Article
Cell Biology
Yunfei Zhang, Linfei Yang, Lihua Huang, Gang Liu, Xinmin Nie, Xinxing Zhang, Xiaowei Xing
Summary: Acephalic spermatozoa syndrome is a rare genetic and reproductive disease, with SUN5 mutations found in approximately 33-47% of patients. Knockout of the Sun5 gene in mice resulted in broken head-to-tail linkage, similar to the human syndrome. Bioinformatic analysis and experimental evidence revealed that Sun5 interacts with Nesprin3 to play a crucial role in maintaining the connection between the head and tail of spermatozoa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Mirjam I. Binner, Anna Kogan, Karin Panser, Alexander Schleiffer, Victoria E. Deneke, Andrea Pauli
Summary: Fertilization is a crucial process in sexual reproduction, but the molecular mechanisms behind it are still unclear. A study on zebrafish reveals that Spaca6, a conserved protein, is essential for sperm-egg binding and fusion. The research also uncovers a previously unknown dependence of Dcst2 expression on Spaca6 in sperm.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Physical
Xiaojie Chai, Jianwei Lian, Chao Wang, Xiaobing Hu, Jie Sun, Jun Jiang, Anquan Jiang
Summary: By controlling charge injection, stabilized H-H DWs, NDWs, and T-T DWs were achieved within a LiNbO3 transistor, expanding the application of domain walls in future nano-devices.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Cell Biology
Marc Llavanera, Yentel Mateo-Otero, Ariadna Delgado-Bermudez, Sandra Recuero, Samuel Olives, Isabel Barranco, Marc Yeste
Summary: This study used a comprehensive approach to investigate the molecular role of the GSTP1-JNK heterocomplex in sperm physiology using pigs as a model. The results demonstrated the essential role of GSTP1 in deactivating JNK, which is crucial for maintaining sperm function. The research also laid the groundwork for understanding the relevance of the GSTP1-JNK heterocomplex in regulating mammalian sperm physiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Sylwia Prochowska, Skarlet Napierkowska, Bartosz Czech, Wojciech Nizanski
Summary: Computer-assisted sperm morphometry analysis is an advanced tool that accurately measures sperm head parameters and distinguishes morphometric subpopulations. This study aims to evaluate the differences in morphometric parameters of spermatozoa from non-pedigree and purebred domestic cats and to check the relationship between sperm morphometry and fertility.
Article
Entomology
Ya-Nan Hou, Ying-Ying Zhang, Ya-Ru Wang, Zhi-Mao Wu, Yun-Xia Luan, Qing Wei
Summary: Cilia are hair-like organelles involved in sensory function or motility, playing critical roles in physiological processes. In Drosophila, the formation of cilia remains poorly understood. We investigated the role of IFT52, a core component of IFT-B, and found it is essential for sensory cilia formation and function in insects.
Review
Andrology
Bao-Jun Zhuang, Su-Yun Xu, Liang Dong, Pei-Hai Zhang, Bao-Lin Zhuang, Xiao-Peng Huang, Guang-Sen Li, Yao-Dong You, Di'Ang Chen, Xu-Jun Yu, De-Gui Chang
Summary: This study reveals the association between DNAH1 gene mutation and severe asthenozoospermia and teratozoospermia. The mutation leads to the deletion of inner dynein arm 3, resulting in multiple morphological abnormalities. The proportion of short flagella is the highest among DNAH1 mutation patients, while the incidence of head deformities is not high.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Automation & Control Systems
Lindsay Spencer, Jared Fernando, Farzan Akbaridoust, Klaus Ackermann, Reza Nosrati
Summary: This study presents a method for automated classification of human sperm head morphology using a stacked ensemble of convolutional neural networks. By combining traditional CNN models with modern structures and a multi-class meta-classifier, the accuracy is significantly improved. This research is of great importance for automated sperm morphology analysis, as it can standardize clinical practice and reduce treatment costs.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Shuai Wang, Hongjie Qiao, Pengxiang Wang, Yuan Wang, Danian Qin
Summary: Zdhhc19 knockout mice did not show disruption in spermatogenesis but exhibited male infertility with defects in sperm morphology and functions, highlighting the essential role of Zdhhc19 in sperm production and fertility in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniel Major, Lara Flanzbaum, Leah Lussier, Carly Davies, Kristian Mark P. Caldo, Jeella Z. Acedo
Summary: Genome mining and gene cluster analysis were used to identify novel head-to-tail cyclized bacteriocins, revealing a greater diversity than previously thought. The approach proved more effective than traditional bioprospecting, laying the groundwork for future isolation of new head-to-tail cyclized bacteriocins.
Article
Cell Biology
Tomer Avidor-Reiss, Luke Achinger, Rustem Uzbekov
Summary: Centrioles are subcellular organelles that are crucial for normal cell function and development. They are found in most animal cell types but are absent in egg cells and exhibit diverse characteristics in sperm cells. The precise role of centrioles in fertility and early embryo development remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lilian Rodrigues de Oliveira, Douglas de Souza Goncalves, Adriano de Souza Carolino, William Marcondes Facchinatto, Diogo de Carvalho Menezes, Cleverton Oliveira Dias, Luiz Alberto Colnago, Yurimiler Leyet Ruiz, Stefan Talu, Henrique Duarte da Fonseca Filho, Puspitapallab Chaudhuri, Pedro Henrique Campelo, Yvonne Primerano Mascarenhas, Edgar Aparecido Sanches
Summary: A systematic investigation of the crystallization process of Poly(p-anisidine) (PPA), a polyaniline derivative, was conducted using experimental and theoretical methods. The results revealed different degrees of crystallinity and crystal structures, with needle and globular morphologies observed. Multifractal analysis showed increased complexity of the PPA surface as the crystallinity decreased. High-resolution C-13 NMR results supported the proposed molecular structures of PPA.
Article
Biochemistry & Molecular Biology
Maria Jose Gomez-Torres, Javier Luna-Romero, Pedro Jose Fernandez-Colom, Jon Aizpurua, Manuel Aviles, Alejandro Romero
Summary: Nuclear vacuoles are specific structures present on the head of the human sperm. This study aimed to define the incidence, position, morphology, and molecular content of the human sperm vacuoles. Results showed that approximately 50% of analyzed human sperm cells contained vacuoles, mainly located in the anterior head region. Furthermore, it was discovered that these vacuoles were invaginations of the nuclear envelope containing cytoskeletal proteins and a cytoplasmic enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Danila M. de Carvalho, Maarit H. Lahtinen, Mamata Bhattarai, Martin Lawoko, Kirsi S. Mikkonen
Summary: Hemicellulose-rich wood extracts play a crucial role in adsorption and stabilization at emulsion interfaces, with lignin-carbohydrate complexes (LCCs) enhancing their functionality. Understanding the structure of the interfacial region is important for designing extraction processes and exploring industrial applications.
Article
Cell Biology
Laurine M. Gilles, Andrea R. M. Calhau, Veronica La Padula, Nathanael M. A. Jacquier, Claire Lionnet, Jean-Pierre Martinant, Peter M. Rogowsky, Thomas Widiez
Summary: Phospholipases play a crucial role in plant reproduction, especially in the development of male gametes and sexual reproduction. The mutation of phospholipase NOT-LIKE-DAD affects the attachment to the pollen endo-plasma membrane through lipid anchoring and electrostatic interactions, where phosphatidylinositol-4,5-bisphosphate is enriched, defining a specific polar domain critical for plant reproduction and gamete formation.
JOURNAL OF CELL BIOLOGY
(2021)
