Review
Cardiac & Cardiovascular Systems
Riccardo Scirpa, Edoardo Cittadini, Lorenzo Mazzocchi, Giacomo Tini, Matteo Sclafani, Domitilla Russo, Andrea Imperatrice, Alessandro Tropea, Camillo Autore, Beatrice Musumeci
Summary: Transthyretin related cardiac amyloidosis (TTR-CA) is increasingly recognized due to a non-invasive diagnostic algorithm. The disease has two stages - presymptomatic and symptomatic, with the need to diagnose in the first stage becoming more urgent. Risk stratification is important to identify patients at higher risk of cardiovascular events and death, with proposed prognostic scores based on biomarkers and laboratory findings. A multiparametric approach combining information from various tests may be necessary for comprehensive risk prediction and management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biology
Saswati Saha, Lionel Spinelli, Jaime A. Castro Mondragon, Anais Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R. Colas, Karen Ocorr, Laurent Perrin
Summary: Studying the cardiac performance variations in Drosophila reveals genetic networks associated with natural variation of cardiac traits and identifies genes related to cardiac function variations. The findings in fruit flies can potentially accelerate the discovery of heart diseases in humans.
Review
Cell Biology
Sander Verheule, Ulrich Schotten
Summary: Fibrosis is recognized as a key determinant of conduction disturbances in both atria and ventricles, with different forms such as replacement, endomysial, perimysial, perivascular, endocardial, and epicardial fibrosis. The impact on conduction depends on how the patterns of electrical connections between myocytes are altered. Evaluating cardiac fibrosis should exclude fibrous tissue that does not affect conduction and differentiate between different types.
Review
Endocrinology & Metabolism
Giovanni Targher, Kathleen E. Corey, Christopher D. Byrne
Summary: NAFLD is strongly associated with an increased risk of cardiovascular events and other cardiac complications, independently of traditional CVD risk factors. The risk of CVD and other cardiac/arrhythmic complications parallels the severity of NAFLD, with multiple underlying mechanisms likely contributing to this increased risk.
DIABETES & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Honghuang Lin, Alan C. Kwan, Cecilia Castro-Diehl, Meghan I. Short, Vanessa Xanthakis, Ibrahim M. Yola, Gerran Salto, Gary F. Mitchell, Martin G. Larson, Ramachandran S. Vasan, Susan Cheng
Summary: The drivers of sexual dimorphism in heart failure phenotypes are poorly understood. This study aimed to assess the heritability and contributions of genetics and environment to cardiac traits and their inter-relations in a large community-based cohort. The results showed significant heritability for all traits in both men and women, with no significant differences between sexes. However, there were differences in the genetic and environmental correlations between cardiac structure and function, suggesting potential pathways for sex-based divergent heart failure phenotypes.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao-Yan Qi, Faezeh Vahdati Hassani, Dennis Hoffmann, Jiening Xiao, Feng Xiong, Louis R. Villeneuve, Senka Ljubojevic-Holzer, Markus Kamler, Issam Abu-Taha, Jordi Heijman, Donald M. Bers, Dobromir Dobrev, Stanley Nattel
Summary: The study revealed that atrial fibrillation (AF) affects nucleoplasmic Ca2+ in atrial cardiomyocytes, leading to the upregulation of IP(3)R1 and enhanced CaMKII-HDAC4 signaling, resulting in the downregulation of L-type calcium current.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Parag N. Jain, Katherine B. Salciccioli, Danielle Guffey, Jinyoung Byun, Timothy B. Cotts, Peter Ermis, Michael Gaies, Nancy Ghanayem, Francis Kim, Javier J. Lasa, Andrew Smith, Stephanie Fuller
Summary: This study analyzed the postoperative care of adults with congenital heart disease in pediatric cardiac intensive care units, finding that high complexity operations, previous sternotomies, preoperative arrhythmias, renal dysfunction, and respiratory failure are independent risk factors for prolonged length of stay and/or major complications.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Kanishk Agnihotri, Paris Charilaou, Dinesh Voruganti, Kulothungan Gunasekaran, Jawahar Mehta, Hakan Paydak, Alexandros Briasoulis
Summary: This study used a national sample of hospitalizations to analyze the impact of atrial fibrillation (AF) on inpatient mortality, length of stay (LOS), and cost of hospitalization in cardiac surgery. The results showed that hospitalizations with AF had lower inpatient mortality risk and stroke prevalence, but higher LOS and hospitalization costs.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Christopher D. Byrne, Giovanni Targher
Summary: NAFLD is associated with an increased risk of CVD events and other cardiac complications, independently of common risk factors. Possible mechanisms include insulin resistance, dyslipidemia, hypertension, and pro-inflammatory mediators from the liver. Genetic polymorphisms may worsen liver disease but also attenuate the strength of the NAFLD-CVD association. Pioglitazone and GLP-1 receptor agonists show promise in treating both NAFLD and benefiting the vasculature.
DIABETES OBESITY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
T. Crespo-Garcia, A. Camara-Checa, M. Dago, M. Rubio-Alarcon, J. Rapun, J. Tamargo, E. Delpon, R. Caballero
Summary: Cardiac electrical activity is regulated by ion channels, and transcription factors play a critical role in controlling this activity. They may serve as potential drug targets for treating cardiac arrhythmias.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Laura C. Palacio, Diana C. Pachajoa, Carlos A. Echeverri-Londono, Javier Saiz, Catalina Tobon
Summary: This study conducted a narrative review of experimental studies to comprehensively assess the impact of atmospheric pollutants on cardiac activity and the development of cardiac diseases. The review found that different pollutants have pathological effects on cardiac activity during both short-term and long-term exposure. This serves as a basis for developing recommendations for public health.
Article
Cardiac & Cardiovascular Systems
Havisha Pedamallu, Rachel Zmora, Amanda M. Perak, Norrina B. Allen
Summary: Since 2010, there has been extensive research on cardiovascular health (CVH) across the life course. This review highlights the importance of prenatal and childhood exposures in shaping CVH trajectories and the strong predictive value of CVH for various health outcomes. Interventions to improve CVH are uncommon, especially in children, and future research needs to focus on effective and sustainable strategies, with technology and community engagement playing key roles.
CIRCULATION RESEARCH
(2023)
Article
Biology
Jack D. Lester, Linda Vigilant, Paolo Gratton, Maureen S. McCarthy, Christopher D. Barratt, Paula Dieguez, Anthony Agbor, Paula Alvarez-Varona, Samuel Angedakin, Emmanuel Ayuk Ayimisin, Emma Bailey, Mattia Bessone, Gregory Brazzola, Rebecca Chancellor, Heather Cohen, Emmanuel Danquah, Tobias Deschner, Villard Ebot Egbe, Manasseh Eno-Nku, Annemarie Goedmakers, Anne-Celine Granjon, Josephine Head, Daniela Hedwig, R. Adriana Hernandez-Aguilar, Kathryn J. Jeffery, Sorrel Jones, Jessica Junker, Parag Kadam, Michael Kaiser, Ammie K. Kalan, Laura Kehoe, Ivonne Kienast, Kevin E. Langergraber, Juan Lapuente, Anne Laudisoit, Kevin Lee, Sergio Marrocoli, Vianet Mihindou, David Morgan, Geoffrey Muhanguzi, Emily Neil, Sonia Nicholl, Christopher Orbell, Lucy Jayne Ormsby, Liliana Pacheco, Alex Piel, Martha M. Robbins, Aaron Rundus, Crickette Sanz, Lilah Sciaky, Alhaji M. Siaka, Veronika Staedele, Fiona Stewart, Nikki Tagg, Els Ton, Joost van Schijndel, Magloire Kambale Vyalengerera, Erin G. Wessling, Jacob Willie, Roman M. Wittig, Yisa Ginath Yuh, Kyle Yurkiw, Klaus Zuberbuehler, Christophe Boesch, Hjalmar S. Kuehl, Mimi Arandjelovic
Summary: The genetic diversity of chimpanzees is largely influenced by isolation by distance, as shown by a diverse genetic structure exhibited with geographical expansion. In contrast to the historically recognized four subspecies, current research indicates a relatively high genetic connectivity among chimpanzees. The relatively permeable nature of geographical barriers has led to strong genetic connectivity among chimpanzees on a global scale.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Veronique M. F. Meijborg, Ruben Coronel
Summary: Obesity is a significant risk factor for arrhythmic cardiovascular death. A review investigates the influence of epicardial adipose tissue (EAT) on arrhythmogenesis, highlighting its impact on atrial and ventricular conduction delay, structural cross talk with the heart, and secretion of substances that influence cardiomyocyte electrophysiology. The interaction between EAT and cardiomyocytes facilitates arrhythmias via activation delay, conduction slowing, and increased risk of block.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Andrea Matteucci, Michela Bonanni, Marco Centioni, Federico Zanin, Francesco Geuna, Gianluca Massaro, Giuseppe Sangiorgi
Summary: The COVID-19 pandemic led to changes in the in-hospital management of patients with CIEDs, with routine controls being shifted to remote home monitoring. The study found a decrease in arrhythmic events and hospital admissions in 2020 compared to 2019, while heart failure alarm activations increased. The combination of home monitoring and telemedicine has proved effective in ensuring surveillance of CIED patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alex Horby Christensen, Pyotr G. Platonov, Anneli Svensson, Henrik K. Jensen, Christine Rootwelt-Norberg, Pia Dahlberg, Trine Madsen, Tanja Charlotte Frederiksen, Tiina Helio, Kristina H. Haugaa, Henning Bundgaard, Jesper H. Svendsen
Summary: This study describes the complications associated with implantable cardioverter-defibrillators (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The results show that during long-term follow-up, approximately 41% of patients experienced potentially life-saving ICD therapy, while 27% had complications requiring surgery, mainly lead-related complications.
Article
Genetics & Heredity
Alex Horby Christensen, Pyotr G. Platonov, Henrik Kjaerulf Jensen, Monica Chivulescu, Anneli Svensson, Pia Dahlberg, Trine Madsen, Tanja Charlotte Frederiksen, Tiina Helio, Oyvind Haugen Lie, Kristina H. Haugaa, Jesper Hastrup Svendsen, Henning Bundgaard
Summary: ARVC is predominantly caused by desmosomal genetic variants. PKP2 genotype is more arrhythmic than DSC2/DSG2/DSP or gene-negative patients, while reduced LVEF is mainly seen in DSC2/DSG2/DSP carriers. Male sex is associated with a more severe phenotype.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Education, Scientific Disciplines
Laerke Marijke Noerholk, Karlen S. Bader-Larsen, Anne Mette Morcke, Anishan Vamadevan, Lisbeth Anita Andreasen, Jesper Hastrup Svendsen, Hanne Jorsboe, Martin G. Tolsgaard
Summary: During a health crisis, clinical clerkships and the roles of medical students and doctors can be significantly affected, leading to emotional triggers, negotiation of legitimacy, and the development of resilience. The health crisis can exacerbate existing conflicts and disrupt the hierarchical structure within clinical clerkships.
Article
Biology
Igor Diemberger, Luca Segreti, Christopher A. Rinaldi, Jesper Hastrup Svendsen, Andrzej Kutarski, Arwa Younis, Cecile Laroche, Christophe Leclercq, Barbara Malecka, Przemyslaw Mitkowski, Maria Grazia Bongiorni
Summary: According to the analysis of patients with infection of implantable pacemakers/defibrillators, about one-third of the cases showed systemic infection, which is associated with increased complications and mortality during hospitalization. Patients with systemic infection have different characteristics compared to those with local infection, suggesting that some infections may be systemic from the beginning. These findings have important implications for further research and treatment.
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Health Care Sciences & Services
Diana My Frodi, Vlad Manea, Soren Zoga Diederichsen, Jesper Hastrup Svendsen, Katarzyna Wac, Tariq Osman Andersen
Summary: This study explores how behaviors reported by a consumer wearable can assist in predicting the risk of ventricular arrhythmia (VA). The results show that longer durations of light to fair activity and higher heart rates increase the odds of a VA event, while longer durations of fair to vigorous activity and sleep decrease the odds of a VA event.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Laura Andreasen, Gustav Ahlberg, Hildur M. Aegisdottir, Gardar Sveinbjornsson, Pia R. Lundegaard, Jacob P. Hartmann, Christian Paludan-Muller, Katra Hadji-Turdeghal, Jonas Ghouse, Steen Pehrson, Henrik K. Jensen, Sam Riahi, Jim Hansen, Niels Sandgaard, Erik Sorensen, Karina Banasik, Susanne G. Saekmose, Mie T. Bruun, Henrik Hjalgrim, Christian Erikstrup, Ole B. Pedersen, Michael Wittig, Stig Haunso, Sisse R. Ostrowski, Andre Franke, Soren Brunak, Jorgen K. Kanters, Christina Ellervik, Henning Bundgaard, Henrik Ullum, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Hilma Holm, David O. Arnar, Kari Stefansson, Jesper H. Svendsen, Morten S. Olesen
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Different event timing modalities have an impact on myocardial work indices, with visual assessment yielding lower global work index (GWI) values compared with Doppler-based methods.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Morten S. Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to characterize the onset and progression of subclinical atrial fibrillation (AF) by analyzing 12-lead electrocardiogram (ECG) parameters. The results showed that P-wave duration (PWD) and interatrial block (IAB) were strongly associated with the onset, burden, and progression of AF.
Letter
Cardiac & Cardiovascular Systems
Oliver Bundgaard Vad, Christian Paludan-Muller, Laia Meseguer Monfort, Gustav Ahlberg, Jesper Hastrup Svendsen, Morten Salling Olesen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Christian Zinck Jensen, Jonas Lynggaard Isaksen, Gustav Ahlberg, Morten Salling Olesen, Birte Nygaard, Christina Ellervik, Jorgen Kim Kanters
Summary: This study found that single-nucleotide variations in certain genes are not associated with psychological well-being, cognitive function, or cardiovascular risk factors in patients receiving levothyroxine treatment. The results do not support a gene-treatment interaction in this context.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Bayer Elming, Rune Boas, Sophia Hammer-Hansen, Inga Voges, Eva Nyktari, Jesper Hastrup Svendsen, Steen Pehrson, Ulrik Dixen, Berit T. Philbert, Sanjay K. Prasad, Lars Kober, Jens Jakob Thune
Summary: There is no relationship between cardiac magnetic resonance late gadolinium enhancement (LGE) and Holter recorded ventricular arrhythmic activity in patients with non-ischemic systolic heart failure. However, the presence of LGE is associated with an increased risk of mortality.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Alia Saed Alhakak, Sofie Reumert Biering-Sorensen, Rasmus Mogelvang, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Allan Zeeberg Iversen, Jesper Hastrup Svendsen, Thomas Jespersen, Gunnar Gislason, Tor Biering-Sorensen
Summary: Peak atrial longitudinal strain (PALS) can be used to predict the risk of developing atrial fibrillation (AF) and ischemic stroke in the general population, especially in participants aged less than 65 years.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)