Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine

3D-Printed Microfluidics

(2016) Anthony K. Au et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance

(2016) Ariel Ionescu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome

(2016) G. E. Rooney et al.   JOURNAL OF NEUROSCIENCE

3D printed nervous system on a chip

(2016) Blake N. Johnson et al.   LAB ON A CHIP

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells

(2016) Qi Gu et al.   Advanced Healthcare Materials

3D Printed Anatomical Nerve Regeneration Pathways

(2015) Blake N. Johnson et al.   ADVANCED FUNCTIONAL MATERIALS

3D printing of layered brain-like structures using peptide modified gellan gum substrates

(2015) Rodrigo Lozano et al.   BIOMATERIALS

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions

(2015) E. E. Zahavi et al.   JOURNAL OF CELL SCIENCE

Microengineered peripheral nerve-on-a-chip for preclinical physiological testing

(2015) Renee M. Huval et al.   LAB ON A CHIP

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

Engineering-Aligned 3D Neural Circuit in Microfluidic Device

(2015) Seokyoung Bang et al.   Advanced Healthcare Materials

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain

(2014) Vincent Y. Ma et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Biological and medical applications of a brain-on-a-chip

(2014) David Pamies et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Minimum conditions for the induction of cortical spreading depression in brain slices

(2014) Yujie T. Tang et al.   JOURNAL OF NEUROPHYSIOLOGY

A two-compartment organotypic model of mammalian peripheral nerve repair

(2014) Rezina Siddique et al.   JOURNAL OF NEUROSCIENCE METHODS

A microfluidic based in vitro model of synaptic competition

(2014) Ainsley Coquinco et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons

(2014) Xi Lu et al.   Molecular Neurodegeneration

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Block-Cell-Printing for live single-cell printing

(2014) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered functional brain-like cortical tissue

(2014) M. D. Tang-Schomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensory axon guidance with semaphorin 6A and nerve growth factor in a biomimetic choice point model

(2014) J Lowry Curley et al.   Biofabrication

Engineering a functional neuro-muscular junction model in a chip

(2014) Ziqiu Tong et al.   RSC Advances

Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix

(2014) Yoojin Shin et al.   Advanced Healthcare Materials

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Size-controllable networked neurospheres as a 3D neuronal tissue model for Alzheimer's disease studies

(2013) Yoon Jung Choi et al.   BIOMATERIALS

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D

(2013) Jennifer Laurent et al.   BMC CANCER

Efficient Retrograde Transport of Pseudorabies Virus within Neurons Requires Local Protein Synthesis in Axons

(2013) Orkide O. Koyuncu et al.   Cell Host & Microbe

Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration

(2013) Kwang Ho Lee et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Microfluidic primary culture model of the lower motor neuron–neuromuscular junction circuit

(2013) Katherine A. Southam et al.   JOURNAL OF NEUROSCIENCE METHODS

Selective pharmacological manipulation of cortical–thalamic co-cultures in a dual-compartment device

(2013) Thirukumaran T. Kanagasabapathi et al.   JOURNAL OF NEUROSCIENCE METHODS

A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments

(2013) Jaewon Park et al.   JOURNAL OF NEUROSCIENCE METHODS

Control of neural network patterning using collagen gel photothermal etching

(2013) Aoi Odawara et al.   LAB ON A CHIP

Formation of microvascular networks in vitro

(2013) John P Morgan et al.   Nature Protocols

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios

(2012) Fabio Bianco et al.   ANALYTICAL CHEMISTRY

Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model

(2012) Katherine A Hosie et al.   ASN Neuro

Structural and molecular micropatterning of dual hydrogel constructs for neural growth models using photochemical strategies

(2012) Elaine L. Horn-Ranney et al.   BIOMEDICAL MICRODEVICES

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Functional connectivity and dynamics of cortical–thalamic networks co-cultured in a dual compartment device

(2012) Thirukumaran T Kanagasabapathi et al.   Journal of Neural Engineering

A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons

(2012) Xi Lu et al.   JOURNAL OF NEUROSCIENCE METHODS

Multi-compartment neuron–glia co-culture platform for localized CNS axon–glia interaction study

(2012) Jaewon Park et al.   LAB ON A CHIP

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices

(2012) Philip J. Kitson et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Microfluidic Chips for In Vivo Imaging of Cellular Responses to Neural Injury in Drosophila Larvae

(2012) Mostafa Ghannad-Rezaie et al.   PLoS One

Alphaherpesvirus axon-to-cell spread involves limited virion transmission

(2012) M. P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-pathological connected primary neurons in a microfluidic device for alzheimer studies

(2011) Anja Kunze et al.   BIOTECHNOLOGY AND BIOENGINEERING

FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy

(2011) S. Kehoe et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

Psychiatric and neurologic aspects of war: an overview and perspective

(2010) JoAnn Difede et al.   Annals of the New York Academy of Sciences

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

Building and manipulating neural pathways with microfluidics

(2010) Yevgeny Berdichevsky et al.   LAB ON A CHIP

Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices

(2010) Larry J. Millet et al.   LAB ON A CHIP

Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses

(2010) Anne M. Taylor et al.   NEURON

The Path to Personalized Medicine

(2010) Margaret A. Hamburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanowire transistor arrays for mapping neural circuits in acute brain slices

(2010) Q. Qing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

3D printing based on imaging data: review of medical applications

(2010) F. Rengier et al.   International Journal of Computer Assisted Radiology and Surgery

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates

(2009) Gregory J. Brewer et al.   JOURNAL OF NEUROSCIENCE METHODS

Three-dimensional micro-electrode array for recording dissociated neuronal cultures

(2009) Katherine Musick et al.   LAB ON A CHIP

Chamber and microfluidic probe for microperfusion of organotypic brain slices

(2009) Arthur Queval et al.   LAB ON A CHIP

Differentiation of Neural Progenitor Cells in a Microfluidic Chip-Generated Cytokine Gradient

(2009) Joong Yull Park et al.   STEM CELLS

Modeling the Nonlinear Properties of the in vitro Hippocampal Perforant Path-Dentate System Using Multielectrode Array Technology

(2008) A. Dimoka et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Three-dimensional neural constructs: a novel platform for neurophysiological investigation

(2008) Hillary R Irons et al.   Journal of Neural Engineering

Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture

(2008) Bradley J. Dworak et al.   LAB ON A CHIP

The coming acceleration of global population ageing

(2008) Wolfgang Lutz et al.   NATURE

Causal Measures of Structure and Plasticity in Simulated and Living Neural Networks

(2008) Alex J. Cadotte et al.   PLoS One