Article
Pharmacology & Pharmacy
Qiuya Wu, Duanfang Zhou, Zhengze Shen, Bo Chen, Gang Wang, Lihong Wu, Limei Zhang, Xiaoli Li, Lie Yuan, Yuanli Wu, Na Qu, Weiying Zhou
Summary: VPS34-IN1 is a specific selective inhibitor of Class III Phosphatidylinositol 3-kinase (PI3K) and has been shown to exhibit a significant antitumor effect in leukemia and liver cancer. In this study, the researchers focused on the anticancer effect and potential mechanism of VPS34-IN1 in estrogen receptor positive (ER+ ) breast cancer. The results showed that VPS34-IN1 inhibited the viability of ER+ breast cancer cells by inducing apoptosis through the activation of the PERK/ATF4/CHOP pathway of ER stress. These findings provide new insights and potential treatment strategies for ER+ breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Summary: The study investigated the effects and underlying mechanisms of valdecoxib on retinal ischemia-reperfusion injury and oxygen-glucose deprivation/recovery injury. The results showed that valdecoxib protected R28 cells by reducing cell apoptosis and exerted a protective effect on retinas by inhibiting retinal ganglion cell apoptosis. In addition, valdecoxib reversed the expression of certain proteins induced by glaucomatous model and the reversal was mediated by the PERK-ATF4-CHOP pathway. These findings suggest that valdecoxib protects against glaucomatous injury by inhibiting ER stress-induced apoptosis via the PERK-ATF4-CHOP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tae Woo Kim
Summary: This study examines the anti-inflammatory and anti-cancer effects of fisetin, a natural flavonoid. The results show that fisetin can reduce inflammation and induce cancer cell death through ER stress. It also overcomes radiation resistance and induces cell death in liver cancer cells. Therefore, fisetin combined with radiation may be a powerful immunotherapy strategy to overcome resistance in an inflammatory tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Peng Wang, Yi Yang, Gaozong Pang, Chaoyi Zhang, Chuansheng Wei, Xiaofang Tao, Jun Liu, Jianming Xu, Weiping Zhang, Yuxian Shen
Summary: The study revealed that mesencephalic astrocyte-derived neurotrophic factor (MANF) has a protective effect in Rifampicin (RFP)-induced liver injury by inhibiting ATF4-CHOP signal activation and subsequent cell apoptosis. Treatment with recombinant human MANF (rhMANF) reduced the levels of abnormal biomarkers induced by liver injury and helped reduce the number of apoptotic cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Fang Fang, Pingting Liu, Haoliang Huang, Xue Feng, Liang Li, Yang Sun, Randal J. Kaufman, Yang Hu
Summary: Endoplasmic reticulum (ER) stress is found to be associated with various neurodegenerative diseases. In this study, it is shown that deletion of CHOP and/or its upstream regulator ATF4 in retinal ganglion cells (RGCs) promotes RGC and optic nerve (ON) survival and preserves visual function in mouse glaucoma models. These findings suggest that blocking the neuronal intrinsic ATF4/CHOP axis of ER stress is a promising neuroprotection strategy for neurodegeneration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Integrative & Complementary Medicine
Xiaobo Hu, Tingting Duan, Zhuan Wu, Cifei Tang, Zhaohui Cao
Summary: The natural isoflavone puerarin has shown potential in preventing apoptosis of MIN6 cells by inhibiting the PERK-eIF2 alpha-ATF4-CHOP axis under ER stress conditions. This effect may be mediated by the inactivation of the JAK2/STAT3 signal pathway. Further understanding of the mechanisms behind puerarin's effects could lead to its development as a potential antidiabetic drug.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Cell Biology
Yuanyang Chen, Sihao Zheng, Zhiwei Wang, Xin Cai, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong
Summary: This study demonstrated that ART treatment prolonged the survival time of mice in the HT group, reduced inflammatory cell infiltration in heart tissue, and lowered CD4+CD8+ T cell proportions in spleen and lymph nodes. Additionally, ART treatment inhibited oxidative stress damage in heart tissue and myocardial apoptosis. In cell experiments, ART slowed down BMDC development and maturation by inhibiting endoplasmic reticulum stress-related protein expression.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiao-xuan Yu, Meng-yuan Zhu, Jia-rong Wang, Hui Li, Po Hu, Ying-jie Qing, Xiang-yuan Wang, Hong-zheng Wang, Zhan-yu Wang, Jing-yan Xu, Qing-long Guo, Hui Hui
Summary: The study shows that LW-213 effectively inhibits the growth of CTCL cells and induces apoptosis. The mechanisms involve ROS formation, calcium release, and activation of different signaling pathways.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo
Summary: The expression of ASS1 was higher in HCC spheroids than in monolayer cells, and high levels of ASS1 were associated with favorable overall survival in Korean HCC patients. Bidirectional interactions between ASS1 ER stress responses in HCC-derived spheroids limit HCC progression. Overexpression of ASS1 inhibited tumor growth and enhanced the efficacy of anti-HCC chemotherapy via activation of the PERK/eIF2 alpha/ATF4/CHOP axis, independent of p53 and arginine metabolism.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shang
Summary: In this study, iron overload induced apoptosis in osteoblasts through activating ER stress, resulting in mitochondrial dysfunction. Pretreatment with NAC or TUDC attenuated cell apoptosis and restored protein expression related to iron metabolism.
CELLULAR SIGNALLING
(2021)
Article
Immunology
Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun
Summary: Limonin mitigates DSS-induced chronic colitis by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-kappa B signaling, showing potential as an effective drug for IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Fenglei Chen, Jiarong Sun, Yujing Wang, Jason William Grunberger, Zhen Zheng, Nitish Khurana, Xianyu Xu, Xin Zhou, Hamidreza Ghandehari, Jinlong Zhang
Summary: This study reveals the mechanisms of silica nanoparticles (SNPs) inducing follicular atresia and apoptosis in granulosa cells. SNPs are found to increase calcium ion concentration in the cytoplasm and activate endoplasmic reticulum (ER) stress. The PERK-ATF4-CHOP-ERO1 alpha pathway plays an essential role in SNP-induced ovarian toxicity, leading to apoptosis via IP3R1-mediated calcium mobilization.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chan Yoon Park, Seul Ki Lee, Jimin Kim, Donguk Kim, Han Choe, Ji-Hoon Jeong, Kyung-Chul Choi, Hye Soon Park, Sung Nim Han, Yeon Jin Jang
Summary: Non-alcoholic fatty liver disease (NAFLD) is often related to obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated levels of hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have been found in NAFLD patients, and the activation of ER stress/UPR signaling seems to induce LECT2 expression, with ATF4 potentially mediating the transcriptional upregulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Saritha S. Nair, P. Prathibha, S. Syam Das, S. Kavitha, M. Indira
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Andrology
S. Syam Das, S. S. Nair, M. Indira
Article
Biochemistry & Molecular Biology
S. H. Priyanka, S. Syam Das, Saritha S. Nair, Arun A. Rauf, M. Indira
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Article
Integrative & Complementary Medicine
K. N. Mala, Jestin Thomas, Das S. Syam, Balu Maliakel, I. M. Krishnakumar
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Chemistry, Applied
E. R. Sindhu, P. P. Binitha, Saritha S. Nair, Balu Maliakel, Ramadasan Kuttan, I. M. Krishnakumar
NATURAL PRODUCT RESEARCH
(2020)
Article
Oncology
Vijayasteltar B. Liju, Angel Thomas, Syam Das Sivadasan, Ramadasan Kuttan, Balu Maliakel, I. M. Krishnakumar
Summary: The study demonstrated the positive role of the bioavailability of curcuminoids in reducing radiation-induced damages in mice, with CGM treatment showing better protective effects compared to UC, despite the lower concentrations of curcuminoids in CGM.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Integrative & Complementary Medicine
Aman Khanna, Sivadasan Syam Das, Thozhuthum Parambil Smina, Jestin V. Thomas, Ajaikumar B. Kunnumakkara, Balu Maliakel, Illathu Madhavamenon Krishnakumar, Ratheesh Mohanan
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Aman Khanna, Febi John, Syam Das, Jestin Thomas, Jyoti Rao, Balu Maliakel, Krishnakumar IM
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Neurosciences
Aman Khanna, Syam S. Das, R. Kannan, Andrew G. Swick, Cristina Matthewman, Balu Maliakel, Sibi P. Ittiyavirah, I. M. Krishnakumar
Summary: The study demonstrated that the CGM supplement improved brain waves in healthy individuals, suggesting its ability to penetrate the blood-brain barrier. The EEG results were consistent with improved audio-visual and working memory tests.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Neurosciences
Ramalingam G. Kannan, Maliakal B. Abhilash, Kumar Dinesh, Das S. Syam, Maliakel Balu, Ittiyavirah Sibi, I. M. Krishnakumar
Summary: The study found that CGM significantly increased the distribution of curcuminoids in rat brain, particularly in the hippocampus. CGM had a positive impact on brain regional pharmacokinetics and showed significant improvement in behavior compared to unformulated natural curcuminoids.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Ashil Joseph, Febi John, Jestin Thomas, Syam Das, Sivadasan, Balu Maliakel, Ratheesh Mohan, I. M. Krishnakumar
Summary: This study demonstrates the safety and tolerability of Capsifen in overweight subjects, showing significant reductions in body weight, waist-to-hip ratio, and body mass index, along with improvements in eating behavior and appetite.
JOURNAL OF DIETARY SUPPLEMENTS
(2021)
Article
Chemistry, Medicinal
Anu Sunny, Kannan Ramalingam, S. Syam Das, Balu Maliakel, I. M. Krishnakumar, Sibi Ittiyavirah
PHARMACOGNOSY MAGAZINE
(2019)
