期刊
CLINICAL INTERVENTIONS IN AGING
卷 12, 期 -, 页码 2069-2076出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S151599
关键词
facial aging; adipose tissue; preadipocytes; adipocytes; inflammation; beiging; adipocyte-myofibroblast transition
资金
- Wellcomet GmbH
Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.
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