Article
Veterinary Sciences
Xueyun Li, Jia Liu, Zengzhao Qiu, Qijun Liao, Yani Peng, Yongkun Chen, Yuelong Shu
Summary: The study identified 54 canine-adaptive signatures in H3N2 CIVs and found that IAVs can establish persistent transmission more easily in lower mammals compared to higher mammals. Additionally, 25 common adaptation signatures of H3 IAVs were observed in diverse avian-mammals comparison.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Rachel J. Oidtman, Philip Arevalo, Qifang Bi, Lauren McGough, Christopher Joel Russo, Diana Vera Cruz, Marcos Costa Vieira, Katelyn M. Gostic
Summary: Immune imprinting refers to the strongest immune protection gained by individuals against influenza strains encountered earliest in life. Differences in early infection history can explain susceptibility differences associated with birth year. Understanding the impact of cohort effects on strain fitness requires a clear conceptual model linking host susceptibility to past infections.
TRENDS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zijing Zhang, Xiaohuan Mu, Qina Cao, Yao Shi, Xiaosong Hu, Hao Zheng
Summary: In this study, a link between honeybee gut Lactobacillus and bee learning and memory abilities was established via indole derivatives that activate the host's aryl hydrocarbon receptor.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Nathaniel L. Hepowit, Eric Blalock, Sangderk Lee, Kimberly M. Bretland, Jason A. MacGurn, Robert C. Dickson
Summary: As the elderly population increases, chronic diseases associated with aging are becoming a challenge for healthcare systems worldwide. Nutrient restriction has been shown to slow down aging and improve health, but it is difficult for most people to practice. Therefore, alternative pharmacological strategies are being explored, such as myriocin, which has been found to increase lifespan in yeast by impairing sphingolipid synthesis and lowering amino acid levels. This study investigates the cellular response to myriocin and reveals a new role for ubiquitin in promoting longevity.
Article
Biology
Eriko Matsuura-Suzuki, Tadahiro Shimazu, Mari Takahashi, Kaoru Kotoshiba, Takehiro Suzuki, Kazuhiro Kashiwagi, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takuhiro Ito, Yoichi Shinkai, Shintaro Iwasaki, Qing Zhang
Summary: In this study, it was discovered that human METTL18 acts as a histidine methyltransferase for the ribosomal protein RPL3. The methylation of RPL3 at His245 position slows ribosome traversal on Tyr codons, allowing proper protein folding and preventing cellular aggregation of Tyr-rich proteins.
Article
Multidisciplinary Sciences
Ketaki Ganti, Anish Bagga, Silvia Carnaccini, Lucas M. Ferreri, Ginger Geiger, C. Joaquin Caceres, Brittany Seibert, Yonghai Li, Liping Wang, Taeyong Kwon, Yuhao Li, Igor Morozov, Wenjun Ma, Juergen A. Richt, Daniel R. Perez, Katia Koelle, Anice C. Lowen
Summary: This study investigates the intra-host dynamics of influenza virus reassortment and finds that reassortment is prevalent in swine, ferrets, and guinea pigs, but less frequent in swine. Tissue-specific differences in reassortment are observed in ferrets, with more reassortants detected in the nasal tract compared to the lower respiratory tract. The study also highlights the impact of spatial compartmentalization on the evolution and transmission of viral variants.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Khairun Nisaa, Anat Ben-Zvi
Summary: Muscle proteostasis is regulated by the myogenic transcription factor MyoD. This study demonstrates that MyoD can modulate chaperone expression in terminally differentiated muscle cells, indicating its role in muscle maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Nidia S. Trovao, Sairah M. Khan, Philippe Lemey, Martha I. Nelson, Joshua L. Cherry
Summary: This study compares the evolution of influenza A virus hemagglutinin protein in five host classes and finds that HA evolution in non-human hosts is more dynamic than expected. The findings emphasize the need for further study of HA evolution in non-human hosts.
Article
Biochemistry & Molecular Biology
Tazeen Qureshi, Subashchandrabose Chinnathambi
Summary: Alzheimer's disease (AD) is a complex condition that requires disease-modifying treatments rather than symptom management. Loss of memory and dementia are major concerns in AD, caused by the loss of neurons and their connections. Histone Deacetylase 6 (HDAC6) has shown potential benefits in AD by regulating Tau protein stability and neuronal rewiring.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Neurosciences
Mirella A. Hernandez-Lima, Margaret Champion, Zachary Mattiola, Matthias C. Truttmann
Summary: In this study, the researchers investigated how the activity of the AMPylase FIC-1 affects physiological processes in Caenorhabditis elegans. They found that over-expression of FIC-1(E274G) impairs development, fertility, and stress resilience in C. elegans. The study also revealed that FIC-1(E274G) over-expression inhibits pathogen avoidance behavior by suppressing production of specific ligands in sensory neurons.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Ecology
Nicole Nova, Ethan R. Deyle, Marta S. Shocket, Andrew J. MacDonald, Marissa L. Childs, Martin Rypdal, George Sugihara, Erin A. Mordecai
Summary: Experiments and models show that climate affects mosquito-borne disease transmission, with temperature and rainfall having net positive and negative effects respectively when susceptible availability is high. This study uses empirical dynamic modeling to effectively capture nonlinear and context-dependent effects of population susceptibility, temperature, and rainfall on dengue dynamics. By doing so, the model improves forecast skill over recent, state-of-the-art models for dengue incidence, providing empirical evidence that host population susceptibility and climate drive dengue dynamics in a nonlinear and complex, yet predictable way.
Article
Virology
Yasuha Arai, Norihito Kawashita, Emad Mohamed Elgendy, Madiha Salah Ibrahim, Tomo Daidoji, Takao Ono, Tatsuya Takagi, Takaaki Nakaya, Kazuhiko Matsumoto, Yohei Watanabe
Summary: This study identified novel clade 2.2.1 virus polymerase mutations that increased viral replication in human cells by analyzing phylogeny-associated PA mutations. These mutations, along with the PB2-E627K substitution, enhanced replication in contemporary clade 2.2.1.2 viruses compared to ancestral clade 2.2.1 viruses, indicating a higher public health risk for humans.
JOURNAL OF VIROLOGY
(2021)
Editorial Material
Microbiology
Joel Rivera-Cardona, Christopher B. Brooke
Summary: Influenza A virus has the ability to recognize and degrade host transcripts using a specific molecular motif, which helps in modifying the host immune response.
NATURE MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kevin Ciminski, Geoffrey P. Chase, Martin Beer, Martin Schwemmle
Summary: Emergent IAV strains from animal hosts typically have poor adaptation to humans and cannot establish sustained transmission. Despite frequent exposure to endemic IAV in animal populations, the number of pandemics in humans remains surprisingly low.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
John Galvin, Elizabeth Curran, Francisco Arteaga, Alicia Goossens, Nicki Aubuchon-Endsley, Michael A. McMurray, Jeffrey Moore, Kirk C. Hansen, Heidi J. Chial, Huntington Potter, Jeffrey L. Brodsky, Christina M. Coughlan
Summary: This study investigates the role of amyloid precursor protein (APP) fragments in Alzheimer's disease (AD). Using a yeast model with compromised proteasomal activity, they induced the expression of the C-terminal fragment of APP (C99) and observed phenotypic changes associated with AD, such as protein aggregates, cellular stress, and abnormal DNA condensation. The findings suggest that this yeast model could be useful for testing AD therapeutics targeting amyloid fragments.
FEMS YEAST RESEARCH
(2022)