Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.
Article
Cell Biology
Tianli Zhang, Chunyan Wang, Kun Wang, Ying Liang, Ting Liu, Liping Feng, Xingsheng Yang
Summary: RacGAP1 is overexpressed in cervical cancer and is associated with poor prognosis. Downregulation of RacGAP1 inhibits proliferation, migration, and invasion of cervical cancer cells, while miR-192 is identified as a downstream target of RacGAP1 and plays a tumor suppressor role.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Mingming Lu, Qing Gao, Yafei Wang, Jie Ren, Tingting Zhang
Summary: LINC00511 is up-regulated in cervical cancer and its overexpression promotes the proliferation, migration, and invasion of cervical cancer cells. LINC00511 targets miR-497-5p to up-regulate the expression of MAPK1, and this axis plays a role in the progression of cervical cancer.
Article
Pathology
Yalan Liu, Lingli Chen, Dongxian Jiang, Lijuan Luan, Jie Huang, Yingyong Hou, Chen Xu
Summary: The study aims to explore the relationship between OPN and HER2 in gastric cancer, particularly in the context of EMT. Nanostring analysis revealed differential gene expression between HER2 3+ and non-3+ areas, with OPN showing a positive correlation with HER2. Knocking down OPN and HER2 resulted in decreased invasion/migration abilities in GC cell lines, indicating a potential role of HER2 in promoting EMT through the regulation of OPN.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Xuewu You, Ying Wang, Jinyu Meng, Sai Han, Lu Liu, Yu Sun, Junhua Zhang, Shuqin Sun, Xinyue Li, Wenxiong Sun, Yajie Dong, Youzhong Zhang
Summary: This study revealed that TGF-beta 1 stimulates cervical cancer cells to release exosomes containing miR-663b, which promotes metastasis. MiR-663b directly targets MGAT3 and is involved in the EMT process that affects cancer cell migration and invasion.
Article
Multidisciplinary Sciences
Yang Yang, Jing Zhou, Wei Hong Li, Zhi Xiong Zhou, Xiao Bo Xia
Summary: NEAT1 regulated the development of EMT in diabetic retinopathy through the miR-204/SOX4 pathway, providing a reference for clinical prevention and treatment.
Article
Medicine, Research & Experimental
Ziwei Li, Jie Wang, Dianting Li, Haiying Chen, Tao Meng
Summary: This study revealed that the expression levels of miR-372-3p were upregulated in placental tissues from patients with PE, especially in those with early-onset PE. In vitro analysis demonstrated that miR-372-3p overexpression inhibited trophoblast cell migration, invasion, and epithelial-mesenchymal transition (EMT). The study also found that miR-372-3p is sponged by twist1 and downregulating twist1 expression can rescue the inhibitory effects of miR-372-3p overexpression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Clinical Neurology
Jie Ren
Summary: This study elucidates the mechanism by which exosomes derived from IH BMSCs promote the progression of LUAD through the activation of WDR5 and the promotion of EMT via miR-31-5p.
SLEEP AND BREATHING
(2023)
Article
Oncology
Anqi Yan, Guanhao Chen, Jichan Nie
Summary: This study revealed that DGUOK-AS1 promotes proliferation of cervical cancer cells by regulating the miR-653-5p/EMSY pathway. miR-653-5p, which is lowly expressed in cervical cancer cells, is sponged by DGUOK-AS1 and inhibits proliferation of cervical cancer. EMSY, a target gene of miR-653-5p, is regulated by DGUOK-AS1 through sponging miR-653-5p and shows significantly high expression in cervical cancer cells.
CANCER BIOLOGY & THERAPY
(2021)
Article
Medicine, Research & Experimental
Mei-Tsz Su, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai, Pao-Lin Kuo
Summary: Preeclampsia is a severe gestational hypertensive disorder that poses a major threat to maternal and fetal health. Aspirin has been shown to effectively reduce the incidence of premature preeclampsia among high-risk pregnant women, possibly by suppressing miR-200 family-mediated cell functions. This study demonstrates a potential mechanism explaining aspirin's effect on preeclampsia prevention and provides a therapeutic target for disease intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Xin Li, Zhou-Sheng Yang, Wen-Wu Cai, Yang Deng, Lei Chen, Sheng-Lan Tan
Summary: DMY treatment inhibits cell proliferation and EMT in CCA cell lines by regulating miR-455-3p and its target ZEB1. Inhibition of miR-455-3p expression abolishes DMY's inhibitory effects on tumor growth and EMT in both CCA cells and cell-engrafted nude mice. DMY also suppresses the expressions of p-PI3K and p-AKT, suggesting its potential as a treatment option for CCA.
Article
Anatomy & Morphology
Yexia Lu, Xiuxiu Hu, Xueyi Yang
Summary: Breast cancer (BC) is a common and deadly malignancy in females, with over 90% of deaths attributed to tumor metastasis. The study found that elevated expression of miR-934 in BC tissues, especially in cases with lymph node metastasis, was associated with poor prognosis. Results indicated that miR-934 promotes BC cell metastasis by regulating PTEN and EMT, rather than cell growth. Targeting miR-934 may be a promising approach for treating BC metastasis.
Article
Genetics & Heredity
Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke, Wataru Takaki, Jun Kiuchi, Hiroki Shimizu, Yusuke Yamamoto, Shuhei Komatsu, Atsushi Shiozaki, Yoshiaki Kuriu, Eigo Otsuji
Summary: In this study, miR-4442 was identified as a potential biomarker for predicting early recurrence in colorectal cancer. The level of miR-4442 was associated with the risk of recurrence and increased with earlier recurrence dates. Furthermore, miR-4442 played a role in promoting the proliferative, migratory, and invasive activities of colorectal cancer cells by directly targeting the messenger RNA of RBMS1, thus regulating epithelial-mesenchymal transition (EMT) in colorectal cancer.
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
