期刊
ELIFE
卷 6, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.27842
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资金
- National Institute on Aging Genetic Approaches to Aging Training Grant postdoctoral fellowship
- Coordenagao de Aperfeigoamento de Pessoal de Nivel Superior Science without Borders
- National Institute of General [R01-GM084947, UO1HL099993, R01GM097372, R01GM083867, 1P01GM081619, U01HL099997]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL099997, U01HL099993] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM097372, R01GM084947, R01GM083867, P01GM081619] Funding Source: NIH RePORTER
Aging stem cells lose the capacity to properly respond to injury and regenerate their residing tissues. Here, we utilized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low doses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration defect in aging GSCs: while aging GSCs survive exposure to IR, they fail to reenter the cell cycle and regenerate the germline in a timely manner. Mechanistically, we identify foxo and mTOR homologue, Tor as important regulators of GSC quiescence following exposure to ionizing radiation. foxo is required for entry in quiescence, while Tor is essential for cell cycle reentry. Importantly, we further show that the lack of regeneration in aging germ line stem cells after IR can be rescued by loss of foxo.
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