Editorial Material
Clinical Neurology
Jacopo C. DiFrancesco, Lorenzo Stanzani
Summary: Cerebral amyloid angiopathy (CAA) is a common neuropathological finding in patients with Alzheimer's disease (AD), characterized by cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). Both CMBs and CAA are associated with progressive cognitive impairment in AD patients, providing further evidence for the interplay between neurovascular and neurodegenerative processes in AD.
Review
Clinical Neurology
Aristeidis H. Katsanos, Vasileios-Arsenios Lioutas, Andreas Charidimou, Luciana Catanese, Kelvin Kuan Huei Ng, Kanjana Perera, Danielle de Sa Boasquevisque, Guido J. Falcone, Kevin N. Sheth, Jose Rafael Romero, Georgios Tsivgoulis, Eric E. Smith, Mukul Sharma, Magdy H. Selim, Ashkan Shoamanesh
Summary: Although statin use is not associated with the presence of cerebral microbleeds overall, it may increase the risk of lobar microbleeds formation. Further investigation within magnetic resonance imaging ancillary studies of randomized trials is warranted to explore this hypothesis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic
Summary: The study reveals that Cerebral amyloid angiopathy (CAA) causes dysfunction of the blood-brain barrier (BBB), triggering intense proinflammatory responses and cognitive decline. Age exacerbates BBB injury in CAA vasculopathy, playing a significant role in the effects of amyloid beta (Aβ).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Neurosciences
Sungyang Jo, E-Nae Cheong, Nayoung Kim, Jungsu S. Oh, Woo Hyun Shim, Hyung-Ji Kim, Sun Ju Lee, Yoojin Lee, Minyoung Oh, Jae Seung Kim, Bum Joon Kim, Jee Hoon Roh, Sang Joon Kim, Jae-Hong Lee
Summary: This study found that microbleeds in cerebral amyloid angiopathy (CAA) can lead to damage in white matter tracts and subsequent cognitive decline, while cortical thickness does not mediate the association between lobar microbleeds and cognition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Aleksandra Stanisavljevic, Joseph M. Schrader, Xiaoyue Zhu, Jennifer M. Mattar, Ashley Hanks, Feng Xu, Mark Majchrzak, John K. Robinson, William E. Van Nostrand
Summary: Hypertension may cause significant changes in the redistribution of amyloid and the size and distribution of thalamic vessel occlusions in cerebral amyloid angiopathy (CAA).
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yasuteru Inoue, Yukio Ando, Yohei Misumi, Mitsuharu Ueda
Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta (Aβ) in brain vessels, leading to vessel fragility, hemorrhages, and neurological symptoms. The pathogenesis of CAA is not fully understood, but recent advances in mass spectrometric methodology have identified potential key molecules associated with CAA. Understanding the interactions between cerebrovascular Aβ deposits and these molecules may lead to the development of effective CAA therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
M. Buciuc, J. R. Duffy, M. M. Machulda, A. J. Spychalla, J. L. Gunter, C. R. Jack, C. Giannini, A. Raghunathan, D. W. Dickson, K. A. Josephs, J. L. Whitwell
Summary: This study compared neuroimaging and pathological data in LPA patients, showing an association between the presence of MB/SS and moderate/severe CAA. However, no clear correlations were found between the topographic distribution of MB/SS and CAA or areas of hypometabolism.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ashwin Ambi, Aleksandra Stanisavljevic, Tiffany W. Victor, Adam W. Lowery, Judianne Davis, William E. Van Nostrand, Lisa M. Miller
Summary: Removing copper does not effectively decrease copper content in vascular amyloid deposits and may even increase the development of disease pathology in cerebral amyloid angiopathy (CAA).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Kana Matsuda, Masaki Shinohara, Yuichiro Ii, Ken-ichi Tabei, Yukito Ueda, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Satoh, Masayuki Maeda, Ryo Momosaki, Hidekazu Tomimoto, Akihiro Shindo
Summary: This study aimed to examine the predictive value of SVD scores and neuropsychological assessment on cognitive function. The results showed that patients with worsened CDR had more lobar microbleeds and prolonged psychomotor speed at baseline, which may serve as predictors of cognitive deterioration in patients visiting memory clinics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Hyemin Jang, Min Young Chun, Hee Jin Kim, Duk L. Na, Sang Won Seo
Summary: This study investigated the relevance of different imaging markers in cerebral amyloid angiopathy (CAA) patients and their clinical trajectories. The presence of cortical superficial siderosis and previous lobar intracerebral hemorrhage were predictors for the development of CAA, while lobar cerebral microbleeds were not. The presence of cerebral microinfarcts (CMIs) and A beta positivity were associated with worse cognitive trajectories in CAA patients.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Review
Geriatrics & Gerontology
Hai-ling Wang, Chun-lin Zhang, Yan-mei Qiu, An-qi Chen, Ya-nan Li, Bo Hu
Summary: Cerebral microbleeds (CMBs) are small lesions in the brain's microvessels that are linked to various neurological conditions. The exact pathogenesis and treatment options for CMBs require further investigation and research.
Article
Medicine, General & Internal
Aikaterini Theodorou, Lina Palaiodimou, Georgia Papagiannopoulou, Odysseas Kargiotis, Klearchos Psychogios, Apostolos Safouris, Eleni Bakola, Maria Chondrogianni, Vasiliki Kotsali-Peteinelli, Konstantinos Melanis, Athanasios Tsibonakis, Elissavet Andreadou, Sofia Vasilopoulou, Stefanos Lachanis, Georgios Velonakis, Elias Tzavellas, John S. Tzartos, Konstantinos Voumvourakis, Georgios P. Paraskevas, Georgios Tsivgoulis
Summary: This study aimed to assess the prevalence of baseline characteristics, clinical and radiological findings, and outcomes among patients with cerebral amyloid angiopathy (CAA) in Greece. The results showed that focal neurological deficits, cognitive decline, and transient focal neurological episodes were the most common clinical manifestations, while hemorrhagic lesions were the most prevalent neuroimaging findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Takahiro Komori, Satoshi Hoshide, Ken-ichi Tabei, Hidekazu Tomimoto, Kazuomi Kario
Summary: This study found that patients with heart failure who exhibit a non-dipper blood pressure pattern have higher white matter hyperintensity volume and percentage, indicating a potential risk factor for future cognitive impairment.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Medicine, General & Internal
Kana Matsuda, Akihiro Shindo, Yuichiro Ii, Ken-ichi Tabei, Yukito Ueda, Hidehiro Ishikawa, Keita Matsuura, Kimiko Yoshimaru, Akira Taniguchi, Natsuko Kato, Masayuki Satoh, Masayuki Maeda, Hidekazu Tomimoto
Summary: This study found significant associations between cerebral amyloid angiopathy (CAA) score and cognitive function, while the hypertensive arteriopathy (HA) score did not show clear association. The modified CAA-SVD score also had a significant correlation with cognitive function, indicating its potential as a predictor for cognitive deterioration in patients with mild cognitive impairment (MCI) and mild dementia.
Article
Neurosciences
Yoshinori Hirata, Natsuko Kato, Kanako Muraga, Akihiro Shindo, Naoko Nakamura, Keita Matsuura, Yuichiro Ii, Mariko Shiga, Ken-ichi Tabei, Masayuki Satoh, Tomoyuki Fukuma, Yoshihiko Kagawa, Satoshi Fujita, Ryota Kogue, Maki Umino, Masayuki Maeda, Hajime Sakuma, Kaoru Dohi, Hidekazu Tomimoto
Summary: The prevalence of cerebral microbleeds (CMBs) is higher in patients with atrial fibrillation (AF), especially lobar type. Hemorrhagic transformation of embolic microinfarctions can account for de novo lobar CMBs in these patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Eisuke Kondo, Ken-ichi Tabei, Ryuhei Okuno, Kenzo Akazawa
Summary: Despite previous studies focusing on patients with mild cognitive impairment, this study demonstrates that even patients with severe dementia can use accessible digital musical instruments and engage in music therapy, even as their cognitive function declines.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Ken-ichi Tabei, Naoki Saji, Noriko Ogama, Makiko Abe, Saeko Omura, Takashi Sakurai, Hidekazu Tomimoto
Summary: White matter hyperintensity (WMH) is an important clinical indicator of aging and dementia, but the quantitative accuracy of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) is unknown. This study analyzed WMH using two MRI imaging analysis software modalities and found significant differences in quantitative data between the two methods, suggesting caution in the quantitative assessments of WMH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Geriatrics & Gerontology
Akira Taniguchi, Akihiro Shindo, Ken-ichi Tabei, Osamu Onodera, Yukio Ando, Takao Urabe, Kazumi Kimura, Kazuo Kitagawa, Yoshihiro Miyamoto, Misa Takegami, Masafumi Ihara, Ikuko Mizuta, Toshiki Mizuno, Hidekazu Tomimoto
Summary: The study found that CADASIL patients with dementia had severe white matter lesions, both periventricular and deep, and a larger number of lacunar infarcts than those without dementia. The risk of dementia may be associated with 6 or more lacunar infarcts, 19 or more cerebral microbleeds, or a Fazekas scale score of 3 in periventricular and deep white matter lesions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Akane Mizutani, Akihiro Shindo, Ken-ichi Tabei, Kimiko Yoshimaru, Masayuki Satoh, Hidekazu Tomimoto
Summary: By using health insurance claims data, it is possible to identify and provide better care and services to dementia patients who do not access the community-based integrated care system (CBICS).
Article
Geriatrics & Gerontology
Masaki Shinohara, Kana Matsuda, Yuichiro Ii, Ken-ichi Tabei, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
Summary: This study investigated the relationship between behavioral and psychological symptoms (BPS) and cerebral small vessel disease (SVD) in patients with mild cognitive impairment (MCI) or mild dementia. The results showed that patients with BPS had worse clinical dementia ratings, reduced psychomotor speed, higher modified CAA-SVD scores, and larger numbers of cerebral microbleeds (CMBs). Therefore, preventing these brain lesions may help mitigate the risk of BPS.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Kana Matsuda, Masaki Shinohara, Yuichiro Ii, Ken-ichi Tabei, Yukito Ueda, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Satoh, Masayuki Maeda, Ryo Momosaki, Hidekazu Tomimoto, Akihiro Shindo
Summary: This study aimed to examine the predictive value of SVD scores and neuropsychological assessment on cognitive function. The results showed that patients with worsened CDR had more lobar microbleeds and prolonged psychomotor speed at baseline, which may serve as predictors of cognitive deterioration in patients visiting memory clinics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Ken-ichi Tabei, Jun-ichi Ogawa, Chiaki Kamikawa, Makiko Abe, Yoshinori Ota, Masayuki Satoh
Summary: Due to the spread of COVID-19, face-to-face non-pharmacological treatment for dementia prevention has been limited. This study utilized an online conferencing system to implement an online version of a physical exercise program with music and examined its effects on cognitive function. The results indicated that the program improved working memory.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Masayuki Satoh, Ken-ichi Tabei, Makiko Abe, Chiaki Kamikawa, Saiko Fujita, Yoshinori Ota
Summary: The short version of the BA exhibited strong correlations with the original version, and the correlation coefficients between age and subtest scores were almost the same between the two versions. The short version of the BA will be useful for cognitive assessments in the clinic.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
Article
Computer Science, Information Systems
Kenta Abe, Ken-Ichi Tabei, Keita Matsuura, Kazuyuki Kobayashi, Tomoyuki Ohkubo
Summary: The study analyzed the gait arm swing of individuals with Parkinson's disease using OpenPose and compared the results with MDS-UPDRS scores. The findings showed a significant relationship between the gait arm swing angle and the MDS-UPDRS score. The proposed method is simpler and can utilize videos of timed up-and-go tests.
Review
Clinical Neurology
Makiko Abe, Ken-ichi Tabei, Masayuki Satoh
Summary: This study analyzed the research on music therapy for dementia using cited original papers from a review in the Cochrane Database of Systematic Reviews. The findings revealed that cognitive function, behavioral and psychological symptoms of dementia (BPSD), and quality of life were frequently investigated domains. Moreover, various types of rating scales were used to assess cognitive function, suggesting the need for standardization in order to contribute to the accumulation of evidence in this field.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
(2022)
Article
Geriatrics & Gerontology
Masayuki Satoh, Ken-ichi Tabei, Makiko Abe, Chiaki Kamikawa, Saiko Fujita, Yoshinori Ota
Summary: The study found moderate correlations between the BA and established neuropsychological tests in intellect, memory, visuospatial function, and frontal function, making it a useful tool for assessing the cognitive function of generally healthy elderly persons.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Kenta Abe, Ken-ichi Tabei, Keita Matsuura, Kazuyuki Kobayashi, Tomoyuki Ohkubo
Summary: This study developed a PD diagnosis system by comparing and analyzing the differences in arm swings between left and right arms, aiming to diagnose the early stage of PD.
2021 INTERNATIONAL CONFERENCE ON ADVANCED MECHATRONIC SYSTEMS (ICAMECHS)
(2021)