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Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Xiao Yu, Pengfei Zhao, Qingyu Luo, Xiaowei Wu, Yating Wang, Yabing Nan, Shi Liu, Wenyan Gao, Bin Li, Zhihua Liu, Zhumei Cui
Summary: This study reveals that lncRNA RUNX1-IT1 plays a critical role in the progression of ovarian cancer. Its overexpression is associated with shorter survival and worse prognosis in patients. Knockdown of RUNX1-IT1 suppresses the proliferation, migration, and invasion of ovarian cancer cells and reduces metastasis formation. Mechanistically, RUNX1-IT1 regulates intracellular reactive oxygen homeostasis by altering histone modification status and activates NF-κB signaling. Targeting RUNX1-IT1 may be a promising therapeutic strategy for ovarian cancer treatment.
Article
Engineering, Biomedical
Zhixiong Chen, Xi Chu, Jinghong Xu
Summary: This study identified differentially expressed EMT-related lncRNAs and mRNAs in keloid tissues compared to normal tissues and interpreted their functions. The differentially expressed mRNAs were found to function in the extracellular matrix, protein binding, the positive regulation of cellular processes, the Set1C/COMPASS complex, and histone acetyltransferase activity. The lncRNA XLOC_000587 may promote cell proliferation and migration by enhancing the expression of ENAH, while AF268386 may facilitate the invasive growth of keloids by upregulating DDR2.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Retraction
Cell Biology
Xinggang Guo, Hongqi Xiao, Sihong Guo, Jing Li, Yuxia Wang, Jie Chen, Ge Lou
Summary: The article published on October 26, 2018, has been retracted due to flaws and inconsistencies between results presented and experimental methods described, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hyeon-Yeol Cho, Jin-Ha Choi, Kyeong-Jun Kim, Minkyu Shin, Jeong-Woo Choi
Summary: Research has shown that in a three-channel microfluidic system mimicking lymphatic metastasis pathways, the inflammatory cytokine IL-6 can induce epithelial-mesenchymal transition and enhance tissue invasion of breast cancer cells, as well as promote human vein endothelial cell growth towards lymphatic channels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Xiaoying Yang, Cheng Qin, Bangbo Zhao, Tianhao Li, Yuanyang Wang, Zeru Li, Tianyu Li, Weibin Wang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with poor prognosis. The molecular mechanisms of pancreatic oncogenesis and malignant progression are not fully understood. Recent studies have shown that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) play important roles in the epithelial-mesenchymal transition (EMT) process in PDAC, affecting the migration and invasion of tumor cells. These RNAs can regulate the expression of EMT-related proteins through different mechanisms, thus influencing the development of cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Samane Khoshbakht, Sadegh Azimzadeh Jamalkandi, Ali Masudi-Nejad
Summary: The study investigated the critical pathways in CTCs using network approaches, revealing interactions among EMT, the immune system, menstrual cycles, and the stemness pathway. Novel metastatic biomarkers were detected, and predictive models for metastasis risk were developed.
BMC MEDICAL GENOMICS
(2021)
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Oncology
Zhenqiang Sun, Bo Shao, Zaoqu Liu, Qin Dang, Yaxin Guo, Chen Chen, Yuying Guo, Zhuang Chen, Jinbo Liu, Shengyun Hu, Weitang Yuan, Quanbo Zhou
Summary: This study found that LINC01296 is highly expressed in NSCLC and CRC tissues, and is associated with poor prognosis. LINC01296 regulates invasion and metastasis of NSCLC and CRC by modulating the EMT process.
Article
Cell Biology
Wei Liu, Jin Meng, Rongjun Su, Changjun Shen, Shuai Zhang, Yantao Zhao, Wenqi Liu, Jiang Du, Shuai Zhu, Pan Li, Zhigang Wang, Xiaoxia Li
Summary: This study elucidates the mechanism by which long non-coding RNA TUG1 promotes tumor formation in colorectal cancer. SP1 regulates TUG1 and the miR-421/KDM2A/ERK axis, providing novel insights into the development of colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Nutrition & Dietetics
Homa Hajimehdipoor, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi
Summary: This study investigated the effects of rutin on the proliferation, metastasis, and angiogenesis of breast cancer cells. Rutin was found to stimulate the proliferation and migration of MDA-MB-231 and MCF-7 cells. It also modulated the expression of genes involved in cell adhesion and angiogenesis.
Article
Biochemistry & Molecular Biology
Merve Yildirim, Fusun Oztay, Ozgecan Kayalar, Ahmet Erdal Tasci
Summary: This study revealed the roles of three LncRNAs in regulating myofibroblast differentiation through EMT, showing they interact with proteins and miRNAs associated with EMT and PF. These LncRNAs could be potential targets for treating PF by reducing EMT.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)