredrickson-like phenotypes and introducing a new hypolipidemic phenotype (Type VI) due to genetic mutations in apoB-metabolism. The validity of the new algorithm was confirmed through lipid analysis by NMR and by concordance with classification by agarose gel electrophoresis/beta-quantification, demonstrating its potential for improving the care of patients at risk for ASCVD.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Medical Laboratory Technology
Ewa Wieczorek, Agnieszka Cwiklinska, Maciej Jankowski
Summary: Epidemiological and clinical studies have shown a causal association between serum triglyceride levels and the development of atherosclerosis and cardiovascular disease. Laboratory parameters reflecting triglyceride content are recommended for routine lipid analysis and risk assessment. In addition to triglycerides and non-high-density lipoprotein cholesterol, there are other biomarkers related to triglyceride metabolism.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emma C. Hudgins, Adam M. Bonar, Thanh Nguyen, Ibra S. Fancher
Summary: The dysregulation of lipid-ion channel interactions plays a critical role in the progression of cardiovascular diseases. Blocking these interactions may provide a novel therapeutic approach for preventing disease mechanisms. Lipid regulation of ion channels occurs through direct binding, and preventing these interactions may restore ion channel function and proper control of vascular tone. Potential therapeutic avenues, such as peptides, monoclonal antibodies, and nanomedicine, could be used to prevent pathological lipid-ion channel interactions. However, challenges with experimental identification and development of these strategies need to be addressed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Seldin, Pauline Morand, Richard Lee, Mary Chen, Angel Baldan, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
Summary: This study reveals a novel role of RNF130 in regulating LDL-C levels by modulating the availability of LDLR.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto J. Lorenzatti, Maria Laura Monsalvo, J. Antonio G. Lopez, Huei Wang, Robert S. Rosenson
Summary: The study demonstrates that evolocumab effectively reduces atherogenic lipids and lipoproteins in patients with T2DM. In individuals with high triglycerides receiving background statin therapy, evolocumab significantly decreased cholesterol levels from various ApoB-containing lipoproteins, and the majority of treated individuals achieved lipid treatment goals recommended by the European Society of Cardiology/European Atherosclerosis Society.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Wynn G. Hunter, Alexander G. Smith, Rui C. Pinto, Suzanne Saldanha, Anamika Gangwar, Mandana Pahlavani, Sneha Deodhar, John Wilkins, Ambarish Pandey, David Herrington, Philip Greenland, Ioanna Tzoulaki, Anand Rohatgi
Summary: This study investigated the associations between metabolites and cholesterol efflux capacity (CEC) and found independent associations between CEC and the largest-sized particle subclasses of VLDL and HDL, as well as their constituent apolipoproteins and lipids. However, metabolite profiles had poor accuracy in predicting CEC, and race was found to be the most important factor influencing CEC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)