Review
Biotechnology & Applied Microbiology
Yu-Ming Cai, Ying-Dan Zhang, Liang Yang
Summary: Nitric oxide (NO) plays a crucial role in controlling microbial infections, particularly in chronic lung infections. While endogenously generated NO helps eradicate invading pathogens in healthy individuals, this pathway is often compromised in patients with chronic lung infections. Exogenous NO supplementation may improve therapeutic outcomes in these cases.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Guiqin Yang, Qijun Mai, Zheng Zhuang, Li Zhuang
Summary: Enhancing the buffer capacity of the electrolyte can improve the anode performance in bioelectrochemical systems, with the buffer concentration positively correlated with the electrochemical activities of the anode biofilms. The spatial structure and microbial community composition of the anode biofilms are regulated by the buffer capacity, with increased buffer concentration leading to decreased microbial heterogeneity within the biofilm.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biology
Nurul Najihah Rawi, Mujahidah Mohd Ramzi, Nor Izzati Abd Rahman, Fazilah Ariffin, Jasnizat Saidin, Kesaven Bhubalan, Noor Wini Mazlan, Nor Atikah Mohd Zin, Julius Yong Fu Siong, Kamariah Bakar, Ahmad Khusairi Azemi, Noraznawati Ismail
Summary: This study aimed to determine the antifouling activities of the marine microorganism P. aeruginosa and characterize it as a potential anti-biofouling agent. The bacterial isolate was cultured, and the extract was screened for antibacterial activities. The results showed high inhibition of biofilm formation and reduction in bacteria colonies. The isolated bacteria, identified as Pseudomonas aeruginosa, have the potential to be used as an alternative to toxic antifoulants.
Article
Anatomy & Morphology
Kumari Uma Mahto, Surajit Das
Summary: Biofilm formation in bacteria is influenced by the nature of substrata. A marine bacterium Pseudomonas aeruginosa PFL-P1 formed dense biofilms with varied aggregation on different substrata, with ceramic substratum showing the highest roughness and maximum biofilm thickness. The study provides insight into how substratum properties can impact biofilm formation in bacteria.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Infectious Diseases
Taehyeong Lim, So-Young Ham, SangJin Nam, Myoungsun Kim, Ki Yong Lee, Hee-Deung Park, Youngjoo Byun
Summary: This article reviews recent studies on small molecules targeting the RhlI/RhlR system in P. aeruginosa, discussing their in vitro and in vivo biological activities. The article focuses on structure-activity relationship studies and the outlook for next-generation anti-biofilm agents.
Article
Biotechnology & Applied Microbiology
James Redfern, Janine Wallace, Alex van Belkum, Magali Jaillard, Elliot Whittard, Roobinidevi Ragupathy, Joanna Verran, Peter Kelly, Mark Charles Enright
Summary: Pseudomonas aeruginosa is a common environmental microorganism that can form biofilms on indwelling device surfaces, promoting adhesion and survival. Research identified accessory genes and core-genome SNPs associated with enhanced biofilm production at 22 degrees C, including a 165 kb genomic island with heavy metal resistance genes.
Article
Infectious Diseases
Tomasz Bogiel, Dagmara Depka, Mateusz Rzepka, Joanna Kwiecinska-Pirog, Eugenia Gospodarek-Komkowska
Summary: The study investigated the frequency and genotype distribution of 10 virulence factor genes in 107 non-duplicated carbapenem-resistant P. aeruginosa isolates. Variations were observed in the prevalence and distribution of virulence genes, especially in terms of their carbapenemase synthesis ability and the strain origin.
Article
Biology
Steffen Geisel, Eleonora Secchi, Jan Vermant
Summary: Biofilms are bacterial communities encased by a self-produced matrix, and the channel networks formed within the biofilm play a vital role in promoting the transport of nutrients and chemicals. This study focuses on the role of the biofilm matrix adhesion in channel formation, specifically in Pseudomonas aeruginosa biofilms grown under constant flow in microfluidic channels. The formation of wrinkles and folds is triggered by a mechanical buckling instability, resulting in hollow channels that facilitate bacterial movement.
Article
Pharmacology & Pharmacy
Mariana Martins Drumond, Ana Paula Tapia-Costa, Elisabeth Neumann, alvaro Cantini Nunes, Jorge Wanderson Barbosa, Diego E. Kassuha, Pamela Mancha-Agresti
Summary: This study aimed to investigate the effect of cell-free spent medium (CFSM) from four lactic acid bacteria on Pseudomonas aeruginosa. The results showed that the CFSM had antibacterial and antibiofilm activity against the pathogenic strains. The findings suggest that the CFSM derived from different Lactobacilli could be a potential adjuvant therapy for hospital infections caused by Pseudomonas aeruginosa.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Anming Xu, Xiaoxiao Zhang, Tong Wang, Fengxue Xin, Luyan Z. Ma, Jie Zhou, Weiliang Dong, Min Jiang
Summary: Pseudomonas aeruginosa is known for its excellent ecological flexibility and can survive in diverse niches. The adaptive mutants RSCVs have been frequently isolated from chronic infections, sparking interest in investigating their formation, persistence, and pathogenesis. RSCVs are believed to play a significant role in biofilm formation and high adaptability.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Xiaodie Yuan, Xia Zhao, Yuan Lin, Zhaohui Su
Summary: This study synthesized PDA nanoparticles of various sizes and introduced different surface groups to investigate their penetration and accumulation abilities in biofilms. The PDA nanoparticles of approximately 60 nm size showed higher penetration and accumulation abilities, and the positively charged amine groups were more effective in enhancing the interactions with the biofilm compared to carboxyl or methoxy groups. The PDA60 nanoparticles with amine surface groups also exhibited good photothermal properties.
Article
Infectious Diseases
Emilie Charpentier, Ludovic Doudet, Ingrid Allart-Simon, Marius Colin, Sophie C. Gangloff, Stephane Gerard, Fany Reffuveille
Summary: The combination of non-antimicrobial molecules with antibiotics can significantly reduce bacterial biofilm formation, potentially offering a solution to combat antibiotic resistance emergence.
Article
Pharmacology & Pharmacy
Davoodbasha MubarakAli, Kannappan Arunachalam, Murugan Lakshmanan, Bazigha Badar, Jung-Wan Kim, Sang-Yul Lee
Summary: Biofilm-related nosocomial infections can cause various life-threatening infections. In this study, hydroxyapatite nanoparticles (HANPs) were synthesized using a co-precipitation method followed by microwave treatment, and their ability to inhibit the biofilm formation of Pseudomonas aeruginosa ATCC 10145 was investigated. The results showed that the synthesized HANPs effectively inhibited biofilm formation, suggesting their potential use in controlling biofilm-related infections caused by Pseudomonas aeruginosa.
Article
Materials Science, Biomaterials
Wei Guo, Yongjie Wang, Pengqi Wan, Hao Wang, Li Chen, Shaokun Zhang, Chunsheng Xiao, Xuesi Chen
Summary: Bacterial infections and antibiotic resistance have become a global healthcare crisis. Cationic amphiphilic dendrons designed and synthesized showed excellent antimicrobial activities, depending highly on the length of the hydrophobic alkyl chain. The identified prime candidate exhibited rapid and broad-spectrum bactericidal activity, disrupting the integrity of a pathogen's membrane and promoting wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Immunology
Zuoji Ye, Liumei Ye, Dingbin Li, Shunsheng Lin, Wusheng Deng, Li Zhang, Jinhua Liang, Jinlong Li, Qingjun Wei, Ke Wang
Summary: In this study, the researchers found that Daphnetin (DAP) can effectively inhibit and eradicate biofilm formation of Pseudomonas aeruginosa. DAP also reduced bacterial motility and pyocyanin production. These findings suggest that DAP may serve as a natural anti-biofilm therapeutic agent.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Electrochemistry
Maira Anam, Sameen Yousaf, Iqra Sharafat, Zargona Zafar, Kamran Ayaz, Naeem Ali
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2017)
Article
Environmental Sciences
S. Yousaf, M. Anam, N. Ali
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2017)
Article
Environmental Sciences
Z. Zafar, K. Ayaz, M. H. Nasir, S. Yousaf, I. Sharafat, N. Ali
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Analytical
Sameen Yousaf, Patrick J. S. King, Aline F. Miller, Alberto Saiani, David J. Clarke, Linda T. Trivoluzzi, Harmesh S. Aojula, Elena V. Bichenkova
ANALYTICAL CHEMISTRY
(2019)