Review
Gastroenterology & Hepatology
Swati G. Patel, Jordan J. Karlitz, Timothy Yen, Christopher H. Lieu, C. Richard Boland
Summary: This Series paper provides a comprehensive review on the topic of early-onset colorectal cancer, including examining the epidemiology, clinical and pathological features, genetic and epigenetic landscapes, and emerging data on clinical risk factors associated with this malignancy. Evidence-based approaches to prevention and early detection are also presented.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Pathology
Hong Fang, Sa A. Wang, Wei Xie, Zhenya Tang, Shimin Hu, Savitri Krishnamurthy, L. Jeffrey Medeiros, Wei Wang
Summary: This study reports on 6 patients with myelodysplastic syndrome (MDS) who underwent lymph node biopsies showing MDS infiltration, with distorted architecture and myeloid cell expansion. Despite treatment, all patients had poor responses and short survival times.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Mizuki Yagishita, Hiroto Tsuboi, Yuki Kuroda, Tomonori Sawabe, Akira Kawashima, Fumina Kawashima, Nana Uematsu, Ryota Sato, Taihei Nishiyama, Mayu Terasaki, Hirofumi Toko, Fumika Honda, Ayako Ohyama, Saori Abe, Ayako Kitada, Haruka Miki, Shinya Hagiwara, Yuya Kondo, Takayuki Sumida, Isao Matsumoto
Summary: Recent studies have shown that the clinical features and cytokine profiles of elderly-onset adult-onset Still's disease (AOSD) differ from those of young and middle-aged-onset patients. Elderly-onset AOSD patients have a higher risk of infection and exhibit different characteristics such as atypical rash, higher white blood cell count, and lower serum IL-6 levels.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Alexandra M. Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura D'Allens, Caterina Allmer, Andrea Alvarez, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc Bludau, Nelleke Brouwer, Carl Brown, Christiane Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W. A. Burger, Nikita Burlov, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee-Hoon Chew, Dimitri Christoforidis, David Clark, Marta Climent, Rowan Collinson, Kyle G. Cologne, Tomas Contreras, Roland Croner, Ian R. Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, Andre Dias, Andre D'Hoore, Evgeniy Drozdov, Daniel Duek, Malcolm Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El-Hussuna, Brodie Elliot, Sameh Emile, Eloy Espin, Martyn Evans, Seraina Faes, Omar Faiz, Nuno Figueiredo, Fergal Fleming, Caterina Foppa, George Fowler, Matteo Frasson, Tim Forgan, Frank Frizelle, Shamil Gadaev, Jose Gellona, Tamara Glyn, Barisic Goran, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiri Hoch, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugne Imbrasaite, Rumana Islam, Mehrenah D. Jafari, Andrea Jimenez Salido, Marta Jimenez Toscano, Yukihide Kanemitsu, Aleksei Karachun, Ahmer A. Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov, Peter Kocian, Cherry Koh, Neils Kok, Katrina A. Knight, Joep Knol, Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde Maarten Kroon, Marius Kryzauskas, Said Kural, Miranda Kusters, Zaher Lakkis, Timur Lankov, David Larson, Gyorgy Lazar, Kai-Yin Lee, Suk Hwan Lee, Jeremie H. Lefevre, Anna Lepisto, Christopher Lieu, Lynette Loi, Craig Lynch, Helene Maillou-Martinaud, Annalisa Maroli, Sean Martin, Anna Martling, Klaus E. Matzel, Julio Mayol, Frank McDermott, Guillaume Meurette, Monica Millan, Martin Mitteregger, Andrei Moiseenko, John R. T. Monson, Stefan Morarasu, Konosuke Moritani, Gabriela Moslein, Martino Munini, Caio Nahas, Sergio Nahas, Ionut Negoi, Anastasia Novikova, Misael Ocares, Koji Okabayashi, Alexandra Olkina, Luis Onate-Ocana, Jaime Otero, Cihan Ozen, Ugo Pace, Guilherme Pagin Sao Juliao, Lidiia Panaiotti, Yves Panis, Demetris Papamichael, Swati Patel, Juan Carlos Patron Uriburu, Sze-Lin Peng, Miguel Pera, Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, Terry P. Phang, Tomas Poskus, Heather Pringle, David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed, Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris, Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh, Avanish Saklani, Tarik Sammour, Deborah Saraste, Martin Schneider, Ryo Seishima, Aleksander Sekulic, Toni Seppala, Kieran Sheahan, Alexandra Shlomina, Guiseppe Sigismondo, Tongplaew Singnomklao, Leandro Siragusa, Neil Smart, Alejandro Solis-Pena, Antonino Spinelli, Roxane D. Staiger, Michael J. Stamos, Scott Steele, Ker-Kan Tan, Pieter J. Tanis, Paris Tekkis, Biniam Teklay, Sabrina Tengku, Petr Tsarkov, Matthias Turina, Alexis Ulrich, Bruna B. Vailati, Meike van Harten, Cornelis Verhoef, Satish Warrier, Steven Wexner, Hans de Wilt, Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Justino Zeballos, Jonathan Zhou, Des C. Winter
Summary: The molecular profile of early-onset colonic cancer is not well-defined. This study analyzed the clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. The results showed that early-onset colonic cancer patients had a higher prevalence of microsatellite instability (MSI) and were associated with family history, proximal colon lesions, and BRAF/KRAS mutations. Compared with older patients with MSI cancers, early-onset patients with MSI tumors had more adverse pathological features.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Urology & Nephrology
Takuya Fujimaru, Kunio Kawanishi, Takayasu Mori, Eikan Mishima, Akinari Sekine, Motoko Chiga, Masayuki Mizui, Noriaki Sato, Motoko Yanagita, Yuki Ooki, Kiyotaka Nagahama, Yuko Ohnuki, Naoto Hamano, Saki Watanabe, Toshio Mochizuki, Katsushi Nagatsuji, Kenichi Tanaka, Tatsuo Tsukamoto, Hideo Tsushima, Mamiko Shimamoto, Takahiro Tsuji, Tamaki Kuyama, Shinya Kawamoto, Kenji Maki, Ai Katsuma, Mariko Oishi, Kouhei Yamamoto, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Mariko Miyazaki, Michio Nagata, Shinichi Uchida, Eisei Sohara
Summary: This study analyzed the genetic background and clinicopathologic features of adult NPH in 18 sporadic adult patients, finding that thick TBM duplication is a specific finding in adult NPH. Patients with pathogenic mutations were significantly younger, and older patients tended to have no pathogenic mutations even when suspected to have NPH by renal biopsy.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, Research & Experimental
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Summary: The study found that early-onset severe preeclampsia and late-onset severe preeclampsia have different molecular mechanisms, with the former associated with metabolism-related pathways and the latter with immune-related pathways. Some key transcription factors may be driving the widespread gene dysregulation in both early-onset and late-onset patients.
Article
Oncology
Namrata Setia, Cindy X. Wang, Angela Lager, Steve Maron, Stuti Shroff, Nicole Arndt, Bryan Peterson, Sonia S. Kupfer, Changqing Ma, Joseph Misdraji, Daniel Catenacci, John Hart
Summary: Early-onset gastric cancer has distinct genomic alterations, such as CDH1 mutations, but shares with traditional gastric cancers a high frequency of TP53 mutations and the TP53 mutagenic signature. Diffuse and indeterminate histologic types and the presence of a CDH1 mutation are associated with worse overall survival.
Article
Cell Biology
William Lee, Zishan Wang, Miriam Saffern, Tomi Jun, Kuan-lin Huang
Summary: Young adult tumors exhibit unique genomic characteristics with more driver mutations and copy-number alterations compared to later-onset tumors, despite lower overall mutation burden. Analysis of tumor immune microenvironments reveals elevated TGF-b response and decreased IFN-g response in young adult tumors, compared to later-onset tumors.
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoe Lang, Yang Zhou, Lei Zhao, Yinjun Gu, Xi Wu, Yuefeng Zhao, Zezhi Li, Xiangyang Zhang
Summary: In this study, metabolic abnormalities patterns, risk factors, and their association with clinical characteristics were found to differ between Chinese EOS and AOS patients.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Oncology
Rose B. McGee, Ninad Oak, Lynn Harrison, Ke Xu, Regina Nuccio, Alise K. Blake, Roya Mostafavi, Sara Lewis, Leslie M. Taylor, Manish Kubal, Annastasia Ouma, Stacy J. Hines-Dowell, Cheng Cheng, Larissa V. Furtado, Kim E. Nichols
Summary: This study retrospectively examined the prevalence and impact of pathogenic variants in adult-onset cancer predisposition genes (aoCPGs) in pediatric tumors. They found that a small percentage of patients had tumors with aoCPG variants, with some of these variants being of germline origin. These variants were associated with alterations in tumor molecular profiles, but were not commonly used to change treatment decisions in pediatric cancers.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Medicinal
Hana Votavova, Zuzana Urbanova, David Kundrat, Michaela Dostalova Merkerova, Martin Vostry, Monika Hruba, Jaroslav Cermak, Monika Belickova
Summary: DFX improves hematopoiesis in anemic myelodysplastic syndrome patients by modulating immune response, suppressing negative regulators of blood cell differentiation, and upregulating heme metabolism.
Article
Oncology
Tomotaka Ugai, Juha P. Vayrynen, Mai Chan Lau, Jennifer Borowsky, Naohiko Akimoto, Sara A. Vayrynen, Melissa Zhao, Rong Zhong, Koichiro Haruki, Andressa Dias Costa, Kenji Fujiyoshi, Kota Arima, Kana Wu, Andrew T. Chan, Yin Cao, Mingyang Song, Charles S. Fuchs, Molin Wang, Jochen K. Lennerz, Kimmie Ng, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Summary: This hypothesis-generating study suggests potential differences in histopathologic lymphocytic reaction patterns, macrophages, and regulatory T cells in the tumor microenvironment based on age at diagnosis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Luigi di Filippo, Laura Castellino, Agnese Allora, Stefano Frara, Roberto Lanzi, Francesca Perticone, Fanny Valsecchi, Alberto Vassallo, Raffaele Giubbini, Clifford J. Rosen, Andrea Giustina
Summary: This study suggests that PoVEO GD may be a new nosologic entity representing one-third of patients evaluated for new-onset GD in our center. Distinctive features included older age at onset, higher male prevalence, and a better initial biochemical and immunologic response to treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Sarah E. Webster, Brinda Ryali, Michael J. Clemente, Naomi L. Tsuji, Nichol E. Holodick
Summary: The protective capacity of serum IgM against pneumococcal infection is maintained in aged female mice but absent in aged male mice. Aged female mice have a more diverse and active CD5+ B-1 cell pool and natural IgM repertoire, which may have implications for sex-related susceptibility to infection and disease.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Hematology
Courtney D. DiNardo, Sangeetha Venugopal, Curtis Lachowiez, Koichi Takahashi, Sanam Loghavi, Guillermo Montalban-Bravo, Xuemei Wang, Hetty Carraway, Mikkael Sekeres, Ameenah Sukkur, Danielle Hammond, Kelly Chien, Abhishek Maiti, Lucia Masarova, Koji Sasaki, Yesid Alvarado, Tapan Kadia, Nicholas J. Short, Naval Daver, Gautam Borthakur, Farhad Ravandi, Hagop M. Kantarjian, Bhumika Patel, Amy Dezern, Gail Roboz, Guillermo Garcia-Manero
Summary: The combination of enasidenib with azacitidine showed a 74% overall response rate in newly diagnosed mIDH2 MDS patients, while enasidenib monotherapy achieved a 35% response rate in patients after HMA failure. These findings demonstrate that enasidenib is an effective treatment option for mIDH2 MDS.
Meeting Abstract
Hematology
Olisaemeka Ogbue, Tariq Kewan, Waled Bahaj, Carmelo Gurnari, Valeria Visconte, Suresh Kumar Balasubramanian, Bhumika J. Patel, Alan Lichtin, Hetty E. Carraway, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Jaymeson Gordon, Christopher Haddad, Ishani Nautiyal, Yasuo Kubota, Hetty E. Carraway, Sudipto Mukherjee, Aaron T. Gerds, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Carmelo Gurnari, Valeria Visconte
Letter
Hematology
Tariq Kewan, Waled Bahaj, Arda Durmaz, Mai Aly, Olisaemeka D. Ogbue, Hetty E. Carraway, Mikkael A. Sekeres, Valeria Visconte, Carmelo Gurnari, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Eric Padron, Sara M. Tinsley-Vance, Amy E. DeZern, Hetty E. Carraway, Marlise R. Luskin, Gail J. Roboz, Onyee Chan, Meagan Horton, Aaron T. Gerds, David A. Sallman, Andrew Kuykendall, David Steensma, Maria E. Balasis, Jeffrey E. Lancet, Mikkael A. Sekeres, Rami S. Komrokji
Meeting Abstract
Hematology
Tariq Kewan, Waled Bahaj, Mai Aly, Arda Durmaz, Olisaemeka Ogbue, Hetty E. Carraway, Abhay Singh Singh, Suresh Kumar Balasubramanian, Mikkael A. Sekeres, Valeria Visconte, Carmelo Gurnari, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Fauzia Ullah, Danai Dima, Carmelo Gurnari, Suresh Kumar Balasubramanian, Olisaemeka Ogbue, Hussein Awada, Naomi Kawashima, Najiullah Omar, Swapna Thota, Hetty E. Carraway, Valeria Visconte, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Nicholas Short, Tae Kon Kim, Rustin Lovewell, Elizabeth A. Griffiths, Hetty E. Carraway, Stephanie Zeidan, Elizabeth Knowles, Megan Nelson, Jahangheer Shaik, Chelsea Zhou, Emilia Alina Barbu, Zachary Cusumano, Subhadip Kundu, Sasan Sharee, Ron Copeland, Dallas Flies, Solomon Langermann, Han Myint, Jessica K. Altman, Farhad Ravandi
Article
Hematology
Amer M. Zeidan, Uwe Platzbecker, Jan Philipp Bewersdorf, Maximilian Stahl, Lionel Ades, Uma Borate, David Bowen, Rena Buckstein, Andrew Brunner, Hetty E. Carraway, Naval Daver, Maria Diez-Campelo, Theo de Witte, Amy E. DeZern, Fabio Efficace, Guillermo Garcia-Manero, Jacqueline S. Garcia, Ulrich Germing, Aristoteles Giagounidis, Elizabeth A. Griffiths, Robert P. Hasserjian, Eva Hellstrom-Lindberg, Marcelo Iastrebner, Rami Komrokji, Austin G. Kulasekararaj, Luca Malcovati, Yasushi Miyazaki, Olatoyosi Odenike, Valeria Santini, Guillermo Sanz, Phillip Scheinberg, Reinhard Stauder, Arjan A. van de Loosdrecht, Andrew H. Wei, Mikkael A. Sekeres, Pierre Fenaux
Summary: The initial response criteria developed by the International Working Group (IWG) in 2000 have limitations in their application to higher-risk MDS and their ability to fully capture the clinical benefits of novel investigational drugs. Therefore, an international panel of MDS experts used a modified Delphi process to develop consensus recommendations for updated response criteria that would be more reflective of patient-centered and clinically relevant outcomes. The updated criteria should lead to a better correlation between patient-centered outcomes and clinical trial results.
Meeting Abstract
Hematology
Julia H. Joo, Yanwen Chen, Aaron T. Gerds, Anjali Advani, Sophia R. Balderman, Hetty E. Carraway, Abhay Singh Singh, Sudipto Mukherjee
Meeting Abstract
Oncology
Sudipto Mukherjee, Weichuan Dong, Aaron T. Gerds, Hetty E. Carraway, Abhay Singh, Anjali S. Advani, Siran M. Koroukian
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Farhad Ravandi-Kashani, Ashwin Kishtagari, Hetty Carraway, Emily Curran, Gary Schiller, Alex Cacovean, Bhagyashree Yadav, Thomas Butler, Jeffrey Lancet
Meeting Abstract
Oncology
Farhad Ravandi, Hetty Carraway, Jack Khouri, Ashwin Kishtagari, Emily Curran, Gary Schiller, Bhagyashree (Kelshikar) Yadav, Steve Morris, Alex Cacovean, Sanchita Mourya, Thomas Butler, Jeffrey Lancet
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Meeting Abstract
Oncology
Farhad Ravandi, Ashwin Kishtagari, Hetty E. Carraway, Gary J. Schiller, Steve Morris, Alexandru Cacovean, Bhagyashree Kelshikar Yadav, Thomas Butler, Jeffrey E. Lancet
JOURNAL OF CLINICAL ONCOLOGY
(2022)