Review
Biochemistry & Molecular Biology
Zehua Liang, Yuquan He, Xin Hu
Summary: Chemotherapy-induced cardiovascular toxicity has become a major concern in cancer therapy. Traditional Chinese medicine formulations and the emerging field of reverse cardio-oncology provide promising approaches for prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jakub Bychowski, Wojciech Sobiczewski
Summary: Cancer and cardiac diseases are the leading causes of death in developed countries. Due to advancements in detection and treatment, more cancer patients are surviving and living longer. However, there is an increasing risk of cardiovascular complications from cancer therapies, such as heart dysfunction and premature heart disease. Cardio-oncology is a new field that focuses on screening, diagnosis, and prevention of these adverse effects. This review discusses the most relevant studies on cardiac effects of oncological therapy and methods for prevention.
Article
Cardiac & Cardiovascular Systems
Alessandra Cuomo, Valentina Mercurio, Gilda Varricchi, Maria Rosaria Galdiero, Francesca Wanda Rossi, Antonio Carannante, Grazia Arpino, Luigi Formisano, Roberto Bianco, Chiara Carlomagno, Carmine De Angelis, Mario Giuliano, Elide Matano, Marco Picardi, Domenico Salvatore, Ferdinando De Vita, Erika Martinelli, Carminia Maria Della Corte, Floriana Morgillo, Michele Orditura, Stefania Napolitano, Teresa Troiani, Carlo G. Tocchetti
Summary: A large Cardio-Oncology unit in Southern Italy has described the impact on 231 consecutive patients referred to their unit, categorizing patients into three types based on their chemotherapeutic statuses. Results showed that patients already being treated with oncological treatments (Type 2) had the highest incidence of cardiovascular events, withdrawals from oncological treatments, and worst 48-month survival compared to other types.
Article
Pediatrics
Molly Brickler, Alexander Raskin, Thomas D. Ryan
Summary: The landscape of pediatric oncology has changed significantly, with improved survival rates due to advancements in chemotherapy and development of novel therapies. However, many targeted treatments can lead to cardiovascular pathologies. Data on prevention and treatment strategies for pediatric cardiac diseases are lacking, leading to practice variability. Future research should focus on prevention strategies, management of cardiovascular risk factors, risk prediction, early detection, and understanding the role of genetic susceptibility. Collaboration between pediatric cardiologists and oncologists is crucial for better understanding and preventing cardiac diseases in pediatric oncology patients.
Article
Cardiac & Cardiovascular Systems
Katarina Yaros, Benay Eksi, Alvin Chandra, Kartik Agusala, Lorenz H. Lehmann, Vlad G. Zaha
Summary: Cardiovascular imaging plays an important role in the care of cancer patients, as they face increased risks of cardiovascular complications. Currently established imaging modalities are evolving towards increased specificity, while new modalities are emerging to target earlier stages of cardiovascular disease. Choosing suitable imaging modalities for individual patients is crucial for successful risk stratification. Future imaging tools have the potential to provide insights into the molecular pathology of cardiovascular complications associated with cancer and oncological therapies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Vera Vaz Ferreira, Arjun K. Ghosh
Summary: Cardio-oncology is a subspecialty that provides cardiac care for cancer patients. Cardiovascular toxicity (CVT) caused by newer oncological agents has emerged as a concern, emphasizing the need for baseline assessment and individualized surveillance during and after cancer therapy. Early diagnosis and management strategies are crucial.
Article
Medicine, Research & Experimental
Carlos D. Vera, Agustin Rodriguez Lopez, Alex S. Ewaneewane, Kasey Lewis, Sophia Parmisano, Gema Mondejar-Parreno, Chandan Upadhyaya, Mckay Mullen
Summary: Cancer and cardiovascular diseases are the top two causes of death in the United States. While novel therapies have slowed down cancer mortality rate, there has been an increase in cardiac failures due to the toxicity of cancer treatments. Understanding the mechanisms behind this relationship is crucial in properly treating patients at risk of developing cardiac failure. Currently, early-stage biomarkers of inflammation and angiogenesis are used to detect cardiotoxicity before it becomes irreversible, with the aim of minimizing the adverse effects of cancer therapies. In the field of cardio-oncology, there is growing focus on gender and racial disparities in cardiotoxicity and their impact on disease outcomes, although data on variations in cardiotoxicity across diverse populations is limited.
Review
Cardiac & Cardiovascular Systems
Yinghui Wang, Yonggang Wang, Xiaorong Han, Jian Sun, Cheng Li, Binay Kumar Adhikari, Jin Zhang, Xiao Miao, Zhaoyang Chen
Summary: Cardiovascular disease (CVD) and cancer are leading causes of death worldwide. The adverse effects of anti-tumor therapy, particularly on the cardiovascular system, have gained significant attention. Incidence of cardiovascular events is higher than tumor recurrence rate, and CVD and malignant tumors share common risk factors. Clinicians should understand this relationship, provide primary and secondary prevention strategies, and follow proper treatment methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Adam Goldman, Elad Maor, David Bomze, Jennifer E. Liu, Joerg Herrmann, Joshua Fein, Richard M. Steingart, Syed S. Mahmood, Wendy L. Schaffer, Miguel-Angel Perales, Roni Shouval
Summary: This study identified an association between CAR-T therapy and various CPAEs, including tachyarrhythmias, cardiomyopathy, pericardial and pleural disorders, and venous thromboembolic events. These findings should be considered in the assessment and monitoring of CAR-T therapy recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Giacomo Tini, Alessandra Cuomo, Allegra Battistoni, Matteo Sarocchi, Valentina Mercurio, Pietro Ameri, Massimo Volpe, Italo Porto, Carlo Gabriele Tocchetti, Paolo Spallarossa
Summary: This study investigated the CV risk assessment, prescriptions of cardioactive drugs, and occurrence of CV events in breast cancer patients. The study found that patients with medium-to-high CV risk were more likely to receive cardioactive therapies, but the risk categories were not associated with LVD occurrence.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Shawn Simek, Brian Lue, Anjali Rao, Goutham Ravipati, Srilakshmi Vallabhaneni, Kathleen Zhang, Vlad G. Zaha, Alvin Chandra
Summary: Gender differences exist in the medical field, including cardio-oncology. Gender may influence cancer susceptibility, cardiotoxicities, healthcare, and cancer treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Johanna E. J. Jacobs, Wouter L'Hoyes, Lieselotte Lauwens, Yu-Ling Yu, Marius Brusselmans, Caroline Weltens, Jens-Uwe Voigt, Hans Wildiers, Patrick Neven, Joerg Herrmann, Lutgarde Thijs, Jan A. Staessen, Stefan Janssens, Lucas N. L. Van Aelst
Summary: This study compared the rates of cardiovascular events in the first decade following curative radiotherapy for breast cancer. It found that heart failure and atrial fibrillation/flutter were common during this period. These results highlight the need for early dedicated cardio-oncological follow-up after radiotherapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Abigail R. Cartus, Marian P. Jarlenski, Katherine P. Himes, Alton Everette James, Ashley Naimi, Lisa M. Bodnar
Summary: The study found that severe maternal morbidity (SMM) is associated with an increased risk of adverse cardiovascular events in the 2 years postpartum, particularly heart failure, ischemic heart disease, and stroke/transient ischemic attack. Women who survive SMM may benefit from more comprehensive postpartum care.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Craig J. Beavers, Jo E. Rodgers, Aaron J. Bagnola, Theresa M. Beckie, Umberto Campia, Katherine E. Di Palo, Tochi M. Okwuosa, Eugene R. Przespolewski, Susan Dent
Summary: In the population of cardio-oncology, drug interactions play a significant role due to the complexity of drugs and potential risks. It is important for clinicians to recognize potential drug-drug interactions to minimize risks in cardiovascular or cancer therapies. This scientific statement provides an overview of pharmacodynamic and pharmacokinetic drug interactions for clinicians treating cancer patients exposed to common cardiovascular and cancer medications.
Review
Oncology
Daniel A. Cehic, Aaron L. Sverdlov, Bogda Koczwara, Jon Emery, Doan T. M. Ngo, Elysia Thornton-Benko
Summary: There is significant interplay between cancer and cardiovascular disease, with shared risk factors and potential influence of cardiovascular events on cancer patients' survival rates. Cardio-toxicity from cancer treatments can increase cardiovascular mortality and morbidity in cancer patients. Cardio-oncology plays a crucial role in the prevention, early detection, and treatment of cardiovascular disease in cancer patients globally. Primary care physicians have a foundation role in managing cancer patients, despite the current lack of adequate clinical framework.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)