Review
Psychiatry
Amber N. Edinoff, Tanner L. Hegefeld, Murray Petersen, James C. Patterson, Christopher Yossi, Jacob Slizewski, Ashley Osumi, Elyse M. Cornett, Adam Kaye, Jessica S. Kaye, Vijayakumar Javalkar, Omar Viswanath, Ivan Urits, Alan D. Kaye
Summary: Post-traumatic stress disorder (PTSD) affects three functional networks in the brain and Transcranial Magnetic Stimulation (TMS) is used to treat this condition. High-frequency stimulation has shown better efficacy than low-frequency stimulation posttreatment, and the most common side effect is headache and scalp pain.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Behavioral Sciences
Lisa-Dounia Soncin, Aileen McGonigal, Iliana Kotwas, Sara Belquaid, Bernard Giusiano, Sylvane Faure, Fabrice Bartolomei
Summary: This study suggests that patients with epilepsy have a higher prevalence of self-reported PTSD symptoms, with a significantly more severe presentation compared to controls. Patients with epilepsy are more likely to have been exposed to traumatic events and suffer from PTSD, especially those who experienced PTSD symptoms concurrently with the onset of epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Lukasz Szeleszczuk, Dawid Fraczkowski
Summary: Propranolol, a non-selective beta blocker, is commonly used in the treatment of cardiovascular diseases and has potential applications in treating mental disorders such as stage fright and post-traumatic stress disorder (PTSD). This review provides information on its mechanisms of action, comparisons with other therapies, and aims to assist in decision-making regarding the use of propranolol for these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Dijana Lucijanic, Alma Mihaljevic Peles, Nevenka Piskac Zivkovic, Marko Lucijanic, Matija Kranjcevic, Lana Muzinic Marinic
Summary: This study investigated the relationship between depressive, anxiety, stress, and PTSD symptoms and disease severity in acutely ill hospitalized COVID-19 patients. The results showed a high prevalence of these psychiatric symptoms, especially in females. Additionally, the severity of COVID-19 symptoms and oxygen requirement were associated with the occurrence of depressive symptoms.
BEHAVIORAL SCIENCES
(2023)
Article
Psychiatry
Claudia Carmassi, Annalisa Cordone, Carlo Antonio Bertelloni, Andrea Cappelli, Virginia Pedrinelli, Gaia Sampogna, Gabriele Massimetti, Valerio Dell'Oste, Liliana Dell'Osso
Summary: This study aimed to investigate the effects of the COVID-19 emergency on the clinical course of BD patients. The results revealed three distinct symptom trajectories in this population, including the Acute reaction group, the Increasing severity group, and the Low symptoms group. Females had a higher prevalence in the Acute reaction group, while the Increasing severity group had higher rates of previous hospitalization and manic symptoms at baseline.
EUROPEAN PSYCHIATRY
(2022)
Article
Clinical Neurology
Flavia Ismael, Joao C. S. Bizario, Tatiane Battagin, Beatriz Zaramella, Fabio E. Leal, Julio Torales, Antonio Ventriglio, Megan E. Marziali, Silvia S. Martins, Joao M. Castaldelli-Maia
Summary: It remains unclear whether COVID-19 is associated with psychiatric symptoms during or after the acute illness phase. This prospective cohort study found that an increased number of COVID-19 symptoms was associated with clinically significant levels of depressive, anxiety, and post-traumatic stress symptoms approximately two months later. Patients should be monitored for the development of psychiatric symptoms after COVID-19 treatment discharge, and early interventions could benefit these individuals.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Lei Yi, Yunling Lian, Ning Ma, Ni Duan
Summary: This study found that yoga intervention can alleviate anxiety and depression, and improve symptoms for women with PTSD who are survivors of motor vehicle accidents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Hakan Ashina, Haidar Muhsen Al-Khazali, Afrim Iljazi, Sait Ashina, Faisal Mohammad Amin, Richard B. Lipton, Henrik Winther Schytz
Summary: The study found that patients with persistent PTH have higher rates of poor sleep quality, anxiety, and depression compared to healthy controls. Some patients also exhibited mild cognitive impairment and probable PTSD.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Psychiatry
Hong Wang Fung, Wai Tong Chien, Stanley Kam Ki Lam, Colin A. Ross
Summary: This study examined the prevalence and correlates of ICD-11 PTSD and CPTSD in individuals with depression. The results showed that individuals with CPTSD had experienced more types of trauma and had higher levels of interpersonal stress, as well as more severe mental health problems. Only disturbances in self-organization (DSO) symptoms were significantly related to depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
David Feely, Brian Slattery, Thomas Walsh, Trish Galvin, Kate Donlon, Michelle Hanlon, Darina Gormley, Gwen-Marie Brown, Sarah Quinn, Stephanie Robinson, Conor Judge, Martin O'Donnell, Kiran Sarma, Brian E. Mcguire
Summary: This study suggests that acute stress symptoms shortly after stroke may predict the development of post-traumatic stress disorder in the future. Early assessment and identification of acute stress symptoms in stroke survivors is crucial in identifying those at risk for PTSD.
Article
Clinical Neurology
Yue Zhu, Lihua Zhang, Xia Zhou, Chenxiang Li, Dong Yang
Summary: Social distancing during COVID-19 may lead to feelings of alienation, which can impact mental health. This study examined the relationship between negative emotions and PTSD, with the mediation effect of alienation and moderation by anxiety. Results showed that negative emotions and alienation predict PTSD symptoms, and their effects are moderated by anxiety levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Jette Borawski, Marietta Papadatou-Pastou, Julian Packheiser, Sebastian Ocklenburg
Summary: The aim of this meta-analysis was to examine handedness in post-traumatic stress disorder. A total of 14 studies were included, with a sample size of 2939 participants. The results showed higher frequencies of non-right-handedness and mixed-handedness in PTSD patients compared to controls. No significant difference was found for left-handedness.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Ju-Yeon Lee, Seon-Young Kim, Jae-Min Kim, Il-Seon Shin, Sung-Wan Kim
Summary: This study found that around 16% of community residents affected by disasters suffered from acute, delayed, or chronic PTSD, with anxiety and depression symptoms closely associated with PTSD. Financial losses and witnessing rescue actions were linked to chronic PTSD in community residents post-disaster.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Alysha-leigh Fameli, Daniel S. J. Costa, Rebecca Coddington, David J. Hawes
Summary: This study examined the psychometric properties of the City Birth Trauma Scale (BiTS) in the Australian population. The results showed that the BiTS is a valid and reliable self-report measure of postpartum PTSD, suitable for use in postpartum populations. Total scores and subscale scores can be used for clinical and research purposes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Donncha S. Mullin, Alastair Cockburn, Miles Welstead, Michelle Luciano, Tom C. Russ, Graciela Muniz-Terrera
Summary: This study aimed to validate the predictive role of motoric cognitive risk (MCR) syndrome on the incidence of dementia and other major causes of morbidity in older adults. The findings showed that individuals with MCR were at an increased risk of cognitive impairment, dementia, falls, and mortality.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Miles Welstead, Michelle Luciano, Tom C. Russ, Graciela Muniz-Terrera
Summary: This study identified heterogeneous trajectories of frailty progression among older adults over a 12-year period, with three distinct subgroups showing different rates of frailty increase. Factors such as age, education level, childhood cognitive ability, and social class were found to be associated with membership in these subgroups, with implications for targeted interventions to reduce the risk of high frailty trajectories. Further research is needed to explore additional risk and protective factors and assess the possibility of shifting individuals to less detrimental frailty trajectories.
Article
Geriatrics & Gerontology
Stina Saunders, Craig W. Ritchie, Tom C. Russ, Graciela Muniz-Terrera, Richard Milne
Summary: This study aims to explore clinicians' views on the assessment and communication of MCI in memory clinics. Initial results show that most clinicians consider MCI to have limitations as a diagnostic term and report using the term MCI. There is a lack of specific and sensitive assessment methods for identifying the etiology of MCI in clinical practice.
Article
Neurosciences
Anna J. Stevenson, Daniel L. McCartney, Danni A. Gadd, Gemma Shireby, Robert F. Hillary, Declan King, Makis Tzioras, Nicola Wrobel, Sarah McCafferty, Lee Murphy, Barry W. McColl, Paul Redmond, Adele M. Taylor, Sarah E. Harris, Tom C. Russ, Andrew M. McIntosh, Jonathan Mill, Colin Smith, Ian J. Deary, Simon R. Cox, Riccardo E. Marioni, Tara L. Spires-Jones
Summary: The study found differences between blood-based inflammation and ageing-related DNA methylation patterns and brain-based patterns, depending on the evaluated regions. The highest epigenetic age acceleration was observed in the hippocampus, while inflammation-related DNA methylation signatures did not vary significantly across brain regions. Reactive microglial burdens were highest in the hippocampus, but the only association between blood- and brain-based methylation signatures and microglia was a significant positive association with acceleration of one epigenetic clock averaged over all five brain regions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Correction
Geriatrics & Gerontology
Stina Saunders, Craig W. Ritchie, Tom C. Russ, Graciela Muniz-Terrera, Richard Milne
Article
Environmental Sciences
Lucy Johnston, Heidi Koikkalainen, Lynda Anderson, Paul Lapok, Alistair Lawson, Susan D. Shenkin
Summary: The care home sector has great potential in developing digital solutions to improve the experiences of residents, their families, and the staff. However, there are barriers such as internet connectivity, digital data collection, data access, and trust in data usage that need to be addressed for widespread adoption of these solutions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Gergo Baranyi, Ian J. Deary, Daniel L. McCartney, Sarah E. Harris, Niamh Shortt, Stefan Reis, Tom C. Russ, Catharine Ward Thompson, Massimo Vieno, Simon R. Cox, Jamie Pearce
Summary: Exposure to air pollution, especially during birth and young-to-middle adulthood, is associated with biological ageing. Males with longer exposure to air pollution are more likely to have shorter DNAmTL, while females are more likely to have shorter DNAmTL.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Ben Carter, Victoria L. Keevil, Atul Anand, Christopher N. Osuafor, Robert J. B. Goudie, Jacobus Preller, Matthew Lowry, Sarah Clunie, Susan D. Shenkin, Kathryn McCarthy, Jonathan Hewitt, Terence J. Quinn
Summary: This study compared the prognostic utility of two frailty assessment methods (modified Frailty Index [mFI], Clinical Frailty Scale [CFS]) in predicting mortality among older adults hospitalized with COVID-19. The results demonstrated that CFS had superior prognostic value compared to mFI in predicting mortality following COVID-19.
Article
Geriatrics & Gerontology
Una Clancy, Ratko Radakovic, Fergus Doubal, Maria del C. Valdes Hernandez, Susana Munoz Maniega, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Tom C. Russ, Simon R. Cox, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Summary: This study aimed to identify the association between apathy, depression, anxiety, and subjective memory complaints with longitudinal white matter hyperintensity (WMH) progression. The study found that apathy symptoms were associated with an increase in WMH, while depression, anxiety, and subjective memory complaints were not.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Danielle Leighton, Morad Ansari, Judith Newton, David Parry, Elaine Cleary, Shuna Colville, Laura Stephenson, Juan Larraz, Micheala Johnson, Emily Beswick, Michael Wong, Jenna Gregory, Javier Carod Artal, Richard Davenport, Callum Duncan, Ian Morrison, Colin Smith, Robert Swingler, Ian Deary, Mary Porteous, Timothy Aitman, Siddharthan Chandran, George Gorrie, Suvankar Pal, Carolyn Lothian Birth Cohorts Grp, CARE-MND Consortium
Summary: This study investigated the phenotypes and genotypes of a cohort of long-surviving individuals with motor neuron disease (MND). The findings suggest that long survivors are characterized by younger age at onset, increased prevalence of primary lateral sclerosis (PLS), and longer diagnostic delay. Genetic analysis revealed potentially pathogenic variants in several MND-associated genes.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janie Corley, Federica Conte, Sarah E. E. Harris, Adele M. M. Taylor, Paul Redmond, Tom C. C. Russ, Ian J. J. Deary, Simon R. R. Cox
Summary: Understanding why some people experience greater cognitive decline than others is a major challenge in the field of cognitive ageing research. A study conducted on a group of 1091 men and women from the longitudinal Lothian Birth Cohort 1936 revealed that addressing multiple risk factors throughout a person's life may be the most effective strategy. The study also found that APOE e4 carrier status is an important factor in identifying individuals at higher risk for accelerated cognitive ageing.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Psychoanalysis
Naomi Entwistle, Adam Polnay, Tom C. Russ
Summary: This study evaluated the service use of 268 patients before and after contact with an NHS psychodynamic psychotherapy department. The results showed that a full course of psychotherapy was associated with a significant reduction in outpatient and medical service contacts for patients who regularly used services at baseline.
PSYCHOANALYTIC PSYCHOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Jure Mur, Riccardo E. Marioni, Tom C. Russ, Graciela Muniz-Terrera, Simon R. Cox
Summary: The aim of this study is to estimate the association between anticholinergic burden, general cognitive ability, and various measures of brain structural MRI. The study found a modest association between anticholinergic burden and poorer cognition, but no association with brain structure.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Ashleigh C. Duthie, Jean Hannah, G. David Batty, Ian J. Deary, John M. Starr, Daniel J. Smith, Tom C. Russ
Summary: This study investigated the association between lithium levels in drinking water and the rate of dementia using data from the Scottish Mental Survey 1932. The results showed that lithium levels in drinking water are very low in Scotland, and extremely low levels of lithium are not associated with an increased risk of dementia. However, there was a slight trend towards increased risk in females at lithium levels below 2.1 mu g/L.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Geriatrics & Gerontology
Pinar Soysal, Nicola Veronese, Lee Smith, Yaohua Chen, Burcu Akpinar Soylemez, Alessandra Coin, Dorota Religa, Tarja Valimaki, Mariana Alves, Susan D. Shenkin
Summary: This systematic review investigated the effects of the COVID-19 lockdown on the psychological well-being of caregivers of people with dementia or mild cognitive impairment (PwD/MCI). The findings showed that there was an increase in depression, anxiety, caregiver burden, and distress in caregivers of PwD/MCI during the lockdown in the COVID pandemic. This could have longer term consequences and highlights the importance of assessing and supporting caregivers' psychological well-being.