Article
Oncology
Hongdian Zhang, Peng Ren, Mingquan Ma, Xiaolei Zhu, Kai Zhu, Wanyi Xiao, Lei Gong, Peng Tang, Zhentao Yu
Summary: The study investigated the prognostic value of AFR and AGR in patients with ESCC, finding that AFR may be an independent predictor of overall survival. The predicted nomogram containing AFR showed higher predictive ability with a higher C-index. Calibration curves and DCA analysis supported the conclusion that a low preoperative AFR could be a valuable predictor of poor prognosis in ESCC patients.
Article
Oncology
Shota Hoshino, Satoru Matsuda, Hirofumi Kawakubo, Shigeo Yamaguchi, Kohei Nakamura, Eriko Aimono, Kazuaki Matsui, Tomoyuki Irino, Kazumasa Fukuda, Rieko Nakamura, Hajime Okita, Hiroshi Nishihara, Hiroya Takeuchi, Yuko Kitagawa
Summary: This study validates the prognostic impact of plasma fibrinogen (FNG) levels in patients with esophageal squamous cell carcinoma (ESCC) and identifies its relationship with an immunosuppressive tumor microenvironment and poor response to nivolumab.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Yufeng Qiao, Mingquan Ma, Hongdian Zhang, Zhentao Yu, Peng Tang
Summary: The study compared the prognostic value of F-TMI system with TMI alone in patients with ESCC, showing that F-TMI system was an independent prognostic factor and more useful prognostic indicator than either fibrinogen or TMI alone.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Cell Biology
Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee, Chao Cheng
Summary: The study revealed significant differences in the microbiota composition between patients with ESCC and those with PN esophagus, with the former showing reduced microbial diversity and decreased abundances of specific taxa. Functional analysis indicated altered nitrate reductase and nitrite reductase functions in the microbiota of ESCC patients. These findings suggest that specific microbes and microbiota may influence the development of ESCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qingfu Zhu, Liu Huang, Qinsi Yang, Zheng Ao, Rui Yang, Jonathan Krzesniak, Doudou Lou, Liang Hu, Xiaodan Dai, Feng Guo, Fei Liu
Summary: Metabolomic analysis of plasma exosomes in patients with ESCC revealed 196 metabolites, with a marker set of 3'-UMP, palmitoleic acid, palmitaldehyde, and isobutyl decanoate showing high accuracy in predicting ESCC recurrence. These exosome metabolome signatures, likely associated with cancer metabolism, could potentially serve as novel biomarkers for diagnosis and prognosis of ESCC.
Article
Oncology
Yasukazu Kanie, Akihiko Okamura, Suguru Maruyama, Kei Sakamoto, Daisuke Fujiwara, Jun Kanamori, Yu Imamura, Masayuki Watanabe
Summary: This study retrospectively analyzed 208 patients with recurrent ESCC after surgery and found that elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. Further research is needed to find alternative treatments for patients with high serum SCC-Ag levels at recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zheng Lin, Wenqing Rao, Zhisheng Xiang, Qiaoyan Zeng, Shuang Liu, Kaili Yu, Jinsong Zhou, Jianwen Wang, Weilin Chen, Yuanmei Chen, Xiane Peng, Zhijian Hu
Summary: The diversity and composition of microbial communities in esophageal tumor tissues were found to be significantly different from tumor-adjacent tissues in patients with esophageal squamous cell carcinoma (ESCC). Certain microbial species were associated with ESCC and were found to be linked to signaling pathways involved in cancer development and progression. These findings suggest that alterations in the esophageal microbiota may play a role in the pathobiology of ESCC.
Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuxian Yang, Shiliang Liu, Chunxia Xie, Qiaoqiao Li, Tiantian Gao, Mengzhong Liu, Mian Xi, Lei Zhao
Summary: This study revealed the oncogenic role of TMED3 in esophageal squamous cell carcinoma (ESCC) and identified the overexpression of a TMED3-related protein FAM60A in ESCC tissues. Functional verification experiments demonstrated the important roles of TMED3 and FAM60A in ESCC cell proliferation and tumorigenicity.
BIOMEDICAL JOURNAL
(2023)
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Qifeng Wang, Bangrong Cao, Lin Peng, Wei Dai, Yinchun Jiang, Tianpeng Xie, Qiang Fang, Yi Wang, Lei Wu, Yongtao Han, Jinyi Lang, Kun Mi
Summary: This study established a prognostic index for patients with esophageal squamous cell cancer based on coagulation factors, which stratified patients into three risk groups and showed a significant association with pT stage and pN stage. Multivariate analysis revealed that the Coagulation Index is an independent predictor of survival for patients with ESCC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Linlin Liang, Fangfang Liu, Wenlei Yang, Wei Yang, Lei Chen, Yu He, Zhen Liu, Liqun Zhang, Fan Zhang, Fen Cai, Huawen Xu, Miaoping Lin, Mengfei Liu, Yaqi Pan, Ying Liu, Zhe Hu, Huanyu Chen, Zhonghu He, Yang Ke
Summary: This study aimed to select blood markers routinely tested in clinical settings for predicting the prognosis of esophageal squamous cell carcinoma (ESCC) patients. It found that the composite index marker MF-A is an independent predictor which may be used to estimate and stratify the prognosis for ESCC patients undergoing esophagectomy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
