Article
Chemistry, Multidisciplinary
Jacopo Oieni, Andrea Lolli, Domenico D'Atri, Nicole Kops, Avner Yayon, Gerjo J. V. M. van Osch, Marcelle Machluf
Summary: The study investigates the use of novel biomimetic nano-vesicles, Nano-Ghosts (NGs), for delivering ASOs to human mesenchymal stem cells (MSCs) and demonstrates their ability to effectively encapsulate and deliver miR-221 inhibitor, resulting in strong knock-down of miR-221 in vitro and in vivo. This approach expands the potential of NGs applications in drug delivery and regenerative medicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Lili Ren, Lirong Qiu, Binbin Huang, Jun Yin, Yaning Li, Xiaolong Yang, Guoguang Chen
Summary: The simple and functional modification of nanoparticle surfaces is used for efficient delivery of chemotherapeutic drugs for cancer treatment. Constructing a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes shows superior properties compared to traditional free drug treatments, providing a promising foundation for further development and clinical trials of anti-cancer drug nanocarriers in the future.
Article
Biochemical Research Methods
Chi-Hua Lee, Jack C. Tang, Nathan G. Hendricks, Bahman Anvari
Summary: This study compared the differences in the proteomes of nano- and micro-sized erythrocyte ghosts with normal RBCs. It was found that the relative abundances of mechano-modulatory proteins and immunomodulatory proteins were higher in the nano-sized particles.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Engineering, Biomedical
Jacob S. Brenner, Samir Mitragotri, Vladimir R. Muzykantov
Summary: Red blood cell hitchhiking is a drug delivery method that increases drug concentration in target organs by adsorbing drug-loaded nanoparticles onto red blood cells. This method has been successfully demonstrated in multiple species and organs, highlighting its versatility and potential clinical applications in various preclinical disease models.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Medicine, Research & Experimental
Haojie Chen, Pengyu Lei, Hao Ji, Jiahui Ma, Yimeng Fang, Haiyang Yu, Jiao Du, Linkai Qu, Qinsi Yang, Li Luo, Kun Zhang, Wei Wu, Libo Jin, Da Sun
Summary: This study evaluated the safety and efficacy of Escherichia coli Nissle 1917 (EcN) ghosts as drug carriers for treating inflammatory bowel disease (IBD). The experiments showed that EcN ghosts had high adhesion and could attenuate IBD symptoms by inhibiting neutrophil chemotaxis and reactive oxygen species production. Due to the unique biological functions of EcN ghosts, they may be used as a strategy for targeted drug delivery in future IBD treatment.
Article
Nanoscience & Nanotechnology
Yuan Zhong, Xian Qin, Yi Wang, Kai Qu, Li Luo, Kun Zhang, Boyan Liu, Essam Abdo Mohammed Saad Obaid, Wei Wu, Guixue Wang
Summary: A nanoplatform based on red blood cells was developed for targeted drug delivery and controlled release for atherosclerosis treatment, addressing challenges such as low location specificity and side effects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Houzong Yao, Zhigang Wang, Na Wang, Zhiqin Deng, Gongyuan Liu, Jianghong Zhou, Shu Chen, Jiahai Shi, Guangyu Zhu
Summary: This study presents a rational design of a platinum(IV) anticancer prodrug that can bind to erythrocytes, greatly extending its circulatory half-life and enhancing tumor accumulation. The prodrug demonstrates significantly enhanced antitumor activity and reduced side effects compared to carboplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Pharmacology & Pharmacy
Mahdi Yonesi, Mario Garcia-Nieto, Gustavo V. Guinea, Fivos Panetsos, Jose Perez-Rigueiro, Daniel Gonzalez-Nieto
Summary: Silk, a natural fiber spun by invertebrates, particularly the silk spun by silkworms, has excellent properties for tissue repair and medical applications. In the field of neural soft tissue engineering, silk has been widely used to promote neuronal growth and treat nervous system diseases such as stroke and Alzheimer's.
Article
Materials Science, Biomaterials
Weifeng Shao, Rui Chen, Gaolong Lin, Kunjie Ran, Yingying Zhang, Jiaojiao Yang, Hanxiao Pan, Jianxun Shangguan, Yingzheng Zhao, Helin Xu
Summary: The in situ mucoadhesive hydrogels using temperature-sensitive PLGA-PEG-PLGA as matrix and EGCG as adhesion enhancer showed potential in treating chemotherapy-induced oral mucositis. EGCG concentration affected the properties of the hydrogel, with 2% EGCG displaying ideal gelation temperature, gelation time, and storage modulus.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang
Summary: The injectable glycopeptide hydrogel fabricated in this study possesses multifunctionality, including inherent antibacterial and antioxidant capabilities, as well as the ability to promote angiogenesis and accelerate wound healing. The spatiotemporal delivery of therapeutic agents within the hydrogel allows for effective anti-infection, anti-oxidation, and anti-inflammation effects, making it a promising strategy for treating chronic diabetic wounds.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Martina H. Stenzel
Summary: Drug delivery with nanoparticles is often likened to a Trojan Horse attack, but this comparison is not always accurate. Increasing drug loading content can sometimes be detrimental to the drug delivery process. Therefore, understanding the physicochemical properties of nanoparticles and the importance of materials scientists working together are crucial for successful nanomedicine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Haojie Chen, Hao Ji, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin, Da Sun
Summary: Bacterial ghosts (BGs) are utilized as vaccine delivery systems and adjuvants, with increasing interest in developing novel BG-based delivery systems for biomedical applications. BGs, with intact bacterial cell membranes, possess inherent immunogenicity for targeted drug delivery and controlled release, offering protection to drugs from external interference.
Article
Nanoscience & Nanotechnology
Thompson Lu, Chi-Hua Lee, Bahman Anvari
Summary: Red blood cell (RBC)-based microparticles have potential applications in the delivery of biomedical agents. This study investigates the morphological and membrane mechanical characteristics of these particles and finds that they have a decreased surface area, volume, and deformability compared to normal RBCs. The membrane bending modulus of the particles is also significantly higher, indicating greater resistance to flow. The changes in membrane mechanical properties are caused by impaired membrane-cytoskeleton attachment. These findings highlight the importance of considering membrane mechanical properties in the design of future RBC-based delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Nur Najihah Izzati Mat Rani, Xiang Yi Chen, Zahraa M. Al-Zubaidi, Hanisah Azhari, Tzar Mohd Nizam Khaitir, Pei Yuen Ng, Fhataheya Buang, Geok Chin Tan, Yin Ping Wong, Mazlina Mohd Said, Adeel Masood Butt, Azmy A. Hamid, Mohd Cairul Iqbal Mohd Amin
Summary: This study focused on the encapsulation of vancomycin into liposomes coated with a red blood cell membrane with a targeting ligand, and successfully achieved targeted drug delivery to bacterial cells. The conjugation of the targeting ligand was confirmed through various analyses, and the formulation exhibited controlled drug release. In vitro and in vivo experiments demonstrated the high antibacterial efficacy of the formulation against MRSA, with low toxicity to mammalian cells and human erythrocytes.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Oncology
Yijun Ren, Chengkai Yan, Huan Yang
Summary: Erythrocytes are the most abundant cells in the blood with a simple structure and long lifespan. They function as oxygen carriers and have immune functions, recognizing antigens and promoting phagocytosis. The immune function of erythrocytes is significant and should not be disregarded.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Xiaoting Dong, Yawei Niu, Yi Ding, Yuemin Wang, Jialan Zhao, Wei Leng, Linghao Qin
NANOSCALE RESEARCH LETTERS
(2017)
Article
Medicine, Research & Experimental
Linghao Qin, Yawei Niu, Yuemin Wang, Xiaomei Chen
MOLECULAR PHARMACEUTICS
(2018)
Article
Medicine, Research & Experimental
Yuemin Wang, Xiaomei Chen, Dahua He, Yi Zhou, Linghao Qin
MOLECULAR PHARMACEUTICS
(2018)
Article
Medicine, Research & Experimental
Ping Zhong, Xuehong Chen, Rishuo Guo, Xiaomei Chen, Zhihao Chen, Cui Wei, Yusheng Li, Wanting Wang, Yi Zhou, Linghao Qin
MOLECULAR PHARMACEUTICS
(2020)
