Article
Medicine, Research & Experimental
Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye, Daofeng Tian
Summary: This study constructed a risk model to predict the prognosis and therapeutic targets for glioblastoma (GBM) patients by analyzing mitochondria and oxidative stress-related genes from public databases. The model demonstrated strong prediction accuracy and correlation with immune cell infiltration and mutation status, providing potential targeted therapeutic drugs for GBM. Further experiments validated that elevated NUDT1 gene in GBM promoted cell proliferation and inhibited apoptosis, while damaging mitochondrial homeostasis and inducing oxidative stress.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Darcy Wear, Eesha Bhagirath, Arpana Balachandar, Caleb Vegh, Siyaram Pandey
Summary: Neuroblastoma is a common tumor in children under 1 year old, while glioblastoma has a poor prognosis. Manipulation of autophagy has shown promise in targeting cancers, including glioblastoma. Combining autophagy inhibitors with standard chemotherapies can improve patient prognosis and reduce side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jonas Knittel, Nadja Itani, Rolf Schreckenberg, Jacqueline Heger, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Serotonin effects on cardiac hypertrophy, senescence, and failure depend on specific receptors or serotonin uptake and degradation by MAOs. MAO-dependent effects are non-specific. MAOA expression increases in maladaptive hypertrophic stages. MAO-A inhibition suppresses serotonin-dependent damage. Serotonin induces mitochondria-dependent oxidative stress.
Article
Chemistry, Multidisciplinary
Fanghui Liang, Jian Jiang, Xinyue Yang, Guoyang Zhang, Jiaying Zhou, Jiahao Han, Yujie Geng, Zhuo Wang
Summary: Neuroinflammation leads to oxidative stress in the brain and is linked to various neurological disorders. A fluorescent probe, SiR-FH, was developed for detecting HClO. This probe demonstrated high selectivity, rapid response, and sensitivity, successfully detecting endogenous and exogenous HClO in living cells. Real-time monitoring of HClO flux in the brains of mice with LPS-induced neuroinflammation was achieved using SiR-FH, providing a practical tool for studying oxidative stress related to neuroinflammation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Dino A. Giussani
Summary: The article explores the impact of chronic fetal hypoxia during pregnancy on the development of cardiovascular disease in offspring and potential therapeutic approaches, with a focus on molecular-level research and potential targets for clinical intervention.
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Review
Cell Biology
Matthew Batty, Martin R. Bennett, Emma Yu
Summary: Atherosclerosis is a leading cause of cardiovascular diseases globally, and excessive generation of reactive oxygen species (ROS) due to oxidative stress is a major risk factor for its development and progression. While ROS are important for maintaining vascular health, they can also activate pro-atherogenic processes. Enzymatic sources of vascular ROS include NADPH oxidases, xanthine oxidase, etc., and antioxidant systems play a role in balancing ROS production. Changes in ROS sources and antioxidants have been observed in human atherosclerosis, and animal models have provided mechanistic insight. However, clinical trials have not yet demonstrated atheroprotective effects of antioxidant molecules.
Article
Neurosciences
Fahim Atif, Seema Yousuf, Claudia Espinosa-Garcia, Donald G. Stein
Summary: Research shows that high doses of progesterone have an inhibitory effect on mitochondrial respiration and glycolysis in glioblastoma multiforme cells, potentially leading to decreased tumor size and growth rate.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Chi Zhang, Hao Li, Jie Li, Jiajin Hu, Keda Yang, Lin Tao
Summary: Osteoporosis is a major concern and high-risk populations need regular bone mineral density testing and appropriate preventive treatment. Oxidative stress, including the direct effect of reactive oxygen species and the reduction of antioxidant enzyme activity, plays a significant role in the development of osteoporosis. Understanding the impact of oxidative stress on osteoporosis can greatly optimize therapeutic schedules.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Jovana Drljaca, Aleksandra Popovic, Dragica Bulajic, Nebojsa Stilinovic, Sasenka Vidicevic Novakovic, Slobodan Sekulic, Ivan Milenkovic, Srdan Ninkovic, Marko Ljubkovic, Ivan Capo
Summary: This study investigates the combined effects of TMZ and DIA on GBM cells. The results show that there is antagonism between TMZ and DIA, and DIA decreases the apoptosis level caused by TMZ. Additionally, the concomitant use of TMZ and DIA increases the mitochondrial bioenergetic response and the activities of key complexes in the electron transport chain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Geriatrics & Gerontology
Sirawit Sriwichaiin, Nattayaporn Apaijai, Arintaya Phrommintikul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Nisakron Thongmung, Usanee Mahantassanapong, Prin Vathesatogkit, Chagriya Kitiyakara, Piyamitr Sritara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Mitochondrial dysfunction is potentially associated with aging, although there is limited evidence regarding the relationship between mitochondrial function and aging. In this study, mitochondrial function was found to decline with age, with several parameters related to mitochondrial respiration significantly lower in older adults. However, mitochondrial ATP production and mitochondrial coupling efficiency were slightly increased in older adults. Additionally, mitochondrial mass and oxidative stress were significantly reduced in older individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Environmental Sciences
Sarah Easson, Radha Dutt Singh, Liam Connors, Taylor Scheidl, Larissa Baker, Anshul Jadli, Hai-Lei Zhu, Jennifer Thompson
Summary: This study found that the commonly used BPA substitute BPS can disturb redox balance and increase the production of reactive oxygen species (ROS), leading to impaired endothelial function.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Jiang Shan, Ding Xiaoqian, Li Xia, Wang Yu, Zheng Zhilong, Shi Zhihui, Qin Yanjie
Summary: This study investigated the cytotoxicity, molecular function disorder, mitophagy, and apoptosis in loach fin cells exposed to doxycycline (DOX) in vitro. The results showed that DOX could induce the production of reactive oxidative species (ROS) at lower concentrations, leading to reduced cell proliferation, while higher concentrations of DOX induced cell apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Seongchun Min, Ji Yeon Kim, Hyo Min Cho, Sujin Park, Ji Min Hwang, Hyejin You, Young Chan Chae, Won-Jae Lee, Woong Sun, Dongmin Kang, Sanghyuk Lee, Sang Won Kang
Summary: This study reveals a novel signaling pathway in which mitochondria communicate with the cytosol via the release of heat shock protein 60, leading to the activation of survival genes in the nucleus.
Article
Biochemistry & Molecular Biology
Shenghao Zhang, Xun Wu, Jin Wang, Yingwu Shi, Qing Hu, Wenxing Cui, Hao Bai, Jinpeng Zhou, Yong Du, Liying Han, Dayun Feng, Shunnan Ge, Yan Qu
Summary: The APN/AdipoR1 signaling pathway plays a protective role in oxidative damage after TBI by restoring SIRT3-mediated mitochondrial homeostasis and antioxidant system.