Article
Medicine, Research & Experimental
Stine Julie Tingskov, Michael Schou Jensen, Casper-Emil Tingskov Pedersen, Isabela Bastos Binotti Abreu de Araujo, Henricus A. M. Mutsaers, Rikke Norregaard
Summary: The study found that the selective estrogen receptor modulator tamoxifen has a mitigating effect on renal fibrosis in female, male, and ovariectomized female rats, as well as demonstrating an anti-fibrotic effect in human kidney slices. Gender differences may play a role in drug treatment response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Chang-Mu Chen, Chen-Yu Lin, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Cheng-Tien Wu, Shing-Hwa Liu
Summary: Nootkatone, a major active ingredient of Alpiniae oxyphyllae, has shown promising effects in preventing and mitigating the progression of chronic kidney diseases (CKD) in a unilateral ureteral obstructive (UUO) mouse model. It was found to reduce pathological changes, collagen deposition, fibrotic markers expression, oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. This suggests that nootkatone may be a potential therapeutic candidate for intervening in CKD.
Article
Medicine, Research & Experimental
Guihua Zhang, Fuxun Yu, Rong Dong, Jiali Yu, Meng Luo, Yan Zha
Summary: The study revealed that verbascoside could alleviate renal fibrosis in UUO rats by ameliorating renal dysfunction, reducing total nucleated cell numbers and collagen fibrils deposition, as well as down-regulating the expression of fibrosis-related proteins. Additionally, macrophage infiltration was mitigated by verbascoside treatment.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Yashu Wang, Xinna Deng, Zhaohua Yang, Haijiang Wu
Summary: This study analyzed the development trends of research on UUO-induced renal fibrosis between 2005 and 2022 using bibliometric and visual analysis. The results indicate that the molecular mechanism of UUO-induced renal fibrosis remains a hot topic, with a focus on the inflammatory response and oxidative stress. International cooperation is expected to expand and deepen in the future.
Article
Plant Sciences
Yu-Teng Chang, Mu-Chi Chung, Chi-Hao Chang, Kuan-Hsun Chiu, Jeng-Jer Shieh, Ming-Ju Wu
Summary: This study evaluated the effects of protocatechuic aldehyde (PCA) on renal fibrosis. The results showed that PCA could inhibit TGF-beta 1-induced fibrosis and EMT, suggesting it as a potential strategy for preventing organ fibrosis in clinics.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenjuan Sun, Chang Hyun Byon, Dong Hyun Kim, Hoon In Choi, Jung Sun Park, Soo Yeon Joo, In Jin Kim, Inae Jung, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrated that MA could alleviate renal fibrosis by regulating the expression of various proteins and interfering with the TGF-beta/Smad and MyD88 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qi Jia, Lin Han, Xiaoyu Zhang, Wenning Yang, Yushan Gao, Yifan Shen, Bing Li, Shuyan Wang, Mingzhen Qin, Scott Lowe, Jianguo Qin, Gaimei Hao
Summary: TLYS decoction showed significant effects on biological processes, cellular components, and molecular functions related to renal fibrosis by regulating lysosome, phagosome, and oxidation pathways. Additionally, TLYS ameliorated mitochondrial dynamics, reduced oxidative stress, and improved mitophagy clearance deficiency in UUO rats, indicating its potential therapeutic effects on chronic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ruiting Wang, Chen Kairen, Lu Li, Lingling Zhang, Haifeng Gong, Xinzhong Huang
Summary: NDUFV1 plays a beneficial role in improving kidney function, maintaining renal structures, and alleviating renal fibrosis in UUO model mice. The study suggests that ETC complex I is important for dealing with acute kidney injury and other mitochondrial-associated renal diseases.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Miaomiao Lu, Hang Li, Wenlin Liu, Xuemei Zhang, Lili Li, Hongli Zhou
Summary: Curcumin has shown promising effects in attenuating renal interstitial fibrosis in UUO rats by inhibiting NLRP3 inflammasome activation, improving mitochondrial function, and promoting autophagy. Its mechanism of action also involves inhibiting the PI3K/AKT/mTOR pathway.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Wang, Zhichao Wang, Fan Xia, Qiong Duan, Xiaoping Peng
Summary: Renal interstitial fibrosis is a common pathological process in chronic kidney diseases, and obstructive kidney disease is a frequent cause of renal fibrosis. In this study, atorvastatin was found to decrease YAP and fibrosis-related gene expression, suggesting its potential as a preventive agent for fibrosis associated with obstructive kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Fernando Enrique Garcia-Arroyo, Isabel Amador-Martinez, Marisol Orozco-Ibarra, Francisca Fernandez-Valverde, Jose Pedraza-Chaverri
Summary: Sulforaphane (SFN) confers protection against unilateral ureteral obstruction (UUO)-induced kidney injury by targeting mitochondrial biogenesis and improving lipid metabolism.
Article
Biochemistry & Molecular Biology
Alexis Paulina Jimenez-Uribe, Belen Bellido, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Jose Antonio Hernandez-Santos, Francisca Fernandez-Valverde, Estefani Yaquelin Hernandez-Cruz, Marisol Orozco-Ibarra, Jose Pedraza-Chaverri
Summary: This study evaluated the time course of mitochondrial mass and bioenergetics alterations induced by a unilateral ureteral obstruction (UUO), a widely used model to study kidney fibrosis induction and progression mechanisms. The results showed a marked reduction in mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial mass during days 7 to 28 of obstruction, suggesting a key role of mitochondrial biogenesis and mitophagy induction in the impairment of OXPHOS capacity during fibrotic progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Ariadna Jazmin Ortega-Lozano, Jose Pedraza-Chaverri
Summary: In the UUO model, overproduction of ROS leads to alterations in signaling pathways, promoting inflammation, oxidative stress, and apoptosis, contributing to fibrosis development. Impairment of mitochondrial metabolism is also involved in this process.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)