Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Article
Endocrinology & Metabolism
Jurhee Freese, Rawan Al-Rawi, Heather Choat, Alexandra Martin, Alison Lunsford, Hubert Tse, Gail Mick, Kenneth McCormick
Summary: Children with new-onset type 1 diabetes undergo progressive beta-cell endoplasmic reticulum stress and abnormal proinsulin processing, as evidenced by increasing proinsulin to C-peptide ratios. Moreover, the ratio reflects a more aggressive beta-cell attack with younger age, as well as decreased glycemic control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Veterinary Sciences
Jun-Hyeong Park, Ju-Hyun An, Se-Hoon Kim, Han-Sol Choi, Tae-Hyeon Kim, Ye-In Oh, Kyoung-Won Seo, Hwa-Young Youn
Summary: This study reported a successful treatment of refractory hypoglycemia and seizures caused by fatal insulin overdose by using glucagon, anticonvulsants, and intermittent mannitol. It has great clinical value in veterinary medicine.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Dahye Lee, Seulggie Choi, Jooyoung Chang, Young Jun Park, Jae Hyun Kim, Sang Min Park
Summary: Antibiotic exposure in early life is not associated with the risk of type 1 diabetes in children. Further studies with long-term follow-up data are needed.
Article
Multidisciplinary Sciences
Daniela Schmid, Walter C. Willett, Michele R. Forman, Ming Ding, Karin B. Michels
Summary: The study suggests that regular TV viewing during early childhood is associated with an increased risk of type 2 diabetes in adult women, especially for those who watched TV for long hours at ages 5-10. Adult BMI partly explains this association.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Jon Edqvist, Christina Lundberg, Karin Andreasson, Lena Bjorck, Pigi Dikaiou, Johnny Ludvigsson, Marcus Lind, Martin Adiels, Annika Rosengren
Summary: Type 2 diabetes is a risk factor for hospitalization and death in COVID-19 infection, while the effect of type 1 diabetes is less significant. Machine learning models were used to identify predictors of outcomes among COVID-19-positive individuals with diabetes.
Article
Endocrinology & Metabolism
Tara Kaushal, Liane J. Tinsley, Lisa K. Volkening, Christine Turcotte, Lori Laffel
Summary: This study assessed the utility of telemedicine for youth with type 1 diabetes during the COVID-19 pandemic. The results showed that telemedicine led to an increase in visit frequency and improved glucose monitoring indicators.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychiatry
Anja Turin, Klemen Dovc, Simona Klemencic, Natasa Bratina, Tadej Battelino, Jasna Klara Lipovsek, Katarina Ursic, Yael Shmueli-Goetz, Maja Drobnic-Radobuljac
Summary: The study found that higher attachment-related anxiety in carers with high education and stressful life events are associated with T1D in children. The security of attachment to mothers showed no significant association with the child's T1D diagnosis.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Endocrinology & Metabolism
John I. Malone, Xiaoyu Gao, Gayle M. Lorenzi, Philip Raskin, Neil H. White, Dean P. Hainsworth, Arup Das, William Tamborlane, Amisha Wallia, Lloyd P. Aiello, Ionut Bebu
Summary: This study indicates that individuals with type 1 diabetes (T1D) who develop retinopathy within the first 5 years of diabetes onset have an increased risk of progressing to advanced diabetic retinopathy, specifically proliferative diabetic retinopathy (PDR). The presence of early-onset diabetic retinopathy may impact prognosis and guide therapeutic management to prevent future visual loss in these individuals.
Article
Endocrinology & Metabolism
Madeleine Hall, Helena Oakey, Megan A. S. Penno, Kelly McGorm, Amanda J. Anderson, Pat Ashwood, Peter G. Colman, Maria E. Craig, Elizabeth A. Davis, Mark Harris, Leonard C. Harrison, Aveni Haynes, Claire Morbey, Richard O. Sinnott, Georgia Soldatos, Peter J. Vuillermin, John M. Wentworth, Rebecca L. Thomson, Jennifer J. Couper
Summary: Overall, there was no significant difference in mental health between women with and without type 1 diabetes during late pregnancy and postpartum, and mental health scores were not correlated with glycemic control.
Article
Endocrinology & Metabolism
Suzanne Bennett Johnson, Kristian F. Lynch, Roswith Roth, Markus Lundgren, Hemang M. Parikh, Beena Akolkar, William Hagopian, Jeffrey Krischer, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette G. Ziegler, Ake Lernmark
Summary: This study examined the association between life events during pregnancy and first-appearing islet autoantibodies in young children with type 1 diabetes-related genetic risk. It found that specific life events during pregnancy are related to different types of autoantibodies and interact with various genetic factors, indicating different endotypes underlying type 1 diabetes.
Article
Public, Environmental & Occupational Health
Alexandra M. Wennberg, Weiyao Yin, Fang Fang, Nancy L. Pedersen, Sara Hagg, Juulia Jylhava, Karin Modig
Summary: This study evaluated the utility of a code-based frailty score in registry data and found that it may not capture the full spectrum of frailty among community-dwelling individuals, particularly at younger ages.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Biology
Hilda Bjork Danielsdottir, Thor Aspelund, Edda Bjork Thordardottir, Katja Fall, Fang Fang, Gunnar Tomasson, Harpa Runarsdottir, Qian Yang, Karmel W. Choi, Beatrice Kennedy, Thorhildur Halldorsdottir, Donghao Lu, Huan Song, Johanna Jakobsdottir, Arna Hauksdottir, Unnur Anna Valdimarsdottir
Summary: The number of adverse childhood experiences (ACEs) is negatively associated with coping ability and psychiatric resilience in adulthood among women. Specific ACEs, such as emotional neglect, bullying, sexual abuse, and mental illness of household member, are consistently associated with reduced adult resilience. Adult socioeconomic factors and social support only partially attenuate these associations.
Article
Clinical Neurology
Stefan Sennfalt, Ulf Klappe, Sebastian Thams, Kristin Samuelsson, Rayomand Press, Fang Fang, Caroline Ingre
Summary: This study aimed to provide a detailed description of the path to a correct diagnosis of amyotrophic lateral sclerosis (ALS), including delays, referrals, alternate diagnoses, and clinical progression. The study found significant variations in the diagnostic pathway based on the clinical phenotype, with substantial delays and clinical progression in all groups.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Endocrinology & Metabolism
Amy E. Mendham, Lisa K. Micklesfield, Fredrik Karpe, Andre Pascal Kengne, Tinashe Chikowore, Clement N. Kufe, Maphoko Masemola, Nigel J. Crowther, Shane A. Norris, Tommy Olsson, Solve Elmstahl, Tove Fall, Lars Lind, Julia H. Goedecke
Summary: Using a targeted proteomics approach, this study aimed to identify and validate circulating proteins associated with impaired glucose metabolism and type 2 diabetes in a Black South African cohort. The results identified 34 proteins associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology. This study highlights the similarity of biomarkers between different populations and emphasizes the need for validation in African cohorts.
Article
Endocrinology & Metabolism
Sabina Davidsson, Anna Messing Eriksson, Ruzan Udumyan, Per Swanholm, Maria Lewin Lundh, Carolina Widing, Christina Lindlof, Jonna Fridfeldt, Sven-Olof Andersson, Katja Fall
Summary: Studies have shown inconsistent results regarding the association between androgen deprivation therapy (ADT) and the risk or severity of SARS-CoV-2 infection in prostate cancer patients. This study found no differences in symptoms or risk of SARS-CoV-2 infection between patients with and without ADT after adjusting for potential confounders.
Article
Cardiac & Cardiovascular Systems
Lars Lind, Tove Fall, Johan Arnlov, Solve Elmstahl, Johan Sundstrom
Summary: This study explored the relationship between a wide range of circulating metabolites and future cardiovascular disease (CVD) as well as subclinical markers of CVD in the general population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Education, Scientific Disciplines
Yin Xu, Ayako Hiyoshi, Katja Fall, Scott Montgomery
Summary: This study examines the relationship between erythrocyte sedimentation rate (ESR), a marker of inflammation, and cognitive function, and investigates the potential influence of shared familial factors. The study includes men born in Sweden between 1950 and 1965 and registered in the Swedish Military Conscription Register between 1969 and 1983 (N = 632,396). ESR and cognitive function were measured at the time of conscription assessment, with analysis conducted using conventional linear regression and multilevel linear regression to control for familial confounding. The findings suggest that while shared familial factors account for some of the association between ESR and cognitive function, there remains an independent relationship.
Article
Medicine, General & Internal
Kejia Hu, Qianwei Liu, Krisztina D. Laszlo, Dang Wei, Fen Yang, Katja Fall, Hans-Olov Adami, Weimin Ye, Unnur A. Valdimarsdottir, Jiong Li, Fang Fang
Summary: There is evidence indicating a higher prevalence of mental illness among spouses of cancer patients. This study aimed to assess the burden of psychiatric disorders among spouses of cancer patients and describe its changes over time. The findings emphasize the importance of clinical attention to prevent mental illness among these spouses.
Article
Multidisciplinary Sciences
Lars Lind, Shafqat Ahmad, Soelve Elmstahl, Tove Fall
Summary: This study found that certain metabolites and lipoprotein particles are associated with fat distribution and general obesity. Specifically, two sphingomyelins were found to be inversely linked to body fat distribution without being associated with fat mass, while large HDL particles were inversely associated with both fat distribution and fat mass.
Article
Multidisciplinary Sciences
Louise Grahnemo, Maria Nethander, Eivind Coward, Maiken Elvestad Gabrielsen, Satya Sree, Jean-Marc Billod, Klara Sjogren, Lars Engstrand, Koen F. Dekkers, Tove Fall, Arnulf Langhammer, Kristian Hveem, Claes Ohlsson
Summary: In this study, the authors use data from the Norwegian HUNT cohort to investigate the association between gut microbial species and lean mass. They find that the presence of three bacterial species - Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum - is associated with higher lean mass.
NATURE COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Ayako Hiyoshi, Mikael Rostila, Katja Fall, Scott Montgomery, Alessandra Grotta
Summary: This study examines the changes in smoking, drinking, eating, physical activity, and leisure pursuits in relation to caregiving. The findings suggest that there are differences in behavior changes between co-resident and out-of-home caregiving, as well as variations based on sex, educational attainment, and welfare state typology.
SOCIAL SCIENCE & MEDICINE
(2023)
Letter
Oncology
Qianwei Liu, Krisztina D. Laszlo, Dang Wei, Carsten Obel, Fen Yang, Katja Fall, Unnur Valdimarsdottir, Maria Feychting, Jiong Li, Fang Fang
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Hronn Hardardottir, Thor Aspelund, Katja Fall, Erika Brostroem, Baldur B. Sigurdsson, Elizabeth Cook, Heiddis Valdimarsdottir, Fang Fang, Erica K. Sloan, Susan K. Lutgendorf, Christer Jansson, Unnur A. Valdimarsdottir
Summary: Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis. Patients diagnosed with lung cancer experienced an increase in psychological distress, whereas patients with non-malignant lung pathology showed a decrease in distress before diagnosis.
Article
Public, Environmental & Occupational Health
Olga E. Titova, John A. Baron, Tove Fall, Karl Michaelsson, Susanna C. Larsson
Summary: This study found that current and former smoking are associated with an increased risk of Type 2 diabetes, while the link between snus use and Type 2 diabetes risk is inconclusive. The study also revealed that even after quitting smoking, the risk of Type 2 diabetes remains elevated up to approximately 15 years later. However, compounds other than nicotine may underlie the detrimental association of smoking with the risk of Type 2 diabetes.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Urology & Nephrology
Emma Ulvskog, Erik K. Persson, Peter Kirrander, Katja Fall, Johan Ahlgren
Summary: The benefit of perioperative oncological treatment in men with penile cancer is uncertain. However, after the introduction of centralised recommendations in Sweden and an increase in the use of such treatment, there appears to be an association with better survival for eligible patients.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)