Article
Biochemistry & Molecular Biology
Wenjuan Wang, Aihua Zhang
Summary: Arsenic is a common environmental pollutant that can cause damage to multiple systems and organs in the body. The lungs are particularly sensitive to arsenic exposure, and respiratory disease is thought to be the leading cause of death from arsenic poisoning. This study found that HIF-1 alpha plays a key role in arsenic-induced lung injury.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Oncology
Isabell Goetting, Safa Larafa, Katharina Eul, Mikhail Kunin, Burkhard Jakob, Johann Matschke, Verena Jendrossek
Summary: Aberrant activation of AKT affects cellular antioxidant defense and radiosensitivity. TRAMPC1 cells overexpressing the clinically relevant AKT variant AKT-E17K exhibit improved antioxidant defense and increased radiation resistance. This change is associated with AKT-dependent regulation of cellular levels of reduced glutathione (GSH), both directly and indirectly. Pharmacological inhibition of AKT-dependent metabolic enzymes supporting defense against oxidative stress, such as glutathione synthase and glutathione reductase, enhances the eradication of clonogenic tumor cells, particularly those overexpressing AKT-E17K.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Rajiv Sainath, Gianluca Gallo
Summary: NGF induces the development of axonal filopodia and branches by activating the PI3K-Akt signaling pathway through the TrkA receptor. The initiation and steady state phases of the PI3K-Akt signaling pathway have different dependencies on cellular energy metabolism pathways, such as oxidative phosphorylation and glycolysis. The initiation phase of PI3K and Akt signaling is associated with the localization of mitochondria, while the steady state phase may involve contributions from mitochondria, glycolysis, and endocytosed signalosomes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Abigail E. Cullen, Ann M. Centner, Riley Deitado, Ahmed Ismaeel, Panagiotis Koutakis, Judy Muller-Delp, Gloria Salazar
Summary: Adiponectin plays a beneficial role in the cardiovascular system by preserving the contractile phenotype of vascular smooth muscle cells. However, the lack of adiponectin leads to abnormalities in AKT signaling, the extracellular matrix, and TGF-beta signaling. Additionally, adiponectin deficiency affects oxidative phosphorylation, glycolysis, and mitochondrial reactive oxygen species levels. Anti-atherogenic mechanisms involve regulating MMPs and decorin in the extracellular matrix.
Article
Cell Biology
Wuching Uen, Tingting Tseng, Ching-Po Wu, Shaochen Lee
Summary: The study found that detachment stress alters the activities, drug sensitivity, and gene expression related to glucose metabolism in melanoma cells, affecting their malignancy and survival ability.
Article
Biochemistry & Molecular Biology
Heng Wang, Wenqi Liang, Xuyang Wang, Yuchun Zhan, Wence Wang, Lin Yang, Yongwen Zhu
Summary: The study reveals that Notch signaling regulates glycolysis through the PI3K/Akt pathway to provide energy for embryonic growth. This study not only elucidates the important role of Notch signaling in embryonic development, but also provides new insights into the energy supply patterns during embryogenesis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Engineering, Biomedical
Maohua Chen, Menghuan Li, Yujia Wei, Chencheng Xue, Maowen Chen, Yang Fei, Lu Tan, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: By packaging CaCO3-Quercetin-chromium nanoparticles into a ROS-responsive coating, it was successfully demonstrated that ATP production and cell mineralization in osteoporotic MSCs can be improved, while excessive ROS can be eliminated. This study lays the foundation for improving osseointegration in osteoporotic bones with implants.
Review
Biochemistry & Molecular Biology
Weiwei Liu, Guokai Chen
Summary: Energy metabolism is crucial for cell survival, proliferation, pluripotency, and cell fate determination in human pluripotent stem cells. Understanding the key factors influencing energy metabolism is important for cellular regulation and stem cell applications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yanhe Zhou, Sidong Chen, Fangying Yang, Yuhua Zhang, Liya Xiong, Junhong Zhao, Ling Huang, Peiyu Chen, Lu Ren, Huiwen Li, Defeng Liang, Peiqun Wu, Huan Chen, Jiayu Chen, Sitang Gong, Wanfu Xu, Lanlan Geng
Summary: The study showed that Rabeprazole inhibits cell proliferation by suppressing HK2-mediated glycolysis in gastric epithelial cells, leading to a decrease in glucose uptake and lactate production. Rabeprazole also targets the STAT3/HK2 signaling pathway to regulate glucose metabolism and inhibit cell proliferation in H. pylori-infected gastric epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Caihong Wang, Fengqi Zhao, Jianxin Liu, Hongyun Liu
Summary: This study revealed that the mammalian target of the rapamycin (mTOR) signaling regulates the expression and function of PepT2 in bovine mammary epithelial cells (BMEC) through Nedd4-2.
Article
Medicine, Research & Experimental
Liangmei Chen, Xiaofan Li, Yiyao Deng, Jianwen Chen, Mengjie Huang, Fengge Zhu, Zhumei Gao, Lingling Wu, Quan Hong, Zhe Feng, Guangyan Cai, Xuefeng Sun, Xueyuan Bai, Xiangmei Chen
Summary: This study found that the transformation of cells into myofibroblasts during renal injury is a common phenomenon and the process is associated with cellular respiration, regulated by TGF-beta 1. By inhibiting the production of cellular respiration, the occurrence of cell transformation can be slowed down.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Meng Li, Xiaoming Luo, Shan Lei, Yurong Liu, Huishan Guo, Yu Zhang, Yuantao Pan, Kaiwei Chen, Jing Lin, Peng Huang
Summary: A glycopolymer containing a caged H2S and H2O2 dual-donor is developed to wrap glucose oxidase, which can deplete tumorigenic energy sources and block glycolysis. This strategy induces defects in mitochondrial function and shows good anticancer performance.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
Yue Wu, Ruijie Lu, Yujie Lin, Jinjin Wang, Zijian Lou, Xiaochun Zheng, Ling Zhang, Ruolang Pan, Gang Lu, Qingxia Fang
Summary: In this study, we found that long-term exposure to DEHP, an EDCs and plasticizer, is significantly associated with increased risks of various human diseases, including colorectal cancer. Our findings suggest that DEHP can trigger metabolic reprogramming in colorectal cancer cells, promoting cell growth and reducing sensitivity to 5-FU. Mechanistic studies showed that DEHP decreases glycolysis and increases OXPHOS in SW620 cells. In vivo experiments further demonstrated that DEHP promotes tumorigenic progression and decreases survival time in mice. Overall, our study highlights the potential risk of DEHP in colorectal cancer development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reem Aboushousha, Evan Elko, Shi B. Chia, Allison M. Manuel, Cheryl van de Wetering, Jos van der Velden, Maximilian MacPherson, Cuixia Erickson, Julie A. Reisz, Angelo D'Alessandro, Emiel F. M. Wouters, Niki L. Reynaert, Ying-Wai Lam, Vikas Anathy, Albert van der Vliet, David J. Seward, Yvonne M. W. Janssen-Heininger
Summary: The study reveals that IL1B induces glycolysis in airway epithelial cells, potentially affecting allergic airway inflammation and remodeling. Cells lacking the enzyme Glrx show modulation of multiple metabolic pathways and increased secretion of TSLP. Targeted inhibition of glycolysis prevents TSLP release, suggesting a potential therapeutic target in pulmonary pathologies.
Article
Immunology
Priya Khurana, Chakkapong Burudpakdee, Stephan A. A. Grupp, Ulf H. H. Beier, David M. M. Barrett, Hamid Bassiri
Summary: Human iNKT cells have distinct bioenergetic requirements compared to T-CONV, displaying a more oxidative metabolic program upon stimulation. These unique features could be leveraged in immunotherapeutic strategies to enhance efficacy and longevity of anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yin P. Hung, Mari Mino-Kenudson
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Michael Michal, Oleksandr Kravtsov, Jeffrey S. Ross, Daniela Skanderova, Petr Martinek, Elaheh Mosaieby, Douglas A. Mata, Erik A. Williams, Yin P. Hung
Summary: In this study, a patient with clear cell mesothelioma was identified, and the presence of an inactivating VHL mutation was confirmed. Further analysis revealed a cohort of four VHL-mutant clear cell mesotheliomas with distinct clinicopathologic and molecular features. These tumors were characterized by prominent clear cells, inactivating VHL mutations, and genomic near-haploidization.
GENES CHROMOSOMES & CANCER
(2023)
Article
Oncology
Abbas Agaimy, Luka Brcic, Laurence M. Briski, Yin P. Hung, Michael Michal, Michal Michal, G. Petur Nielsen, Robert Stoehr, Andrew E. Rosenberg
Summary: A focal adenomatoid-microcystic pattern is not uncommon in peritoneal mesothelioma, but tumors composed almost exclusively of this pattern are distinctly rare and have not been well characterized. Herein, we describe five peritoneal mesothelial neoplasms that are pure adenomatoid/microcystic in morphology and unified by the presence of an NR4A3 fusion. These tumors showed morphological similarities and lacked a conventional epithelioid or sarcomatoid component. At the last follow-up, all five patients were alive and disease-free.
GENES CHROMOSOMES & CANCER
(2023)
Review
Cell Biology
S. Krisztian Kovacs, Atikankul Manassaporn, G. Petur Nielsen, Yin P. Hung
Summary: This review provides a brief update on select bone tumours, including their molecular features and immunohistochemical correlates, as well as some tips to avoid common diagnostic pitfalls.
Article
Pathology
Yin P. Hung, Ivan Chebib, Miriam A. Bredella, Emily A. Berner, Quinn Taylor-Black, Edwin Choy, Gregory M. Cote, Yen -Lin Chen, Shannon M. MacDonald, Joseph H. Schwab, Kevin A. Raskin, Erik T. Newman, Martin K. Selig, Vikram Deshpande, Jason L. Hornick, Santiago A. Lozano-Calderon, Petur Nielsen
Summary: This study evaluated the percentages and sizes of dedifferentiation in a series of dedifferentiated chondrosarcoma patients and found that the degree of dedifferentiation was a better predictor of prognosis than the total tumor size.
Article
Multidisciplinary Sciences
Margarete Diaz-Cuadros, Teemu P. Miettinen, Owen S. Skinner, Dylan Sheedy, Carlos Manlio Diaz-Garcia, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R. Manalis, William M. Oldham, Olivier Pourquie
Summary: Animals display inter-species variation in embryonic development rates, with differences in biochemical reaction rates being thought responsible for species-specific rates. This study establishes an in vitro system using pluripotent stem cells to simulate the twofold difference in developmental rates between mouse and human embryos. The mass-specific metabolic rates were found to scale with developmental rate, higher in mouse cells than in human cells. Manipulating metabolic rates could control developmental rate and have translational applications.
Article
Clinical Neurology
Jessica J. J. Ye, Marc A. Bouffard, Earllondra Brooks, Yin P. Hung, Eyal Y. Kimchi
Summary: This case emphasizes the rare possibility of giant cell arteritis as a cause of multiple cranial neuropathies and highlights the importance of temporal artery biopsy in diagnosis.
Article
Oncology
Anastasia L. Berg, Megan R. Showalter, Nont Kosaisawe, Michelle Hu, Nathanial C. Stephens, Michael Sa, Hailey Heil, Noemi Castro, Jenny J. Chen, Kacey VanderVorst, Madelyn R. Wheeler, Zachary Rabow, Tomas Cajka, John Albeck, Oliver Fiehn, Kermit L. Carraway
Summary: Bis(monoacylglycero)phosphates (BMPs), lipid components within endolysosomal organelles, have been associated with pathological states such as neurodegenerative diseases and lysosomal storage disorders. This study identified lower BMP levels in transformed cells compared to normal cells, and observed an enrichment of 22:6 BMP species in breast cancer models. Functional analysis suggests that 22:6 BMPs serve as reactive oxygen species scavengers, protecting lysosomes from oxidant-induced damage. These findings highlight the potential therapeutic target of BMP-mediated lysosomal protection in breast tumor cells.
Correction
Multidisciplinary Sciences
Margarete Diaz-Cuadros, Teemu P. Miettinen, Owen S. Skinner, Dylan Sheedy, Carlos Manlio Diaz-Garcia, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R. Manalis, William M. Oldham, Olivier Pourquie
Article
Oncology
Myrsini Ioakeim-Ioannidou, Andrzej Niemierko, Daniel W. Kim, Athena Tejada, Tobias Urell, Shannon Leahy, Judy Adams, Barbara Fullerton, G. Petur Nielsen, Yin P. Hung, Angela R. Shih, Manuel Patino, Karen Buch, Sandra Rincon, Hilary Kelly, Mary Beth Cunnane, Maria Tolia, Brigitte C. Widemann, Mary F. Wedekind, Liny John, David Ebb, John H. Shin, Gregory Cote, William Curry, Shannon M. MacDonald
Summary: Limited data on clinical outcomes of BOS chordomas in pediatric population. Study reports effective outcomes with low side effects after surgery and proton radiotherapy in pediatric patients with BOS chordomas. This is the largest cohort study on BOS chordomas.
Review
Cell Biology
Vilasinee Rerkpichaisuth, Yin P. Hung
Summary: Primary mesenchymal tumours of the pleura are rare and difficult to diagnose due to overlapping histopathologic and immunophenotypic features. This article discusses various mesenchymal tumours of the pleura, including solitary fibrous tumour, calcifying fibrous tumour, desmoid fibromatosis, synovial sarcoma, schwannoma, malignant peripheral nerve sheath tumour, inflammatory myofibroblastic tumour, follicular dendritic cell sarcoma, epithelioid hemangioendothelioma, and desmoplastic small round cell tumour. The clinicopathologic characteristics and updated immunohistochemical and molecular features are reviewed.
Article
Cell Biology
Thomas Denize, Catherine B. Meador, Anna B. Rider, Maria L. Ganci, Jaimie L. Barth, Marina Kem, Mari Mino-Kenudson, Yin P. Hung
Summary: SCLC subtypes show variation over time and among locations in patients, and there is discordance in transcription factor-based subtyping among multiple samples. Technical and biological factors may limit the concordance in SCLC subtyping.
Article
Biochemistry & Molecular Biology
Elisa M. York, Anne Miller, Sylwia A. Stopka, Juan Ramon Martinez-Francois, Md Amin Hossain, Gerard Baquer, Michael S. Regan, Nathalie Y. R. Agar, Gary Yellen
Summary: The metabolic demands of neuronal activity are dynamic, and disruptions in fuel and oxygen supply can affect neurons. Glucose is considered a necessary fuel for brain metabolism, but the contribution of alternative fuels is debated. Differential fuel metabolism depends on cell type, location, and activity state. Mass spectrometry imaging was used to study the fuel metabolism of dentate granule cells in murine hippocampal slices, revealing glucose as the primary fuel, but with contributions from lactate/pyruvate, beta HB, octanoate, and glutamine. Brief stimulation or fuel competition affected fuel metabolism.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Anne Miller, Elisa M. York, Sylwia A. Stopka, Juan Ramon Martinez-Francois, Md Amin Hossain, Gerard Baquer, Michael S. Regan, Nathalie Y. R. Agar, Gary Yellen
Summary: The study reveals that neuronal activity induces metabolic changes in neurons, including increased glycolytic activity and conversion of endogenous inosine. The purine nucleotide phosphorylase (PNP) reaction is crucial for the neuronal response to stimulation, and inhibition of PNP leads to energy impairment in neurons during recovery.
Article
Cell Biology
Nicholas J. Caldwell, Jeanne B. Ackman, Ivan Chebib, Mari Mino-Kenudson, G. Petur Nielsen, Yin P. Hung
Summary: This study reports the clinicopathological, radiological, and molecular characteristics of mediastinal anastomosing haemangiomas, including seven patients with a median age of 72 years. The tumors showed anastomosing capillary-sized vessels on radiology and had no recurrence after surgery.