Review
Cardiac & Cardiovascular Systems
Daniela Crousillat, Joan Briller, Niti Aggarwal, Leslie Cho, Thais Coutinho, Colleen Harrington, Eric Isselbacher, Kathryn Lindley, Maral Ouzounian, Ourania Preventza, Jyoti Sharma, Ranya Sweis, Melissa Russo, Nandita Scott, Nupoor Narula
Summary: Despite being more common in men, women with thoracic aortic aneurysm and dissection (TAAD) receive lower rates of treatment and surgical intervention, leading to worse outcomes. Additionally, an increasing number of women with TAAD desire pregnancy, which poses an increased risk of aortic complications. Understanding the sex-specific differences in TAAD holds the potential to enhance care delivery, reduce treatment disparities, and optimize outcomes for women with TAAD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Isabel Rodriguez, Alvaro Del Rio-Garcia, Yamina Mohamedi, Maria Martin, Valentina Chiminazzo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: The study found an association between the C allele of rs12526196 in the CCN2 gene and the presence of thoracic aortic aneurysm (TAA), suggesting a potential protective role of CCN2 in TAA development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Linda Sharples, Priya Sastry, Carol Freeman, Colin Bicknell, Yi-Da Chiu, Srinivasa Rao Vallabhaneni, Andrew Cook, Joanne Gray, Andrew McCarthy, Peter McMeekin, Luke Vale, Stephen Large
Summary: The study aimed to observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. It found that the risk of death increased with aneurysm size at baseline and with growth, while hospital admissions also increased with aneurysm size.
EUROPEAN HEART JOURNAL
(2022)
Article
Hematology
John DePaolo, Michael G. Levin, Catherine Tcheandjieu, James R. Priest, Dipender Gill, Stephen Burgess, Scott M. Damrauer, Julio A. Chirinos
Summary: Observational studies have shown that high blood pressure is a significant risk factor for thoracic aortic dilation, and reducing blood pressure is recommended for preventing the progression of aortic aneurysms. However, the causal relationship between blood pressure and aortic size has not been conclusively established.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammad A. Zafar, Julia Fayanne Chen, Jinlin Wu, Yupeng Li, Dimitra Papanikolaou, Mohamed Abdelbaky, Thais Faggion Vinholo, John A. Rizzo, Bulat A. Ziganshin, Sandip K. Mukherjee, John A. Elefteriades
Summary: The study revealed that the mean growth rate of descending thoracic and thoracoabdominal aortic aneurysms was 0.19 cm/year, increasing with aortic size. Acute type B dissections frequently occurred at small aortic sizes, while fatal complications increased dramatically at 6.0 cm, suggesting the importance of preemptive intervention before this criterion to save lives.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Hanaa Dakour-Aridi, Kanhua Yin, Farhan Hussain, Satinderjit Locham, Ali Azizzadeh, Mahmoud B. Malas
Summary: The outcomes of thoracic endovascular aortic repair (TEVAR) in octogenarians for thoracic aortic aneurysms and dissection differ from those of nonoctogenarians. While there was no significant difference in in-hospital mortality in octogenarians undergoing TEVAR for thoracic aortic dissection, they may face a higher risk of in-hospital complications in thoracic aortic aneurysm repair.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Wael Ahmad, Paula Weidler, Oroa Salem, Ursula Werra, Payman Majd, Bernhard Dorweiler
Summary: This study evaluates the incidence, etiology, and clinical implications of aortic neck dilation following thoracic endovascular aortic repair (TEVAR) for aneurysms with landing zones II and III. The results show that proximal aortic dilation after TEVAR is a common and progressive phenomenon, and the management strategies for aortic neck dilation should be carefully considered to optimize patient outcomes and improve the long-term success of the procedure.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Amer Harky, Ahmed Othman, Matthew Shaw, Omar Nawaytou, Deborah Harrington, Manoj Kuduvalli, Johnathan Kendall, Francesco Torella, Mark Field
Summary: Open thoracoabdominal aortic surgery carries significant risk to life, which is related to age, extent of aortic replacement, timing of surgery, and left ventricular function. Morbidity is considerable. Understanding these risks is fundamental for patient selection and the consent process of potential candidates for surgery, particularly in the elderly.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Juan Manuel Chao de la Barca, Alexis Richard, Pauline Robert, Maroua Eid, Olivier Fouquet, Lydie Tessier, Celine Wetterwald, Justine Faure, Celine Fassot, Daniel Henrion, Pascal Reynier, Laurent Loufrani
Summary: Aortic aneurysm is the second-most common disease affecting the aorta worldwide, and there has been no report on deep metabolomic phenotyping in experimental animal models of aortic aneurysm. In this study, targeted metabolomics analysis was performed on the blood and aortas of an experimental mice model of aortic aneurysm. The results revealed profound alterations in the metabolic profile of the aortas and blood, mainly centered on changes in NO, lipid, and energetic metabolisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. Rueckel, P. Reidler, N. Fink, J. Sperl, T. Geyer, M. P. Fabritius, J. Ricke, M. Ingrisch, B. O. Sabel
Summary: The study showed that AI-assisted radiology reporting can significantly reduce reporting time, improve accuracy in evaluating aortic aneurysm extension, and decrease inter-reader variabilities.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Genetics & Heredity
Sohei Ito, Hong S. Lu, Alan Daugherty, Hisashi Sawada
Summary: This review aims to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
Article
Hematology
Enkhjargal Budbazar, Sandra Sulser Ponce De Leon, Yuko Tsukahara, Hanxiao Liu, Yuhao Huangfu, Yu Wang, Pedro Maria Seabra, Xiaoqiu Yang, Jena Brooke Goodman, Xueping Wan, Vipul Chitalia, Jingyan Han, Francesca Seta
Summary: This study found that S-glutathionylation of SirT1 may play a crucial role in the pathogenesis of thoracic aortic aneurysms. Preventing or reversing the rOPTM of SirT1 could be a novel therapeutic strategy to prevent TAA and TAA dissection/ruptures in individuals with Marfan syndrome.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Genetics & Heredity
Juan J. Velasco, Yupeng Li, Bulat A. Ziganshin, Mohammad A. Zafar, John A. Rizzo, Deqiong Ma, Hui Zang, Asanish Kalyanasundaram, John A. Elefteriades
Summary: The KIF6 gene's 719Arg variant is strongly associated with an increased risk of aortic dissection in patients with thoracic aortic aneurysms. These findings have potential implications for predicting and managing aortic dissection, providing a valuable non-size criterion in surgical decision making.
Review
Cardiac & Cardiovascular Systems
Preethi Mani, Reza Reyaldeen, Bo Xu
Summary: Acute aortic syndromes have high mortality rates, particularly in patients with aortic dilation. Monitoring and measuring the thoracic aorta using various imaging modalities is crucial for timely interventions and to prevent progression to acute aortic syndromes. Despite lack of consensus on measurement techniques, a multimodality imaging strategy including echocardiography and cardiac computed tomography or magnetic resonance imaging is recommended for high-risk individuals.
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2021)
Article
Surgery
Michele Piazza, Francesco Squizzato, Andrea Xodo, Gianna Saviane, Edoardo Forcella, Chiara Dal Pont, Franco Grego, Michele Antonello
Summary: The study aimed to determine the optimal and safest proximal sealing length during thoracic endovascular aortic repair (TEVAR). For type II and III aortic arches, a proximal sealing length of 25-30mm may be required for a safe and durable procedure.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
