Article
Engineering, Biomedical
Xiufeng Ju, Tongtong Miao, Haiyan Chen, Jiang Ni, Liang Han
Summary: Mfsd2a plays a crucial role in regulating the transcytosis and permeability of the blood-brain barrier. Strategies involving priming nanoparticles and drug-loaded nanoparticles have shown promising results in enhancing BBB crossing efficiency and brain accumulation of therapeutics for breast cancer brain metastases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Geok-Lin Chua, Bryan C. Tan, Randy Y. J. Loke, Menglan He, Cheen-Fei Chin, Bernice H. Wong, Alvin C. Y. Kuk, Mei Ding, Markus R. Wenk, Lan Guan, Federico Torta, David L. Silver
Summary: Mfsd2a is a sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain barrier that is crucial for omega-3 fatty acid transport and brain development. Although the transport mechanism of Mfsd2a has been proposed through cryo-EM structures, the biochem-ical evidence of flippase activity and sodium-dependent LPC inversion is still lacking. In this study, an in vitro assay using recombinant Mfsd2a reconstituted in liposomes was established to demonstrate the flipping of lysophosphatidylserine (LPS) from the outer to the inner leaflet of a membrane bilayer in a sodium-dependent manner. Through cryo-EM structures, mutagenesis, and cell-based transport assay, amino acid residues important for Mfsd2a activity were identified, providing direct biochemical evidence of Mfsd2a functioning as a lysolipid flippase.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nanoscience & Nanotechnology
Cong Yang, Mengmeng Han, Ruoyu Li, Ligui Zhou, Ying Zhang, Lining Duan, Shiyu Su, Min Li, Qi Wang, Tongkai Chen, Yousheng Mo
Summary: Intracerebral hemorrhage (ICH) is a severe form of stroke with pathology related to ferroptosis, a type of programmed cell death. Curcumin (Cur) has therapeutic potential for ICH but faces challenges due to poor solubility and bioavailability. Encapsulating Cur in nanoparticles (Cur-NPs) improves its delivery to the brain and shows promising therapeutic effects in treating ICH, including suppressing ferroptosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Neurosciences
Fei Wang, Xiangyu Zhang, Yang Liu, Zhe Li, Ruixue Wei, Yan Zhang, Ruiyi Zhang, Suliman Khan, V. Wee Yong, Mengzhou Xue
Summary: In a mouse model of ICH, treatment with Ozanimod improved neurobehavioral deficits, reduced weight loss, decreased density of activated microglia and infiltrated neutrophils, reduced hematoma volume and brain water content, mitigated brain cell death, and reduced BBB destruction, thereby exerting neuroprotective roles.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yu-Xin Ding, Gao-Wa Eerduna, Si-Jin Duan, Ting Li, Rong-Xia Liu, Lei-Ming Zhang, Tian Wang, Feng-Hua Fu
Summary: The study demonstrates that escin improves neurological function in ICH mice by ameliorating systemic inflammation instead of directly targeting the brain, notably by inhibiting the IL-1 beta/RhoA/NF-kappa B signaling pathway in the blood-brain barrier. This suggests a potential therapeutic approach for brain injury post-ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Yan Zhang, Yang Liu, Xiangyu Zhang, V. Wee Yong, Mengzhou Xue
Summary: This study aims to investigate the protective effects of omarigliptin on the destruction of the blood-brain barrier (BBB) following intracerebral hemorrhage (ICH) in mice. The results showed that omarigliptin reduced DPP4 expression, decreased hematoma formation and neurobehavioral deficits, and inhibited the activation and infiltration of microglia/macrophages and neutrophils. Furthermore, omarigliptin protected the integrity of the BBB after ICH by reducing MMP-9 expression and preserving tight junction proteins on endothelial cells.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shengpan Chen, Lingzhi Li, Chao Peng, Chunjing Bian, Pinar Eser Ocak, John H. Zhang, Yong Yang, Dong Zhou, Guangzhong Chen, Yumin Luo
Summary: This review examines the breakdown of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) and focuses on strategies to protect the BBB integrity and potential therapeutic targets.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Neurosciences
Yuan Zhang, Lin Wang, Qiuling Pan, Xiaomin Yang, Yunchuan Cao, Jin Yan, Yingwen Wang, Yihao Tao, Runjin Fan, Xiaochuan Sun, Lin Li
Summary: CYM-5442 protects the integrity of the BBB in TBI mice by reducing vesicle transcytosis of cerebrovascular endothelial cells, alleviating neurological deficits and cerebral edema in the acute stage of TBI.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Review
Pharmacology & Pharmacy
Hai -Jun Liu, Peisheng Xu
Summary: Compared to surgery and radiation therapy, chemotherapy is not as effective in treating brain cancer and cancer brain metastases due to the physiological characteristics of intracranial tumors. Nanomedicines have shown promising therapeutic potential in brain tumors by employing various strategies. It is important to comprehensively summarize these practices for the development of therapeutic regimens for brain tumors.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Neurosciences
Cuiying Peng, Yilin Wang, Zhiping Hu, Chunli Chen
Summary: The inhibition of HDAC6 has a protective effect on BBB disruption after intracerebral hemorrhage (ICH) by upregulating acetylated a-tubulin and reducing stress fiber formation, which suggests that HDAC6 could be a potential target for ICH treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Min Zhou, Samuel X. Shi, Ning Liu, Yinghua Jiang, Mardeen S. Karim, Samuel J. Vodovoz, Xiaoying Wang, Boli Zhang, Aaron S. Dumont
Summary: Disruption of the blood-brain barrier following ischemic stroke can lead to various complications, with recent studies showing a stepwise impairment of the transcellular barrier followed by the paracellular barrier as a potential cause. Increased endothelial transcytosis, which is caveolae-mediated, has been identified as a factor independent of tight junction disintegration, challenging previous beliefs and providing new insights for future research and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Min Zhou, Dongna Li, Qian Shen, Lei Gao, Pengwei Zhuang, Yanjun Zhang, Hong Guo
Summary: The study showed that treatment with Storax can inhibit the caveolae-mediated transcytosis at the blood-brain barrier (BBB) in rats with ischemic stroke. This treatment also attenuated the ultrastructural disruption of BBB and regulated the expressions of key proteins involved in BBB function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hui Wang, Zhiyan Xu, Ziyue Xia, Michael Rallo, Andrew Duffy, Michael P. Matise
Summary: The study demonstrates that astrocytes are the predominant cell type in the adult CNS that transduce Hh signaling, and Gli1+ Hh-responsive astrocytes have regionally distinct molecular and functional properties. Inactivation of Hh pathway in astrocytes leads to region-specific BBB defects, affecting transcytosis but not paracellular diffusion. The findings suggest that the Hedgehog pathway is required to maintain BBB properties in specific regions of the adult mammalian CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Jie Lin, Ya Xu, Peiwen Guo, Yu-Jie Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen
Summary: Due to metabolic disequilibrium and immune suppression, intracerebral hemorrhage patients are prone to infections. The intrinsic mechanisms underlying the effects of infection-related peripheral inflammation after ICH remain unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Lais Ribovski, Edwin de Jong, Olga Mergel, Guangyue Zu, Damla Keskin, Patrick van Rijn, Inge S. Zuhorn
Summary: This study investigated the effect of nanoparticle stiffness on transport across the blood-brain barrier, finding that more densely cross-linked nanogels showed higher uptake by brain endothelial cells, while less densely cross-linked nanogels demonstrated higher transcytotic potential. These findings suggest that nanogel stiffness has opposing effects on nanogel uptake and transcytosis at the BBB.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Neuroimaging
Johannes Kaesmacher, Adnan Mujanovic, Kilian Treurniet, Manon Kappelhof, Thomas R. Meinel, Pengfei Yang, Jianmin Liu, Yongwei Zhang, Wenjie Zi, Qingwu Yang, Raul G. Nogueira, Kazumi Kimura, Yuji Matsumaru, Kentaro Suzuki, Bernard Yan, Peter J. Mitchell, Zhongrong Miao, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Jan Gralla, Jeffrey L. Saver, Urs Fischer
Summary: This study investigated the acceptable level of uncertainty for experienced stroke clinicians in deciding whether to administer intravenous thrombolysis (IVT) before endovascular treatment (EVT). The results showed that clinicians would generally feel comfortable skipping IVT if there was reasonable comparability between IVT+EVT and EVT alone, with no more than 3% of patients being unable to achieve functional independence at 90 days due to skipping IVT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Geriatrics & Gerontology
Zhouzhou Peng, Hui Lu, Qingwu Yang, Qi Xie
Summary: This review introduces the method of astrocyte reprogramming and its application in stroke. By targeting key transcription factors or microRNAs, astrocytes in the mouse brain could be reprogrammed into functional neurons. Current controversies over the lack of cell lineage tracing and single-cell sequencing experiments are also summarized.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Qin Zhang, Wei-lin Kong, Jun-Jie Yuan, Qiong Chen, Chang-Xiong Gong, Liang Liu, Fa-Xiang Wang, Jia-Cheng Huang, Guo-Qiang Yang, Kai Zhou, Rui Xu, Xiao-Yi Xiong, Qing-Wu Yang
Summary: This study investigates the contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection in an intracerebral hemorrhage-induced acute brain injury rat model. The findings reveal that neuroinflammation-associated genes are upregulated in ICH rat brains regardless of age, with interferon-gamma response genes activated in both age groups. Anti-IFN-gamma treatment effectively reduces acute brain injury in older rats. Additionally, histone modifications, particularly H3K4me3 and H3K27me3, are redistributed in neuroinflammation-associated genes in both age groups and are correlated with gene expression. These findings highlight the potential of targeting histone modifications as a therapeutic approach for age-related diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Fan Qinlin, Wang Bingqiao, Hu Linlin, Shi Peixia, Xie Lexing, Yang Lijun, Yang Qingwu
Summary: The study identified that overexpression of miR-129-5p significantly reduced neuronal cell autophagy levels and expressions of related proteins. It also revealed that FEZ1, SCOC, ULK1, and NBR1 are target genes of miR-129-5p and can form a protein complex. These findings suggest a potential regulatory role of miR-129-5p in autophagy processes and neuronal function.
Article
Immunology
Chang Liu, Fengli Li, Shuai Liu, Qiong Chen, Hongfei Sang, Qingwu Yang, Kai Zhou, Wenji Zi
Summary: MCE plays a crucial role in worsening prognosis for ABAO after EVT. A high neutrophil count at admission is associated with MCE and a poor outcome among ABAO patients, and incorporating this factor into clinical decision-making could guide immunomodulation therapy effectively.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Likun Wang, Sheng Luo, Siying Ren, Hui Yu, Guiquan Shen, Guofeng Wu, Qingwu Yang
Summary: This study found that irregular-shaped hematoma was an independent predictor of postoperative rehemorrhage after sMIS, which can be used to assess the risk of rehemorrhage in patients before surgery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jiacheng Huang, Maolin Wang, Fengli Li, Weilin Kong, Da Liu, Huagang Li, Peiyang Zhou, Zhizhong Yan, Yan Wang, Jiaxing Song, Weidong Luo, Shuai Liu, Linyu Li, Jinrong Hu, Yan Tian, Zhongming Qiu, Rui Xu, Wouter J. Schonewille, Wenjie Zi, Qingwu Yang
Summary: This study identified potential modifiable risk factors for early mortality in patients with basilar artery occlusion, including recanalization failure, herniation, gastrointestinal hemorrhage, and pneumonia.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Wenjie Zi, Jiaxing Song, Zhongming Qiu, Weilin Kong, Jiacheng Huang, Weidong Luo, Shuai Liu, Hongfei Sang, Jie Yang, Linyu Li, Yan Tian, Jinrong Hu, Jeffrey L. Saver, Raul G. Nogueira, Fengli Li, Qingwu Yang
Summary: This study aims to compare the efficacy and safety of tirofiban with aspirin in patients with acute ischemic stroke. The study will be conducted in multiple stroke centers in China and will evaluate the functional outcomes and potential safety issues in patients after 90 days of treatment.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Immunology
Lexing Xie, Shuang Zhang, Li Huang, Zhouzhou Peng, Hui Lu, Qian He, Ru Chen, Linlin Hu, Bingqiao Wang, Baoliang Sun, Qingwu Yang, Qi Xie
Summary: Stroke is a leading cause of death and disability worldwide. Researchers have found that peripheral immune cells infiltrate the brain and cause inflammation after cerebral ischemia. However, it is still unclear how and when these immune cells affect the central inflammatory response, and whether interventions targeting these processes can reduce ischemia-reperfusion injury.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Zhouzhou Peng, Jiaxing Song, Linyu Li, Changwei Guo, Jie Yang, Weilin Kong, Jiacheng Huang, Jinrong Hu, Shuai Liu, Yan Tian, Dahong Yang, Fengli Li, Wenjie Zi, Dongjing Xie, Qingwu Yang
Summary: This study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and clinical outcomes at 90 days in acute ischemic stroke due to large vessel occlusion receiving endovascular treatment. The study found that SHR was negatively associated with the odds of achieving favorable functional outcomes at 90 days.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Zhiyi Chen, Xuerong Liu, Qingwu Yang, Yan-Jiang Wang, Kuan Miao, Zheng Gong, Yang Yu, Artemiy Leonov, Chunlei Liu, Zhengzhi Feng, Hu Chuan-Peng
Summary: This study systematically evaluated the clinical applicability and reporting quality of neuroimaging-based AI models for psychiatric diagnosis. The results showed high risk of bias and poor reporting quality. The application of these models in clinical practice still faces challenges and needs to address the risk of bias and improve reporting quality.
Article
Clinical Neurology
Chenhao Zhao, Ting Hu, Weilin Kong, De Yang, Junfang Wan, Kefeng Lv, Jiasheng Liao, Zhao Chen, He Jiang, Deping Wu, Ping Yang, Wenjie Zi, Fengli Li, Qingwu Yang
Summary: This study aimed to evaluate the impact of FPE on efficacy and safety for patients with acute basilar artery occlusion (BAO). The results showed that achieving FPE was strongly associated with favorable clinical outcomes, lower mortality rate, and shorter time to recanalization. Compared with final successful reperfusion, FPE also independently contributed to favorable outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Jie Yang, Fengli Li, Zhongming Qiu, Yan Wang, Jun Luo, Youlin Wu, Guoyong Zeng, Yue Wan, Shuai Liu, Chengsong Yue, Jiaxing Song, Weidong Luo, Chang Liu, Linyu Li, Ruidi Sun, Jiacheng Huang, Hongfei Sang, Chenhao Zhao, Qingwu Yang, Wenjie Zi
Summary: The study aimed to investigate the efficacy and safety of combining endovascular treatment (EVT) with standard medical treatment (SMT) in Chinese patients with acute basilar artery occlusion (BAO) within 6 hours of occlusion. Patients were divided into SMT-alone group or EVT+SMT group. Results showed that EVT was associated with a higher rate of favorable functional outcome and a lower proportion of deaths. Predictors of favorable outcome in the EVT+SMT group included younger age, lower baseline National Institutes of Health Stroke Scale score, higher baseline posterior circulation Alberta Stroke Program Early CT Score, absence of diabetes mellitus, and modified Thrombolysis in Cerebral Infarction scores 2b-3.
JOURNAL OF NEUROSURGERY
(2023)
