Article
Biochemistry & Molecular Biology
Barbara Kramar, Tinkara Pirc Marolt, Maria Monsalve, Dusan Suput, Irina Milisav
Summary: The study reveals that aripiprazole, in contrast to olanzapine, can protect liver cells against oxidative stress, which could be crucial for schizophrenia patients with high-oxidative-stress-risk lifestyles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Chih-Sung Liang, Tung-Ping Su, Ming-Hsien Hsieh, Chau-Shoun Lee, Joseph Kuo, Nan-Ying Chiu, Po-See Chen, Yung-Chieh Yen, Ya-Mei Bai
Summary: The study developed nine consensus recommendations for safely switching from oral or long-acting injectable atypical antipsychotics to Aripiprazole long-acting once-monthly (AOM), including dose adjustment and considerations for pregnancy/breastfeeding. An 80% agreement among panel members was required for final adoption of the recommendations, highlighting the importance of expert consensus in guiding safe medication transitions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Abigail R. Walker, Camilla B. Larsen, Samit Kundu, Christina Stavrinidis, Sung Hye Kim, Asuka Inoue, David F. Woodward, Yun S. Lee, Roberta Migale, David A. Macntyre, Vasso Terzidou, Francesca Fanelli, Shirin Khanjani, Philip R. Bennet, Aylin C. Hanyaloglu
Summary: Current strategies to manage preterm labor focus on inhibiting uterine contractions, but do not improve neonatal outcomes. This study identifies a mechanism in which activated oxytocin receptor reprograms prostaglandin E2 receptor to promote pro-labor/inflammatory responses during human labor. It suggests a potential therapeutic solution by exploiting the functional associations between these receptors to delay preterm labor.
Article
Psychiatry
L. A. Stabell, E. Johnsen, R. A. Kroken, E. M. Loberg, A. Blindheim, I. Joa, S. K. Reitan, M. Rettenbacher, P. Munk-Jorgensen, R. Gjestad
Summary: This study investigates the impact of antipsychotic treatment on clinical insight. It finds that antipsychotics, such as amisulpride and olanzapine, can improve insight over and above the reduction in total psychosis symptoms. However, the effect on insight compared to the effect of symptom reduction is still uncertain.
Article
Multidisciplinary Sciences
Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P. Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappes, Sandrine Betuing, Roman Walle, Ying Zhu, Charlene Josephine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A. Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte
Summary: The study reveals that addictive drugs induce heteromerization of dopamine receptors with glutamate NMDA receptors, playing a key role in cocaine-induced adaptive changes. Blocking the formation of heteromers between dopamine receptor D2R and NMDA receptor can prevent the persistence of these adaptive changes.
Article
Biology
Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane, Kenneth R. Pryde
Summary: Antipsychotic drugs, including the newer generation ones, can induce mitochondrial toxicity that leads to movement disorders. It is important to understand the underlying mechanisms to minimize these adverse effects.
Article
Cell Biology
Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Angela M. Valverde, Jan W. Eriksson, Maria J. Pereira
Summary: We investigated the effects of second-generation antipsychotics (SGAs) on adipocyte differentiation and metabolism and found that aripiprazole (ARI) can impair adipocyte glucose uptake and increase fatty acid oxidation gene expression, while olanzapine (OLA) can increase leptin gene expression. These findings have important implications for understanding the metabolic effects of antipsychotic drugs and suggest that different SGAs may have different mechanisms of action.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Psychiatry
Chih-Min Liu, Chen -Chung Liu, Ming-Hsien Hsieh, Tzung-Jeng Hwang, Yi-Ting Lin, Yi-Ling Chien, Hai-Gwo Hwu
Summary: The plasma level of C4A decreased with aripiprazole treatment, and the decrease rate was associated with the treatment response of the positive dimension in patients with early psychosis.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tinkara Pirc Marolt, Barbara Kramar, Andrej Vovk, Helena Podgornik, Dusan Suput, Irina Milisav
Summary: Aripiprazole affects mitochondrial function and liver cells, leading to mitochondrial hyperpolarization and increased ROS production. However, it also induces a heightened antioxidative response. It disrupts the balance of energy production in cells.
Article
Pharmacology & Pharmacy
Yan Hong
Summary: This study examined the efficacy and safety of aripiprazole in patients with schizophrenia. The results demonstrated that the aripiprazole treatment group had significantly better outcomes in terms of the interactive voice response system total score, quality of life, and adverse effects compared to the standard of care group.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Balog, Allison Anderson, Thiago C. Genaro-Mattos, Zeljka Korade, Karoly Mirnics
Summary: Polypharmacy, the common practice of using multiple drugs to treat a single patient in psychiatry, is investigated in this study. The effects and interactions of two commonly prescribed psychotropic medications, trazodone and aripiprazole, with sterol inhibiting side effects are examined. The study reveals that these medications disrupt neuronal and astroglial sterol biosynthesis and may have undesired side effects on the adult brain.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Adriana Stelmach, Katarzyna Guzek, Alicja Roznowska, Irena Najbar, Anna Sadakierska-Chudy
Summary: Second-generation antipsychotics, including aripiprazole, are commonly used for treating schizophrenia. Aripiprazole is a third-generation antipsychotic drug that acts on dopamine and serotonin receptors, with minimal side effects. However, some patients may have an inadequate response to aripiprazole treatment, and genetic polymorphisms, including CYP2D6, CYP3A4, CYP3A5, ABCB1, DRD2, and 5-HTRs, may influence the therapeutic effects and metabolic response to the drug. A pharmacogenetic approach may be beneficial in predicting drug response and improving the management of schizophrenia patients.
PHARMACOLOGICAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak
Summary: We previously reported that alpha(1)-adrenoceptor (alpha(1)-AR) ligands can inhibit chemokine receptor (CR) heteromerization partners of alpha(1B/D)-AR. In this study, we investigated the mechanisms underlying this inhibition and provided in vivo evidence using a murine air pouch model. Our findings demonstrate that alpha(1B)-AR enhances G(alpha i) signaling of CCR2, and phenylephrine and phentolamine can reduce the heteromerization propensity and inhibit G(ai) signaling of CCR2. Additionally, phenylephrine was found to recruit beta-arrestin-2 to CCR2 and decrease the expression of alpha(1B/D)-AR, CR partners, and corresponding heteromers, while phentolamine specifically reduced CR: alpha(1B/D)-AR heteromers without affecting beta-arrestin-2 recruitment or receptor expression. Overall, our study provides new insights into the pharmacology of GPCR heteromers and highlights the potential therapeutic significance of targeting alpha(1B)-AR:CR heteromerization.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Physiology
Davide Calebiro, Zsombor Koszegi, Yann Lanoiselee, Tamara Miljus, Shannon O'Brien
Summary: Recent research has revealed transient interactions between GPCRs and G proteins in living cells, resulting in short-lived signaling nanodomains that may confer rapidity and specificity to signal transduction. These findings could potentially offer new strategies for modulating GPCR function and pave the way for innovative drug development for common diseases like diabetes or heart failure.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Anesthesiology
Renata C. M. Ferreira, Douglas L. de Almeida, Igor D. G. Duarte, Daniele C. Aguiar, Fabricio A. Moreira, Thiago R. L. Romero
Summary: The study provides evidence that aripiprazole induces peripheral antinociceptive effects via PI3K/NO/cGMP/K-ATP pathway activation.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Clinical Neurology
Marta Capannolo, Irene Fasciani, Stefania Romeo, Gabriella Aloisi, Mario Rossi, Pierangelo Bellio, Giuseppe Celenza, Benedetta Cinque, Maria Grazia Cifone, Marco Scarselli, Roberto Maggio
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Review
Pharmacology & Pharmacy
Biancamaria Longoni, Irene Fasciani, Shivakumar Kolachalam, Ilaria Pietrantoni, Francesco Marampon, Francesco Petragnano, Gabriella Aloisi, Maria F. Coppolino, Mario Rossi, Marco Scarselli, Roberto Maggio
CURRENT PHARMACEUTICAL DESIGN
(2019)
Review
Chemistry, Medicinal
Marco Carli, Shivakumar Kolachalam, Biancamaria Longoni, Anna Pintaudi, Marco Baldini, Stefano Aringhieri, Irene Fasciani, Paolo Annibale, Roberto Maggio, Marco Scarselli
Summary: Atypical antipsychotics can cause metabolic syndrome, including weight gain, dyslipidemia, type 2 diabetes, and high blood pressure. Olanzapine and clozapine have the highest risk of metabolic alterations, while newer medications like ziprasidone and lurasidone may be more tolerable in terms of metabolic profile. Differences in efficacy among antipsychotics should be considered, with clozapine being the most effective but potentially associated with increased metabolic risks. A multidisciplinary approach combining psychoeducation and therapeutic drug monitoring is proposed as a first-line strategy to avoid metabolic syndrome.
Article
Biochemistry & Molecular Biology
Matteo Cassandri, Silvia Pomella, Alessandra Rossetti, Francesco Petragnano, Luisa Milazzo, Francesca Vulcano, Simona Camero, Silvia Codenotti, Francesca Cicchetti, Roberto Maggio, Claudio Festuccia, Giovanni Luca Gravina, Alessandro Fanzani, Francesca Megiorni, Marialuigia Catanoso, Cinzia Marchese, Vincenzo Tombolini, Franco Locatelli, Rossella Rota, Francesco Marampon
Summary: The study evaluated the effects of MS-275 in combination with radiation therapy on RMS cells, showing that MS-275 could enhance radio-sensitivity and affect cell growth and DNA repair mechanisms through multiple pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Roberto Maggio, Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Marampon, Mario Rossi, Marco Scarselli
Summary: The passage discusses the importance of information exchange and interpretation in biology, particularly in how cells integrate signals from various molecules. G protein-coupled receptors (GPCRs) play a crucial role in signal recognition and transduction within cells, and their formation of higher order oligomers helps organize cell compartments along the membrane. This structural basis allows for cells to perceive and discriminate localized increases in second messengers, contributing to the understanding of physiological roles played by receptor homo- and hetero-oligomerization in cell biology.
Article
Chemistry, Medicinal
Marco Carli, Eleonora Risaliti, Mena Francomano, Shivakumar Kolachalam, Biancamaria Longoni, Guido Bocci, Roberto Maggio, Marco Scarselli
Summary: This study reports the drug plasma concentrations of lithium and valproic acid in bipolar patients undergoing treatment at an Italian clinical center. Both lithium and valproic acid are commonly used drugs for bipolar disorder, and therapeutic drug monitoring is strongly recommended. The study found that a significant number of patients had subtherapeutic drug concentrations during their treatment, indicating the need for improvement in pharmacological treatments.
Review
Biochemistry & Molecular Biology
Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Colaianni, Gabriella Aloisi, Roberto Maggio, Marco Scarselli, Mario Rossi
Summary: The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which allows G protein-coupled receptors (GPCRs) to signal from intracellular compartments and regulate different cell pathways. This review summarizes the current knowledge of GPCR signaling compartmentalization, including how GPCRs reach intracellular sites, are stimulated by ligands, and their potential physiological/pathophysiological roles. The modulation of compartmentalized GPCR signaling by drugs and ligands is also discussed.
Article
Oncology
Silvia Sideri, Francesco Petragnano, Roberto Maggio, Simonetta Petrungaro, Angela Catizone, Luisa Gesualdi, Viviana De Martino, Giulia Battafarano, Andrea Del Fattore, Domenico Liguoro, Paola De Cesaris, Antonio Filippini, Francesco Marampon, Anna Riccioli
Summary: The study found that highly metastatic prostate cancer cells show increased sensitivity to Docetaxel after radiotherapy failure and suggests immediate chemotherapy after radiotherapy failure may benefit certain patients. Furthermore, using a higher dose per fraction for radiotherapy in castration-resistant prostate cancer cells was not successful, but the results may vary between different cell lines.
Review
Biochemistry & Molecular Biology
Serena Barachini, Letizia Biso, Shivakumar Kolachalam, Lacopo Petrini, Roberto Maggio, Marco Scarselli, Biancamaria Longoni
Summary: Pancreatic islet transplantation is a treatment for Type 1 diabetic patients, and mesenchymal stem cells (MSCs) have shown potential in controlling graft rejection. MSCs can interact with immune system cells through direct contact or their secretome. This review discusses the role of MSCs in controlling the immune system and promoting repair in pancreatic islet transplantation, as well as challenges such as oxidative stress and impaired vasculogenesis. Preconditioning MSCs with hypoxia exposure or using stem cells with angiogenic potential in organoids may help improve transplant outcomes.
Review
Biochemistry & Molecular Biology
Roberto Maggio, Irene Fasciani, Francesco Petragnano, Maria Francesca Coppolino, Marco Scarselli, Mario Rossi
Summary: Unstructured regions in functional proteins, specifically the i3 loop and C-terminus in G protein-coupled receptors (GPCRs), have been recognized as crucial elements in GPCR function and regulation. They play critical roles in allosterically regulating GPCR activation, as autoregulators in receptor coupling specificity, and in facilitating receptor stability and interactions with intracellular protein partners.
Review
Chemistry, Medicinal
Irene Fasciani, Francesco Petragnano, Gabriella Aloisi, Francesco Marampon, Marco Carli, Marco Scarselli, Roberto Maggio, Mario Rossi
Article
Neurosciences
Stefania Romeo, Flora Vitale, Cristina Viaggi, Stefano di Marco, Gabriella Aloisi, Irene Fasciani, Carla Pardini, Ilaria Pietrantoni, Mattia Di Paolo, Serena Riccitelli, Rita Maccarone, Claudia Mattei, Marta Capannolo, Mario Rossi, Annamaria Capozzo, Giovanni U. Corsini, Eugenio Scarnati, Luca Lozzi, Francesca Vaglini, Roberto Maggio
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)