Visible-Light-Mediated Dehydrogenative Cross-Coupling: Synthesis of Nonsymmetrical Atropisomeric Biaryls

The direct cross-dehydrogenative coupling reactions of 2-naphthylamine/2-naphthol derivatives with aniline/phenol derivatives for the preparation of nonsymmetrical atropisomeric biaryl compounds, especially BINOL-type biaryls, using a photocatalyst with irradiation under blue LEDs at room temperature, are described. This protocol provides efficient and simple access to nonsymmetrical atropisomeric biaryls in good yields, which are often found in natural products and are useful for materials chemistry.