Article
Geriatrics & Gerontology
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen, Kevin D. Laugero
Summary: The study examined the relationship between cumulative physiological stress and lymphocyte changes associated with aging. The results showed that physiological stress load increased with age and was negatively correlated with the frequency of regulatory T lymphocytes. The findings suggest that physiological stress load may affect the frequencies of Treg cells in younger individuals, leading to levels similar to those seen in older adults.
Article
Cell Biology
Qingle Ma, Chenhui Weng, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang
Summary: Severe pneumonia may lead to long-term effects including sequelae and accelerated aging, but the mechanism is not well understood and requires further research. This study found that mice recovered from severe pneumonia exhibited lung immunosenescence, characterized by an imbalanced naive-memory ratio of T lymphocytes in the lung. The reduction of naive T cells is associated with decreased immune response and is a key change in the aging process. The results also suggest a link between severe pneumonia and the aging process, mediated by disrupted T cell homeostasis in the lungs following pneumonia.
Article
Geriatrics & Gerontology
Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han, Hui Zeng
Summary: Circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
Review
Immunology
Gonzalo Soto-Heredero, Manuel M. Gomez De las Heras, J. Ignacio Escrig-Larena, Maria Mittelbrunn
Summary: There are significant changes in the T cell compartment during aging, including the reduction of naive T cells and the accumulation of memory-like T cells. Memory-like T cells in older individuals exhibit characteristics of terminally differentiated and senescent cells. This review focuses on different subsets of age-associated T cells, such as highly cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells with proinflammatory features. Importantly, these subsets lose their ability to home to lymph nodes and preferentially migrate to nonlymphoid tissues, contributing to tissue deterioration and inflammaging.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Alan Bruno Silva Vasconcelos, Jose Carlos Aragao-Santos, Antonio Gomes de Resende-Neto, Lorranny Santana Rodrigues, Cristiane Bani Correa, Dulce Marta Schimieguel, Enilton Aparecido Camargo, Solange de Paula Ramos, Marzo Edir Da Silva-Grigoletto
Summary: This study investigated the effects of functional and combined training on memory T cells and functional fitness of postmenopausal women. The results showed that both training protocols reduced the percentage of certain memory T cells, increased the percentage of different types of T cells, and improved functional fitness.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cell Biology
Takuya Asami, Katsunori Endo, Rina Matsui, Toko Sawa, Yuna Tanaka, Takeru Saiki, Naotaka Tanba, Hadsuki Haga, Sachi Tanaka
Summary: The study found that long-term caloric restriction can help reduce age-related decline in immune system function, including improving the frequency of spleen NK cells, NKT cells, as well as naïve CD4(+) and CD8(+) T cells, and suppressing the upregulation of T cell exhaustion markers.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Geriatrics & Gerontology
Heqiang Sun, Xia Kang, Xingchi Chen, Lili Cai, Yuru Li, Jihong Yu, Chao Wu, Xinli Deng
Summary: Immunosenescence is characterized by a decline in immune system function with age. A study involving 957 healthy donors aged 20-95 found that T cells, CD4 T cells, and B cells decreased while NK cells increased in elderly individuals. Additionally, the study suggested that older individuals may have stronger inhibition with more regulatory CD4 T cells.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nana Makiuchi, Shun Takano, Yuki Tada, Kaichi Kasai, Naoya Igarashi, Koudai Kani, Miyuna Kato, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, Yukihiro Furusawa, Koichi Tsuneyama, Yoshinori Nagai
Summary: Macrophages play a critical role in the development of NASH, and the accumulation of different subsets of macrophages in the liver is influenced by the composition of the diet and the strain of mice.
Article
Immunology
Qin Feng, Wenkai Xia, Guoxin Dai, Jingang Lv, Jian Yang, Deshan Liu, Guimin Zhang
Summary: The problem of aging is characterized by an increase in age-related diseases, longer hospitalization, and worse prognosis for elderly patients. This study investigated the relationship between thyrotoxicosis and aging in mice, and found that immunosenescence and homeostasis disturbance played important roles in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Martina Formentini, Ana Navas, Fakhri Hassouneh, Nelson Lopez-Sejas, Corona Alonso, Raquel Tarazona, Rafael Solana, Alejandra Pera
Summary: Immunosenescence affects innate and adaptive immunity, with chronic CMV infection contributing to early immunosenescence. The markers CD57, CD300a, and CD161 define distinct T-cell subsets, showing varied functionality and molecular signatures. Different T-cell populations based on these markers have implications for disease risk in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Dhara Patel, Tae Jin Lee, Sandeep Kumar, Sagar Vyavahare, Alison Worth, William D. Hill, Mark Hamrick, Carlos M. Isales, Rahul S. Shinde, Sadanand Fulzele
Summary: Understanding the pathophysiology of age-related diseases is crucial as the elderly population grows. Metabolic changes play an important role in age-related degeneration, affecting musculoskeletal health. Gender-specific differences in metabolic signaling pathways may contribute to the manifestation of musculoskeletal diseases in males and females.
Article
Immunology
William Stohl, Ning Yu, Ying Wu
Summary: The interactions between TACI and/or BCMA and BAFF may modulate the expression of B cell subsets and Foxp3+ cells, which could help explain the contradictory observations of autoimmunity and autoimmune disease in mice without functional engagement of BR3 by BAFF.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Hongyan Xie, Shihao Xie, Mei Wang, Haixia Wei, He Huang, Anqi Xie, Jiajie Li, Chao Fang, Feihu Shi, Quan Yang, Yanwei Qi, Zhinan Yin, Xinhua Wang, Jun Huang
Summary: This study explores the role of gamma delta T cells in malaria infection and finds that these cells can promote both cellular and humoral immune responses. Using single-cell RNA sequencing, the study reveals the diversity of gamma delta T cells in the spleen. Additionally, the depletion of gamma delta T cells has a negative impact on the immune response in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Kyeong Jin Yoon, Aram Ahn, Soo Hong Park, Seung Hee Kwak, Seong Eun Kwak, Wonsang Lee, Yong Ryoul Yang, Minji Kim, Hyun Mu Shin, Hang-Rae Kim, Hyo Youl Moon
Summary: This study confirmed that 4 weeks of treadmill exercise can significantly improve metabolic function in aged mice, including increased lean mass and decreased fat mass, while decreasing the expression level of the senescence marker p16 in white adipose tissue. Exercise also induced changes in immune-cell subsets in the stromal vascular fraction of WAT, as well as activating pathways involved in the interaction between WAT and immune cells, particularly NK cells, in aged mice. These results suggest that exercise has a profound effect on immune-cell distribution and senescent-cell scavenging in WAT of aged mice, ultimately affecting overall energy metabolism towards a more youthful state.