Article
Chemistry, Multidisciplinary
Zui Zhang, Yuxiu Chu, Cheng Li, Wenjing Tang, Jun Qian, Xiaoli Wei, Weiyue Lu, Tianlei Ying, Changyou Zhan
Summary: This study utilized PEG single-chain variable fragment (PEG-scFv) to ameliorate the ABC phenomenon of PEGylated nanomedicines, showing promising results in animal and human experiments. The application of anti-PEG scFv provides a new avenue for improving the performance of PEGylated nanomedicines and mitigating individual differences caused by varying levels of anti-PEG antibodies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Andrew Kerr, Erny Sagita, Edward D. H. Mansfield, Tri-Hung Nguyen, Orlagh M. Feeney, Colin W. Pouton, Christopher J. H. Porter, Joaquin Sanchis, Sebastien Perrier
Summary: In this study, the behavior of molecular bottle-brush and cyclic peptide self-assembled nanotubes was investigated in vitro and in vivo. The results showed that the molecular bottle-brush had the longest circulation time, while the cyclic peptide nanotubes were able to avoid organ accumulation.
Article
Chemistry, Multidisciplinary
Xianyan Qin, Lihua Pan, Tao Chen, Daming Li, Xin Lin, Guojiao Li, Chenglan Feng, Wenchao Ye, Wenlang Liang, Junying Chen, Qin Wang
Summary: This study presents a dual-stimulus responsive transformable nanoparticle that exhibits prolonged circulation and preferential targeting in inflamed joints. Under physiological conditions, the nanoparticles maintained a stable nanosized morphology, while in inflamed joints, they transformed into nanofibers, leading to extended drug retention and enhanced therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu, Jianxin Wang
Summary: It has been discovered that utilizing ginsenoside Rg3 instead of cholesterol and PEG in liposome preparation can prolong the blood circulation time of liposomes and avoid triggering the accelerated blood clearance phenomenon and immune responses.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Yu Ishima, Nio Yamazaki, Victor T. G. Chuang, Taro Shimizu, Hidenori Ando, Tatsuhiro Ishida
Summary: This study evaluates the effect of MAL-PEG-DSPE liposomes (PL-MAL) on the accelerated blood clearance (ABC) phenomenon compared to PL-OCH3. The results show that PL-MAL induces ABC phenomenon independent of IgM antibodies against PEG. These findings are valuable for further studies using ligand-bound liposomes.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Chemistry, Multidisciplinary
Peifu Cheng, Nicholas Ferrell, Carl M. Oberg, Steven F. Buchsbaum, Melinda L. Jue, Sei Jin Park, Dan Wang, Shuvo Roy, Francesco Fornasiero, William H. Fissell, Piran R. Kidambi
Summary: This study demonstrates the scalable fabrication of wafer-scale carbon nanotube (CNT) membranes with highly aligned, low-friction, straight channels/capillaries and narrow pore-diameter distributions for hemofiltration/hemodialysis. The CNT membranes show significantly higher hydraulic permeability and enhanced removal of middle molecules compared to commercial membranes, while maintaining comparable albumin retention. The unique transport characteristics of CNTs offer transformative advances for hemofiltration and have potential applications in other bio-systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Surya Prakash Singh, Tejaswini Appidi, Aravind Kumar Rengan
Summary: The study explores the potential of nanohybrids using biocompatible and biodegradable materials for photothermal mediated theranostic applications. Various gold-based nanosystems with NIR absorption have been developed for photothermal therapy, but face challenges such as toxicity, stability, and clearance. The thermosensitive liposome-gold hybrid nanosystem has been demonstrated for photothermal therapy and drug delivery, showing promise for future applications in cancer treatment.
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2021)
Article
Chemistry, Physical
Anne-Elisabeth Molza, Ping Gao, Justine Jakpou, Julien Nicolas, Nicolas Tsapis, Tap Ha-Duong
Summary: The molecular dynamics simulation study on poly(ornithine-co-citrulline) nanoparticles revealed that the fully reparametrized version 3.0 of the MARTINI force field can accurately capture the temperature-dependent aggregation and dissolution processes. The phase separation observed in the simulations allowed for the extrapolation of a phase diagram based on the Flory-Huggins theory, providing insights for the rational design of drug delivery nanoparticles in the future.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Chemistry, Multidisciplinary
Paul Galanopoulo, Noemie Gil, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf, Maelle Lages, Julien Nicolas, Muriel Lansalot, Franck D'Agosto
Summary: Aqueous emulsion copolymerizations of dibenzo[c,e]oxepane-5-thione (DOT) with n-butyl acrylate (BA), styrene (S) and a combination of both were successfully performed. DOT showed limited solubility in BA compared to S, resulting in a more homogeneous integration of DOT units in the latex. Emulsion terpolymerization also produced stable latexes with a broad range of glass transition temperatures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Romy Ettlinger, Ulrich Laechelt, Ruxandra Gref, Patricia Horcajada, Twan Lammers, Christian Serre, Patrick Couvreur, Russell E. Morris, Stefan Wuttke
Summary: The field of metal-organic frameworks (MOFs), particularly MOF nanoparticles, has seen significant growth in the last two decades. This tutorial review emphasizes the importance of systematic toxicity assessment and discusses the current state of in vitro and in vivo toxicity studies of MOF nanoparticles, as well as the key factors affecting their toxicity.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Chen Zhu, Stephanie Denis, Julien Nicolas
Summary: This study developed a novel method for synthesizing degradable vinyl copolymer nanoparticles through a two-step radical ring-opening copolymerization-induced self-assembly process in water. The synthesized nanoparticles not only have potential applications in drug delivery, but also offer environmentally friendly materials.
CHEMISTRY OF MATERIALS
(2022)
Article
Multidisciplinary Sciences
Amaury Bossion, Chen Zhu, Lea Guerassimoff, Julie Mougin, Julien Nicolas
Summary: The authors demonstrate a system based on acrylamide and cyclic ketene acetals to obtain copolymers with faster degradation rates, which have potential applications in drug release and environmental fields.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Theo Pesenti, Daniel Domingo-Lopez, Emilie Gillon, Nada Ibrahim, Anne Imberty, Samir Messaoudi, Julien Nicolas
Summary: A small library of degradable glycopolymers was prepared by copolymerization and thioglycoconjugation, followed by the formulation into self-stabilized nanoparticles. The nanoparticles showed stability and enzymatic degradation, and exhibited good cytocompatibility. The interactions between the nanoparticles and lectins were investigated, and the internalization of the nanoparticles by lung adenocarcinoma cells was proven, indicating the potential biomedical applications of the copolymers.
Review
Biochemistry & Molecular Biology
Chen Zhu, Julien Nicolas
Summary: Polymerization-induced self-assembly (PISA) and crystallization-driven self-assembly (CDSA) techniques are powerful approaches to produce synthetic nano-objects suitable for biomedical applications.
Article
Polymer Science
Theo Pesenti, Chen Zhu, Natalia Gonzalez-Martinez, Ruben M. F. Tomas, Matthew I. Gibson, Julien Nicolas
Summary: Degradable polyampholytes with ester-containing cryoprotective properties were synthesized using radical ring-opening (ter)polymerization. These polyampholytes showed enhanced post-thaw recovery when supplemented into DMSO, suggesting their potential application in biotechnology and biomedicine.
Article
Chemistry, Multidisciplinary
Alexandre Bordat, Tanguy Boissenot, Nada Ibrahim, Marianne Ferrere, Manon Leveque, Lea Potiron, Stephanie Denis, Sebastien Garcia-Argote, Olivia Carvalho, Jerome Abadie, Catherine Cailleau, Gregory Pieters, Nicolas Tsapis, Julien Nicolas
Summary: Chemotherapy is commonly administered via the intravenous route, but has limitations. Researchers have developed a new method for subcutaneous administration of anticancer drugs through the design of hydrophilic polymer prodrugs, which successfully avoids local toxicity and outperforms commercial formulations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Polymer Science
Maelle Lages, Noemie Gil, Paul Galanopoulo, Julie Mougin, Catherine Lefay, Yohann Guillaneuf, Muriel Lansalot, Franck D'Agosto, Julien Nicolas
Summary: The synthesis of degradable vinyl polymer nanoparticles/latexes in aqueous dispersed media is important for biomedical applications and plastic pollution control. Polymerization-induced self-assembly (PISA) has become a popular process for generating aqueous suspensions of diblock copolymer nano-objects. However, the direct aqueous PISA method for degradable vinyl polymer nanoparticles has not been reported. This study presents a novel aqueous emulsion PISA method for generating degradable vinyl polymer nanoparticles, which has the potential to greatly expand the use of PISA in various fields.
Article
Biochemistry & Molecular Biology
Theo Pesenti, Emilie Gillon, Seika Ishii, Samir Messaoudi, Yohann Guillaneuf, Anne Imberty, Julien Nicolas
Summary: By copolymerizing 2-methylene-1,3,6-trioxocane (MTC) with vinyl ether (VE) or maleimide (MI) derivatives, degradable vinyl copolymers with high CKA content and enhanced degradation profiles were successfully designed. The hydrophilicity of MTC led to faster hydrolytic degradation of the copolymers under both accelerated and physiological conditions. MTC-based glycopolymers formulated into surfactant-free nanoparticles exhibited excellent colloidal stability up to 4 months and complete degradation under enzymatic conditions, with stronger lectin affinity compared to MDO-based glyconanoparticles.
Review
Polymer Science
Maelle Lages, Julien Nicolas
Summary: This review discusses the in situ encapsulation of active ingredients (peptides, proteins, enzymes, drugs) in polymer particles obtained by polymerization in dispersed media for potential biomedical applications. Both physical and chemical encapsulation methods are considered based on the polymerization technique used, with a focus on adjusting drug loading and encapsulation efficiency.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Maelle Lages, Theo Pesenti, Chen Zhu, Dao Le, Julie Mougin, Yohann Guillaneuf, Julien Nicolas
Summary: This study reports the synthesis of degradable polyisoprene (PI) by radical ring-opening polymerization (rROP) via copolymerization of isoprene (I) and dibenzo[c,e]oxepane-5-thione (DOT). The resulting P(I-co-DOT) copolymers showed adjustable molecular weights and DOT contents, and could be successfully degraded under basic conditions. Stable and narrowly dispersed nanoparticles were formulated from the P(I-co-DOT) copolymers and exhibited cytocompatibility and significant cytotoxicity on cancer cells. The P(I-co-DOT) and Gem-P(I-co-DOT) nanoparticles were degraded under various conditions.
Article
Polymer Science
Paul Galanopoulo, Laura Sinniger, Noemie Gil, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf, Maelle Lages, Julien Nicolas, Franck D'Agosto, Muriel Lansalot
Summary: Degradable poly(methyl methacrylate) (PMMA) particles were synthesized using radical emulsion polymerization in water, with a cyclic ketene acetal, 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), as a co-monomer. The stability of BMDO in aqueous media and the degradation mechanism were studied to understand its use in emulsion and its incorporation into the copolymer chains. Stable latexes with varying amounts of BMDO inserted units (2-6.4 mol%) were obtained, and the resulting copolymer exhibited an average molar mass loss of 90% during degradation in a basic medium.
Article
Polymer Science
Chen Zhu, Julien Nicolas
Summary: RAFT-mediated rROPISA was successfully used to copolymerize BzMA with MDO, resulting in stable diblock copolymer nanospheres with degradable units that exhibited significant degradation under accelerated hydrolytic conditions. Surface-degradable diblock copolymer nanoparticles were also synthesized by using different macro-CTAs.