Article
Agriculture, Dairy & Animal Science
Wenfeng Ma, Pei Mao, Yanzhi Zhu, Liang Guo, Shihai Zhang, Zhanbin Wang, Furong Zhao
Summary: The results of this study indicate that the optimal SID Trp to Lys ratio of 0.18 can improve the growth performance and jejunal amino acid transporter mRNA expression levels in weaning pigs fed a low crude protein diet.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Review
Immunology
Rebecca R. Crowther, Joseph E. Qualls
Summary: This article provides a summary of the current knowledge on anti-Mtb immunity, focusing on immune cell amino acid metabolism, specifically discussing the roles of L-arginine and L-tryptophan in TB patients. By uncovering the immune cell contribution during Mtb infection and how amino acid utilization regulates their functions, novel host-directed therapies may be developed and refined to help eradicate TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Xitong Fei, Haichao Hu, Yingli Luo, Qianqian Shi, Anzhi Wei
Summary: This study evaluated the quality characteristics of amino acids in peppers using various methods and identified the key genes involved in amino acid synthesis. The findings have important implications for the development of pepper functional food.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ahad Hussain, Li Xie, Guozhe Deng, Xuejun Kang
Summary: Amino acids have important roles in synthesizing proteins in cancer cells and activating immune cells in the tumor microenvironment. Abnormal changes in amino acid metabolism are closely related to tumor development and immunity. This study aimed to examine the amino acid profiles and tryptophan metabolites in five types of cancer patients to determine if there are common amino acid changes across tumors.
Article
Spectroscopy
Amirmostafa Amirjani, Kimia Salehi, S. K. Sadrnezhaad
Summary: L-tryptophan functionalized AgNPs sensor was successfully fabricated using a one-pot synthesis method and showed selective response towards Mg2+ ions with high stability and selectivity. The sensor detected Mg2+ with a limit of detection much lower than the concentration range in human serum and demonstrated potential application in clinical diagnostics.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Veterinary Sciences
Stacie C. Summers, Jessica Quimby, Amanda Blake, Deborah Keys, Joerg M. Steiner, Jan Suchodolski
Summary: This study aimed to compare the serum and fecal amino acid concentrations between cats with chronic kidney disease (CKD) and healthy cats. The results showed that cats with CKD had lower concentrations of certain amino acids and higher concentrations of others in their serum, indicating significant differences compared to healthy cats.
VETERINARY SCIENCES
(2022)
Article
Geriatrics & Gerontology
Yushuang Duan, Kuan Tao, Zilong Fang, Yifan Lu
Summary: This study investigates the variations in plasma amino acid concentrations in elderly individuals with possible sarcopenia and identifies glutamine, serine, lysine, threonine, and proline as potential markers for possible sarcopenia.
Article
Biochemistry & Molecular Biology
Takumi Yokosawa, Keisuke Wakasugi
Summary: The study shows that Trp-deficient condition is critical for Trp uptake, not only in cells with added TrpRS protein but also in TrpRS-overexpressing cells. Tryptophanyl-AMP production by TrpRS is essential for high-affinity Trp uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Kazunori Otsuka, Masayoshi Miyahara, Sara Takaki, Ryoya Wakabayashi, Kei Miyako, Raku Irie, Satoshi Takamizawa, Ryuichi Sakai, Masato Oikawa
Summary: In this study, we report on the synthetic studies of protoaculeine B, originally proposed structure, isolated from a marine sponge. Starting from tryptophan, two candidates of suitably protected heterotricyclic subunits were synthesized over 8 and 16 steps, respectively. Furthermore, two diastereomeric heterotricyclic amino acids, finally synthesized, were found to have neuroactive properties, with the natural-type configuration being hyperactive and the diastereomeric configuration being hypoactive upon mice intracerebroventricular injection.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Angelo D'Alessandro, Tiffany Thomas, Imo J. Akpan, Julie A. Reisz, Francesca Cendali, Fabia Gamboni, Travis Nemkov, Kiruphagaran Thangaraju, Upendra Katneni, Kenichi Tanaka, Stacie Kahn, Alexander Z. Wei, Jacob E. Valk, Krystalyn E. Hudson, David Roh, Chiara Moriconi, James C. Zimring, Eldad A. Hod, Steven L. Spitalnik, Paul W. Buehler, Richard O. Francis
Summary: This large study analyzed metabolic features of COVID-19 patients and found significant changes in amino acid and fatty acid/acylcarnitine metabolism as relevant markers of disease severity, progression, and prognosis. Machine learning models achieved around 78% prediction accuracy when trained with metabolomics and clinical data from half of the patient cohort, providing a foundation for further research and data sharing opportunities.
Article
Biochemistry & Molecular Biology
George M. Anderson
Summary: In this study, the microbial metabolite indolepropionic acid (IPA) and related indolic metabolites were measured in human plasma, plasma ultrafiltrate, and saliva. The levels of IPA in plasma ultrafiltrate and of indolelactic acid (ILA) in saliva were reported for the first time. The detection of free plasma IPA provides valuable information on the physiologically active pool of this important microbial metabolite.
Article
Agriculture, Dairy & Animal Science
Bin Wang, Lili Jiang, Zhenlong Wu, Zhaolai Dai
Summary: This study investigated the effects of L-tryptophan (Trp) on lipopolysaccharide (LPS)-induced changes in glucose and amino acid transport in the rat jejunum. The results showed that Trp alleviated LPS-induced increase in permeability and decrease in short-circuit current of various nutrients. Trp also reversed the downregulation of certain transporters while increasing the expression of an acidic amino acid transporter. These findings have implications for nutritional interventions to improve gut function in the presence of inflammation.
Article
Cell Biology
William O. Jonsson, Jonathan Ponette, Oscar Horwath, Tomas Rydenstam, Karin Soderlund, Bjorn Ekblom, Michele Azzolini, Jorge L. Ruas, Eva Blomstrand
Summary: Administration of BCAA can enhance mitochondrial biogenesis and lower plasma levels of aromatic amino acids, kynurenine, and kynurenic acid. However, BCAA did not affect muscle kynurenine levels, suggesting that kynurenine metabolism was altered in tissues other than muscle.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Liang Yao, Jiang Xu, Liwei Zhang, Tao Zheng, Lei Liu, Lei Zhang
Summary: The study utilized an amphiphilic peptide with tryptophan amino acid to co-assemble with anthocyanin, resulting in nanocomposites with enhanced stability and antioxidant activity. The interaction between peptide and anthocyanin was characterized using spectroscopy and fluorescence methods, demonstrating the potential for expanding the application of anthocyanin through this approach.
Article
Fisheries
Claudia Teixeira, Rita Pedrosa, Carolina Castro, Rui Magalhaes, Elisabete Matos, Aires Oliva-Teles, Helena Peres, Amalia Perez-Jimenez
Summary: This study aimed to assess the potential role of dietary tryptophan supplementation in meagre juveniles in order to minimize the deleterious effect of potential stress conditions. The results indicated that tryptophan supplementation had a negative impact on the growth and feed utilization of the fish, but did not affect these parameters at doses below 0.5%.
Article
Anthropology
Hidehiro Nakamura, Natsumi Nishikata, Nobuhiro Kawai, Akira Imaizumi, Hiroshi Miyano, Maiko Mori, Hiroshi Yamamoto, Yasushi Noguchi
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2016)
Article
Biochemical Research Methods
Hiroo Yoshida, Kazuhiro Kondo, Hiroyuki Yamamoto, Naoko Kageyama, Shin-ichi Ozawa, Kazutaka Shimbo, Takahiko Muramatsu, Akira Imaizumi, Toshimi Mizukoshi, Junichi Masuda, Daisuke Nakayama, Yoshihiro Hayakawa, Kyoko Watanabe, Kazuo Mukaibatake, Hiroshi Miyano
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2015)
Article
Multidisciplinary Sciences
Tadakazu Hisamatsu, Nobukazu Ono, Akira Imaizumi, Maiko Mori, Hiroaki Suzuki, Michihide Uo, Masaki Hashimoto, Makoto Naganuma, Katsuyoshi Matsuoka, Shinta Mizuno, Mina T. Kitazume, Tomoharu Yajima, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi, Takanori Kanai
Article
Multidisciplinary Sciences
Minoru Yamakado, Kenji Nagao, Akira Imaizumi, Mizuki Tani, Akiko Toda, Takayuki Tanaka, Hiroko Jinzu, Hiroshi Miyano, Hiroshi Yamamoto, Takashi Daimon, Katsuhisa Horimoto, Yuko Ishizaka
SCIENTIFIC REPORTS
(2015)
Article
Medical Laboratory Technology
Hiroyuki Yamamoto, Kazuhiro Kondo, Takayuki Tanaka, Takahiko Muramatsu, Hiroo Yoshida, Akira Imaizumi, Kenji Nagao, Yasushi Noguchi, Hiroshi Miyano
ANNALS OF CLINICAL BIOCHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Kenji Toyoshima, Marie Nakamura, Yusuke Adachi, Akira Imaizumi, Tomomi Hakamada, Yasuko Abe, Eiji Kaneko, Soiciro Takahashi, Kentaro Shimokado
Article
Multidisciplinary Sciences
Minoru Yamakado, Takayuki Tanaka, Kenji Nagao, Akira Imaizumi, Michiharu Komatsu, Takashi Daimon, Hiroshi Miyano, Mizuki Tani, Akiko Toda, Hiroshi Yamamoto, Katsuhisa Horimoto, Yuko Ishizaka
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Nobuyasu Fukutake, Makoto Ueno, Nobuyoshi Hiraoka, Kazuaki Shimada, Koichi Shiraishi, Nobuhiro Saruki, Toshifumi Ito, Minoru Yamakado, Nobukazu Ono, Akira Imaizumi, Shinya Kikuchi, Hiroshi Yamamoto, Kazuhiro Katayama
Article
Biochemistry & Molecular Biology
Akira Imaizumi, Yusuke Adachi, Takahisa Kawaguchi, Koichiro Higasa, Yasuharu Tabara, Kazuhiro Sonomura, Taka-aki Sato, Meiko Takahashi, Toshimi Mizukoshi, Hiro-o Yoshida, Naoko Kageyama, Chisato Okamoto, Mariko Takasu, Maiko Mori, Yasushi Noguchi, Nobuhisa Shimba, Hiroshi Miyano, Ryo Yamada, Fumihiko Matsuda
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Geriatrics & Gerontology
Yusuke Adachi, Kenji Toyoshima, Rumi Nishimoto, Satoko Ueno, Takayuki Tanaka, Akira Imaizumi, Naoko Arashida, Marie Nakamura, Yasuko Abe, Tomomi Hakamada, Eiji Kaneko, Soichiro Takahashi, Hiroko Jinzu, Kentaro Shimokado
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Nobuyoshi Hiraoka, Sakino Toue, Chisato Okamoto, Shinya Kikuchi, Yoshinori Ino, Rie Yamazaki-Itoh, Minoru Esaki, Satoshi Nara, Yoji Kishi, Akira Imaizumi, Nobukazu Ono, Kazuaki Shimada
SCIENTIFIC REPORTS
(2019)
Article
Geriatrics & Gerontology
K. Kinoshita, Rei Otsuka, M. Takada, M. Tsukamoto-Yasui, Y. Nishita, C. Tange, M. Tomida, H. Shimokata, M. Kuzuya, A. Imaizumi, H. Arai
Summary: This study found that intake of lysine, phenylalanine, threonine, and alanine is crucial for maintaining cognitive function in older people, independently of total protein intake.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Michihiro Takada, Shin Tanaka, Koh Tanaka, Tamao Tsukie, Masako Tsukamoto-Yasui, Katsuya Suzuki, Yasushi Noguchi, Akira Imaizumi, Makoto Ishii, Takeshi Ikeuchi
Summary: This exploratory study evaluated the efficacy and safety of a mixture containing nine essential amino acids on behavioral and psychological symptoms of dementia (BPSD) and cognitive function in patients with Alzheimer's disease (AD). The results showed that the mixture did not improve BPSD, but may improve executive function in patients with AD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
K. Kinoshita, Rei Otsuka, M. Takada, M. Tsukamoto-Yasui, Y. Nishita, C. Tange, M. Tomida, H. Jinzu, H. Shimokata, M. Kuzuya, A. Imaizumi, H. Arai
Summary: This study investigated the relationship between PDCAAS of a diet and cognitive impairment in older adults, and found a significant association between a low PDCAAS of breakfast and the incidence of cognitive impairment.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)