Review
Immunology
Shao Yin, Fengya Zhu
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of probiotics in the treatment of constipation in patients with PD. The results showed that probiotics could effectively increase the frequency of defecation in PD patients, but the evidence quality was low. Probiotics had no significant effect on other indicators of gastrointestinal dysfunction and insufficient evidence on their ability to improve nonmotor symptoms and quality of life in PD patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Alice van der Schoot, Carina Helander, Kevin Whelan, Eirini Dimidi
Summary: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of probiotics and synbiotics on chronic constipation. The results showed that probiotics may have significant benefits in improving stool frequency, symptoms, and quality of life. However, the effectiveness of synbiotics in the management of chronic constipation is still unclear. Caution is needed when interpreting the results due to high heterogeneity and risk of bias among the studies.
CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Ligang Liu, Anlin Wang, Hekai Shi, Heqing Tao, Milap C. Nahata
Summary: This study aimed to evaluate the effectiveness and safety of probiotics and synbiotics in treating childhood functional constipation. The current evidence does not support the use of probiotics and synbiotics in the treatment of childhood functional constipation. Further research is needed to evaluate the effectiveness and safety of specific probiotic strains, probiotic mixtures, and optimal doses and treatment durations.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Xue Shang, E. Fen-Fen, Kang-Le Guo, Yan-Fei Li, Hong-Lin Zhao, Yan Wang, Nan Chen, Tao Nian, Chao-Qun Yang, Ke-Hu Yang, Xiu-Xia Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of probiotics in treating constipation-predominant irritable bowel syndrome (IBS-C). The findings suggest that probiotics can improve stool consistency and increase the number of Bifidobacteria and Lactobacilli in feces with good safety. However, the certainty of the evidence is low and more high-quality studies are needed to verify the results.
Article
Biochemistry & Molecular Biology
Kaige Zhang, Hui Liu, Peng Liu, Qi Feng, Lihong Gan, Ling Yao, Gen Huang, Ziling Fang, Tingtao Chen, Nian Fang
Summary: This study shows that the administration of Lactiplantibacillus plantarum MH-301 can improve postoperative symptoms in patients with internal hemorrhoids. High-throughput sequencing analysis reveals that the group treated with L. plantarum MH-301 has a higher diversity of intestinal microbiota and a higher relative abundance of beneficial bacteria such as Bifidobacterium, Megamonas, and Lactobacillus. Therefore, L. plantarum MH-301 can enhance the efficacy of endoscopic sclerotherapy and improve bowel movements.
Article
Gastroenterology & Hepatology
Kyung Jae Lee, Eell Ryoo, Yoo Min Lee, Jung Min Yoon, Hyo-Jeong Jang, So Yoon Choi, You Jin Choi, Hyun Jin Kim, Ju Young Chung, Jung Ok Shim
Summary: This study investigated the effectiveness of Saccharomyces boulardii and lactulose for treating childhood functional constipation. The results showed that Saccharomyces boulardii monotherapy was not superior to lactulose monotherapy or combination therapy, and had a lower drug maintenance rate.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Nutrition & Dietetics
Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu, Wang-Tso Lee
Summary: The study suggests that probiotics may not reduce tics in children with Tourette syndrome, but they may benefit comorbidities such as attention deficit and hyperactivity disorder. Further research is needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
Review
Biochemistry & Molecular Biology
Chuanqi Chu, Leilei Yu, Yiwen Li, Hang Guo, Qixiao Zhai, Wei Chen, Fengwei Tian
Summary: Patients with Parkinson's disease (PD) show dysbiosis in the gut microbiota and significant gastrointestinal dysfunction. Recent studies have shown that oral probiotic consumption can improve motor symptoms, gastrointestinal dysfunction, anxiety, and depression in PD patients.
Article
Nutrition & Dietetics
Zengbin Li, Guixian Zhu, Chao Li, Hao Lai, Xin Liu, Lei Zhang
Summary: Bayesian network meta-analysis showed that Saccharomyces boulardii may be the most effective probiotic for treating acute diarrhea in children.
Review
Geriatrics & Gerontology
X. Deng, X. Shang, L. Zhou, X. Li, K. Guo, M. Xu, L. Hou, X. Hui, Shuangping Li
Summary: This study assessed the efficacy and safety of probiotics in managing constipation among the elderly. The meta-analysis findings showed that probiotics can increase stool frequency and improve constipation-related symptoms compared to a placebo. However, further well-designed investigations are needed to substantiate these findings due to the limited quality of the included studies.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Immunology
Rachael G. Horne, Stephen B. Freedman, Kathene C. Johnson-Henry, Xiao-Li Pang, Bonita E. Lee, Ken J. Farion, Serge Gouin, Suzanne Schuh, Naveen Poonai, Katrina F. Hurley, Yaron Finkelstein, Jianling Xie, Sarah Williamson-Urquhart, Linda Chui, Laura Rossi, Michael G. Surette, Philip M. Sherman
Summary: The compositional analysis of the intestinal microbiome in pre-schoolers is not well studied. This study evaluated the effects of probiotics on the gut microbiota in children under 4-years-old with acute gastroenteritis. It was found that bacterial infection and participant age had the largest effects on microbiota composition, microbial diversity, and deduced bacterial functions. The advancement in age was associated with differences in gut microbiota composition and deduced microbial functions which may impact health later in life.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Chien -Tai Hong, Jia-Hung Chen, Tsai-Wei Huang
Summary: This study investigated the effects of probiotics on Parkinson's disease patients and found that probiotics significantly alleviated constipation symptoms and may have systemic effects on inflammation and metabolism.
Article
Pediatrics
Braden T. Tierney, James Versalovic, Alessio Fasano, Joseph F. Petrosino, Bruno P. Chumpitazi, Emeran A. Mayer, Jared Boetes, Gerard Smits, Shanthi G. Parkar, Noah Voreades, Ece Kartal, Gabriel A. Al-Ghalith, Marco Pane, Peter A. Bron, Gregor Reid, Raja Dhir, Christopher E. Mason
Summary: This study aimed to evaluate the efficacy of a synbiotic on increasing weekly bowel movements in constipated children. The results showed that treatment with the synbiotic increased the number of bowel movements in children with low baseline bowel movements, despite distinct baseline microbiome signatures. These findings suggest that multi-species synbiotic interventions may improve digestive health in pediatric population and that bioinformatics-based methods can predict response to microbial interventions in children.
PEDIATRIC RESEARCH
(2023)
Review
Nutrition & Dietetics
Jenifer F. Kruger, Elaine Hillesheim, Amanda C. S. N. Pereira, Carolina Q. Camargo, Estela Rabito
Summary: Probiotic supplementation did not show significant benefits on cognitive function in individuals with dementia, but did improve certain metabolic markers. The current evidence is insufficient to support the clinical application of probiotics and synbiotics for individuals with dementia.
Article
Food Science & Technology
Hui Jin, Jiwon Park, Rui Li, Geun Eog Ji, Tony V. Johnston, Deokyeong Choe, Se -Ho Park, Myeong Soo Park, Seockmo Ku
Summary: This study investigated the effect of consuming exopolysaccharide-enriched VP30 fermented milk on functional constipation. The results showed that the EPS-enriched VP30 fermented milk was more effective in increasing defecation frequency, volume, and fecal type. However, it did not significantly change symptoms such as flatulence, pain, and bloating. Gut microbiome analysis revealed slight changes in bacterial proportions. This study is the first to demonstrate the functional effect of EPS produced by Weissella strain in reducing functional constipation through human clinical studies.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Dermatology
Xiaoyu Gu, Minxue Shen, Shuang Zhao, Xiang Chen
Summary: This study systematically evaluated the efficacy of the combined use of targeted UVB and calcipotriene in the treatment of plaque-type psoriasis. The results showed that the addition of calcipotriene ointment can improve the efficacy of targeted UVB phototherapy.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Immunology
Panpan Liu, Yehong Kuang, Li Ye, Cong Peng, Wangqing Chen, Minxue Shen, Mi Zhang, Wu Zhu, Chengzhi Lv, Xiang Chen
Summary: This study developed a predictive model for psoriatic arthritis (PsA) risk in plaque psoriasis patients based on available features. The model showed good calibration, discrimination, and clinical utility. This novel PsA nomogram can efficiently assess the risk of PsA in patients with plaque psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Danyi Zhang, Jianing Qiu, Xing Liao, Yi Xiao, Minxue Shen, Yaxiong Deng, Danrong Jing
Summary: The short-term efficacy of IL-17 inhibitors in the treatment of psoriasis shows no significant difference between Caucasians and Asians.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Zhenwei Tang, Minxue Shen, Yi Xiao, Hong Liu, Xiang Chen
FRONTIERS IN MEDICINE
(2022)
Letter
Medicine, General & Internal
Jennifer Horwitz, Shi Wu Wen, Hongzhuan Tan, Shujin Zhou, Chang Ye, Minxue Shen, Ravi Retnakaran
Summary: This cohort study examines the relationship between preconception paternal smoking and neonatal outcomes.
Article
Psychology, Clinical
Yu Yu, Wei Zhou, Minxue Shen, Yao Wang, Shuiyuan Xiao, Jacob Kraemer Tebes
Summary: This study investigated the overlap between clinical and personal recovery among people living with schizophrenia. The results showed that personal recovery and overall recovery were less common, particularly among people with schizophrenia in China.
JOURNAL OF MENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Zhenwei Tang, Shenxin Li, Minxue Shen, Yi Xiao, Juan Su, Juan Tao, Xiaohui Wang, Shijun Shan, Xiaojing Kang, Bin Wu, Bin Zou, Xiang Chen
Summary: This study revealed that exposure to artificial light at night (ALAN) during adolescence may contribute to a higher risk of atopic diseases in young adulthood.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Nutrition & Dietetics
Zhen Ling, Chengcheng Zhang, Jun He, Feiyun Ouyang, Dan Qiu, Ling Li, Yilu Li, Xuping Li, Yanying Duan, Dan Luo, Shuiyuan Xiao, Minxue Shen
Summary: This study suggests that a combined healthy lifestyle pattern may considerably decrease the risk of NAFLD in Chinese government employees.
Article
Pharmacology & Pharmacy
Beibei Lu, Shunyou Hu, Chengyu Wu, Jichuan Zhang, Jianglin Zhang, Jiaheng Zhang
Summary: A multifunctional nanoplatform based on molybdenum disulfide (MoS2) was developed using ionic liquid (IL) exfoliation and surface modification to prepare IL-MoS2 nanosheets. The nanosheets showed good photothermal stability and effects, effectively inhibiting tumor cell growth under laser irradiation. The nanosheets also exhibited biocompatibility, physiological stability, and biodegradability, indicating their potential in clinical cancer treatments.
ADVANCED THERAPEUTICS
(2023)
Article
Food Science & Technology
Hong Gao, Na Zhu, Shuxiang Deng, Can Du, Yan Tang, Peng Tang, Shuaishuai Xu, Wenya Liu, Minxue Shen, Xinhua Xiao, Fei Yang
Summary: Evidence has shown that exposure to environmental pollutants, such as microcystins, arsenic, and cadmium, can lead to the occurrence and development of chronic kidney disease (CKD). The combined effect of microcystins and arsenic on CKD remains unclear. A case-control study conducted in Hunan province, China, found that both microcystins and arsenic were significantly associated with CKD risk. Additionally, there was a positive interaction effect between microcystins and arsenic on CKD. The combined exposure to microcystins, arsenic, and cadmium increased the risk of CKD.
Article
Food Science & Technology
Shuidong Feng, Mengyue Cao, Peng Tang, Shuxiang Deng, Limou Chen, Yan Tang, Lemei Zhu, Xiang Chen, Zhijun Huang, Minxue Shen, Fei Yang
Summary: Increasing experimental evidence suggests a link between exposure to microcystins (MCs) and lipid metabolism disorder. This population-based study in China examined the association between MCs exposure and dyslipidemia risk. The results showed that higher levels of MCs exposure were significantly associated with an increased risk of dyslipidemia, elevated triglyceride levels, and reduced high-density lipoprotein cholesterol levels. The study also found an additive antagonistic effect between MCs and a metal called Zn on dyslipidemia.
Article
Materials Science, Biomaterials
Beibei Lu, Chengyu Wu, Jichuan Zhang, Jianglin Zhang, Jiaheng Zhang
Summary: Currently, more than 70% of adults suffer from obesity, including chronic and long-term obesity cases. As diabetes patients continue to rise worldwide, there is an urgent need for effective oral drugs to replace insulin. However, the gastrointestinal tract poses a major obstacle for oral drug preparations. In this study, a highly effective oral drug in the form of an ionic liquid (IL) was developed using L-(-)-carnitine and geranic acid. The IL was found to significantly enhance transdermal drug transport and exhibited good biocompatibility and stability. Therefore, IL holds potential as a valuable carrier for oral drug delivery, providing an effective treatment for diabetes and a potential solution to the obesity epidemic.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Xueqin Huang, Lingzhi Chen, Tianjian Sha, Yongjian Lin, Runmin Zeng, Jun Xu, Shanze Chen, Huai-Hong Cai, Jianglin Zhang, Haibo Zhou, Ping-Hua Sun, Xingyu Jiang
Summary: This study presents a sensing platform for melanoma screening that combines a wearable microneedle patch and nanoparticles. The platform can detect real-time changes of tyrosinase in human skin and distinguish melanoma patients from normal individuals, providing potential clinical significance for early diagnosis and monitoring of cutaneous melanoma.
Article
Computer Science, Artificial Intelligence
Zheng Wang, Ying Xiao, Li Peng, Zhuolin Zhang, Xiaojun Li, Yang Xue, Jie Zhang, Jianglin Zhang
Summary: An AI-based approach is developed to automatically quantify ascites from CT scans, which is more efficient than manual segmentation. The proposed model demonstrates good performance and can aid radiologists in rapidly grading ascites on CT volume images.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Beibei Lu, Jianglin Zhang, Jiaheng Zhang
Summary: In this study, curcumin-based ionic liquid liposome (Cur-Bet-IL-Lip) was prepared using a combination of theoretical calculation and experimental research. The Cur-Bet-IL-Lip showed good stability and biocompatibility, and it could penetrate the skin's stratum corneum and deliver curcumin to the epidermis and dermis. Compared to other forms of curcumin, Cur-Bet-IL-Lip had better uptake ability and could reduce the expression of inflammatory factors and increase collagen expression in human immortalized keratinocyte cells.
ACS APPLIED BIO MATERIALS
(2023)