Review
Biochemistry & Molecular Biology
Raquel Guillamat-Prats
Summary: MSCs play a vital role in controlling various phases in response to injuries, immune reactions, wound healing, and regeneration. They can regulate coagulation pathways, trigger platelet production, and contribute to platelet activation. Proper characterization of MSCs is important to prevent adverse coagulation events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Amelie V. Villard, Anthony Genna, Justine Lambert, Marianna Volpert, Agnes Noel, Brett Hollier, Myriam Polette, Aline M. Vanwynsberghe, Christine Gilles
Summary: CD44 regulates the expression of tissue factor (TF) in tumor cells, promoting procoagulant activity and metastatic seeding. CD44 acts at the transcriptional level to modulate TF expression, which is important for cancer research.
Review
Cell & Tissue Engineering
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao, Qing Niu, Fengping Wu, Liyun Zhang
Summary: This review discusses the characteristics of MSCs, their interaction with the microenvironment, and the importance of the microenvironment in maintaining cell function and disease progression.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta
Summary: The number and types of mesenchymal stromal/stem cell (MSC) therapeutics and clinical applications have greatly increased, but there is also a risk of poorly regulated Stem Cell Clinics offering unproven interventions. It is important to critically evaluate the identity and suitability of MSC products for safe intravascular administration.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Naoki Ishiuchi, Ayumu Nakashima, Satoshi Maeda, Yoshie Miura, Kisho Miyasako, Kensuke Sasaki, Toshio Uchiki, Ayano Sasaki, Shogo Nagamatsu, Naoki Nakao, Masataka Nagao, Takao Masaki
Summary: Fibrosis is a common histological feature in chronic organ injury, leading to organ failure. Adipose-derived mesenchymal stem cells (ASCs) have been studied as a therapeutic tool to prevent organ failure. This study compared the therapeutic effects of ASCs from superficial and deep layers and found that both types of ASCs are equally effective and safe for treating organ injury.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Veterinary Sciences
Faezeh Rezaei, Samira Khasaf, Samaneh Ghasemi, Abbas Parham, Pezhman Mirshokraei
Summary: This study evaluates the impact of different conditions on MSCs derived from adipose tissue and finds suitable transportation methods to minimize changes in MSCs.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Asma Mechakra, Junxin Lin, Yuwei Yang, Xiaotian Du, Jingwei Zhang, Paul Maswikitu Ewetse, Feifei Zhou, Enateri Alakpa
Summary: This study investigates the role of Mkx in tendon pathology and its underlying mechanisms. It provides evidence of the transition from tendon stem progenitor cells to myofibroblasts and the modulation of angiofibrosis in tendon healing. These findings open potential therapeutic avenues for treating tendonopathy patients.
SCIENTIFIC REPORTS
(2022)
Review
Rheumatology
Mohamed Gadelkarim, Aya Abd Elmegeed, Ahmed Hafez Allam, Ahmed K. Awad, Mostafa Ahmed Shehata, Asmaa AbouEl-Enein, Mohamed Eid Alsadekh, Mohammad Abo Deebi, Ahmed M. Afifi
Summary: This research examined the safety and efficacy of ADMSCs for knee osteoarthritis. The findings indicate that ADMSCs treatment can significantly improve patients' quality of life and reduce pain, especially in the low-dose group. Furthermore, ADMSCs treatment showed no serious adverse effects.
Article
Biochemistry & Molecular Biology
Veronika Smolinska, Michaela Debreova, Martina Culenova, Maria Csobonyeiova, Andrey Svec, Lubos Danisovic
Summary: Healing of articular cartilage defects is challenging and traditional reparative approaches are limited. Mesenchymal stromal cells have been extensively studied and proven to have therapeutic effects on articular cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Qiong Wu, Shuangli He, Yu Zhu, Shiming Pu, Zuping Zhou
Summary: This study demonstrated the effectiveness of adipose-derived stromal/stem cells (ASCs) in treating obesity and aging in aged mice. ASCs treatment led to significant weight loss, improved organ function, increased antioxidant capacity, enhanced lipid metabolism, and reduced inflammation in old mice. The positive effects of ASCs suggest their potential as primary antiaging and antiobesity agents for the elderly.
Article
Biotechnology & Applied Microbiology
Rayana L. L. Bighetti-Trevisan, Natalia P. Bueno, Alann T. P. Souza, Marcia M. Marques, Adalberto L. L. Rosa, Marcio M. M. Beloti, Emanuela P. P. Ferraz
Summary: Adipose tissue is a potential source of mesenchymal stem cells (MSCs), but their limited osteogenic potential hinders their use in bone regeneration. The release of TNF-alpha by adipose tissue can have a negative effect on the differentiation of MSCs into osteoblasts. By targeting TNF-alpha receptors, the inhibition of TNF-alpha can enhance bone formation in MSCs.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Engineering, Biomedical
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.
ACTA BIOMATERIALIA
(2023)
Review
Cell & Tissue Engineering
Zhaohua Wang, Si Wen, Meiqi Zhong, Ziming Yang, Wei Xiong, Kuo Zhang, Shude Yang, Huizheng Li, Shu Guo
Summary: Bone has limited capacity to repair critical-sized bone defects, but stem cells, particularly mesenchymal stem cells (MSCs), show promise in enhancing bone regeneration. Epigenetic modification, including nucleic acids methylation, histone modification, and non-coding RNAs, plays a crucial role in determining MSCs fate and differentiation. Understanding the epigenetic mechanisms of MSCs can improve stem cell activity and function. This review highlights the potential of harnessing epigenetic modification of MSCs for treating bone defects and promoting bone regeneration, providing therapeutic targets for bone-related diseases.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Review
Veterinary Sciences
Hussein M. M. El-Husseiny, Eman A. A. Mady, Mahmoud A. Y. Helal, Ryou Tanaka
Summary: The use of stem cells in veterinary practice is rapidly evolving, with significant research efforts focused on both experimental animals and clinical cases. Stem cells, particularly mesenchymal stem cells (MSCs), are promising for therapeutic applications due to their immunomodulatory capabilities and ease of isolation. However, challenges remain in their clinical implementation for treating various animal diseases, driving further advancements in stem cell therapies.
VETERINARY SCIENCES
(2022)
Article
Critical Care Medicine
Barbara A. Christy, Maryanne C. Herzig, Robbie K. Montgomery, Christopher Delavan, James A. Bynum, Kristin M. Reddoch, Andrew P. Cap
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Critical Care Medicine
Michael A. Meledeo, Maryanne C. Herzig, James A. Bynum, Xiaowu Wu, Anand K. Ramasubramanian, Daniel N. Darlington, Kristin M. Reddoch, Andrew P. Cap
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Critical Care Medicine
Michael A. Meledeo, Maryanne C. Herzig, James A. Bynum, Xiaowu Wu, Anand K. Ramasubramanian, Daniel N. Darlington, Kristin M. Reddoch, Andrew P. Cap
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Hematology
Kristin M. Reddoch-Cardenas, Robbie K. Montgomery, Crystal B. Lafleur, Grantham C. Peltier, James A. Bynum, Andrew P. Cap
Article
Hematology
James A. Bynum, Michael A. Meledeo, Grantham C. Peltier, Colby S. McIntosh, Ashley S. Taylor, Robbie K. Montgomery, Kristin M. Reddoch-Cardenas, Todd M. Getz, Michael G. Fitzpatrick, Andrew P. Cap
Review
Hematology
Thomas Scorer, Ashleigh Williams, Kristin Reddoch-Cardenas, Andrew Mumford
Review
Hematology
Prajeeda M. Nair, Matthew J. Rendo, Kristin M. Reddoch-Cardenas, Jason K. Burris, Michael A. Meledeo, Andrew P. Cap
SEMINARS IN HEMATOLOGY
(2020)
Article
Hematology
Thomas G. Scorer, Lucy FitzGibbon, Riyaad Aungraheeta, Umang Sharma, Grantham C. Peltier, Colby S. McIntosh, Kristin M. Reddoch-Cardenas, Andrew Meyer, Andrew P. Cap, Andrew D. Mumford
Article
Hematology
Kristin M. Reddoch-Cardenas, Umang Sharma, Christi L. Salgado, Carolina Cantu, Daniel N. Darlington, Heather F. Pidcoke, James A. Bynum, Andrew P. Cap
Article
Hematology
Alisa Agey, Kristin Reddoch-Cardenas, Colby McIntosh, Umang Sharma, Carolina Cantu, Andrew Cap, James Bynum
Summary: The study evaluated the effects of Intercept pathogen reduction technology on platelets stored for up to 21 days, showing comparable platelet metabolism but altered clotting dynamics after 14 days. Pathogen-reduced platelets with extended shelf life have the potential to greatly impact transfusion practices in both deployed and civilian settings.
Article
Hematology
Kristin M. Reddoch-Cardenas, Grant C. Peltier, Tiffani C. Chance, Prajeeda M. Nair, Michael A. Meledeo, Anand K. Ramasubramanian, Andrew P. Cap, James A. Bynum
Summary: The study found that cold storage of platelets in platelet additive solution can preserve mitochondrial integrity, reduce apoptosis, and maintain function for up to 15 days. Moreover, mitochondrial function and molecular analyses of cold-stored platelets revealed distinct differences from the well-known storage lesion of room temperature platelets, presenting a potential opportunity to extend storage duration.
Article
Hematology
Kristin M. Reddoch-Cardenas, Bopaiah P. Cheppudira, Thomas Garza, Chad D. Hopkins, Kevin D. Bunker, Deborah H. Slee, Andrew P. Cap, James A. Bynum, Robert J. Christy
Summary: KP-1199 demonstrates antinociceptive activity in a rat model of thermal injury without inducing platelet activation or inhibiting coagulation, making it a potentially attractive alternative to APAP for pain relief.
Article
Hematology
Kristin M. Reddoch-Cardenas, Colby McIntosh, Gema Barrera, James A. Bynum
Summary: The use of an additive solution (AS) containing apoptotic and necrotic inhibitors in refrigerated whole blood storage can better preserve platelet count but does not improve platelet function. This is more convenient for the treatment of hemorrhagic shock on the battlefield than component therapy.
Article
Hematology
Kristin M. M. Reddoch-Cardenas, Heather F. F. Pidcoke, Anand K. K. Ramasubramanian, M. Adam Meledeo, Andrew P. P. Cap
Summary: Storing platelets in a cold and high-pressure xenon gas environment extends the shelf life to 14 days, but does not significantly improve platelet function. However, this method complicates platelet storage and delivery logistics.