Article
Pediatrics
Kyle J. Whittington, Yinjiao Ma, Anne M. Butler, Patrick G. Hogan, Faria Ahmed, JessieAnn Flowers, Grace Milburn, John J. Morelli, Jason G. Newland, Stephanie A. Fritz
Summary: This study aimed to evaluate the impact of infectious diseases consultation on the management and outcomes of children with Staphylococcus aureus bacteremia. The results showed that children who received infectious diseases consultation had higher adherence to quality-of-care indicators and that adherence to these indicators was associated with improved clinical outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Immunology
Guillaume Menard, Astrid Rouillon, Gevorg Ghukasyan, Mathieu Emily, Brice Felden, Pierre-Yves Donnio
Summary: Utilizing a G. mellonella infection model allows for rapid and effective research on the roles of Staphylococcus aureus sRNAs during infection, providing important insights into the involvement of sRNAs as transcriptional regulators in staphylococcal virulence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Philip Nikolic, Poonam Mudgil, David G. Harman, John Whitehall
Summary: This study aimed to identify and compare the general differences in protein profiles among clinical strains of S. aureus sensitive and resistant to methicillin. The proteomic analysis revealed differences in protein abundances related to virulence, metabolism, and protein synthesis between MSSA and MRSA strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
LewisOscar Felix, Biswajit Mishra, Rajamohammed Khader, Narchonai Ganesan, Eleftherios Mylonakis
Summary: Alpha mangostin exhibits antimicrobial activity against MRSA persisters and biofilms, causing membrane permeabilization and bacterial cell death. It also inhibits biofilm formation and attachment and down-regulates genes associated with persister cell and biofilm formation. In vivo experiments show that alpha mangostin increases the survival of MRSA-infected larvae. These findings contribute to our understanding of the antimicrobial activity and toxicity of this natural compound.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Mariana Andrade, Ketlyn Oliveira, Catarina Morais, Patricia Abrantes, Constanca Pomba, Adriana E. Rosato, Isabel Couto, Sofia Santos Costa
Summary: This study reveals the frequent biofilm production by antimicrobial-resistant coagulase-positive staphylococci in companion animals, which is associated with a higher virulence potential and persistent or recurrent infections.
Review
Pharmacology & Pharmacy
Sandra Truong, Poonam Mudgil
Summary: This systematic review examines the antibacterial properties of lavender essential oil (LEO) against Staphylococcus aureus and MRSA. The findings suggest mixed results, with some studies reporting significant effectiveness and others reporting minimal to negligible effect. However, it is noted that LEO works synergistically with other antibacterial substances, highlighting the need for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Jacqueline Meredith, Jennifer Onsrud, Lisa Davidson, Leigh Ann Medaris, Marc Kowalkowski, Kristin Fischer, Jennifer Priem, Michael Leonard, Lewis McCurdy
Summary: This study compared outcomes associated with TM and onsite SOC ID consultation after implementing an antimicrobial stewardship (AMS)-led Staphylococcus aureus bacteremia (SAB) bundle, finding no significant differences in clinical outcomes.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Na Xie, Lifang Jiang, Mingtao Chen, Guijun Zhang, Yanyan Liu, Jiabin Li, Xiaohui Huang
Summary: This study aimed to evaluate the in vitro/vivo activities of linezolid plus fosfomycin against Staphylococcus aureus isolates with varying susceptibility. The combination of antibiotics showed synergistic or additive effects on original and linezolid-resistant strains, but indifferent effects on fosfomycin-resistant strains. In the Galleria mellonella infection model, the survival rate of the antibiotic combination was improved compared to single drug treatment, showing a good correlation between in vivo efficacy and in vitro susceptibility.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Aisling M. Towell, Cecile Feuillie, Pauline Vitry, Thaina M. Costa, Marion Mathelie-Guinlet, Sanja Kezic, Orla M. Fleury, Maeve A. McAleer, Yves F. Dufrene, Alan D. Irvine, Joan A. Geoghegan
Summary: Staphylococcus aureus interacts with the host protein corneodesmosin on atopic dermatitis corneocytes, taking advantage of the aberrant display of corneodesmosin caused by low natural moisturizing factor levels. The bacterial proteins FnBPB and ClfB bind to the N-terminal region of corneodesmosin, facilitating strong adherence of S. aureus to atopic dermatitis corneocytes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Infectious Diseases
Liam S. Acheson, Krista J. Siefried, Brendan Clifford, Emily Murray, Maureen Steele, Liesa Clague, Victoria Malone, Darren M. Roberts, Lisa-Jayne Ferguson, Gail V. Matthews, Nadine Ezard
Summary: This article reports the first audit of inpatient parenteral treatment completion of Staphylococcus aureus bacteremia among people who inject drugs (PWID) in Australia, indicating higher rates of discharge against medical advice and readmission within 28 days among PWID.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Philip Nikolic, Poonam Mudgil
Summary: Antibiotic resistant strains of bacteria pose a serious threat to human health and alternative methods are needed to treat resistant bacterial infections. Methicillin resistant Staphylococcus aureus bacteria are resistant to most antibiotics, including last resort drugs. Changes in cell wall, cell membrane, and virulence factors contribute to antibiotic resistance. New antimicrobial strategies can target cell membrane lipids and virulence factors as adjuvant to traditional antibiotic therapy.
Article
Infectious Diseases
Robert C. Duguid, Mohammed Al Reesi, Adam W. Bartlett, Pamela Palasanthiran, Brendan J. McMullan
Summary: Children with Staphylococcus aureus bacteremia who received infectious diseases consultation in a tertiary pediatric setting were more likely to have appropriate investigations and management, leading to improved outcomes.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Microbiology
Biswajit Mishra, Rajamohammed Khader, Lewis Oscar Felix, Marissa Frate, Eleftherios Mylonakis, Susan Meschwitz, Beth Burgwyn Fuchs
Summary: AMI 82B is a potent compound that disrupts virulence factors of S. aureus, promoting larval survival in the G. mellonella infection model. This compound also has minimal toxicity in G. mellonella and mammalian cells, while significantly depressing quorum sensing genes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Yoshiro Hadano, Tatsuyuki Kakuma, Takanori Matsumoto, Kazushige Ishibashi, Miwako Isoda, Hiroshi Yasunaga
Summary: This study conducted in Japan at a tertiary care hospital found that mandatory infectious disease consultations for patients with Staphylococcus aureus bacteremia (SAB) improved 30-day mortality and adherence to quality-of-care indicators (QCIs).
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Cell Biology
He Liu, Zhen Hu, Mengyang Li, Yi Yang, Shuguang Lu, Xiancai Rao
Summary: G(+) bacterial infections pose a significant burden and require urgent development of antimicrobial agents due to the prevalence of multidrug-resistant G(+) bacteria. Endolysins, phage-encoded enzymes, are promising alternatives for combating resistance due to their low bacterial resistance. This review classifies and summarizes the mechanisms, efficacy, and advantages of endolysins as antibacterial drug candidates targeting G(+) bacteria. Safety, challenges, and potential solutions are also addressed, with indications that endolysin-based drugs will be approved in the near future.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang, Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu
Summary: The study found that gut microbiota composition significantly affects cigarette smoking-induced COPD development, and fecal microbiota transplantation can restore COPD pathogenesis. A beneficial bacterium Parabacteroides goldsteinii was isolated and shown to ameliorate COPD, with its derived active component having anti-inflammatory effects and ameliorating COPD through inhibition of lung inflammation and regulation of host metabolism.
Article
Engineering, Electrical & Electronic
Mohammadrahim Kazemzadeh, Colin L. Hisey, Priscila Dauros-Singorenko, Simon Swift, Kamran Zargar-Shoshtari, Weiliang Xu, Neil G. R. Broderick
Summary: Bacterial extracellular vesicles (EVs) are nano-scale lipid-enclosed packages that play important roles in various biological processes. This study demonstrates the potential of using surface-enhanced Raman spectroscopy (SERS) and machine learning algorithms to rapidly classify and characterize bacterial EVs, which is crucial for the development of their laboratory and clinical applications.
IEEE SENSORS JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Marija Gizdavic-Nikolaidis, Julia Moreira Pupe, Luciano Paulino Silva, Dragomir Stanisavljev, Darren Svirskis, Simon Swift
Summary: This study presents a facile and rapid method for the synthesis of PANI and PANI/Ch composites using enhanced microwave synthesis. The morphology and structure of the composites can be fine-tuned by adjusting the synthesis conditions. The PANI/Ch composites exhibit enhanced antibacterial efficacy against both Gram-negative and Gram-positive bacteria compared to pure Chs and PANI samples. This eco-friendly method can serve as an alternative for large-scale industrial production of these polymer composites.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Melissa M. Cadelis, Natasha S. L. Nipper, Alex Grey, Soeren Geese, Shara J. van de Pas, Bevan S. Weir, Brent R. Copp, Siouxsie Wiles
Summary: Screening of fungi from the New Zealand International Collection of Microorganisms from Plants identified two strains of Penicillium with antimicrobial activity. Further investigation led to the discovery of five known polyketide metabolites and a novel derivative. One of the polyketide metabolites and one derivative showed inhibitory activity against Methicillin-resistant Staphylococcus aureus.
Article
Food Science & Technology
Manasweeta Angane, Simon Swift, Kang Huang, Christine A. Butts, Siew Young Quek
Summary: Essential oils (EOs) can be considered as a natural food-grade preservative alternative, as they are Generally Recognized as Safe (GRAS) and have shown potential to inhibit the proliferation of food-borne pathogens. However, their antibacterial activity differs between Gram-positive and Gram-negative bacteria, and their application at a commercial scale is limited due to flavor and odor concerns. Further research is needed to develop strategies for industrial-scale application.
Article
Economics
Shaun C. Hendy, Siouxsie Wiles, Rachelle Binny, Michael J. Plank
Summary: This article questions Gibson's analysis and points out the problems in his research. He neglects the spatio-temporal heterogeneity in the spread of COVID-19 in the United States, selects arbitrary cross-sectional data, and chooses an instrument variable that may be correlated with the explanatory variable, introducing bias.
NEW ZEALAND ECONOMIC PAPERS
(2022)
Article
Ophthalmology
Sanjay Marasini, Simon J. Dean, Simon Swift, Janesha Perera, Ilva D. Rupenthal, Tao Wang, Hannah Read, Jennifer P. Craig
Summary: This study evaluated the therapeutic potential of using 265 nm UVC to treat infectious keratitis. The results showed that UVC inhibited the growth of bacteria and fungi, including those with antibiotic resistance, in vitro. In vivo and ex vivo experiments confirmed the therapeutic potential of 15 s UVC. In a mouse trial, two doses of 15 s UVC administered 4 hours apart effectively treated bacterial keratitis.
Article
Biotechnology & Applied Microbiology
Shilpa Saseendran Nair, Vikash Anand, Karnika De Silva, Siouxsie Wiles, Simon Swift
Summary: This study aims to determine the antimicrobial potency and mechanism of a surface-anchored quaternary ammonium salt (SAQAS)-based biocide during in vitro wet and dry fomite assays. The biocide showed effective killing of Gram-positive and Gram-negative bacteria, but not endospores. The mechanism of killing involved membrane depolarization, increased ROS production, and membrane permeability, leading to cell death.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Lingdai Liu, Simon Swift, Cherie Tollemache, Janesha Perera, Paul A. Kilmartin
Summary: Films based on chitosan and Lemon Myrtle essential oil were prepared with dose-dependent fluorescent patterns. The films showed promising properties for multifunctional food packaging.
FOOD HYDROCOLLOIDS
(2022)
Article
Microbiology
Benedict Uy, Simon Swift, Francesca Casu, David Mahuika, Maurice A. Curtis, Deborah Prendergast
Summary: Individuals naturally carry bacteria and other microbes, including opportunistic pathogens. Commensal bacteria on cadavers pose a risk to those who handle the bodies. The embalming process can eliminate some bacteria on the bodies, but storing at lower temperatures can further reduce the number of viable bacteria.
Article
Materials Science, Multidisciplinary
Sara Beikzadeh, Alireza Akbarinejad, John Taylor, Simon Swift, Denis Simonov, Jacqueline Ross, Janesha Perera, Paul A. Kilmartin, Jadranka Travas-Sejdic
Summary: The capacitance-based antibacterial and antiviral properties of graphene-based materials were investigated in this study. Laser-induced graphene (LIG) electrodes with tunable capacitances were produced using a CO2 laser. The charged LIG electrodes showed high antibacterial and antiviral performance against various bacteria and viruses. The novel concept of capacitance-based antibacterial and antiviral surfaces is promising in applications where sustainable and rechargeable active surfaces are required.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemical Research Methods
Ayomikun Esan, Frederique Vanholsbeeck, Simon Swift, Cushla M. M. McGoverin
Summary: With the global increase in food exchange, it has become crucial to efficiently separate bacterial cells from debris in order to protect consumers from bacterial contamination. In this study, passive-based inertial microfluidics was used to separate bacterial cells from debris extracted from ground meat and meat swabs, achieving average recovery efficiencies of approximately 80% and 70%, respectively.
Article
Materials Science, Biomaterials
Sara Beikzadeh, Alireza Akbarinejad, John Taylor, Janesha Perera, Jacqueline Ross, Simon Swift, Paul A. Kilmartin, Jadranka Travas-Sejdic
Summary: This study explores the use of solid-state supercapacitors as antibacterial and antiviral devices, developing a low-cost and flexible carbon cloth supercapacitor with efficient surface properties. The optimized supercapacitor exhibited excellent electrochemical stability and high-rate capability, and effectively disinfects bacteria and neutralizes viruses upon surface contact with the positive and negative electrodes.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Food Science & Technology
Manasweeta Angane, Simon Swift, Kang Huang, Janesha Perera, Xiao Chen, Christine A. Butts, Siew Young Quek
Summary: Essential oils and plant extracts have inhibitory activity against pathogenic bacteria. This study found that certain combinations of oils and extracts exhibit synergistic effects and have higher antimicrobial activity against multiple pathogens. Using these synergistic combinations could potentially reduce the required dosage and broaden their application as natural preservatives in food products.
FOOD SCIENCE & NUTRITION
(2023)