Article
Environmental Sciences
Hsiu-Yung Pan, Fu-Jen Cheng, Kuo-Chen Huang, Chia-Te Kung, Wan-Ting Huang, Huey-Ling You, Shau-Hsuan Li, Chin-Chou Wang, Wen-Chin Lee, Ping-Chi Hsu
Summary: This study demonstrated the adverse effects of TBEP exposure on male reproductive function in rats, including abnormal sperm morphology, increased production of superoxide anion and hydrogen peroxide, as well as disruption of testicular structure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Shengwu Yuan, Mei Ma, Xiaoshan Zhu, Yingnan Han, Kaifeng Rao, Zijian Wang
Summary: This study found that TDCPP and TBOEP can cause cytotoxicity, mitochondrial impairment, and cell cycle arrest-associated DNA damage in A549 cells, with oxidative stress being the initial molecular event. Furthermore, p53 activation was shown to be involved in regulating DNA damage after exposure to these flame retardants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy
Summary: Recent reports confirm the widespread presence of TBEP, an organophosphorus flame retardant, in various waste sites and treatment facilities. This study demonstrates the hepatotoxic and carcinogenic potential of TBEP in human liver cells, highlighting its ability to induce DNA damage, cell cycle disturbances, and mitochondrial dysfunction. The findings suggest that workers handling waste and residents living near disposal areas are at risk of adverse health effects from direct or indirect ingestion of TBEP-containing dusts.
Article
Agriculture, Multidisciplinary
Zhilin He, Jinming Lin, Dong Peng, Jieyu Zeng, Xiangmin Pan, Rui Zheng, Pan Li, Bing Du
Summary: This study found that peptides derived from Sacha inchi have an anti-hepatoma effect by inducing apoptosis and arresting the cell cycle in HepG2 cells. Nine novel peptides identified in Sacha inchi exhibited higher inhibitory rates on cell proliferation. These findings suggest the potential pharmacological effects of Sacha inchi peptides in liver cancer treatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Engineering, Environmental
Yi Liang, Xiangyu Zhou, Yiding Wu, Yang Wu, Xiangying Zeng, Zhiqiang Yu, Ping'an Peng
Summary: In this study, bacterial transformation of the emerging contaminant tris(2-butoxyethyl) phosphate (TBOEP) was investigated. The enrichment culture degraded TBOEP primarily through ether bond cleavage, with other transformation pathways including terminal oxidation and hydrolysis. Metagenomic sequencing identified key degraders of TBOEP and its metabolites as Rhodocuccus ruber strain C1 and Ottowia. These findings provide a comprehensive understanding of bacterial TBOEP degradation at the community level.
Article
Biochemistry & Molecular Biology
Mohamed M. Tawfik, Nourhan Eissa, Fayez Althobaiti, Eman Fayad, Ali H. Abu Almaaty
Summary: The study demonstrated the significant cytotoxic effect of Rhopilema nomadica jellyfish venom on liver cancer cells, inducing apoptosis in hepatocellular carcinoma cells. This is the first scientific evidence of the induction of apoptosis and cell cycle arrest by Rhopilema nomadica jellyfish venom.
Article
Biochemistry & Molecular Biology
Mina Raileanu, Mihai Straticiuc, Decebal-Alexandru Iancu, Radu-Florin Andrei, Mihai Radu, Mihaela Bacalum
Summary: The increased use of proton therapy has led to the need for a better understanding of the cellular mechanisms involved. This study investigated the effects of accelerated proton beam on hep-atocarcinoma cells. The results showed that proton irradiation induced both morphological and functional changes in HepG2 cells, including alterations in mitochondrial levels and cell cycle regulation, as well as changes in nuclear and membrane structures.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Environmental Sciences
Weilai Sha, Ying Wang, Fengsen Cai, Chen Zhang, Chao Wang, Junfeng Chen, Chunchen Liu, Renjun Wang, Peike Gao
Summary: This study investigated the concentration distribution of the plastic additive TBEP in the Nanyang Lake estuary and its toxic effects on carp liver. The results showed that TBEP concentrations in the polluted water environment were high and TBEP exposure induced severe oxidative stress in carp liver tissue, resulting in the release of inflammatory factors, changes in mitochondrial structure, and the expression of apoptotic proteins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Tienthanh Nguyen, Ruiyin Guo, Jinwei Chai, Jiena Wu, Junfang Liu, Xin Chen, Mohamed A. Abdel-Rahman, Hu Xia, Xueqing Xu
Summary: Scorpion-venom-derived peptide Smp24 exhibits inhibitory effects on liver cancer cells HepG2 through endocytosis, pore formation, interaction with mitochondrial membrane, mitochondrial dysfunction, apoptosis, and alteration of autophagy-related signaling pathways. Smp24 also shows protective activity in a liver cancer mouse model.
Article
Biochemistry & Molecular Biology
Tin-Tin Win-Shwe, Rie Yanagisawa, Thet-Thet Lwin, Fumitaka Kawakami, Eiko Koike, Hirohisa Takano
Summary: This study investigated the effects of long-term exposure to TBEP on brain and behavior in mice. The results showed that TBEP exposure impaired memory function and led to changes in gene expression and inflammatory markers in the hippocampus. Furthermore, activation of mast cells and microglia was observed. These findings suggest that interactions between neurons, glia, and mast cells may play a role in TBEP-induced neurobehavioral toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Menghao Guo, Wenli Zhang, Shuyan Niu, Mengting Shang, Xiaoru Chang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: Silver nanoparticles (AgNPs) are widely used for their antibacterial properties, but their use raises health concerns. This study evaluated the toxic effects of AgNPs on liver cells and found that the human hepatoma cell line (HepG2) was more sensitive to AgNPs than normal hepatic cell line (L02), possibly due to different responses to AgNPs by cancer cells and normal cells. N-acetylcysteine (NAC) was able to inhibit the increase in apoptosis induced by AgNPs and alleviate the imbalance of antioxidant system and cell cycle arrest. The knockdown of nuclear factor erythroid-derived factor 2-related factor (Nrf2) showed that Nrf2 has a protective role in AgNPs-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Hao Xiong, Yangyang Huang, Yuchao Mao, Chunsheng Liu, Jianghua Wang
Summary: The study revealed that TBOEP can lead to decreased early developmental parameters and increased malformation rate in zebrafish larvae. Gene expression analysis showed that the Wnt signaling pathway may be a key factor influencing the developmental toxicity of TBOEP. Additionally, the research also found that TBOEP induced oxidative stress and cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Toxicology
S. H. Yu, C. M. Lee, S. H. Ha, J. Lee, K. Y. Jang, S. H. Park
Summary: Tomentosin, a sesquiterpene lactone, exhibited cytotoxic effects on human HCC cell lines HepG2 and Huh7 by inducing cell cycle arrest and apoptosis. This study suggested that Tomentosin could be a promising therapeutic option against HCC.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Environmental Sciences
Yu Shang, Qianyun Liu, Lu Wang, Xinghua Qiu, Yingjun Chen, Jing An
Summary: This study investigates the role of miR-146a-5p in regulating cytokine expression in response to PM2.5 exposure, and finds that autophagy process plays a crucial role in modulating cytokine expression and inflammatory response caused by PM2.5.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Jianzhong Song, Meiju Li, Chunlin Zou, Tao Cao, Xingjun Fan, Bin Jiang, Zhiqiang Yu, Wanglu Jia, Ping'an Peng
Summary: NOCs in HULIS are important components originating from both BB and CC, characterized by different CHON+ and CHN+ groups with distinct features and sources. The study found that biomass burning generates more NOCs with higher AImod values compared to coal combustion, indicating the potential source difference between the two combustion processes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Yong Han, Yingjun Chen, Yanli Feng, Yu Shang, Jun Li, Qing Li, Jianmin Chen
Summary: Elemental carbon (EC) from different sources contains different sub-fractions with varying properties, posing challenges for accurate EC emission inventory assessment. The emission characteristics and formation pathways of Soot-EC and Char-EC are influenced by fuel composition and combustion temperatures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Hongwei Pang, Yiqun Wang, Yang Wu, Jiazhuo He, Huifan Deng, Pan Li, Jinli Xu, Zhiqiang Yu, Sasho Gligorovski
Summary: The aqueous-phase reaction of dissolved ozone with phenolic compounds may serve as an important source of H2O2 and OH in the atmosphere, with pH-dependent yields. Lower pH conditions promote the formation of H2O2 through ring-opening mechanism, while higher pH conditions favor the ring-retaining pathways yielding OH.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Yi Liang, Han Song, Yang Wu, Shutao Gao, Xiangying Zeng, Zhiqiang Yu
Summary: The study found that triclosan concentrations in Taihu Lake were low, but the transformation products were abundant, with different transformation products showing distinct spatial distributions in the lake.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Lingling Yuan, Hongli Wang, Yaqin Gao, Guofa Ren, Yiqun Lu, Shengao Jing, Wen Tan, Liang Zhu, Yu Shang, Jing An, Cheng Huang
Summary: Monocyclic aromatic hydrocarbons (MAHs) and polycyclic aromatic hydrocarbons (PAHs) are hazardous air pollutants and important precursors of tropospheric ozone and secondary organic aerosols. This study conducted mobile measurements of aromatic hydrocarbons in eastern China, revealing their concentration variations, chemical composition, source contributions, and spatial distributions. PAHs accounted for approximately 9% of the total concentration of aromatic hydrocarbons but contributed 23% to the formation of secondary organic aerosols. Industrial processes were identified as the largest source of aromatic hydrocarbons, while coal combustion was the dominant source of PAHs in eastern China. These findings highlight the importance of reducing emissions from anthropogenic sources to mitigate health risks.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Environmental Sciences
Tan He, Yang Wu, Dian Wang, Jing Cai, Jianzhong Song, Zhiqiang Yu, Xiangying Zeng, Ping 'an Peng
Summary: This study investigated the seasonal variations of the optical and molecular properties of water-soluble BrC in Guangzhou and identified the key factors affecting its light absorption and fluorescence properties. It was found that water-soluble BrC had a stronger light absorption capacity in winter and the dominant fluorophores were humic-like components. The aromaticity and N-containing species were found to be the most important chromophores affecting the light absorption of water-soluble BrC.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Engineering, Environmental
Xiangying Zeng, Qiongpu Hu, Jiawen Zhang, Qian Song, Liang Xu, Yi Liang, Yang Wu, Zhiqiang Yu
Summary: The regional characteristics of atmospheric organophosphate triesters (OPEs) and organophosphate diesters (Di-OPs) were investigated in the Pearl River Delta (PRD) using passive air samplers. OPEs were mainly distributed in the central part of the region, possibly due to the presence of industries related to OPE-containing products. Di-OPs, on the other hand, were scattered throughout the PRD, indicating direct industrial emission from their applications. Lower levels of certain compounds were detected in summer, suggesting partitioning off particles and photo-transformation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yi Liang, Xiangyu Zhou, Yiding Wu, Yang Wu, Xiangying Zeng, Zhiqiang Yu, Ping'an Peng
Summary: In this study, bacterial transformation of the emerging contaminant tris(2-butoxyethyl) phosphate (TBOEP) was investigated. The enrichment culture degraded TBOEP primarily through ether bond cleavage, with other transformation pathways including terminal oxidation and hydrolysis. Metagenomic sequencing identified key degraders of TBOEP and its metabolites as Rhodocuccus ruber strain C1 and Ottowia. These findings provide a comprehensive understanding of bacterial TBOEP degradation at the community level.
Article
Engineering, Environmental
Fei Cheng, Jiehui Huang, Huizhen Li, Beate I. I. Escher, Yujun Tong, Maria Konig, Dali Wang, Fan Wu, Zhiqiang Yu, Bryan W. W. Brooks, Jing You
Summary: In order to improve the accuracy of mixture risk assessment, researchers propose a data-driven suspect screening and risk assessment method informed by mining big data. By collecting bioactivity concentrations from high-throughput screening platforms and exposure metadata from literature, they generated a regional distribution map of aquatic hazards. This study presents a novel big data approach for objectively selecting analytes during suspect screening to advance sustainable environmental quality.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Environmental Sciences
Jing An, Jingjing Jiang, Waner Tang, Yufang Zhong, Guofa Ren, Yu Shang, Zhiqiang Yu
Summary: This study investigates the cytotoxicity and molecular regulatory mechanisms of TPHP and its metabolites in HepG2 cells. TPHP and OH-TPHP affect lipid metabolism-related genes and signal pathways, leading to lipid metabolism disorders. Additionally, TPHP and OH-TPHP induce endoplasmic reticulum stress, resulting in cell damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Toxicology
Kunming Zhao, Ying Zhang, Mingyuan Liu, Yuecheng Huang, Siyan Wang, Jing An, Yan Wang, Yu Shang
Summary: This study investigated the neurodevelopmental toxicity induced by combined exposure of TBBPA and polystyrene NPs in C. elegans. The results showed that combined exposure had synergistic inhibitory effects on survival rate, body length/width, and locomotor ability. The overproduction of ROS, lipofuscin accumulation, and dopaminergic neuronal loss indicated the involvement of oxidative stress. The increased expressions of pink-1 and hop-1 genes played an important role in neurodevelopmental toxicity induced by TBBPA and polystyrene NPs.
TOXICOLOGY RESEARCH
(2023)
Article
Toxicology
Jing An, Yuting Yi, Jingjing Jiang, Weiwei Yao, Guofa Ren, Yu Shang
Summary: The purpose of this study was to investigate the cytotoxicity of methyl triclosan (MTCS) and explore the underlying mechanism using human hepatocyte L02 cells as an in vitro model. Results revealed that MTCS inhibited cell viability, disrupted the cellular redox balance, reduced mitochondrial membrane potential, and disturbed cellular metabolic processes. RNA-sequencing and bioinformatics analysis indicated disorder of glucose and lipid metabolism after MTCS exposure. Serine hydroxy methyltransferase 2 (SHMT2), Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), Asparagine synthetase (ASNS), and Phosphoglycerate dehydrogenase (PHGDH) were identified as potential molecular markers of metabolism imbalance induced by MTCS.
TOXICOLOGY RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Liang Li, Fan Wu, Yuanyu Cao, Fei Cheng, Dali Wang, Huizhen Li, Zhiqiang Yu, Jing You
Summary: Shale gas has the potential to complement the world's natural gas supply, but its environmental tradeoffs and sustainability need to be carefully assessed. A meta-analysis was conducted to harmonize environmental tradeoff data, and sustainable development indexes (SDIs) were analyzed and compared for shale gas exploitation in China, the United States, and the United Kingdom. The study provides insights to improve the sustainability potential of regional development and global energy supply.
ENVIRONMENTAL SCIENCE AND ECOTECHNOLOGY
(2022)
Review
Toxicology
Shahid Yousuf Ganie, Darakhshan Javaid, Younis Ahmad Hajam, Mohd Salim Reshi
Summary: Arsenic toxicity is a complex and pervasive public health problem that affects millions of people worldwide. This review aims to consolidate current knowledge on arsenic toxicity, including its sources, chemical forms, and the pathways through which it affects human health. The study found that arsenic is associated with chronic diseases such as cancer, cardiovascular disorders, and neurotoxicity, and oxidative stress, genotoxicity, and epigenetic modifications play important roles in arsenic-induced cellular damage. Further research is needed to fill gaps in our understanding of arsenic toxicity and inform public health policies aimed at minimizing exposure.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Lu Zhang, Min Li, Dalong Zhang, Shujing Zhang, Li Zhang, Xiaojun Wang, Zhiyong Qian
Summary: With the increasing incidence of neurodevelopmental disorders, it is important to screen and evaluate developmental neurotoxicity (DNT) compounds from a large number of environmental chemicals and understand their mechanisms. This study conducted a DNT qualitative structure-activity relationship (QSAR) study for the first time, and preliminarily illustrated the structural characterization of DNT compounds. Multiple models and methods were used to construct prediction models, resulting in the best model with good predictive ability. By combining different models, both MCC values and application domain values were improved. Additionally, through modeling descriptors analysis and structure alerts (SAs) identification, electronical properties, van der Waals volume-related properties, and S, Cl or P containing substructure were found to be associated with DNT. This study lays a foundation for further DNT prediction of environmental exposures in human and contributes to the understanding of DNT mechanism.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Khushboo Sharma, Satish Koundal, Mandeep Singh, Pooja Chadha, Harvinder Singh Saini
Summary: The unregulated discharge of untreated or partially treated industrial wastewater poses a serious threat to aquatic ecosystems. This study exposed Channa punctata fish to untreated and microbially treated textile industry effluent to analyze their toxicity effects. The results showed that the untreated effluent group had more severe hematological, biochemical, histopathological, and ultrastructural alterations compared to the microbially treated group. This highlights the importance of finding more effective microbial treatments to protect aquatic life and human health.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Chen Gu, Yan Sun, Meiqi Mao, Jinguo Liu, Xiongyao Li, Xiaoping Zhang
Summary: This study investigated the mechanism of lunar dust simulant (CLDS-i) in inducing inflammatory lung injury. The results showed that CLDS-i regulated immune inflammatory cells and activated signaling pathways related to inflammatory diseases, promoting the occurrence and development of inflammatory injury. The study also found that amino acid metabolism imbalance might be related to the activation of the NF-kappa B signaling pathway.
TOXICOLOGY RESEARCH
(2024)
