Article
Genetics & Heredity
Nicolas Fragoso-Bargas, Christian M. Page, Bonnie R. Joubert, Stephanie J. London, Sindre Lee-Odegard, Julia O. Opsahl, Line Sletner, Anne K. Jenum, Elisabeth Qvigstad, Rashmi B. Prasad, Gunn-Helen Moen, Kare Birkeland, Christine Sommer
Summary: This research conducted an epigenome-wide association study on serum folate levels in maternal blood and identified CpG sites associated with folate levels. The findings provide new insights into the epigenomic component of serum folate levels.
Article
Biochemistry & Molecular Biology
Aurelie Nakamura, Lucile Broseus, Joerg Tost, Daniel Vaiman, Silvia Martins, Katherine Keyes, Kim Bonello, Mathilde Fekom, Katrine Strandberg-Larsen, Anne-Laure Sutter-Dallay, Barbara Heude, Maria Melchior, Johanna Lepeule
Summary: The placenta plays a crucial role in fetal and brain development, and its epigenome reflects the prenatal environment and can be linked to the future health of the fetus. This study investigated the association between placental DNA methylation and child behavioral and emotional difficulties. The results revealed sex-specific associations and provided insights into the mechanisms of neurodevelopment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Daniel L. McCartney, Robert F. Hillary, Eleanor L. S. Conole, Daniel Trejo Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, Robin Flaig, Archie Campbell, Alison D. Murray, Susana Munoz Maniega, Maria Del C. Valdes-Hernandez, Mathew A. Harris, Mark E. Bastin, Joanna M. Wardlaw, Sarah E. Harris, David J. Porteous, Elliot M. Tucker-Drob, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, Simon R. Cox, Matthew R. Robinson, Riccardo E. Marioni
Summary: By analyzing blood-based DNA methylation, individual differences in general cognitive function can be explained, which is important for tracking the development of neurodegenerative diseases. Assessing cognitive function using DNAm data may be valuable in environments where reliable or accessible cognitive testing is lacking.
Article
Genetics & Heredity
Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Robert Lyle, Kristina Gervin
Summary: Pharmacoepigenetic studies are crucial for understanding how medications impact the development of the fetus. This study aimed to expand previous findings on the association between prenatal paracetamol exposure and ADHD in offspring, as well as examine the interaction effect of folic acid and paracetamol on DNA methylation in children with ADHD. The results showed no significant impact of paracetamol or interaction effect of paracetamol and folic acid on cord blood DNA methylation in children with ADHD. Replication of these findings in other cohorts is essential to validate and enhance the clinical relevance of pharmacoepigenetic studies.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Seyma Katrinli, Yuanchao Zheng, Aarti Gautam, Rasha Hammamieh, Ruoting Yang, Suresh Venkateswaran, Varun Kilaru, Adriana Lori, Rebecca Hinrichs, Abigail Powers, Charles F. Gillespie, Aliza P. Wingo, Vasiliki Michopoulos, Tanja Jovanovic, Erika J. Wolf, Regina E. McGlinchey, William P. Milberg, Mark W. Miller, Subra Kugathasan, Marti Jett, Mark W. Logue, Kerry J. Ressler, Alicia K. Smith
Summary: The study identified two differentially methylated regions associated with PTSD, one in the gene body of HLA-DPB1 and one in the promoter of SPATC1L. These regions also showed associations with nearby sequence variations and the expression of their respective genes.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Behavioral Sciences
Mandy Meijer, Barbara Franke, Carmen Sandi, Marieke Klein
Summary: DNA methylation is an important epigenetic mechanism that plays a role in the interaction between genes and the environment, and is associated with externalizing behaviors and psychiatric disorders. Previous studies on externalizing behaviors have been limited in sample size, leading to a lack of candidate genes and biomarkers with strong evidence. In this study, we conducted a systematic literature review and identified candidate genes and biological systems for attention-deficit/hyperactivity disorder (ADHD) and aggressive behaviors based on epigenome-wide association studies (EWAS) conducted in peripheral tissue and cord blood. The findings suggest the involvement of neuronal processes and cell marker genes in ADHD, and the relevance of astrocytes and granulocytes to both ADHD and aggression-related behaviors. Only a small proportion of the significant epigenetic findings can be directly explained by genetic factors associated with ADHD. Larger sample sizes and harmonization of assessment instruments are needed to advance the field.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Environmental Sciences
Yuan Chun Ding, Susan Hurley, June-Soo Park, Linda Steele, Michele Rakoff, Yun Zhu, Jinying Zhao, Mark LaBarge, Leslie Bernstein, Shiuan Chen, Peggy Reynolds, Susan L. Neuhausen
Summary: The study revealed associations between PBDE levels and DNA methylation, with these methylation changes being significantly associated with breast cancer risk.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Ida K. Karlsson, Malin Ericsson, Yunzhang Wang, Juulia Jylhava, Sara Hagg, Anna K. Dahl Aslan, Chandra A. Reynolds, Nancy L. Pedersen
Summary: The study found associations between leukocyte DNA methylation and level of cognitive abilities but not with change in cognitive abilities. These associations were significantly attenuated in within-pair analyses, indicating they are influenced in part by genetic factors.
CLINICAL EPIGENETICS
(2021)
Article
Genetics & Heredity
Kai Wang, Shujie Wang, Xiang Ji, Dong Chen, Qi Shen, Yang Yu, Pingxian Wu, Xuewei Li, Guoqing Tang
Summary: This study aimed to identify CpG sites associated with DNA methylation levels and meat quality traits in Yorkshire pigs. Genome-wide methylation levels were measured using RRBS, and linear mixed-effect models were used to examine associations. Eight CpG sites were associated with drip loss, two CpG sites with yellowness, and five CpG sites with lightness. No significant associations were found with pH levels or meat redness. This study provides new insights into the epigenetic molecular mechanisms of meat quality traits in pigs.
FRONTIERS IN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Gao, Huifang Pang, Bowang Chen, ChaoQun Wu, Yanping Wang, Libo Hou, Siming Wang, Dianjianyi Sun, Xin Zheng
Summary: This study identified novel CpGs associated with CVD development and revealed their additional predictive power in the risk of CVD for high-risk subjects.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Chemistry, Multidisciplinary
Siyu Wei, Junxian Tao, Jing Xu, Xingyu Chen, Zhaoyang Wang, Nan Zhang, Lijiao Zuo, Zhe Jia, Haiyan Chen, Hongmei Sun, Yubo Yan, Mingming Zhang, Hongchao Lv, Fanwu Kong, Lian Duan, Ye Ma, Mingzhi Liao, Liangde Xu, Rennan Feng, Guiyou Liu, Yongshuai Jiang
Summary: EWAS has been utilized for a decade to analyze DNA methylation variation in complex diseases, and has gradually become a hot topic of current studies. The progress of EWAS research, contributions to clinical applications, achievements in typical diseases, challenges encountered, and bold predictions for future development are all discussed.
Article
Environmental Sciences
Ainash Childebayeva, Jaclyn M. Goodrich, Nathan Chesterman, Fabiola Leon-Velarde, Maria Rivera-Ch, Melisa Kiyamu, Tom D. Brutsaert, Abigail W. Bigham, Dana C. Dolinoy
Summary: The study found that individuals in Cerro de Pasco had higher levels of Pb compared to those in Lima, with males having higher levels than females. Pb was positively associated with hemoglobin, and in Cerro de Pasco, blood Pb decreased with distance from the mine. Associations were identified between Pb and specific genes related to neurological function through differential methylation analysis.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Xiyang Cai, Kaixuan Li, Xia Meng, Qinglin Song, Su Shi, Wenran Li, Yue Niu, Li Jin, Haidong Kan, Sijia Wang
Summary: This study is the first epigenome-wide association study on ozone exposure conducted in a large-scale Han Chinese cohort. The study identified DNA methylation changes on CpGs and regions, as well as related gene functions and pathways.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Oncology
Anne K. Bozack, Sheryl L. Rifas-Shiman, Brent A. Coull, Andrea A. Baccarelli, Robert O. Wright, Chitra Amarasiriwardena, Diane R. Gold, Emily Oken, Marie-France Hivert, Andres Cardenas
Summary: This study examined the association between prenatal metal exposure and DNA methylation, revealing significant correlations between certain metals and methylation levels of specific genes in cord blood, with these associations attenuating in blood collected in mid-childhood. Additionally, differences in methylation responses to metals were observed in infants of different genders.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Sandve, Robert Lyle, Kristina Gervin
Summary: This study investigates the concordance between two different platforms for measuring DNA methylation levels in cord blood, and finds differences between the platforms. These findings have important implications for future epigenome-wide association studies.
CLINICAL EPIGENETICS
(2022)
Article
Psychology, Developmental
Tarjei Widding-Havneraas, Simen Markussen, Felix Elwert, Ingvild Lyhmann, Ingvar Bjelland, Anne Halmoy, Ashmita Chaulagain, Eivind Ystrom, Arnstein Mykletun, Henrik Daae Zachrisson
Summary: The rate of ADHD diagnosis varies across regions, but the relationship with symptom levels has not been studied. This study uses data from Norway to investigate if ADHD symptom levels explain the variation in ADHD diagnoses. The findings show that geographical variation has a larger impact on ADHD diagnosis than symptom levels. Additionally, the free and universally available treatment in the Norwegian child and adolescent mental health services may not be the sole factor contributing to the geographical variation in ADHD diagnosis.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Eshim S. Jami, Anke R. Hammerschlag, Hill F. Ip, Andrea G. Allegrini, Beben Benyamin, Richard Border, Elizabeth W. Diemer, Chang Jiang, Ville Karhunen, Yi Lu, Qing Lu, Travis T. Mallard, Pashupati P. Mishra, Ilja M. Nolte, Teemu Palviainen, Roseann E. Peterson, Hannah M. Sallis, Andrey A. Shabalin, Ashley E. Tate, Elisabeth Thiering, Natalia Vilor-Tejedor, Carol Wang, Ang Zhou, Daniel E. Adkins, Silvia Alemany, Helga Ask, Qi Chen, Robin P. Corley, Erik A. Ehli, Luke M. Evans, Alexandra Havdahl, Fiona A. Hagenbeek, Christian Hakulinen, Anjali K. Henders, Jouke Jan Hottenga, Tellervo Korhonen, Abdullah Mamun, Shelby Marrington, Alexander Neumann, Kaili Rimfeld, Fernando Rivadeneira, Judy L. Silberg, Catharina E. van Beijsterveldt, Eero Vuoksimaa, Alyce M. Whipp, Xiaoran Tong, Ole A. Andreassen, Dorret Boomsma, Sandra A. Brown, S. Alexandra Burt, William Copeland, Danielle M. Dick, K. Paige Harden, Kathleen Mullan Harris, Catharina A. Hartman, Joachim Heinrich, John K. Hewitt, Christian Hopfer, Elina Hypponen, Marjo-Riitta Jarvelin, Jaakko Kaprio, Liisa Keltikangas-Jarvinen, Kelly L. Klump, Kenneth Krauter, Ralf Kuja-Halkola, Henrik Larsson, Terho Lehtimaki, Paul Lichtenstein, Sebastian Lundstrom, Hermine H. Maes, Per Magnus, Marcus R. Munafo, Jake M. Najman, Pal R. Njolstad, Albertine J. Oldehinkel, Craig E. Pennell, Robert Plomin, Ted Reichborn-Kjennerud, Chandra Reynolds, Richard J. Rose, Andrew Smolen, Harold Snieder, Michael Stallings, Marie Standl, Jordi Sunyer, Henning Tiemeier, Sally J. Wadsworth, Tamara L. Wall, Andrew J. O. Whitehouse, Gail M. Williams, Eivind Ystrom, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp
Summary: The study investigates the genetic architecture of internalizing symptoms in children and adolescents, finding rater-based heterogeneity in genetic effects and genetic correlations with adult internalizing disorders and other childhood psychiatric traits. Additionally, reducing phenotypic heterogeneity in childhood samples is crucial for future GWAS success.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Clinical
Eivind Ystrom, Eirik Degerud, Martin Tesli, Anne Hoye, Ted Reichborn-Kjennerud, Oyvind Naess
Summary: Moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease mortality, but the mechanisms behind this association are still unclear. This study aimed to estimate the familial and individual risk for CVD mortality related to alcohol consumption by analyzing data from twin pairs. The results showed that familial factors accounted for the protective association of moderate to high alcohol consumption with a lower risk of CVD mortality. Early life genetic and environmental familial factors may mask any absence of health effects of moderate to high alcohol consumption on cardiovascular mortality.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ingunn Olea Lund, Njal Andersen, Marte Handal, Helga Ask, Svetlana Skurtveit, Eivind Ystrom, Jasmina Burdzovic Andreas
Summary: Parental risk constellations of drinking, mental health and education are associated with offspring's risk for anxiety/depression, but not with the extent of their healthcare service utilization for anxiety/depression.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Fartein Ask Torvik, Espen Moen Eilertsen, Laurie J. Hannigan, Rosa Cheesman, Laurence J. Howe, Per Magnus, Ted Reichborn-Kjennerud, Ole A. Andreassen, Pal R. Njolstad, Alexandra Havdahl, Eivind Ystrom
Summary: This study examines the genetic similarities between partners, siblings, and in-laws in genetic factors related to educational attainment, height, and depression using data from over 25,000 Norwegian families.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nikolai Haahjem Eftedal, Thomas Haarklau Kleppesto, Nikolai Olavi Czajkowski, Jennifer Sheehy-Skeffington, Espen Roysamb, Olav Vassend, Eivind Ystrom, Lotte Thomsen
Summary: This study examines people's propensity to perceive injustice and finds evidence for principled and opportunistic motives towards injustice. Principled justice sensitivity leads to increased sensitivity to injustices of all categories, while opportunistic justice sensitivity is associated with increased sensitivity to being a victim and a decreased propensity to see oneself as a perpetrator.
SCIENTIFIC REPORTS
(2022)
Article
Sociology
Tina Baier, Espen Moen Eilertsen, Eivind Ystrom, Imac M. Zambrana, Torkild H. Lyngstad
Summary: This study examines the intergenerational correlation of educational attainment (ICE) and highlights the role of genetic factors in addition to family background. The results show that genetic transmission is the main driver of the ICE, and the genetic variants influencing educational attainment in parents only partially overlap with those influencing their children's attainment.
RESEARCH IN SOCIAL STRATIFICATION AND MOBILITY
(2022)
Article
Psychology, Developmental
Espen M. Eilertsen, Rosa Cheesman, Ziada Ayorech, Espen Roysamb, Jean-Baptiste Pingault, Pal R. Njolstad, Ole A. Andreassen, Alexandra Havdahl, Tom A. McAdams, Fartein A. Torvik, Eivind Ystrom
Summary: This study examines the joint contributions of direct and indirect genetic effects of children and parents on childhood externalizing problems. The results show that parents play a significant role in the development of externalizing behaviors, and gene-environment correlations can reduce the variation in inattention and conduct problems. Not accounting for indirect parental genetic effects can lead to biases in identifying genetic variants for childhood externalizing behaviors.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychology, Clinical
Ludvig D. Bjorndal, Kenneth S. Kendler, Ted Reichborn-Kjennerud, Eivind Ystrom
Summary: This study, using a co-twin control design, found an association between stressful life events (SLEs) and an increased risk of adult depression, and this association was at least partially due to the causal influence of SLE exposure on depression risk.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jean-Baptiste Pingault, Wikus Barkhuizen, Biyao Wang, Laurie J. Hannigan, Espen Moen Eilertsen, Elizabeth Corfield, Ole A. Andreassen, Helga Ask, Martin Tesli, Ragna Bugge Askeland, George Davey Smith, Camilla Stoltenberg, Neil M. Davies, Ted Reichborn-Kjennerud, Eivind Ystrom, Alexandra Havdahl
Summary: This study explores the mechanisms underlying the intergenerational transmission of risk for ADHD traits. The results suggest that genetic factors play a major role in this transmission, rather than environmental influences from parents. The findings emphasize the importance of considering genetic transmission in understanding the development of ADHD.
MOLECULAR PSYCHIATRY
(2023)
Article
Orthopedics
E. Gjefsen, K. Gervin, L. C. H. Brtten, G. L. Goll, H. C. D. Aass, E. I. Schistad, M. Wigemyr, L. M. Pedersen, J. S. Skouen, M. D. Vigeland, K. K. Selmer, K. Storheim, J. A. Zwart
Summary: This study explored the serum cytokine levels over time in patients with chronic low back pain and Modic changes, and investigated the difference in change between treatment groups as well as the associations between cytokine changes and low back pain. The results showed that certain cytokines were associated with low back pain intensity, and there were small differences in the cytokine change networks between treatment groups.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Psychology, Clinical
Line C. Gjerde, Espen Moen Eilertsen, Tom A. McAdams, Rosa Cheesman, Terrie E. Moffitt, Avshalom Caspi, Thalia C. Eley, Espen Roysamb, Tom H. Rosenstrom, Eivind Ystrom
Summary: This study investigated the joint factor structure of psychopathology and personality in eight-year-old children. The results showed that correlations between normative and pathological traits mostly reflect one heritable and psychometrically interpretable factor. Furthermore, the association between the factor and low gestational age indicates the need for further study of early developmental mechanisms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Laurie John Hannigan, Ingunn Olea Lund, Adrian Dahl Askelund, Eivind Ystrom, Elizabeth C. Corfield, Helga Ask, Alexandra Havdahl
Summary: This study evaluated the association between maternal at-risk drinking and childhood emotional and behavioral problems, finding that the association almost disappeared after controlling for genetic confounding. There was no significant moderation of these associations by gene-environment interaction.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Thomas H. Kleppesto, Espen Moen Eilertsen, Elsje van Bergen, Hans Fredrik Sunde, Brendan Zietsch, Magnus Nordmo, Nikolai Haahjem Eftedal, Alexandra Havdahl, Eivind Ystrom, Fartein Ask Torvik
Summary: The intergenerational resemblance of ADHD behaviors is primarily due to genetic transmission, with little evidence for parental ADHD behaviors causing children's ADHD behaviors. Individual-specific environmental factors also play a role in the variability of ADHD behaviors.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Social
Andrea Constantinou, Tilmann von Soest, Henrik Daae Zachrisson, Fartein Ask Torvik, Rosa Cheesman, Eivind Ystrom
Summary: This study explores the relationship between personality traits at age 8 and academic performance between ages 10 and 14, taking into account genetic and environmental confounders. The findings suggest that traits such as openness to experience and conscientiousness have a strong positive association with educational performance, while agreeableness and extraversion have smaller associations. Neuroticism, on the other hand, is negatively associated with academic performance.
JOURNAL OF PERSONALITY
(2023)
