Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Daiqin Chen, Jinhao Liu, Jerry Wu, Jung Soo Suk
Summary: This article discusses the challenges posed by the airway mucus barrier to inhaled drug delivery nanoparticles and strategies to enhance particle penetration through the airway mucus. It introduces methods for modifying the physicochemical properties of nanoparticles and altering the barrier properties of airway mucus. State-of-the-art approaches to overcome the airway mucus barrier have been introduced and experimentally validated.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Elisa Corazza, Angela Abruzzo, Barbara Giordani, Teresa Cerchiara, Federica Bigucci, Beatrice Vitali, Massimiliano Pio di Cagno, Barbara Luppi
Summary: This study evaluated the potential of using biosurfactants produced by Lactobacillus gasseri BC9 as natural excipients to improve nasal drug delivery. Results showed that BC9-BS interacted with nasal mucosa components and enhanced drug solubility and permeation at low concentrations.
Review
Pharmacology & Pharmacy
Xin Yan, Xianyi Sha
Summary: This paper reviews strategies to enhance drug penetration and retention in airway mucus mediated by nano-delivery systems based on the physiopathological mechanisms of airway mucus. It also reveals the potential and challenges of nano-delivery systems for improving airway mucus clearance and provides new ideas and approaches for designing novel nano-delivery systems that effectively improve drug retention and penetration in the airway mucus layer.
Article
Pharmacology & Pharmacy
Mulazim Hussain Asim, Muhammad Ijaz, Arshad Mahmood, Patrick Knoll, Aamir Jalil, Shumaila Arshad, Andreas Bernkop-Schnuerch
Summary: Thiolated beta-cyclodextrin was synthesized and characterized for its potential use as an auxiliary agent for ocular drug delivery, showing enhanced permeation and mucoadhesive properties. The newly synthesized thiolated oligomer exhibited improved aqueous solubility, viscosity enhancement of mucus, prolonged ocular residence time, and enhanced permeation of sodium fluorescein on various ocular tissues, making it a promising candidate for ocular drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Ilker S. Bayer
Summary: Mucoadhesion is an important field in adhesion science, and understanding and controlling mucoadhesion can lead to life-saving materials and technologies. Mucin plays a crucial role in mucoadhesion processes. This review discusses the role of mucin in wet adhesion under different physiological conditions and highlights advancements in mucoadhesion measurement techniques and new mucoadhesive systems. This knowledge expands our understanding of mucoadhesion in soft materials and contributes to the design and application of new membranes, drugs, pharmaceutical devices, and lubricated surfaces.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Matthias Marczynski, Ceren Kimna, Oliver Lieleg
Summary: This review summarizes the advances in drug delivery research with mucin-based model systems, including mucin purification, suitability of model systems reconstituted from purified mucins, techniques to study mucin binding, and approaches using mucins for drug delivery platforms.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Engineering, Biomedical
Sony Priyanka Bandi, Shubhmita Bhatnagar, Venkata Vamsi Krishna Venuganti
Summary: Mucus is a viscoelastic gel that traps pathogens and foreign particles, while also being essential for drug carriers to access underlying epithelial tissues. Various strategies have been developed to achieve mucoadhesion and mucus penetration in drug delivery systems. Advances in materials chemistry have led to the expansion of materials available for mucosal drug delivery applications.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Cosmin Butnarasu, Paola Petrini, Francesco Bracotti, Livia Visai, Giuseppe Guagliano, Alessandra Fiorio Pla, Ettore Sansone, Sara Petrillo, Sonja Visentin
Summary: Mucosomes, a novel class of glycosylated nanoparticles based on mucin, are introduced to overcome the complex barrier of mucus during transmucosal drug delivery. They improve drug absorption and residence time on mucosal tissues and can be loaded with different physicochemical properties. Mucosomes exhibit good mucoadhesive properties and have shown no adverse effects in in vitro and in vivo tests.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Mary E. Vanlandingham, Rebekah A. Heintz, Chathuri S. Kariyawasam, Donovan S. Darlington, Claylee M. Chism, Sara X. Edgecomb, Angela Roberts, Jorden Marzette, Nicholas C. Fitzkee, Eden E. L. Tanner
Summary: This study demonstrates the potential of choline carboxylic acid-based ionic liquids (ILs) to control the diffusion behavior of polymer nanoparticles (NPs) through mucosal barriers, which can improve intranasal drug delivery.
ACS APPLIED NANO MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Sean Swetledge, Jangwook P. Jung, Renee Carter, Cristina Sabliov
Summary: Polymeric nanoparticles as drug delivery systems offer advantages such as controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. However, their properties, administration route, and suspension media can impact their distribution and effectiveness in the eye, requiring careful design for specific target tissues and ocular diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
Summary: The complex nature of the ocular drug delivery barrier poses challenges to effective drug administration. One promising approach is the use of biodegradable formulations, such as hydrogels, implants, and polymeric nanocarriers. Research in these areas is rapidly growing. This review provides an overview of recent updates in biodegradable formulations for ocular drug delivery, exploring their clinical use in different ocular diseases and highlighting their potential for future trends and practical clinical applications.
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Review
Pharmacology & Pharmacy
Liping Li, Fan Jia, Youxiang Wang, Jiamin Liu, Yi Tian, Xinghuai Sun, Yuan Lei, Jian Ji
Summary: This review focuses on recent advancements in using nanomaterials for efficient drug transport across the cornea, categorizing and analyzing their mechanisms, and examining potential principles to improve drug penetration through the cornea and other natural barriers in the eye. The aim is to inspire the development of more effective drug delivery systems for better treatment of ocular diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoshu Gao, Yin Xiong, Hening Chen, Xuheng Gao, Jiaxin Dai, Yutong Zhang, Wanhang Zou, Yang Gao, Zhenyan Jiang, Bing Han
Summary: Nanocarrier-aided drug delivery techniques have improved the absorption and permeability of drugs in nose-to-brain delivery. This study focused on mucoadhesive nanoparticles (MAPs) and mucopenetrating nanoparticles (MPPs), and used molecular dynamics simulations to reveal the interaction between these delivery systems and nasal mucus protein MUC5AC. The results provide insight into the screening and optimization of nanomaterials suitable for nasal inhalation.
JOURNAL OF CONTROLLED RELEASE
(2023)
