Article
Pharmacology & Pharmacy
Lili Ren, Junfang Nie, Jie Wei, Yaning Li, Jun Yin, Xiaolong Yang, Guoguang Chen
Summary: A block copolymer with active targeting and disulfide bond response was designed for simultaneous delivery of chemotherapy and photothermal therapy drugs, showing ideal therapeutic effect in antitumor activity.
Article
Polymer Science
Yannik Olszowy, Janick Wesselmann, Shenja Fabienne Over, Florian Paetzold, Ralf Weberskirch
Summary: This study investigated core crosslinked micelles based on poly(2-ethyl-2-oxazoline)-block-poly(n-butyl acrylate-co-d,l-homocysteine thiolactone acrylamide) by employing different di- and triamines and nucleophilic ring-opening reaction. The quantity of crosslinked micelle and free block copolymer was quantified by size exclusion chromatography (SEC), and the crosslinking conditions were optimized. Subsequently, micelles crosslinked with cystamine exhibited degradation times of 1.5 h to 5 h in the presence of dithiothreitol (DTT), depending on the composition of the hydrophobic core.
Article
Integrative & Complementary Medicine
Zhaopei Guo, Ka Hong Wong, Enze Li, Xingzhi Zhou, Di Jiang, Jiebing Gao, Meiwan Chen
Summary: A polypeptide-based nanoscale drug delivery system was developed to enhance the solubility and biodistribution of chemotherapeutic drugs and photosensitizers. The system exhibited pH-sensitive drug release and improved cellular uptake, leading to enhanced anticancer efficacy.
Article
Biochemistry & Molecular Biology
Qiang Zhang, Yuanyuan Liu, Yucheng Fei, Jiguo Xie, Xiaofei Zhao, Zhiyuan Zhong, Chao Deng
Summary: The study presents a novel synthesis method for phenylboronic acid-functionalized copolypeptides based on an L-boronophenylalanine N-carboxyanhydride (BPA-NCA) monomer, and demonstrates their potential for co-encapsulation and responsive release of dual anticancer drugs. The synthesized copolypeptides show controlled compositions and can self-assemble into uniform micellar nanoparticles for drug delivery. The resulting nanoparticles exhibit enhanced anticancer effects and have potential applications in smart cancer nanomedicines.
Review
Chemistry, Physical
Bingyang Chu, Hanzhi Deng, Ting Niu, Ying Qu, Zhiyong Qian
Summary: This review comprehensively summarizes the latest research advances in stimulus-responsive CPT nano-prodrugs, including preparation strategies, responsive release mechanisms, and their applications in cancer therapy. Special focus is placed on the release mechanisms and characteristics of various stimulus-responsive CPT nano-prodrugs and their application in cancer treatment. Furthermore, clinical applications of CPT prodrugs are discussed. Finally, challenges and future research directions for CPT nano-prodrugs are discussed.
Article
Pharmacology & Pharmacy
Athar Mahdieh, Hamidreza Motasadizadeh, Hamid Yeganeh, Bo Nystrom, Rassoul Dinarvand
Summary: Clickable and cleavable nanomicelles with stimuli-responsiveness have been developed for targeted drug delivery to tumor tissues, showing potential value in breast cancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Yawei Li, Qing Pei, Baiji Cui, Hongmei Zhang, Liu Han, Wenqing Li, Wenhe Zhu, Xianmin Feng, Zhigang Xie
Summary: Redox-responsive DHA dimeric prodrug nanoparticles show promising potential for tumor treatment, with preferable antitumor activity and a possible anti-cancer mechanism involving apoptosis induction and glycolysis inhibition via PI3K/AKT/HIF-1 alpha signaling pathway regulation.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ka Hong Wong, Zhaopei Guo, Di Jiang, Xingzhi Zhou, Lizhu Lin, Denggao Zhao, Meiwan Chen
Summary: A novel dual-sensitive polypeptide-based micelle with high drug loading of CPT for cancer therapy is reported in this study. The micelle possesses pH-sensitive properties and can release the drug in the tumor microenvironment, enhancing cellular uptake. The linear morphology of the micelle improves cellular internalization and significantly enhances the anticancer efficacy against lung cancer cells.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sonyabapu Yadav, Kalyan Ramesh, Obireddy Sreekanth Reddy, Viswanathan Karthika, Parveen Kumar, Sung-Han Jo, Seong Yoo, Sang-Hyug Park, Kwon Taek Lim
Summary: In this study, redox-responsive core-cross-linked (CCL) micelles were synthesized using diselenide (Se-Se) and disulfide (S-S) bonds, and their sensitivity to oxidation and reduction was compared. The micelles showed structural stability under physiological conditions but de-cross-linked in response to GSH and H2O2 treatments. DLS studies demonstrated that the Se-Se micelles were more responsive to changes in the redox environment compared to the S-S micelles. The developed micelles exhibited a pH-dependent drug release and showed cytotoxicity against cancer cells while remaining non-toxic to normal cells.
Article
Biochemistry & Molecular Biology
Sarvin Shirani, Jaleh Varshosaz, Mahboubeh Rostami, Mina Mirian
Summary: In this study, a redox-sensitive micelle was designed for targeted delivery of Ribociclib to breast cancer cells. The micelle showed promising redox sensitivity and high cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Ajaya Bhattarai, Malik Abdul Rub, Mihalj Posa, Bidyut Saha, Abdullah M. Asiri, Dileep Kumar
Summary: This study investigates the behavior of ninhydrin (N) and phenylalanine (Phe) in a cationic gemini micellar system using a spectrophotometer. The results show that the reaction of N follows fractional-order kinetics, while the reaction of Phe follows first-order kinetics. The gemini surfactant system significantly catalyzes the reactions, even at concentrations lower than the critical micelle concentration (cmc).
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Pierre Picchetti, Stefano Volpi, Marianna Rossetti, Michael D. Dore, Tuan Trinh, Frank Biedermann, Martina Neri, Alessandro Bertucci, Alessandro Porchetta, Roberto Corradini, Hanadi Sleiman, Luisa De Cola
Summary: The development of smart nanoparticles with responsive features has expanded the applications of NP-based drugs, vaccines, and diagnostic tools. By combining nucleic acid interactions and sol-gel chemistry, researchers have successfully incorporated synthetic nucleic acids into organosilica nanoparticles, enabling them to respond to various biological, physical, and chemical inputs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Biomedical
Kai Xiao, Qiangqiang Liu, Nell Suby, Wenwu Xiao, Rinki Agrawal, Michael Vu, Hongyong Zhang, Yan Luo, Yuanpei Li, Kit S. Lam
Summary: A nanoparticle system targeted at luteinizing hormone-releasing hormone (LHRH) receptor and responsive to the tumor microenvironment has been developed for selective delivery of chemotherapeutic drugs to triple-negative breast cancer (TNBC) cells. This system shows high drug loading efficiency, receptor-mediated internalization into TNBC cells, and improved cytotoxicity compared to non-targeted counterparts. In vivo studies demonstrate enhanced tumor distribution and penetration of payloads, leading to superior therapeutic efficacy in TNBC models. These results offer new insights into precise drug delivery for TNBC treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kuldeep Kumar Bansal, Ezgi Ozliseli, Ari Rosling, Jessica Marianne Rosenholm
Summary: This study successfully synthesized a novel polymer derived from renewable feedstock with the possibility of post-synthesis functionalization, conjugated a drug to it, and demonstrated its drug release effect in cancer cells in vitro.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Yanhong Liu, Linjiao Chen, Qingyang Shi, Qing Zhao, Hongshuang Ma
Summary: Tumor microenvironment-responsive polypeptide nanogels have excellent biocompatibility and degradability, and can be used for selective delivery of antitumor drugs. These nanogels can release drugs in response to stimuli from tumor tissues or cells, reducing side effects and improving efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ludan Yue, Kuikun Yang, Jianwen Wei, Mengze Xu, Chen Sun, Yuanfu Ding, Zhen Yuan, Shu Wang, Ruibing Wang
Summary: In this study, a facile strategy was proposed to remotely control intracellular gene expression using gold nanorods (Au NRs) as gene carriers and photothermal transducers. This strategy allows precise spatiotemporal initiation of gene expression and deferred photothermal therapy, leading to enhanced therapeutic outcomes.
Article
Chemistry, Physical
Yuyan Zhang, Yingying Hu, Huayu Tian, Xuesi Chen
Summary: With the outbreak of SARS-CoV-2, mRNA vaccines have played a crucial role in COVID-19 vaccine development and have made significant advances in the field of mRNA therapeutic techniques. However, there are still challenges in terms of stability and cellular delivery. Therefore, exploring efficient and safe delivery technologies is essential for improving mRNA therapeutic techniques.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Lisi Xie, Jie Li, Guohao Wang, Wei Sang, Mengze Xu, Wenxi Li, Jie Yan, Bei Li, Zhan Zhang, Qi Zhao, Zhen Yuan, Quli Fan, Yunlu Dai
Summary: In this study, phototheranostic metal-phenolic networks were engineered for precise photo thermal therapy. This therapy could relieve exosomal suppression, restore T cells, and enhance ferroptosis. The synergy of photo thermal therapy with antiexosomal PD-L1 evoked potent antitumor immunity and immunological memory against metastatic tumors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyu Yang, Lin Lin, Zhaopei Guo, Xiaoya Guo, Zhaohui Tang, Huayu Tian, Xuesi Chen
Summary: This study developed a facile and effective strategy to construct polymeric gene delivery systems with high transfection efficiency. It was found that a cationic polypeptide with a stable alpha-helical conformation significantly improved the cellular uptake and endosomal escape of polymeric gene delivery systems, thereby enhancing transfection efficiency.
Article
Engineering, Biomedical
Lin Lin, Yingying Hu, Zhaopei Guo, Jie Chen, Pingjie Sun, Huayu Tian, Xuesi Chen
Summary: A gene-guided self-killing therapy based on anchoring OX40L to tumor cell membrane was developed to enhance the effectiveness of immune checkpoint blockade therapy. It transformed cold tumors to hot, prevented tumor recurrence and metastasis, and offered a new possibility for immunotherapy of various solid tumors.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sijia Zhang, Ying Zhang, Yuanji Feng, Jiayan Wu, Yingying Hu, Lin Lin, Caina Xu, Jie Chen, Zhaohui Tang, Huayu Tian, Xuesi Chen
Summary: This study explores the combination of regulating tumor glycometabolism with anti-PD-L1 therapy for tumor treatment. By using nanoparticles combined with anti-PD-L1, tumor development is significantly inhibited, increasing the survival time of mice. This strategy also has an immunological memory effect, successfully preventing tumor recurrence and metastasis.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dianwei Wang, Lin Lin, Tong Li, Meng Meng, Kai Hao, Zhaopei Guo, Jie Chen, Huayu Tian, Xuesi Chen
Summary: A covalent organic framework (COF) sonosensitizer is developed using a new nanoscale COF preparation strategy, which improves the therapeutic effect of sonodynamic therapy (SDT). The COF structure prevents aggregation of the sonosensitizer molecules and enhances their chemical stability. Additionally, the coordination of Fe3+ to COF enables chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and alpha-PD-L1 antibody achieves effective antitumor effects.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Shu Sheng, Lin Lin, Feng Liu, Ying Zhang, Caina Xu, Kai Hao, Dianwei Wang, Huayu Tian, Xuesi Chen
Summary: This study developed a strategy for tumor-specific imaging-guided enhanced combination tumor therapy by introducing endogenous biocatalytic reaction. The reaction produced endogenous melanin with the capabilities of photoacoustic imaging and photothermal therapy. The nanocarrier MIL-100 played dual roles in the reaction, coordinating with the catechol moieties and promoting biocatalysis, and also converting overexpressed H2O2 to O-2, which enhanced the therapeutic outcomes.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jiayan Wu, Zhaopei Guo, Weidong Ni, Yuanji Feng, Xiaoya Guo, Meng Meng, Yunan Yuan, Lin Lin, Jie Chen, Huayu Tian, Xuesi Chen
Summary: The immune checkpoint blockade (ICB) has a low response rate in clinical cancer treatment. Chemotherapy can enhance the response rate of the ICB, but it leads to side effects. Loading chemotherapy drugs through nanocarriers can reduce off-target toxicity. In this study, researchers developed doxorubicin (DOX) nanoparticles (DOX NPs) loaded in a polymeric carrier that was responsive to the tumor microenvironment (TME). However, a combination therapy of DOX NPs and ICB induced tumor adaptive resistance, which was found to be caused by TGF-beta 1. To overcome this resistance, an immune cocktail therapy containing DOX NPs, ICB, and TGF-beta 1 gene silencing nanoparticles was developed, successfully reversing the immunosuppressive TME and improving tumor treatment efficiency.
Article
Chemistry, Multidisciplinary
Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen
Summary: Researchers synthesized a nanoparticle TMP containing tannic acid, Polymyxin B, and Mn2+ by a simple one-pot method. TMP has good biocompatibility, simple preparation process, antibacterial and anti-inflammatory properties, and effectively mitigates cytokine storms in sepsis models.
Article
Engineering, Biomedical
Shengyang Liu, Jiayan Wu, Yuanji Feng, Xiaoya Guo, Tong Li, Meng Meng, Jie Chen, Daquan Chen, Huayu Tian
Summary: Researchers have developed a nanovaccine that activates the immune system to trigger tumor-specific immune responses, with potential clinical applications in tumor prevention and treatment. The nanovaccine promotes the uptake and maturation of antigens and adjuvants in dendritic cells, leading to an antitumor immune response.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Tong Li, Dianwei Wang, Zhaopei Guo, Lin Lin, Meng Meng, Cong Liu, Kai Hao, Xuan Pang, Huayu Tian, Xuesi Chen
Summary: The emergence of nanocarriers has greatly improved the therapeutic efficacy of chemotherapeutic drugs. Covalent organic frameworks (COFs) have been increasingly used in biomedicine. However, existing COF nanocarriers hardly undergo in vivo degradation, which may pose potential safety hazards.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Huixin Li, Kai Hao, Jiayan Wu, Chaoliang He, Shasha He, Huayu Tian, Xuesi Chen
Summary: This study developed a theragnostic nano-platform for real-time imaging and treatment of acute liver injury (ALI). The nano-platform consists of a liver-targeted probe for real-time imaging and a drug for ALI treatment. After systemic administration, the nano-platform passively targets liver tissue and activates an infrared signaling module for non-invasive longitudinal imaging, while releasing the drug for timely treatment. The nano-platform provides comprehensive estimations for ALI, comparable to standard methods including blood tests and flow cytometric analysis.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Yuanji Feng, Zhaopei Guo, Jie Chen, Sijia Zhang, Jiayan Wu, Huayu Tian, Xuesi Chen
Summary: This study proposes a strategy to achieve efficient nucleic acid and protein delivery through multiple interactions and develops a novel delivery system. By introducing an enhancer that promotes multiple interactions with the cell membrane, efficient intracellular delivery is achieved. For nucleic acid delivery, gene editing and protein expression are achieved, while for protein delivery, enhanced immune responses are induced. Furthermore, the delivery system exhibits negligible cytotoxicity.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Weidong Ni, Jiayan Wu, Yuanji Feng, Yingying Hu, Haiyan Liu, Jie Chen, Fangfang Chen, Huayu Tian
Summary: Tumor stroma plays a crucial role in colorectal cancer, and a novel treatment strategy utilizing antitumor stroma and nanoscale materials has shown promising results in reshaping the tumor immune microenvironment.
BIOMATERIALS SCIENCE
(2022)
