Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo

PIC Activation through Functional Interplay between Mediator and TFIIH

(2017) Sohail Malik et al.   JOURNAL OF MOLECULAR BIOLOGY

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

(2017) Kayo Nozawa et al.   NATURE

Mediator structure and rearrangements required for holoenzyme formation

(2017) Kuang-Lei Tsai et al.   NATURE

Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters

(2016) Sebastian Grünberg et al.   EMBO JOURNAL

Mediator Undergoes a Compositional Change during Transcriptional Activation

(2016) Natalia Petrenko et al.   MOLECULAR CELL

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

(2016) Célia Jeronimo et al.   MOLECULAR CELL

Architecture of the RNA polymerase II–Mediator core initiation complex

(2015) C. Plaschka et al.   NATURE

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular architecture of the yeast Mediator complex

(2015) Philip J Robinson et al.   eLife

Genome-Wide Association of Mediator and RNA Polymerase II in Wild-Type and Mediator Mutant Yeast

(2014) Emily Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Kin28 regulates the transient association of Mediator with core promoters

(2014) Célia Jeronimo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The two faces of Cdk8, a positive/negative regulator of transcription

(2013) Josipa Nemet et al.   BIOCHIMIE

Mediator is an intrinsic component of the basal RNA polymerase II machinery in vivo

(2013) Thierry Lacombe et al.   NUCLEIC ACIDS RESEARCH

The multitalented Mediator complex

(2013) Jonas O.P. Carlsten et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Mediator complex and transcription elongation

(2012) Ronald C. Conaway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast

(2011) Suraiya A Ansari et al.   EMBO JOURNAL

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

The Anchor-Away Technique: Rapid, Conditional Establishment of Yeast Mutant Phenotypes

(2008) Hirohito Haruki et al.   MOLECULAR CELL

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments

(2008) X. Fan et al.   NUCLEIC ACIDS RESEARCH