Review
Biochemistry & Molecular Biology
Ralf Gaebel, Cajetan Lang, Praveen Vasudevan, Larissa Luhrs, Katherine Athayde Teixeira de Carvalho, Eltyeb Abdelwahid, Robert David
Summary: Cardiovascular diseases are a leading cause of death in industrialized nations and have a significant impact on healthcare costs. Obesity and sedentary lifestyle contribute to an increased risk of heart-related complications, and there is a lack of comprehensive understanding and evidence on the underlying mechanisms and effective interventions. Therefore, there is a need for intensified research efforts in order to prevent and effectively manage cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E. Grobbee, Dipak Kotecha, Stefan D. Anker, Tomasz Dyszynski, Benoit Tyl, Spiros Denaxas, R. Thomas Lumbers, Harry Hemingway
Summary: This study aimed to evaluate the evidence and prevalence of risk factors (RFs) for incident heart failure (HF) and their impact on prognosis. The study found that the range of RFs for HF is wide, but only a few factors have high-quality observational evidence and effective interventions supported by randomized controlled trials (RCTs). In addition, the study found that the co-occurrence of multiple RFs is common in HF patients and having multiple RFs simultaneously leads to poor prognosis.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, Erin Howden, Justin Lawley, Mitchel Samels, Benjamin D. Levine
Summary: Patients with HFpEF have lower peak oxygen consumption and heart rate compared to senior controls, but there were no significant differences in peak heart rate response during static handgrip exercise and metaboreceptor function between the two groups. The key reflex autonomic pathways regulating exercise heart rate responsiveness are intact in HFpEF despite lower peak exercise heart rates.
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearon, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
Summary: Exercise intolerance is a common symptom in patients with heart failure with preserved ejection fraction (HFpEF), which is believed to be caused by a marked rise in pulmonary capillary wedge pressure (PCWP). This study investigated the effect of nitroglycerin on PCWP and exercise capacity in patients with HFpEF. The results showed that nitroglycerin successfully reduced PCWP during exercise, but did not improve peak oxygen uptake. These findings suggest that reducing PCWP alone is not sufficient to enhance exercise capacity in patients with HFpEF.
Article
Medicine, Research & Experimental
Giuseppe Potrick Stefani, Lucas Capalonga, Lucas Ribeiro da Silva, Thiago Gomes Heck, Matias Nunes Frizzo, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Diovana de Batista, Samlai Vedovatto, Ana Paula Santin Bertoni, Marcia Rosangela Wink, Pedro Dal Lago
Summary: The study found that combined exercise training (CET) with 13-alanine and L-histidine supplementation in rats with heart failure (HF) can improve functional capacity and biochemical variables, reduce oxidative stress and inflammation, and affect mRNA expression of calcium transporters in the skeletal muscle.
Article
Cardiac & Cardiovascular Systems
Benjamin J. R. Buckley, Stephanie L. Harrison, Elnara Fazio-Eynullayeva, Paula Underhill, Rajiv Sankaranarayanan, David J. Wright, Dick H. J. Thijssen, Gregory Y. H. Lip
Summary: Exercise-based cardiac rehabilitation was associated with lower odds of all-cause mortality, hospitalization, incident stroke, and incident atrial fibrillation at 2-year follow-up for patients with heart failure (including patients with reduced ejection fraction and preserved ejection fraction).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Soeren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuss, Tim Seidler, Andreas Schuster
Summary: Real-time cardiac magnetic resonance (RT-CMR) exercise imaging can accurately diagnose HFpEF, providing a suitable noninvasive diagnostic alternative, which may be beneficial for routine clinical use pending further multicenter studies.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Yogesh N. V. Reddy, Amanda Braun, Hidemi Sorimachi, Massar Omar, Dejana Popovic, Alessio Alogna, Michael D. Jensen, Rickey Carter
Summary: This study found that treatment with dapagliflozin can reduce pulmonary capillary wedge pressure (PCWP) at rest and during exercise in patients with HFpEF, and has favorable effects on plasma volume and body weight.
Article
Medicine, General & Internal
Jani Rankinen, Petri Haataja, Leo-Pekka Lyytikainen, Heini Huhtala, Terho Lehtimaki, Mika Kahonen, Markku Eskola, Suvi Tuohinen, Andres Ricardo Perez-Riera, Antti Jula, Harri Rissanen, Kjell Nikus, Jussi Hernesniemi
Summary: In the presence of ECG left ventricular hypertrophy (ECG-LVH), longer QRS duration is associated with increased risk of mortality and heart failure. Even within normal limits, QRS duration in ECG-LVH carries a risk of heart failure compared to individuals without ECG-LVH.
Article
Cardiac & Cardiovascular Systems
Nilay S. Shah, Anubha Agarwal, Mark D. Huffman, Deepak K. Gupta, Clyde W. Yancy, Sanjiv J. Shah, Alka M. Kanaya, Hongyan Ning, Donald M. Lloyd-Jones, Namratha R. Kandula, Sadiya S. Khan
Summary: The study found that almost two-thirds of South Asian Americans in the cohort are at intermediate or high predicted 10-year HF risk, with varying risk across demographic and clinical characteristics.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Nutrition & Dietetics
Daniela Lucini, Eleonora Pagani, Francesco Capria, Michele Galiano, Marcello Marchese, Stefano Cribellati, Gianfranco Parati
Summary: Workplace health promotion programs and services provided by insurers are important in fostering health and preventing chronic diseases. These programs should be tailored to meet the specific needs and characteristics of companies and employees. Age is an important factor to consider, as younger workers have different lifestyle patterns and stress levels compared to older workers.
Article
Cardiac & Cardiovascular Systems
Daniel Z. L. Chan, Andrew Kerr, Corina Grey, Vanessa Selak, Mildred Ai Wei Lee, Mayanna Lund, Katrina Poppe, Rob N. Doughty
Summary: Studies show that the overall incidence of heart failure in New Zealand decreased from 2006 to 2018, but contrasting trends were observed in different age groups, with rates increasing in younger individuals and decreasing in the elderly since 2013. The proportion of HF hospitalisations associated with ischaemic heart disease also decreased during this period.
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Arnaud D. Kaze, Gregg C. Fonarow, Sam Dagogo-Jack
Summary: In individuals with type 2 diabetes, severe hypoglycemia is independently associated with a higher risk of incident heart failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Christoph Ahlgrim, Sascha Kocher, Jan Minners, Nikolaus Jander, Gianluigi Savarese, Franz-Josef Neumann, Thomas Arentz, Amir Jadidi, Bjoern Mueller-Edenborn
Summary: Invasive exercise testing can improve the prediction of mortality in patients with heart failure. Patients with a favorable response to exercise have a relatively low mortality, regardless of left ventricular systolic function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Phillip H. Lam, Kalliopi Keramida, Gerasimos S. Filippatos, Neha Gupta, Charles Faselis, Prakash Deedwania, Brandon George, Ami Iskandrian, John G. Cleland, Gaurav Choudhary, Wen-Chih Wu, Charity J. Morgan, Gregg C. Fonarow, Ali Ahmed
Summary: A low right ventricular ejection fraction (RVEF) is a marker of poor outcomes in patients with heart failure with reduced ejection fraction (HFrEF). The effect of beta-blockers on outcomes in HFrEF may be modified by RVEF, but further research is needed to confirm these findings.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cell Biology
Chris S. Mantsounga, Cadence Lee, Jade Neverson, Sheila Sharma, Abigail Healy, Joshua M. Berus, Crystal Parry, Nicolle M. Ceneri, Francesc Lopez-Giraldez, Hyung J. Chun, Qing Lu, Frank Sellke, Gaurav Choudhary, Alan R. Morrison
Summary: IL-1β in inflammatory macrophages activates STAT3 and NF-κB to promote VEGF-A transcription, thereby facilitating angiogenesis. Macrophage IL-1β expression is crucial for blood flow recovery in a PAD model.
Article
Multidisciplinary Sciences
Hamed Babaei, Emilio A. Mendiola, Sunder Neelakantan, Qian Xiang, Alexander Vang, Richard A. F. Dixon, Dipan J. Shah, Peter Vanderslice, Gaurav Choudhary, Reza Avazmohammadi
Summary: This paper introduces a machine learning model that can accurately predict the passive properties of the myocardium, bypassing the tedious steps of traditional finite element inverse problems. The model performs excellently in predicting stiffness parameters related to fiber direction. The ML model's predictions demonstrate good agreement with both rat-specific and patient-specific data.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Patrick Koo, Paul Muntner, Michael E. Hall, Annie Gjelsvik, Franklin Dennis McCool, Charles B. Eaton
Summary: There is a relationship between the risks for obstructive sleep apnea and increased aldosterone levels, as well as the prevalence of resistant hypertension, among African Americans.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Obstetrics & Gynecology
Nina K. Ayala, Lauren Schlichting, Adam K. Lewkowitz, Martha B. Kole-White, Annie Gjelsvik, Karine Monteiro, Siraj Amanullah
Summary: This study, using a large dataset, found no association between antenatal depression and cesarean delivery among women delivering for the first time.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emilio A. Mendiola, Denielli da Silva Goncalves Bos, Dana M. Leichter, Alexander Vang, Peng Zhang, Owen P. Leary, Richard J. Gilbert, Reza Avazmohammadi, Gaurav Choudhary
Summary: This study investigated the effect of architectural remodeling on right ventricular (RV) adaptation in pulmonary hypertension (PH) using two rodent models. The results showed that in rats with mild RV maladaptation, there was a decrease in fiber orientation helical range in the RV free wall, preserved global circumferential strain, and less reduction in RV-pulmonary arterial coupling. These findings suggest that adaptive RV architectural remodeling could improve RV function in PH.
CIRCULATION-HEART FAILURE
(2023)
Article
Immunology
Shuai Xie, Karine Monteiro, Annie Gjelsvik
Summary: This study examined the association between maternal influenza vaccination and adverse birth outcomes. Using data from the Pregnancy Risk Assessment Monitoring System (PRAMS) during 2012-2017, it was found that influenza vaccination during pregnancy was associated with a lower risk of low birth weight and preterm birth. However, it did not have an association with small for gestational age (SGA) regardless of trimester.
Article
Obstetrics & Gynecology
Shuai Xie, Karine Monteiro, Annie Gjelsvik
Summary: This study analyzed data from pregnant women in the United States and found that smoking during pregnancy is associated with increased risks of adverse birth outcomes, while smoking cessation has little impact on the risk of preterm birth and small-for-gestational-age.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Meeting Abstract
Behavioral Sciences
Mary Ann De Banate, Annie Gjelsvik, Siraj Amanullah, Yvette Yatchmink, Pamela High
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Hojune Chung, Dhairyasheel Ghosalkar, Alice Chu, Jacob R. Heath, Tiffany Ho, Wen-Chih Wu, Gaurav Choudhary, Alan Morrison
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kyari Sumayin Ngamdu, Dhairyasheel Ghosalkar, Hojune Chung, Cadence Lee, Tiffany Ho, Alice Chu, Muhammad Baig, Wen-Chih Wu, Gaurav Choudhary, Alan Morrison
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vishal Khetpal, Julia Berkowitz, Lan Jiang, Shilpa Vijayakumar, Khansa Ahmad, Justin Echouffo Tcheugui, Anupama Menon, Daithi S. Heffernan, Gaurav Choudhary, James Rudolph, Wen-Chih Wu, Sebhat Erqou
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bradley A. Maron, Gaurav Choudhary, Rebekah L. Goldstein, Eric Garshick, Matthew Jankowich, Troo J. S. Tucker, Kathleen A. LaCerda, Brack Hattler, Edward C. Dempsey, Ruxana T. Sadikot, Shelley Shapiro, Sharon Rounds, Ronald H. Goldstein
Summary: This study aimed to investigate the efficacy of tadalafil in treating Veterans with chronic obstructive pulmonary disease complicated by pulmonary hypertension (COPD-PH). The results showed that tadalafil did not improve the patients' 6-minute walk distance or cardiopulmonary hemodynamics, but it did show some improvement in shortness of breath. However, due to under-enrollment and imbalanced randomization, the interpretation of conclusions from this study is confounded and the generalization of the findings is limited.
PULMONARY CIRCULATION
(2022)
Meeting Abstract
Biophysics
Wenzhuo Ma, Alexander Vang, Scarlett Huck, Clarissa C. Muller, Thomas Mancini, Preston Nicely, Peng Zhang, Gaurav Choudhary, Richard T. Clements
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Obstetrics & Gynecology
Nina K. Ayala, Lauren Schlichting, Adam K. Lewkowitz, Martha B. Kole-White, Annie Gjelsvik, Siraj Amanullah
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)