Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

(2016) Leonid P. Shutov et al.   JOURNAL OF NEUROSCIENCE

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat

(2015) D.R. Sagar et al.   OSTEOARTHRITIS AND CARTILAGE

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice – potential role of TRPA1 in osteoarthritis

(2015) L.J. Moilanen et al.   OSTEOARTHRITIS AND CARTILAGE

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

(2015) Lars Arendt-Nielsen et al.   Current Osteoporosis Reports

Protective Actions of Aspirin-Triggered (17R) Resolvin D1 and Its Analogue, 17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1 Methyl Ester, in C5a-Dependent IgG Immune Complex–Induced Inflammation and Lung Injury

(2014) Huifang Tang et al.   JOURNAL OF IMMUNOLOGY

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis

(2013) Devi Rani Sagar et al.   ANNALS OF THE RHEUMATIC DISEASES

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives

(2013) Sungjae Yoo et al.   Current Neuropharmacology

The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study

(2013) Y. Shimura et al.   OSTEOARTHRITIS AND CARTILAGE

Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis

(2013) P.I. Mapp et al.   OSTEOARTHRITIS AND CARTILAGE

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Spinal Actions of Lipoxin A4 and 17(R)-Resolvin D1 Attenuate Inflammation-Induced Mechanical Hypersensitivity and Spinal TNF Release

(2013) Sally Abdelmoaty et al.   PLoS One

Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn

(2012) Feng Quan-Xin et al.   BMC GASTROENTEROLOGY

Resolvin E1 and Chemokine-like Receptor 1 Mediate Bone Preservation

(2012) L. Gao et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury

(2012) Zhen-Zhong Xu et al.   Journal of Neuroimmune Pharmacology

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Rationing of total knee replacement: a cost-effectiveness analysis on a large trial data set

(2012) Helen Dakin et al.   BMJ Open

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

(2011) JF Lima-Garcia et al.   BRITISH JOURNAL OF PHARMACOLOGY

17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

(2011) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

The Contribution of Spinal Glial Cells to Chronic Pain Behaviour in the Monosodium Iodoacetate Model of Osteoarthritic Pain

(2011) Devi Rani Sagar et al.   Molecular Pain

Monosodium Iodoacetate-Induced Joint Pain is Associated with Increased Phosphorylation of Mitogen Activated Protein Kinases in the Rat Spinal Cord

(2011) Younglim Lee et al.   Molecular Pain

A role for lipoxin A4 as an anti-inflammatory mediator in the human endometrium

(2011) Linsay J Macdonald et al.   REPRODUCTION

Emerging roles of resolvins in the resolution of inflammation and pain

(2011) Ru-Rong Ji et al.   TRENDS IN NEUROSCIENCES

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception

(2010) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid   Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

(2010) Y. Kong et al.   JOURNAL OF NEUROSCIENCE

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption

(2008) B S Herrera et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis

(2008) M.A. Álvarez-Soria et al.   OSTEOARTHRITIS AND CARTILAGE