Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation

(2016) Mahalakshmi Ramadass et al.   IMMUNOLOGICAL REVIEWS

The role of the inflammasome in patients with autoinflammatory diseases

(2016) Hal M. Hoffman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation

(2016) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis

(2016) Mahalakshmi Ramadass et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses

(2016) Jing He et al.   MOLECULAR BIOLOGY OF THE CELL

F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2

(2016) Danielle Burger et al.   Scientific Reports

Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

(2015) Alyssa D. Gregory et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NLRP3 inflammasome senses multiple types of bacterial RNAs

(2014) Wenwen Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models

(2012) M. D. McGeough et al.   JOURNAL OF IMMUNOLOGY

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein

(2012) Jennifer L. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Increased Survival and Reduced Neutrophil Infiltration of the Liver in Rab27a- but Not Munc13-4-Deficient Mice in Lipopolysaccharide-Induced Systemic Inflammation

(2011) Jennifer L. Johnson et al.   INFECTION AND IMMUNITY

Munc13-4 Restricts Motility of Rab27a-expressing Vesicles to Facilitate Lipopolysaccharide-induced Priming of Exocytosis in Neutrophils

(2010) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis

(2010) Nikhil Kothari et al.   JOURNAL OF CRITICAL CARE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity

(2009) Susannah D. Brydges et al.   IMMUNITY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

(2009) Jennifer L. Johnson et al.   TRAFFIC

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules

(2008) Agnieszka A. Brzezinska et al.   TRAFFIC