Article
Nanoscience & Nanotechnology
Yufeng Wu, Kun Huang, Xiaodi Weng, Ruyue Wang, Peng Du, Junchen Liu, Sen Lin, Kai Huang, Hujiang Yang, Ming Lei
Summary: This article proposes a method to improve the stability of electromagnetic shielding fabrics using PVB coating. By fixing the metal on the fabric and protecting it with PVB coating, the attenuation of the electromagnetic shielding fabric can be effectively reduced, and its physical and chemical stability can be improved, suitable for the protection and prolongation of the service life of electromagnetic shielding fabrics.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Polymer Science
Daniel L. Vigil, Timothy Quah, Dan Sun, Kris T. Delaney, Glenn H. Fredrickson
Summary: Using self-consistent field theory, the phase boundaries between periodic microphases for linear, comb-like, and bottlebrush diblock copolymers were mapped, revealing a universal phase diagram for sphere phases including A15 and sigma phases. However, a transition from comb-like to bottlebrush scaling with architectural parameter variation was not observed.
Article
Clinical Neurology
Natsuhi Sasaki, Akira Ishii, Shinichi Yagi, Hidehisa Nishi, Ryo Akiyama, Masakazu Okawa, Yu Abekura, Hirofumi Tsuji, Shinichi Sakurai, Susumu Miyamoto
Summary: A study compared the biological reactions and phenomena induced by a bioresorbable poly (L-lactic acid) flow diverter (PLLA-FD) with a metallic flow diverter (CoCr-FD) for the treatment of intracranial aneurysms. The results showed no significant differences between PLLA-FD and CoCr-FD in terms of aneurysm occlusion and branch patency. The local inflammation and neointima thickness of PLLA-FD over a 1-year period were also similar to those of CoCr-FD.
Article
Chemistry, Multidisciplinary
Paul Strasser, Bianca Montsch, Silvia Weiss, Haider Sami, Christoph Kugler, Sonja Hager, Hemma Schueffl, Robert Mader, Oliver Brueggemann, Christian R. R. Kowol, Manfred Ogris, Petra Heffeter, Ian Teasdale
Summary: The design and synthesis of novel bottlebrush polymers (PPz-g-PGA) with exceptional control over their structure and molecular dimensions have been reported. These polymers show outstanding aqueous solubility, ultra-high multivalency, and biodegradability, making them ideal as nanomedicines. They exhibit enhanced cellular uptake, pharmacokinetics, and tumor accumulation, offering valuable insights into the influence of architecture on the in vivo performance of nanomedicines.
Article
Chemistry, Medicinal
Heloise Cahuzac, Antoine Sallustrau, Carole Malgorn, Fabrice Beau, Peggy Barbe, Victor Babin, Steven Dubois, Alberto Palazzolo, Robert Thai, Isabelle Correia, Ki Baek Lee, Sebastien Garcia-Argote, Olivier Lequin, Mathilde Keck, Herve Nozach, Sophie Feuillastre, Xin Ge, Gregory Pieters, Davide Audisio, Laurent Devel
Summary: This article presents a bioanalytical strategy based on dual radiolabeling and ex vivo digital imaging for accurate determination of the plasma and tissue profiles of protein-drug conjugates. The strategy involves enzymatic and chemical reactions to obtain dual-labeled anti-MMP-14 Fabs conjugated to monomethyl auristatin E, allowing for simultaneous monitoring and accurate quantification of the components during circulation phase and accumulation in different organs.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Hayden R. Montgomery, Marco S. Messina, Evan A. Doud, Alexander M. Spokoyny, Heather D. Maynard
Summary: This study presents a facile and benign organometallic approach for synthesizing poly(ethylene glycol) protein conjugates. The method exhibits rapid kinetics and high chemoselectivity, enabling near quantitative conversion at room temperature.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dipankar Chaudhuri, Tiangong Lu, Binu Jacob, Sojan Abraham, Premlata Shankar, Michael A. Poss, Nouri Neamati, Julio A. Camarero
Summary: The CXCR4 chemokine is a crucial regulator of leukocyte functions, embryonic development, and cancer progression. CXCR4 antagonists show promise as therapeutic agents for cancer and HIV. This study shows that lipidation can improve the half-life of a bioactive cyclotide antagonist, but the choice of lipid may affect its biological activity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Tahir Khuroo, Eman M. Mohamed, Sathish Dharani, Canberk Kayalar, Tanil Ozkan, Mathew A. Kuttolamadom, Ziyaur Rahman, Mansoor A. Khan
Summary: The focus of this research was to investigate the effects of formulation and processing variables on the rapid dissolving printlets of isoniazid (INH) manufactured using selective laser sintering (SLS) 3D printing method. The results showed that the printlets had rapid disintegration and dissolution, and were stable with similar oral bioavailability as compressed tablets.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Sangho Cho, Jeongwook Lee, Yongwon Yoo, Minyong Cho, Seil Sohn, Beom-Jin Lee
Summary: The study successfully developed oral dosage forms of DAP cocrystals with improved physicochemical properties and bioavailability, which can substitute Forxiga(R); adjusting particle size distribution and using roller compaction can achieve better manufacturing results; pharmacokinetic analysis confirmed the bioequivalence of a 10 mg DAP cocrystal tablet with RC to a 10 mg Forxiga(R) tablet.
Article
Food Science & Technology
Pascal Moll, Hanna Salminen, Elena Griesshaber, Christophe Schmitt, Jochen Weiss
Summary: High-pressure homogenization improved the foaming properties of insoluble pea proteins at pH 3 and 5. At pH 3, the homogenization disrupted large protein aggregates into smaller particles, resulting in the generation of foams. At pH 5, homogenization resulted in the formation of aggregates made of smaller protein entities, allowing insoluble pea proteins to foam.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Chemistry, Medicinal
Wei Shi, Jianxin Zhang, Liya Liu, Wanzhen Li, Zhi Liu, Anni Ren, Jie Wang, Caihong Tang, Yang Yang, Dandan Xu, Qianqian Huang, Yongqin Wang, Caili Luo, Wei Huang, Feng Tang
Summary: The inadequate understanding of the structure-activity relationship (SAR) of glycosite-specific antibody-drug conjugates (ADCs) hinders its design and development. In this study, we constructed and examined 50 gsADC structures with various glycan subtypes and linker-drug combinations to reveal the systematic SAR and structure-toxicity relationship (STR) of gsADCs. Our findings suggest that the use of extra hydrophilic linkers is crucial for intact glycan-based gsADCs to improve in vivo efficacy. Additionally, gsADCs that conjugate linker-drug complexes onto the terminal sialic acid demonstrate greater stability and potency compared to those conjugated onto the terminal galactose. Moreover, LacNAc-based gsADCs, which adopt a shorter spacer and locate the linker-drug more inside the immunoglobulin class G (IgG) Fc cavity, exhibit excellent hydrophilicity, in vivo activity, pharmacokinetics, and safety. Overall, we found that concealing the linker-toxin within the Fc cavity can significantly enhance the therapeutic index of LacNAc-based gsADCs, facilitating the design of ADCs with optimal druggability.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Qian Peng, Xing Liu, Jian Zhou
Summary: In this study, novel one-dimensional cuprous iodides were successfully synthesized and demonstrated excellent dual luminescent sensing performance towards Fe3+ and Cr2O72- ions in aqueous solution. This is the first report of cuprous iodides as dual sensors for detecting both Fe3+ and Cr2O72- ions.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Pharmacology & Pharmacy
Junfeng Shi, Dan Wang, Yang Tian, Zengming Wang, Jing Gao, Nan Liu, Xiang Gao, Aiping Zheng, Hui Zhang, Meixian Xiang
Summary: The quality of active pharmaceutical ingredients (APIs) is crucial for the safety and efficacy of pharmaceuticals. This study found that different crystallization processes of paliperidone palmitate (PP) can impact the appearance, surface free energy (SFE), and crystallinity of PP, consequently affecting the stability, state, and pharmacokinetics of formulations in vivo. Therefore, the choice of crystallization methods for preparing APIs can have significant implications on the overall performance of pharmaceutical formulations.
Article
Multidisciplinary Sciences
M. Yasmin Begum, Riyaz Ali M. Osmani, Ali Alqahtani, Mohammed Ghazwani, Umme Hani, Hissana Ather, Akhtar Atiya, Mohamed Rahamathulla, Ayesha Siddiqua
Summary: This study developed stealth liposomes of CLB to reduce its side effects and increase drug accumulation in inflammation sites. The results showed that stealth liposomes significantly reduced inflammation and had extended drug bioavailability with lower toxicity.
Article
Pharmacology & Pharmacy
Bing Wang, Liuliu Yang, Bing Wang, Chunlin Luo, Yuhan Wang, Hao Wang, Fang Chen, Xiaoqiang Xiang
Summary: The present study successfully developed orodispersible films (ODFs) containing 30 mg racecadotril for pediatric patients. Through optimization of preparation process and formulation, ideal drug release and mechanical properties were achieved.
Article
Biochemistry & Molecular Biology
V. H. Giang Phan, Huu Thuy Trang Duong, Phu-Tri Tran, Thavasyappan Thambi, Duy-Khiet Ho, Xabier Murgia
Summary: Core-shell structured starch nanoparticles synthesized using squalenoylation technology showed potential for versatile drug delivery applications for mucosal drug delivery and treatment of persistent infections. The nanoparticles demonstrated good drug loading capacity and penetration through biofilms.
Article
Engineering, Environmental
Rini Sharma, Ujjal Haldar, Md Hasan Turabee, Hyung-il Lee
Summary: A thermogelling triblock copolymer PCLPEG-PCL was synthesized and attached with a fluorescent group to achieve rapid and selective detection of Hg(II) in aqueous media. The selective removal of Hg(II) was achieved through a sol-gel-dehydrated gel process under specific conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
V. H. Giang Phan, Thai Minh Duy Le, Gopinathan Janarthanan, Phuong-Khanh Thi Ngo, Doo Sung Lee, Thavasyappan Thambi
Summary: The development of a thermo-sensitive triblock copolymer composed of BSA protein has shown promising potential in wound healing and tissue regeneration. The bioconjugate gel exhibited good adhesive properties to major organs and promoted rapid wound contraction, increased angiogenesis, and collagen deposition compared to controls in in vivo trials. These biocompatible, biodegradable, and thermos-sensitive bioconjugate gels may offer a new approach for wound healing without the need for additional biofactors or inorganic nanoparticles.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Cell Biology
Jun Young Lee, Jin Woo Hong, Thavasyappan Thambi, A-Rum Yoon, Joung-Woo Choi, Yi Li, Quang Nam Bui, Doo Sung Lee, Chae-Ok Yun
Summary: The study synthesized two folate-conjugated nanocomplexes with lower cytotoxicity and higher tumor cell transduction efficiency, showing increased circulation retention and intratumoral accumulation in vivo, as well as lower nonspecific accumulation in normal organs.
Review
Immunology
Thai Minh Duy Le, A-Rum Yoon, Thavasyappan Thambi, Chae-Ok Yun
Summary: Immunotherapy holds great promise in cancer therapy and polymeric systems have played a significant role in enhancing its efficacy. Recent advancements in immune checkpoint inhibitors, CAR-T cell therapy, and oncolytic virus therapy have shown remarkable success in clinical trials. This review discusses the monotherapy status of these immunotherapies and their combination strategies with various polymeric systems.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Panchanathan Manivasagan, Ara Joe, Hyo-Won Han, Thavasyappan Thambi, Manickam Selvaraj, Kumarappan Chidambaram, Jungbae Kim, Eue-Soon Jang
Summary: PT-enhanced Fenton-based CDT is a promising cancer treatment approach that triggers the Fenton or Fenton-like reactions within the tumor microenvironment to generate highly cytotoxic hydroxyl radicals. However, existing CDT therapies are hindered by limitations such as low levels of endogenous hydrogen peroxide and low catalytic efficacy, prompting the combination of photothermal therapy (PTT) to enhance therapeutic efficacy.
MATERIALS TODAY BIO
(2022)
Review
Biotechnology & Applied Microbiology
Thavasyappan Thambi, JinWoo Hong, A-Rum Yoon, Chae-Ok Yun
Summary: Polymer-complexed adenoviruses can enhance tumor-specific delivery and antitumor activity, but challenges remain in systemic administration and intratumoral retainment of the virus.
CANCER GENE THERAPY
(2022)
Article
Pharmacology & Pharmacy
Thavasyappan Thambi, Jeongmin Lee, A-Rum Yoon, Dayananda Kasala, Chae-Ok Yun
Summary: In this study, a pH- and glutathione-responsive polymer was developed to increase the transduction efficiency of adenoviruses in cancer gene therapy.
Article
Pharmacology & Pharmacy
V. H. Giang Phan, Mohanapriya Murugesan, Panchanathan Manivasagan, Thanh Loc Nguyen, Thuy-Hien Phan, Cuong Hung Luu, Duy-Khiet Ho, Yi Li, Jaeyun Kim, Doo Sung Lee, Thavasyappan Thambi
Summary: This study developed an injectable protein-polymer-based porous hydrogel network that can actively recruit dendritic cells and form stable hydrogel depot in the human body, facilitating the activation and modification of immune response.
Review
Materials Science, Biomaterials
Thavasyappan Thambi, Jae Min Jung, Doo Sung Lee
Summary: Smart biomaterials that respond to pathological abnormalities are being developed as personalized medications. Injectable pH-responsive biomaterials are one promising therapeutic platform that can adapt to changes in environmental pH. These biomaterials can transition from liquid to gel, allowing controlled release of drugs and bioactive agents. This review highlights the design and development of biodegradable and in situ forming injectable pH-responsive biomaterials, with a focus on amphoteric pH-responsive biomaterials and their potential in biomedical applications. It also discusses the challenges and future directions of pH-responsive biomaterials in clinical translation.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Panchanathan Manivasagan, Sekar Ashokkumar, Ala Manohar, Ara Joe, Hyo-Won Han, Sun-Hwa Seo, Thavasyappan Thambi, Hai-Sang Duong, Nagendra Kumar Kaushik, Ki Hyeon Kim, Eun Ha Choi, Eue-Soon Jang
Summary: Novel calcium ion-doped magnesium ferrite nanoparticles have been developed as efficient and biocompatible photothermal therapeutic materials for cancer treatment, with their high near-infrared absorption, short treatment period, strong cytotoxicity to cancer cells under laser irradiation, and minimal damage to healthy cells.
Article
Biochemistry & Molecular Biology
Thuy An Trinh, Thai Minh Duy Le, Hien Thi-Thanh Nguyen, Thanh Loc Nguyen, Jaeyun Kim, Dai Phu Huynh, Doo Sung Lee
Summary: An injectable hydrogel system has been developed that can provide sustained release of a glucagon-like peptide-1 receptor agonist at the injection site, reducing the need for daily injections in type 2 diabetes patients. The system exhibits excellent biocompatibility and holds promise for the treatment of this chronic disease.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Polymer Science
Ramya Mathiyalagan, Anjali Kariyarath Valappil, Deok Chun Yang, Se Chan Kang, Thavasyappan Thambi
Summary: The incidence of skin cancer, particularly metastatic melanoma, has increased dramatically. Drug treatments encounter difficulties due to side effects and reduced bioavailability. Mutations in skin cancer driver genes promote tumor progression. This review focuses on the molecular pathways of hydrogel drug delivery systems, exploring potential targets for skin cancer treatment.
Article
Polymer Science
Cuong Hung Luu, Giang Nguyen, Thanh-Tuyen Le, Thanh-Mai Ngoc Nguyen, V. H. Giang Phan, Mohanapriya Murugesan, Ramya Mathiyalagan, Lu Jing, Gopinathan Janarthanan, Deok Chun Yang, Yi Li, Thavasyappan Thambi
Summary: Lidocaine is a local anesthetic that has gained attention, but its use is limited by side effects. This study developed a hydrogel formulation comprising sodium alginate and graphene oxide for prolonged release of lidocaine. The addition of graphene oxide to the hydrogel resulted in a sustained release of lidocaine. In vitro and in vivo experiments confirmed the biocompatibility, in-situ gelation, and biodegradability of the hydrogel.
Article
Materials Science, Biomaterials
Jae Min Jung, Seong Han Kim, V. H. Giang Phan, Thavasyappan Thambi, Doo Sung Lee
Summary: A thermo-responsive hydrogel was developed for targeted delivery of drugs to tumor tissues, showing stable formation in vivo and potential for suppressing tumor growth. This study suggests that the pH-responsive drug-releasing hydrogel has great promise for localized anticancer therapy.
BIOMATERIALS SCIENCE
(2021)
