Review
Oncology
Melina de Moraes Santos Oliveira, Carla de Moraes Salgado, Lais Rosa Viana, Maria Cristina Cintra Gomes-Marcondes
Summary: This review highlights the importance of studying cancer during pregnancy and the role of leucine in improving placenta metabolism. It emphasizes the significance of researching the prognosis of mother and fetus in cases of cancer during pregnancy, as well as the similarities between trophoblastic and neoplastic cells and their implications for new research areas.
Review
Multidisciplinary Sciences
Jean-Laurent Casanova, Laurent Abel
Summary: Disease and inflammation are rare outcomes of viral infection in humans, often due to a failure in cell-intrinsic and leukocytic immunity to viruses. Inflammation indicates the efforts of newly recruited and activated leukocytes to resolve infection. Genetic studies can help clarify the underlying causes of inflammation and disease in viral infections.
Review
Cell Biology
Bum-Kyu Lee, Jonghwan Kim
Summary: Understanding the molecular mechanisms of early human placenta development is crucial for maternal and fetal health. Recent advancements in human trophoblast models offer new opportunities, but the application of high-throughput omics tools in this field remains limited. Integration of omics approaches with human in vitro model systems has the potential to enhance our understanding of placental development and associated complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chunmei Cai, Yan-Dong Tang, Guocai Xu, Chunfu Zheng
Summary: Viral infections pose a severe threat to humans, and understanding how the host immune system responds to viral infections has become increasingly important. Gene detection and intracellular sensing can induce immune responses to limit viral infections. The overlap between RNA- and DNA-sensing mechanisms enhances antiviral responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Emily Xu, W. Mark Saltzman, Alexandra S. Piotrowski-Daspit
Summary: Non-viral vehicles show promise in delivering various cargos, but face challenges like endolysosomal degradation at the cellular level. Understanding factors contributing to intracellular trafficking, especially endosomal escape, is crucial for improving delivery efficiency. Strategies informed by mechanistic studies are essential for designing effective delivery vehicles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Takako Tabata, Matthew Petitt, Julia Li, Xiaoyuan Chi, Wei Chen, Irina Yurgelonis, Sabine Wellnitz, Simon Bredl, Tiago Vicente, Xinzhen Yang, Philip R. Dormitzer, Lenore Pereira
Summary: Human cytomegalovirus (HCMV), the leading viral cause of congenital disease and permanent birth defects, could potentially be prevented by a prophylactic vaccine targeting the pentameric complex and gB, as they elicit neutralizing antibodies.
Review
Dermatology
Paulo F. L. da Silva, Bjoern Schumacher
Summary: Aging is characterized by progressive functional decline and increased mortality, driven by cellular damage accumulation, low-grade inflammation, and disrupted intercellular communication and homeostasis. This process is influenced by epigenetic changes, gene expression dysregulation, and altered endocrine signaling, making age the main risk factor for age-associated diseases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jaskaren Kohli, Iris Veenstra, Marco Demaria
Summary: Cellular senescence is a stable cell cycle arrest associated with macromolecular alterations and inflammation, which play important roles in controlling viral spread and activating immune responses. However, excessive and aberrant senescent cells can lead to pathology and dysfunction. Pharmacological interventions, including antiviral therapies, can induce premature senescence and have detrimental effects if not controlled properly.
Review
Cell Biology
Raphael Gaudin, Jacky G. Goetz
Summary: The dissemination and replication of viruses within hosts is a complex multistep process where viruses can reach tissues distant from their point of entry by subverting subcellular mechanisms. Modeling these steps in appropriate resolution and within animal models is challenging, and mimicking them in vitro fails to replicate the complexity of the cellular ecosystem. The zebrafish model provides a transparent window to study new cellular mechanisms of viral dissemination in vivo.
TRENDS IN CELL BIOLOGY
(2021)
Review
Hematology
Alexis L. Caulier, Vijay G. Sankaran
Summary: This article provides an overview of the complex process of erythropoiesis and the various mechanisms of regulation involved. It highlights the importance of both extrinsic and intrinsic regulation, as well as posttranscriptional regulation and gatekeeping mechanisms. The article also discusses the insights gained from studying genetic variation and the discovery of BCL11A as a regulator of hemoglobin switching. It concludes by discussing the potential for therapeutic modulation of erythropoiesis.
Article
Biochemistry & Molecular Biology
Veronica Zaga-Clavellina, Lorenza Diaz, Andrea Olmos-Ortiz, Marisol Godinez-Rubi, Argelia E. Rojas-Mayorquin, Daniel Ortuno-Sahagun
Summary: During pregnancy, an immunological dialogue is established between maternal immune cells and trophoblasts to protect the fetus from rejection. The maternal-placental-fetal interface plays a crucial role in this defense. Research focuses on viral infections affecting the placenta and trophoblasts, along with their defensive mechanisms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Igor P. Shilovskiy, Kirill V. Yumashev, Alexandr A. Nikolsky, Liudmila I. Vishnyakova, Musa R. Khaitov
Summary: RSV causes severe lower respiratory tract pathology in infants, immunocompromised individuals, and the elderly. Despite the lack of a licensed vaccine, research using mouse models has provided valuable insights into the molecular and cellular mechanisms of RSV infection pathology.
BIOCHEMISTRY-MOSCOW
(2021)
Review
Virology
Krishneel Singh, Stuart T. Hamilton, Antonia W. Shand, Natalie J. Hannan, William D. Rawlinson
Summary: Cellular receptors in human cytomegalovirus (HCMV) transmission play a crucial role in congenital infection, with placental trophoblast cells expressing various receptors for HCMV entry. This review summarizes the different HCMV receptors expressed in placental cells and their role in viral entry and tropism.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Review
Chemistry, Multidisciplinary
John Jairo Aguilera-Correa, Jaime Esteban, Maria Vallet-Regi
Summary: Infectious diseases rank third in the top 10 causes of death worldwide, accounting for over 6.7 million deaths in 2016. Nanomedicine, which uses nanotechnology for medical purposes, involves the use of nanoparticles for diagnosing, monitoring, controlling, preventing, and treating diseases, including infectious ones. Nanoparticles, with their highly tunable physical and optical properties, are widely used in nanomedicine for preventing and treating human infectious diseases caused by various viruses and bacteria.
Review
Medicine, General & Internal
Brahim Tighilet, Christian Chabbert
Summary: While age-related auditory deficits and cochlear alterations are well described, research on the vestibular system's aging process and related deficits is lacking. This review examines the cellular and molecular changes occurring in the peripheral and central vestibular system during aging and explores their impact on age-related vestibular deficits.
JOURNAL OF CLINICAL MEDICINE
(2023)