Article
Endocrinology & Metabolism
Liu Shi, Dongmei Zhang, Jianqing Ju, Anlu Wang, Tianyi Du, Xuanye Chen, Yewen Song, Zhuye Gao, Hao Xu
Summary: In the general US adult population, remnant cholesterol (RC) is associated with hypertension beyond LDL-C levels. Elevated RC levels are linked to a higher prevalence of hypertension, independent of BMI, LDL-C, HDL-C, or triglycerides.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Federica Galimberti, Manuela Casula, Elena Olmastroni
Summary: The retention of apoB-containing lipoproteins in the subendothelial layer is crucial for the development of atherosclerotic processes. Recent evidence suggests that the number of atherogenic particles trapped in the arterial lumen, rather than their lipid content, plays a key role in this process. Hence, apoB level is proposed as a better indicator than LDL-cholesterol for assessing cardiovascular disease risk, particularly in specific patient subgroups. Routine measurement of both LDL-cholesterol and apoB is essential for estimating overall cardiovascular risk, evaluating residual risk, and monitoring therapeutic effectiveness.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Cardiac & Cardiovascular Systems
Kyung An Kim, Na Jin Kim, Eun-Ho Choo
Summary: This meta-analysis aimed to evaluate the effect of fibrate treatment on cardiovascular risk. It found that fibrate therapy was associated with decreased risk of major adverse cardiovascular outcomes (MACE), primarily through the reduction of low-density lipoprotein cholesterol (LDL-C) rather than triglyceride levels.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Review
Endocrinology & Metabolism
Chunyan Zhao, Yueqi Wang, Liu Xiao, Lin Li
Summary: The results of this meta-analysis suggest that levothyroxine treatment may reduce total cholesterol, triglycerides, low-density lipoprotein cholesterol, and apolipoprotein B levels in older patients with subclinical hypothyroidism (SCH). However, it does not significantly affect bone mineral density, fatigue, hypothyroidism symptoms, quality of life, body mass index, cognitive function, depression, blood pressure, or increase the incidence of adverse events in older SCH patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Bagherniya, Thomas P. Johnston, Amirhossein Sahebkar
Summary: This paper reviewed the effect of bioactive natural compounds on plasma Apo B concentrations, concluding that medicinal plants and nutraceuticals can generally be used as complementary medicine to reduce plasma Apo B levels in a safe, accessible, and inexpensive manner in an attempt to prevent and treat cardiovascular disease.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Geyue Qu, Zhongying Zhang, Hong Zhu
Summary: This study found discordance between LDL-C and non-HDL-C or apoB in middle-aged and elderly Chinese individuals, which was associated with a higher risk of arterial stiffness. Non-HDL-C or apoB levels could be used to identify individuals who may benefit from more comprehensive lipid modification.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Urology & Nephrology
Chuanfei Zeng, Qing Zhan, Linghai Lv, Yanbing Chen, Xiaojiang Zhan
Summary: This study investigated the association between the LDL-C/apo B ratio (LAR) and all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. The results showed that a low LAR was significantly associated with an increased risk of all-cause mortality and cardiovascular events.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Wenjing Dong, Xiaoyan Zhong, Ke Yuan, Mengyuan Miao, Yujia Zhai, Bizhong Che, Tan Xu, Xiang Xu, Chongke Zhong
Summary: Elevated plasma Lp(a) levels were associated with an increased risk of major disability and death at 6 months in patients with acute ischemic stroke. Especially, discordantly high Lp(a)/low LDL-C levels were linked to an unfavorable functional outcome, highlighting the predictive potential of plasma Lp(a) after ischemic stroke, particularly when discordant with LDL-C.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Hongen Meng, Li Jiang, Zijun Song, Fudi Wang
Summary: This study used Mendelian randomization to evaluate the genetic causal effects of circulating apolipoproteins and lipoprotein lipids on osteoarthritis (OA) risk. The results showed that genetic predisposition to Apolipoprotein B (APOB) and low-density lipoprotein (LDL) was associated with a decreased risk of OA, providing new insights into the relationship between lipids and OA risk.
Article
Multidisciplinary Sciences
Gozde Erturk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlita, Halef Okan Dogan, Gokmen Zararsiz
Summary: Multiple studies have shown a high prevalence of dyslipidemia in children, emphasizing the importance of early recognition to prevent future coronary heart disease. Among the various equations for estimating LDL-C, the extended Martin-Hopkins formula was found to provide the most reliable results in a large pediatric population.
Article
Cardiac & Cardiovascular Systems
Richard J. Webb, Mohsen Mazidi, Gregory Y. H. Lip, Andre P. Kengne, Maciej Banach, Ian G. Davies
Summary: This study investigated the impact of adiposity, diet, and inflammation on the discordance between apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C). The results showed that body mass index, dietary saturated fatty acids, dietary fiber, serum C-reactive protein, and uric acid were strongly associated with the discordance. Additionally, Mendelian randomization analysis indicated that higher body fat percentage was causally related to elevated ApoB.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Allan Sniderman, Michel Langlois, Christa Cobbaert
Summary: The 2019 European Society of Cardiology/European Atherosclerosis Society Guidelines emphasize the importance of measuring apolipoprotein B (apoB) as a more accurate indicator of cardiovascular risk and better guide for lipid lowering therapy compared to LDL-C or non-HDL-C. Despite the limited endorsement of apoB by the 2018 American College of Cardiology/American Heart Association Multisociety Guidelines, both guidelines still retain LDL-C as the primary metric to guide statin/ezetimibe/PCSK9 therapy.
CURRENT OPINION IN LIPIDOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qi Yu, Ying Chen, Cang-Bao Xu
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Oncology
Qi Yu, Fang Wang, Xiaodong Meng, Yiren Gong, Yanli Wang, Cangbao Xu, Siwang Wang
MOLECULAR MEDICINE REPORTS
(2018)
Article
Oncology
Ya-Wen Cheng, Wen-Juan Li, Xiang-Jun Dou, Rui Jia, Hua Yang, Xin-Guang Liu, Cang-Bao Xu, Jing Liu, Yong-Xiao Cao, Guo-Gang Luo
MOLECULAR MEDICINE REPORTS
(2018)
Article
Oncology
Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu, Ling-yu Zhao
CANCER CELL INTERNATIONAL
(2018)
Article
Pharmacology & Pharmacy
Zhong-San Zeng, Jie Lin, Cang-Bao Xu, Lei Cao, Chen Chen, Jie Li
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Min Jia, Yaping Zhang, Han Zhang, Qiaohong Qin, Cang-Bao Xu
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2019)
Article
Peripheral Vascular Disease
Min Jia, Xuan-Xuan Zhou, Qiaohong Qin, Fang Wang, Jie Li, Cang-Bao Xu, Siwang Wang
MICROVASCULAR RESEARCH
(2019)
Article
Peripheral Vascular Disease
Gen Chen, Xiao-Lan Chen, Cang-Bao Xu, Jie Lin, Hong-Li Luo, Xi Xie, Jie Li
MICROVASCULAR RESEARCH
(2020)
Review
Pathology
Yaping Zhang, Cang-Bao Xu
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Biochemistry & Molecular Biology
Yuying Wang, Pan Zhang, Ting Wang, Dongfeng Yao, Yongheng Shi, Jiping Liu, Bin Wang, Hao Wei, Weihai Liu, Cang-bao Xu, Chuan Wang
Summary: Smoking is a risk factor for cardiovascular diseases, however, the mechanisms behind how smoking leads to vasospasm are not fully understood. This study found that cigarette smoke could up-regulate vascular endothelin receptors through AMPK-SIRT1 and MAPK pathways, resulting in vasoconstriction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Ying Chen, Qi Yu, Cang-Bao Xu
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Article
Pharmacology & Pharmacy
Yaping Zhang, Wei Zhang, Lars Edvinsson, Cang-Bao Xu
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2017)