Review
Microbiology
Kalliopi D. Synodinou, Maroulla D. Nikolaki, Konstantinos Triantafyllou, Arezina N. Kasti
Summary: The human gastrointestinal tract ecosystem, known as gut microbiota, is extensively studied and is associated with various diseases. The interaction between gut and lung microbiota affects immune and inflammatory responses. COVID-19 disrupts gut microbiota, leading to increased inflammation and lung damage. Probiotics can modulate cytokine secretion, stimulate immune response, and inhibit NLRP3 inflammasome activation in COVID-19 infection.
Editorial Material
Microbiology
Lisa D. Blackmer-Raynolds, Timothy R. Sampson
Summary: Recent research has shown the important role of indigenous microbes in host neurological functions. A new study reveals the impact of gut-resident bacteriophages on microbiome structure and metabolism, and their downstream effects on neuronal gene expression and cognition.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Ding Yang, Zixu Wang, Yaoxing Chen, Qingyun Guo, Yulan Dong
Summary: The role of the gut-brain axis in maintaining homeostasis of the brain and gut has been recognized. The NLRP3 inflammasome plays a crucial role in coordinating host physiology and immunity. More research is needed to determine the causal link between gut microbiota structure and NLRP3 activation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Immunology
Giovanni Monteleone, Eleonora Franze, Edoardo Troncone, Claudia Maresca, Irene Marafini
Summary: Interleukin-34 (IL-34) plays a crucial role in chronic inflammatory bowel diseases (IBD) by promoting interactions between immune cells and stromal cells, leading to increased mucosal inflammation and production of fibrogenic molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Luigi Donato, Simona Alibrandi, Concetta Scimone, Andrea Castagnetti, Giacomo Rao, Antonina Sidoti, Rosalia D'Angelo
Summary: Analysis of microbiota from TMAU patients and mentally ill controls showed alterations in certain bacterial families that may lead to excessive release of neurotransmitters, causing a wide spectrum of psychiatric disorders. These metabolites are also related to TMA accumulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jeff P. Bruce, Ka-Fai To, Vivian W. Y. Lui, Grace T. Y. Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y. Yip, Brigette B. Y. Ma, John K. S. Woo, Edwin P. Hui, Michael K. F. Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y. Y. Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie Prokopec, Man Wu, Johnny S. H. Kwan, Yuchen Liu, Jason Y. K. Chan, C. Andrew van Hasselt, Lawrence S. Young, Christopher W. Dawson, Ian C. Paterson, Lee-Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T. C. Chan, Trevor J. Pugh, Kwok-Wai Lo
Summary: This study performed whole-genome sequencing for 70 NPCs with EBV gene expression, revealing the collaborative effects of genomic aberrations and EBV infection in NPC development, as well as the impact of EBV-mediated effects on NF-kappa B activation and immune escape. Furthermore, homozygous MTAP deletions were identified as a potential target for therapy in a subset of NPC cases.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Oncology
Chi Chun Wong, Winnie Fong, Jun Yu
Summary: This study tracked gut bacteria and metabolites in rectal cancer patients undergoing neoadjuvant chemoradiotherapy and identified Bacteroides vulgatus as a driver bacterium of therapeutic resistance by supplying tumors with nucleotides.
Review
Immunology
Sonakshi Rastogi, Sneha Mohanty, Sapna Sharma, Prabhanshu Tripathi
Summary: This review summarizes the recent progress in understanding the effects of dietary metabolites, particularly short-chain fatty acids (SCFAs), on the gut-lung axis and its impact on lung health. The role of the gut-lung axis in SARS-CoV-2 mediated inflammation is also highlighted. By analyzing global research progress and knowledge gaps, the study predicts future research directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Rui Li, Yaoyuan Hu, Shuhong Hou
Summary: Oral-gut pathogens potentially promote pancreatic cancer evasion of host immune surveillance by activating the miR-21/PTEN axis and immune-suppressive cells. Understanding the pattern of the effects of gut pathogens on the miR-21/PTEN axis will provide insights into the specific mechanisms associated with the immune escape of pancreatic cancer caused by oral-gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Valentin Sencio, Marina Gomes Machado, Francois Trottein
Summary: The gut microbiota plays a critical role in pulmonary immunity and host defense against viral respiratory infections. Disease settings can profoundly impact the composition and function of the gut microbiota, leading to increased disease severity.
MUCOSAL IMMUNOLOGY
(2021)
Review
Immunology
Amanda Jacobson, Daping Yang, Madeleine Vella, Isaac M. Chiu
Summary: The gastrointestinal tract is regulated by a dense network of interconnected neurons that coordinate important physiological functions. Studies have shown complex interactions between gut neurons, immune cells, and epithelial cells, highlighting their roles in immune regulation and intestinal function. Integration of intestinal microbiota into the neuro-immune axis through tuning neuronal and immune interactions may offer new therapeutic targets for inflammatory diseases.
MUCOSAL IMMUNOLOGY
(2021)
Editorial Material
Oncology
Khiem Lam, Romina Goldszmid
Summary: The recent study in Nature Medicine highlights the role of gut microbiota in response and toxicity to immune checkpoint blockade, offering insights for leveraging microbiota in anticancer therapy design to enhance efficacy and mitigate toxicity.
Review
Medicine, Research & Experimental
Salma Naqvi, Turky Omar Asar, Vikas Kumar, Fahad A. Al-Abbasi, Sultan Alhayyani, Mohammad Amjad Kamal, Firoz Anwar
Summary: This article discusses the role of gut microbiota in hypertension and cardiovascular diseases, highlighting the importance of SCFAs and TMAO. Dietary interventions can regulate gut microbiota and prevent cardiovascular complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Lin Zhu, Yixuan Wang, Calvin Q. Q. Pan, Huichun Xing
Summary: Alcohol-related liver disease (ALD) patients have a distinct gut microbiota profile, and the degree of gut dysbiosis is associated with disease progression and survival. The vicious cycles between gut dysbiosis and disease progression in ALD include increased acetaldehyde production and bile acid secretion, impaired gut barrier, enrichment of circulating microbiota, toxicities of microbiota metabolites, pro-inflammatory chemokines or cytokines cascade, and increased generation of reactive oxygen species. These pathophysiological processes play a crucial role in various disease stages of ALD, including alcohol hepatitis, ALD cirrhosis, neurological dysfunction, and hepatocellular carcinoma. This review aims to explain the pathophysiology of gut microbiota and the gut-brain crosstalk in ALD, providing potential targets for future therapeutic interventions in ALD.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Neurosciences
Narengaowa, Wei Kong, Fei Lan, Umer Farooq Awan, Hong Qing, Junjun Ni
Summary: Alzheimer's disease is a progressive neurological disorder with high rates of brain atrophy and is associated with the deposition of neurofibrillary tangles and amyloid-beta protein. Dysbiosis of oral and gut microbiota can induce and accelerate the formation of pathological features in AD patients, highlighting the potential role of the gut-brain connection in the pathogenesis of AD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Microbiology
Anica Graf, Richard J. Lewis, Stephan Fuchs, Martin Pagels, Susanne Engelmann, Katharina Riedel, Jan Pane-Farre
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2018)
Article
Biochemical Research Methods
Susanne Sievers, Silvia Dittmann, Tim Jordt, Andreas Otto, Falko Hochgraefe, Katharina Riedel
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Biotechnology & Applied Microbiology
O. Handorf, T. Weihe, S. Bekeschus, A. C. Graf, U. Schnabel, K. Riedel, J. Ehlbeck
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Microbiology
Andrea Soellinger, Alexander Tosdal Tveit, Morten Poulsen, Samantha Joan Noel, Mia Bengtsson, Joerg Bernhardt, Anne Louise Frydendahl Hellwing, Peter Lund, Katharina Riedel, Christa Schleper, Ole Hojberg, Tim Urich
Article
Microbiology
Bernd Neumann, Karola Prior, Jennifer K. Bender, Dag Harmsen, Ingo Klare, Stephan Fuchs, Astrid Bethe, Daniela Zuehlke, Andre Goehler, Stefan Schwarz, Kirsten Schaffer, Katharina Riedel, Lothar H. Wieler, Guido Werner
JOURNAL OF CLINICAL MICROBIOLOGY
(2019)
Article
Virology
Florian Pfaff, Sara Hagglund, Martina Zoli, Sandra Blaise-Boisseau, Eve Laloy, Susanne Koethe, Daniela Zuehlke, Katharina Riedel, Stephan Zientara, Labib Bakkali-Kassimi, Jean-Francois Valarcher, Dirk Hoeper, Martin Beer, Michael Eschbaumer
Article
Evolutionary Biology
Kristin Franke, Isabell Karl, Tonatiuh Pena Centeno, Barbara Feldmeyer, Christian Lassek, Vicencio Oostra, Katharina Riedel, Mario Stanke, Christopher W. Wheat, Klaus Fischer
BMC EVOLUTIONARY BIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea Schluter, Gilles Malherbe, Susanne Sievers, Daniela Zuhlke, Thomas Sura, Emma Dave, Katharina Riedel, Colin Robinson
MICROBIAL CELL FACTORIES
(2019)
Article
Biochemical Research Methods
Alexander C. Graf, Anne Leonard, Manuel Schaeuble, Lisa M. Rieckmann, Juliane Hoyer, Sandra Maass, Michael Lalk, Doerte Becher, Jan Pane-Farre, Katharina Riedel
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Multidisciplinary Sciences
Viktoria Heine, Christina Meinert-Berning, Janina Lueck, Nadine Mikowsky, Birgit Voigt, Katharina Riedel, Alexander Steinbuechel
Article
Microbiology
Susanne Sievers, Nicole G. Metzendorf, Silvia Dittmann, Daniel Troitzsch, Viola Gast, Sophie Marlen Troeger, Christian Wolff, Daniela Zuehlke, Claudia Hirschfeld, Rabea Schlueter, Katharina Riedel
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Physics, Applied
Oliver Handorf, Harald Below, Uta Schnabel, Katharina Riedel, Joerg Ehlbeck
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2020)
Article
Environmental Sciences
Doreen Schultz, Daniela Zuehlke, Joerg Bernhardt, Thomas Ben Francis, Dirk Albrecht, Claudia Hirschfeld, Stephanie Markert, Katharina Riedel
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Carl Simon Strittmatter, Jessica Eggers, Vanessa Biesgen, Jan-Niklas Hengsbach, Akihiro Sakatoku, Dirk Albrecht, Katharina Riedel, Alexander Steinbuechel
Summary: This study investigated the degradation process of fatty acids in Cupriavidus necator H16 and found differences in the degradation of carboxylic acids with different chain lengths. The findings are important for understanding the metabolic pathways of C. necator H16 and its applications in organic acid production.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Dominik Schneider, Aygun Ganbarzade, Sina Post, Daniela Zuehlke, Tjorven Hinzke, Jacqueline Hollensteiner, Anja Poehlein, Katharina Riedel, Rolf Daniel
Summary: The imipenem-resistant Citrobacter braakii strain GW-Imi-1b1 was found in a hospital wastewater sample in Greifswald, Germany. Its genome consists of one chromosome (5.09 Mb), one prophage (41.9 kb), and 13 plasmids (2 to 140.9 kb). The genome contains 5,322 coding sequences, shows high potential for genomic mobility, and includes genes encoding proteins for multiple drug resistances.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
