Review
Engineering, Biomedical
Elisa Scalco, Giovanna Rizzo, Alfonso Mastropietro
Summary: The use of deep neural networks (DNN) in the MRI radiomic workflow shows potential for improving image quality, obtaining accurate and reproducible segmentations, and generating standardized images. DNN methods can partially overcome the issues related to radiomic stability and have potential value in tumor diagnosis, prognosis, and treatment response prediction.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Review
Oncology
Arnaldo Stanzione, Renato Cuocolo, Lorenzo Ugga, Francesco Verde, Valeria Romeo, Arturo Brunetti, Simone Maurea
Summary: Radiomics has the potential to enhance the value of medical images for oncologic patients, but its clinical application faces challenges and requires a rigorous methodology. This review provides guidelines to facilitate state-of-the-art radiomics research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matias Fernandez Paton, Leonor Cerda Alberich, Cinta Sanguesa Nebot, Blanca Martinez de Las Heras, Diana Veiga Canuto, Adela Canete Nieto, Luis Marti-Bonmati
Summary: The study evaluated the performance of 5 denoising filters on T2-weighted MR images, eventually selecting ADF and UNLM filters, and studied their preservation of 107 radiomics features under different noise levels.
JOURNAL OF DIGITAL IMAGING
(2021)
Article
Geosciences, Multidisciplinary
Oscar Ferreira, Sunna Kupfer, Susana Costas
Summary: The study predicts an increase in overwash potential return periods with rising sea levels and intensified coastal occupation, leading to significant deterioration in overwash under future sea level conditions. Urgent detailed local studies are recommended to identify climate change impacts on coastal sectors.
Review
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyang Liu, Mohamed G. Elbanan, Antonio Luna, Masoom A. Haider, Andrew D. Smith, Carl F. Sabottke, Bradley M. Spieler, Baris Turkbey, David Fuentes, Ahmed Moawad, Serageldin Kamel, Natally Horvat, Khaled M. Elsayes
Summary: This article reviews the radiomics pipeline and the application of radiomics in abdominopelvic solid-organ cancers. The limitations of the available literature are highlighted, indicating a need for stronger evidence to support clinical adoption.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Surgery
Kavitha Ranganathan, Puneet Singh, Krishnan Raghavendran, Edwin G. Wilkins, Jennifer B. Hamill, Oluseyi Aliu, Lisa A. Newman, David Hutton, Adeyiza O. Momoh
Summary: The study revealed that breast cancer mortality rates are significantly higher in low and middle-income countries, with the economic burden increasing over time. Efforts to improve access to surgical care for breast cancer patients globally could reduce mortality rates and alleviate the social and economic impact of the disease in low and middle-income countries.
Article
Oncology
Andrew J. Sinnamon, Eric Luo, Aileen Xu, Sarah Zhu, Jason W. Denbo, Jason B. Fleming, Daniel A. Anaya
Summary: The sequence of therapies for synchronous liver metastasis is complex, and individualized approaches are supported by data but lack guiding tools. This study assessed the impact of simultaneous hepatic and visceral resections on treatment outcomes and the return to intended oncologic therapy, and developed risk-stratification tools for decision-making and counseling.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Andrew J. Sinnamon, Eric Luo, Aileen Xu, Sarah Zhu, Jason W. Denbo, Jason B. Fleming, Daniel A. Anaya
Summary: This study evaluated the impact of simultaneous hepatic and visceral resections on the treatment outcomes of synchronous liver metastasis patients and provided risk-stratification tools for individualized decision making. The study found that simultaneous hepatic and visceral resections were associated with reduced likelihood of achieving textbook outcome and delayed return to intended oncologic therapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Colton Ladbury, Arya Amini, Ameish Govindarajan, Isa Mambetsariev, Dan J. Raz, Erminia Massarelli, Terence Williams, Andrei Rodin, Ravi Salgia
Summary: The goal of oncology is to provide the longest possible survival outcomes in lung cancer without sacrificing patients' quality of life. Artificial intelligence (AI) can utilize available data, including molecular information and radiomics, to help clinicians provide individualized care. AI can create models to identify cancer early in diagnosis and deliver tailored therapy based on available information, both at the time of diagnosis and in real time during treatment.
CELL REPORTS MEDICINE
(2023)
Article
Multidisciplinary Sciences
Juliet P. Sefton, Andrew C. Kemp, Simon E. Engelhart, Joanna C. Ellison, Makan A. Karegar, Blair Charley, Mark D. McCoy
Summary: This study reveals that the rise of relative sea level due to subsidence may have concealed evidence of early settlement in Remote Oceania. Additionally, famous sites were constructed at lower sea levels than previously thought, making them more vulnerable to future sea level rise.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Oncology
Valisha Shah, William Lotter
Summary: This commentary discusses a recently published article by Zhao et al, which presents a CT radiomics model for diagnosing vein wall invasion in patients with renal cell carcinoma and venous tumor thrombus.
Article
Multidisciplinary Sciences
Akshayaa Vaidyanathan, Marly F. J. A. van der Lubbe, Ralph T. H. Leijenaar, Marc van Hoof, Fadila Zerka, Benjamin Miraglio, Sergey Primakov, Alida A. Postma, Tjasse D. Bruintjes, Monique A. L. Bilderbeek, Hammer Sebastiaan, Patrick F. M. Dammeijer, Vincent van Rompaey, Henry C. Woodruff, Wim Vos, Sean Walsh, Raymond van de Berg, Philippe Lambin
Summary: The deep learning approach for MRI inner ear segmentation showed high accuracy, low error rates, and can play a crucial role in clinical applications such as surgical planning and image analysis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Milica Zekovic, Uros Bumbasirevic, Marko Zivkovic, Tomislav Pejcic
Summary: Cancer, especially prostate cancer, is a heterogeneous disease with complex mutational landscape. Lipid metabolism alterations play a critical role in tumorigenesis and progression, influencing various processes in cancer development. Understanding the unique metabolic signature of prostate cancer could lead to novel approaches for diagnosis and clinical management of this complex pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geochemistry & Geophysics
Yanming Huang, William W. Sager, Jinchang Zhang, Masako Tominaga, John Greene, Masao Nakanishi
Summary: Shatsky Rise oceanic plateau was formed during a period of frequent geomagnetic polarity reversals, with reconstruction of its tectonic evolution using magnetic anomalies. The study found that linear magnetic anomalies are ubiquitous in the region, suggesting that these volcanic edifices may have formed through spreading similar to mid-ocean ridges.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2021)
Review
Oncology
Valentina Brancato, Marco Cerrone, Marialuisa Lavitrano, Marco Salvatore, Carlo Cavaliere
Summary: Radiomics is a promising tool that can enhance the value of imaging in the differential diagnosis of glioma. However, current radiomic studies lack the required quality for implementation in clinical practice. This study provides new insights and contributes to reaching a consensus on the use of radiomics for glioma differential diagnosis.
Review
Health Care Sciences & Services
J. Isabelle Choi, Jana Fox, Richard Bakst, Shaakir Hasan, Robert H. Press, Arpit M. Chhabra, Brian Yeh, Charles B. Simone, Oren Cahlon
Summary: Partial breast irradiation (PBI) delivered with proton therapy offers a shorter treatment duration and reduced toxicities, targeting less non-target breast tissue and limiting unnecessary radiation dose to thoracic organs. Proton therapy is a precision radiotherapy technology that further limits normal tissue exposure to improve quality of life for early stage breast cancer patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Minglei Kang, Shouyi Wei, J. Isabelle Choi, Charles B. Simone, Haibo Lin
Summary: This study focuses on quantifying the dose rate of organs-at-risk and targets based on three proposed proton PBS dose rate metrics, showing significant impact of differences in dose rate metrics on the assessment of organ-at-risk dose rate, posing challenges to the clinical implementation of FLASH. Additional investigations are needed to explore the correlation between FLASH efficacy and the dose rate metrics in proton PBS therapy.
Article
Oncology
Shouyi Wei, Haibo Lin, J. Isabelle Choi, Charles B. Simone, Minglei Kang
Summary: This study compares the performance of single-energy Bragg peak proton beams with transmission proton beams in lung tumor treatment planning, finding that Bragg peak plans achieve superior dosimetry performances in OARs while maintaining comparable dose rate performances. Beam angle optimization further improves OAR dosimetry parameters without compromising the 3D FLASH dose rate coverage.
Review
Oncology
Jana M. Kobeissi, Charles B. Simone, Haibo Lin, Lara Hilal, Carla Hajj
Summary: Radiation therapy plays a central role in the management of pancreatic cancer, and proton therapy is an emerging treatment modality. Proton irradiation remains a challenge in radiation therapy, but no significant differences in oncologic outcomes and toxicity rates have been shown compared to photon radiation treatment.
Review
Oncology
Jana M. Kobeissi, Charles B. Simone, Lara Hilal, Abraham J. Wu, Haibo Lin, Christopher H. Crane, Carla Hajj
Summary: Radiation treatment is crucial in managing luminal gastrointestinal cancers, particularly esophageal and anorectal cancers. Proton therapy is gaining interest for its ability to decrease dose to nearby organs at risk. In esophageal cancer, protons have shown superior dosimetric characteristics in sparing organs at risk, but clinical significance is conflicting. However, evidence suggests that protons offer similar or improved oncologic outcomes with reduced toxicity compared to photons. In anorectal cancers, proton therapy has shown improved organ sparing, but clinical data is limited and toxicity benefits have not been clinically proven.
Review
Oncology
Jana M. Kobeissi, Lara Hilal, Charles B. Simone, Haibo Lin, Christopher H. Crane, Carla Hajj
Summary: This review provides a concise and comprehensive summary on the use of proton therapy in the management of hepatocellular carcinoma (HCC). Proton radiation therapy plays a central role in the treatment of HCC, and evidence suggests it may be superior to photons in terms of survival and toxicity outcomes.
Article
Oncology
Beatriz E. Amendola, Anand Mahadevan, Jesus Manuel Blanco Suarez, Robert J. Griffin, Xiaodong Wu, Naipy C. Perez, Daniel S. Hippe, Charles B. Simone Ii, Majid Mohiuddin, Mohammed Mohiuddin, James W. Snider, Hualin Zhang, Quynh-Thu Le, Nina A. Mayr
Summary: SFRT shows promising potential as a new treatment modality for challenging tumors. However, the development of clinical trials is hindered by the variability in SFRT methods and the unfamiliarity with heterogeneous dosing, requiring a broad consensus.
Article
Medicine, General & Internal
Rulon Mayer, Baris Turkbey, Peter L. Choyke, Charles B. Simone
Summary: This study predicts the risk of clinically significant prostate cancer (CsPCa) and correlates it with the ISUP grade using processed SCR derived from SRBP-MRI. The results show a high correlation between SCR values and ISUP grade and CsPCa/CiPCa, indicating the potential of SRBP-MRI in non-invasive management of prostate cancer.
Article
Oncology
Michael Pennock, Shouyi Wei, Chingyun Cheng, Haibo Lin, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Richard L. Bakst, Rafi Kabarriti, Charles B. Simone II, Nancy Y. Y. Lee, Minglei Kang, Robert H. Press
Summary: Bragg peak proton FLASH is a novel radiotherapy technique that combines ultra-high dose rates and conformal organ sparing for cancer treatment. By modifying the planning software and treatment delivery, Bragg peak FLASH can improve organ sparing and target coverage compared to conventional proton therapy. This study demonstrates the potential benefits of Bragg peak proton FLASH in head and neck reirradiation.
Article
Oncology
Grant Lattery, Tyler Kaulfers, Chingyun Cheng, Xingyi Zhao, Balaji Selvaraj, Haibo Lin, Charles B. Simone II, J. Isabelle Choi, Jenghwa Chang, Minglei Kang
Summary: This study focused on developing ultra-high dose rate intensity-modulated proton therapy (IMPT) for hypofractionated treatment of early-stage breast cancer. The results showed that the Bragg peak FLASH-RT technique achieved comparable plan quality to conventional IMPT, demonstrating the feasibility of early-stage breast cancer clinical applications.
Article
Oncology
Pingfang Tsai, Yu-Lun Tseng, Brian Shen, Christopher Ackerman, Huifang A. Zhai, Francis Yu, Charles B. Simone II, J. Isabelle Choi, Nancy Y. Lee, Rafi Kabarriti, Stanislav Lazarev, Casey L. Johnson, Jiayi Liu, Chin-Cheng Chen, Haibo Lin
Summary: This study evaluates the potential of cone-beam computed tomography (CBCT)-based synthetic CT (sCT) as an alternative to verification CT (vCT) in proton therapy for enhanced treatment monitoring and early adaptation. The study found that sCT agreed with vCT in regions of homogeneous tissues, but discrepancies were observed in the thorax and abdomen. The study also observed outliers in sCT plans when there was an anatomy change or in low-density regions. The target coverage variance in most sCT cases compared to vCT was less than 5%. The study concludes that the use of sCT allows for precise treatment and prompt early adaptation in proton therapy, but quality assurance of sCT is crucial in the early stages of clinical implementation.
Article
Medicine, General & Internal
Rulon Mayer, Baris Turkbey, Peter L. Choyke, Charles B. Simone
Summary: This study aims to assess tumor aggressiveness through analysis of bi-parametric MRI images using methods like signal to clutter ratio. The results show that the processed tumor eccentricity and volume computations from spatially registered BP-MRIs have a significant correlation with the ISUP grade.
Article
Cardiac & Cardiovascular Systems
Vivek Verma, Rodney E. Wegner, Sebastian Adeberg, Zachary D. Horne, Surbhi Grover, Joseph S. Friedberg, Charles B. Simone
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra D. Dreyfuss, Pegah Jahangiri, Charles B. Simone, Abass Alavi
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie R. Rice, Michael Chuong, Antony Koroulakis, Osman M. Siddiqui, Ankur M. Sharma, Charles B. Simone, Jason K. Molitoris, Adeel Kaiser