期刊
PATHOGENS AND DISEASE
卷 75, 期 2, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftx023
关键词
Neisseria meningitidis; blood-cerebrospinal fluid barrier; surface adhesins and invasins; signal-transduction mechanisms; ceramide
资金
- DFG [SCHU2394/2-1, SCHU2394/2-2, SCHU2394/3-1]
Neisseria meningitidis is one of the most common aetiological agents of bacterial meningitis, affecting predominantly children and young adults. The interaction of N. meningitidis with human endothelial cells lining blood vessels of the blood-cerebrospinal fluid barrier (B-CSFB) is critical for meningitis development. In recent decades, there has been a significant increase in understanding of the molecular mechanisms involved in the interaction of N. meningitidis with brain vascular cells. In this review, we will describe how N. meningitidis adheres to the brain vasculature, may enter inside these cells, hijack receptor signalling pathways and alter host-cell responses in order to traverse the B-CSFB.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据