Article
Polymer Science
Junyeol Rhyou, Jaeseung Youn, Seongsu Eom, Dong Sung Kim
Summary: This study introduces a new method for fabricating a nanofiber membrane-integrated polydimethylsiloxane (NFM-PDMS) microfluidic chip by using a silver nanowires-embedded uncured PDMS adhesive layer to improve the efficiency and sealing performance of traditional electrospinning. The chip demonstrates good growth performance when culturing the human keratinocyte cell line HaCaT cells.
Article
Nanoscience & Nanotechnology
Aline O. Pereira, Isabella M. I. Lopes, Thiago R. Silva, Thaila Q. Correa, Rafaella T. Paschoalin, Natalia M. Inada, Ievgeniia Iermak, Francisco van Riel Neto, Juliana C. Araujo-Chaves, Alexandre Marletta, Jose R. Tozoni, Luiz Henrique C. Mattoso, Vanderlei S. Bagnato, Iseli L. Nantes-Cardoso, Osvaldo N. Oliveira Jr, Patricia T. Campana
Summary: This research demonstrates that nanofibers can be utilized as an alternative method for bacterial inactivation, instead of UV and blue irradiation. The use of PLGA nanofiber scaffolds can effectively kill Staphylococcus aureus and Escherichia coli bacteria at lower light intensities. The enhanced effect of PLGA scaffolds is attributed to their nanofiber structures, which could pave the way for a more cost-effective and environmentally friendly surface sterilization method.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Chemical
Wenji Zheng, Ziheng Li, Tianqi Sun, Xuehua Ruan, Yan Dai, Xiangcun Li, Chuling Zhang, Gaohong He
Summary: This study constructed a continuous metal organic frameworks (MOFs) transport pathway in a mixed matrix membrane (MMM) for CO2 capture using electrospun nanofibers. The continuous transport pathway enhanced the CO2 permeability and CO2/N-2 selectivity of the MMM by improving size screening and interfacial compatibility.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Giulia Massaglia, Adriano Sacco, Angelica Chiodoni, Candido Fabrizio Pirri, Marzia Quaglio
Summary: This study aims to optimize electrospun polymeric nanofibers as reservoirs for mixed electroactive consortia to be used as anodes in Single Chamber Microbial Fuel Cells. By directly embedding microorganisms into nanofibers, a nanostructured scaffold capable of storing and releasing microorganisms in water-based solutions is designed. The bio-NFs showed improved power density in SCMFCs compared to PEO-NFs and bare CP, indicating good performance of the novel nanomaterials in energy production.
Article
Chemistry, Multidisciplinary
Xiuling Yang, Haina Qi, Shaohua Jiang, Chunmei Zhang, Xiangting Dong
Summary: This article describes a novel three-dimensional di-aeolotropic conductive Janus tubule with dual-mode fluorescence and magnetism. Through meticulous design and integration, the material achieves multifunctionality at both microscopic and macroscopic levels.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Polymer Science
Oana Maria Ionescu, Arn Mignon, Andreea Teodora Iacob, Natalia Simionescu, Luminita Georgeta Confederat, Cristina Tuchilus, Lenuta Profire
Summary: The study incorporated natural active components such as propolis and Calendula officinalis into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. The nanofiber membranes showed best antioxidant activity, cytocompatibility, and antimicrobial properties, making them suitable for clinical use as wound dressings.
Article
Biophysics
Salvatore Federico, Giovanna Pitarresi, Fabio S. Palumbo, Calogero Fiorica, Fang Yang, Gaetano Giammona
Summary: This study aimed to investigate the effects of chemical derivatization of hyaluronic acid on osteoinductive potential for guided bone regeneration. The results showed that the electrospun membranes with alkyl pendant grafts and crosslinking process demonstrated tunable resistance and enhanced drug release properties, as well as good cytocompatibility and cell proliferation. Osteogenic differentiation and mineralization were observed after 35 days, indicating the potential for application in bone regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cell Biology
Katharina V. V. Meyer, Steffen Winkler, Pascal Lienig, Gerald Draeger, Janina Bahnemann
Summary: The use of 3D cell cultures is on the rise for drug discovery, disease modelling, and tissue engineering. New hydrogels are being developed to mimic the extracellular matrix, and the presented 3D-printed microfluidic perfusion system offers a novel solution for cultivating and evaluating four separate 3D cell cultures simultaneously. This customizable system enables easy monitoring and reduces the volume of required materials.
Review
Chemistry, Analytical
Bishweshwar Pant, Mira Park, Allison A. Kim
Summary: Recently MXenes have been investigated as a promising class of two-dimensional materials with unique layered microstructure, various functional groups, and attractive properties. MXene-polymer nanocomposites have great potential in biomedical applications due to their easy dispersibility and metallic conductivity. However, the interaction between polymeric nanofibers and MXenes needs further exploration.
Review
Chemistry, Multidisciplinary
Humaira, Sayyad Ali Raza Bukhari, Hafiz Abdullah Shakir, Muhammad Khan, Shagufta Saeed, Irfan Ahmad, Khursheed Muzammil, Marcelo Franco, Muhammad Irfan, Kun Li
Summary: Hyaluronan is a biodegradable and versatile biopolymer with potential applications in the medical field. Electrospun hyaluronan-based nanofibers, which mimic the characteristics of the extracellular matrix, have shown great promise for tissue regeneration, wound dressings, and drug delivery. This review provides an overview of the structural and physicochemical features of hyaluronan, discusses the production methods via microbial fermentation, highlights the parameters affecting the synthesis of electrospun hyaluronan-based nanofibers, and explores their current medical applications and future prospects.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Cristina Chircov, Alexandra Catalina Birca, Bogdan Stefan Vasile, Ovidiu-Cristian Oprea, Keng-Shiang Huang, Alexandru Mihai Grumezescu
Summary: This study investigated a one-step synthesis and functionalization of magnetite nanoparticles using microfluidics, and characterized the obtained nanoparticles using various analysis methods. The results demonstrated the potential of microfluidic platform for developing functionalized MNPs.
Article
Chemistry, Multidisciplinary
Donghee Lee, Navatha Shree Sharma, S. M. Shatil Shahriar, Kai Yang, Zheng Yan, Jingwei Xie
Summary: Electrospun nanofibers have found wide applications in neurobiology studies due to their biomimetic properties. However, current in vitro culture systems lack control of cell-nanofiber interactions and monitoring of single cell behavior. To address these challenges, researchers have developed a unique nanofiber embedded microfluidic device that combines microfluidic technology with electrospun nanofibers to study interactions between neurons and nanofiber materials. The device allows testing of how different topographies affect axonal growth and conducting laser-based axotomy to investigate axonal regeneration. This device can be a valuable tool for investigating nerve injury mechanisms and high-throughput screening of biomaterials or drugs for nerve repair, and can be applied in the design of medical devices such as nerve conduits for effective nerve regeneration.
Article
Materials Science, Biomaterials
Bozhen Zhang, Canran Wang, Yingjie Du, Rebecca Paxton, Ximin He
Summary: The iCatch device utilizes a temperature-responsive hydrogel and reversible binding of affinity handle modified to achieve cell capture, transportation, and release. Validated for biocompatibility and cell sorting capability, it achieves high capture efficiency and recovery rate.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemical Research Methods
Olivia S. Kanies, Katelyn R. Kremer, Brittany M. Mason, Mitchell G. Dudley, Joseph M. Hlavay, Cass T. Miller, Richard Chasen Spero, Jay K. Fisher
Summary: Magnetic beads are commonly used for target enrichment in life science assays, but their performance is limited in microfluidic contexts due to diffusion-limited analyte transport. A new method called BeadPak uses magnetically actuatable microposts to enhance analyte transport, achieving up to 1000x faster capture than diffusion alone. This method has the potential to improve target capture, concentration, and purification in systems that utilize magnetic beads.
Article
Biochemical Research Methods
Vinit Kumar Yadav, Preetha Ganguly, Prashant Mishra, Samaresh Das, Dhiman Mallick
Summary: This study developed a versatile magnetic microfluidic device for concentration-dependent compartmentalization of a magnetically controlled anticancer drug. By optimizing the microfluidic design and magnet configuration, predictable concentration control and gradient generation were achieved. The results of drug screening and cytotoxicity testing using the device were consistent with traditional methods.
Article
Engineering, Environmental
Meijuan He, Tingting Xiao, Yihui Wang, Hongwei Yu, Zilin Wang, Xiangyang Shi, Han Wang
Summary: In this study, we developed an immunostimulated nanoplatform for MRI-guided radiotherapy against GBM. The platform effectively enhances the immune response and shows promising therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Polymer Science
Jieting Xu, Xiao Qin, Yongkang Lin, Chaofeng Cao, Junhong Liu, Qingjian Huang
Summary: This paper aims to solve the durability problem of pavement concrete caused by deicing salt in northern winter. Super absorbent polymer (SAP) was used as an internal curing agent to enhance its durability. The optimal curing parameters and the deterioration rule of pavement concrete after salt freeze-thaw cycles were explored through experiments. It was found that SAP internal curing significantly improved the mass loss rate and relative dynamic modulus, increased the strength, and decreased the chloride ion erosion depth.
Article
Materials Science, Biomaterials
Jin Li, Liang Chen, Huxiao Sun, Mengsi Zhan, Regis Laurent, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Shi
Summary: We present an original gene delivery nanoplatform based on pyrrolidinium-modified amphiphilic generation 1 phosphorus dendron (C12G1) nanomicelles for anti-inflammatory therapy. These nanomicelles exhibit higher gene delivery efficiency and cytocompatibility compared to counterpart materials. The C12G1 nanomicelles can co-deliver miR-146a mimic and miR-429 inhibitor to inhibit specific signaling pathways, leading to the repression of M1 phenotype macrophage polarization. This nanoplatform shows promising potential in treating inflammatory diseases.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Liang Chen, Mengsi Zhan, Jin Li, Liu Cao, Huxiao Sun, Regis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi
Summary: This study introduces a nanosystem based on amphiphilic phosphorus dendron micelles for combination therapy of triple negative breast cancer. The micelles exhibit excellent stability and high drug loading efficiency. The co-delivery system of miR-21 inhibitor and doxorubicin can effectively inhibit cancer cells through different anticancer mechanisms, as demonstrated in in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Medicine, General & Internal
Honglei Ma, Yuqun Wang, Junhong Liu, Linping Du, Xiaodong Wang, Yingliang Wang
Summary: This is a case of a patient with SLE complicated with cryptococcal meningitis. Due to the lack of specificity of clinical symptoms, it is easily misdiagnosed as neuropsychiatric lupus or tuberculous meningitis, leading to delayed treatment. Through this case, the early improvement of India ink stain of cerebrospinal fluid and metagenomic next generation sequences to identify microbial infection is suggested, along with early empirical anti-infection therapy.
Editorial Material
Biotechnology & Applied Microbiology
Mengsi Zhan, Huxiao Sun, Joao Rodrigues, Dzmitry Shcharbin, Mingwu Shen, Xiangyang Shi
Article
Nuclear Science & Technology
Yicheng Yi, Xingyin Guan, Zhaohui Song, Xinjian Tan, Shuai Gao, Hetong Han, Yi Lu, Gang Li, Kan Zhang, Junhong Liu
Summary: This paper proposes a scintillation detector system based on scattered gamma rays using a tungsten target. The system's design parameters were investigated using Monte Carlo simulation and verified through 60Co/137Cs radiation experiments. The results show that the system can significantly increase the upper limit of gamma intensity detection. The signal-to-noise ratio of the system was also studied in 60Co radiation experiments, indicating that it is a suitable alternative for future ultra-intense gamma-ray measurements.
RADIATION MEASUREMENTS
(2023)
Article
Biology
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li
Summary: Mechanical force loading is crucial for maintaining bone homeostasis, and Ano1 mediates osteoclast responses to mechanical stimulation, playing an important role in mechanical stimulation-induced osteoclast activity changes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Engineering, Biomedical
Rui Yang, Mengsi Zhan, Zhijun Ouyang, Honghua Guo, Jiao Qu, Jindong Xia, Mingwu Shen, Xiangyang Shi
Summary: The microfluidic synthesis of artesunate (ART)-loaded polydopamine (PDA)/iron (Fe) nanocomplexes (NCs) coated with fibronectin (FN) was reported in this study. These multifunctional Fe-PDA@ART/FN NCs exhibit desired properties for tumor therapy with improved chemodynamic therapy (CDT) and immunogenic cell death, and can be guided through magnetic resonance (MR) imaging. The developed FDRF NCs are considered an advanced nanomedicine formulation for chemo-chemodynamic-immune therapy of different tumor types under MR imaging guidance.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Yijing Zhang, Qin Zhang, Fengshuo Wang, Meng Li, Xiangyang Shi, Jingchao Li
Summary: This study presents activatable semiconducting polymer nanoinducers (ASPN(FP)) that amplify oxidative damage through sono-ferroptosis for bone metastasis treatment. ASPN(FP) consist of plasma amine oxidase-based semiconducting polymer nanoparticles (SPNP) and Fe3O4 nanoparticles encapsulated in singlet oxygen (O-1(2))-responsive nanocarriers. Under ultrasound (US) irradiation, ASPN(FP) generate O-1(2) via sonodynamic effect, leading to the destabilization of O-1(2)-responsive nanocarriers and triggering the release of SPNP and Fe3O4 nanoparticles. SPNP decompose polyamines in tumor cells, producing acrolein and hydrogen peroxide (H2O2), with H2O2 facilitating Fenton reaction mediated by Fe3O4 nanoparticles. This induces enhanced ferroptosis and hydroxyl radicals (& BULL;OH) generation, resulting in amplified oxidative damage to inhibit bone metastasis growth and restrict tumor metastasis.
Article
Chemistry, Multidisciplinary
Zhijun Ouyang, Yue Gao, Siyan Shen, Bingyang Jia, Hongwei Yu, Han Wang, Mingwu Shen, Xiangyang Shi
Summary: In this study, an indocyanine green (ICG) modified dendrimer nanomedicine loaded with an autophagy inhibitor chloroquine (CQ) was developed for enhanced photothermo-immunotherapy. The G5.NHAc-ICG/CQ (GIC) complexes showed good stability, cytocompatibility, and high photothermal conversion efficiency. Under laser irradiation, the GIC complexes inhibited autophagy, induced apoptosis and immunogenic cell death, promoted dendritic cell maturation and the infiltration of activated CD4+/CD8+ T cells into tumors.
Article
Materials Science, Biomaterials
Bingyang Jia, Yue Gao, Zhijun Ouyang, Siyan Shen, Mingwu Shen, Xiangyang Shi
Summary: In this study, a multifunctional drug delivery system was developed for improved chemotherapy against malignant tumors. The system consisted of diselenide-crosslinked poly(N-vinylcaprolactam) (PVCL) nanogels co-loaded with gold nanoparticles (Au NPs) and methotrexate (MTX). The designed nanogels showed excellent colloidal stability under physiological conditions, but rapidly released Au NPs and MTX in the tumor microenvironment. The released Au NPs and MTX induced apoptosis of cancer cells and repolarized tumor-associated macrophages from protumor M2-like phenotype to antitumor M1-like phenotype. This nanogel system also enabled CT imaging of tumors, showing great promise for immune modulation-enhanced tumor chemotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Junli Gong, Cong Song, Gaoming Li, Yunqi Guo, Zhiqiang Wang, Honghua Guo, Jindong Xia, Yuchen Tao, Qiusheng Shi, Xiangyang Shi, Mingwu Shen
Summary: In this study, a multifunctional nanoplatform combined with UTMD technology was designed to enhance tumor accumulation for theranostics. The platform, PCSTD-Gd, consisted of zwitterion-modified gadolinium (Gd)-chelated core-shell tecto dendrimers (CSTDs) for MR imaging-guided chemo-gene therapy. The CSTDs were covalently linked with Gd-chelators and modified with 1,3-propane sultone for protein-resistance, and were used for co-delivery of miR 21i and DOX. This design provided advantages in tumor targeting, MR imaging sensitivity, gene delivery efficiency, and drug loading.
BIOMATERIALS SCIENCE
(2023)
Article
Forestry
ZhiHao Dong, XiaoDong Liu, Anoop Kumar Srivastava, QiLing Tan, Wei Low, Xiang Yan, SongWei Wu, XueCheng Sun, ChengXiao Hu
Summary: Nutritional enhancement can effectively alleviate the symptoms of Huanglongbing in citrus, but little research has focused on the role of plant nutrition in the interaction between citrus and the Asian citrus psyllid. This is considered an important aspect in developing effective management strategies.
Article
Chemistry, Multidisciplinary
Yue Gao, Zhijun Ouyang, Siyan Shen, Hongwei Yu, Bingyang Jia, Han Wang, Mingwu Shen, Xiangyang Shi
Summary: This study reports the development of a nanoscale drug delivery system using manganese dioxide-entrapping dendrimer nanocarriers for improved tumor therapy. The system codelivers glucose oxidase and cyclic GMP-AMP, leading to enhanced chemodynamic/starvation/immune therapy. The nanocarriers display efficient glutathione depletion ability and enable T-1-weighted magnetic resonance imaging. The system shows promising results in vitro and in a mouse colorectal tumor model, significantly improving survival rates.