Part II: Diastereoselective Reactions Involving β-Mono- and β,β′-Disubstituted Alkylidene Oxindoles: Pondering Alkene Geometry

A DBU-catalyzed Michael–Pinner–isomerization cascade reaction of 3-hydroxyoxindoles with isatylidene malononitriles: access to highly functionalized bispirooxindoles containing a fully substituted dihydrofuran motif

(2017) Yan-Shuo Zhu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipole and Base Catalyzed Michael Addition with β-Nitrostyrene via C3 Umpolung of Oxindole

(2017) Xiao Wang et al.   ORGANIC LETTERS

Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipole and Abnormal [3 + 2]-Cycloaddition with Maleimide in the Presence of 1,4-Diazabicyclo[2.2.2]octane

(2017) Xiao Wang et al.   ORGANIC LETTERS

Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast

(2017) Arianna Rossetti et al.   TETRAHEDRON

Grinding assisted, column chromatography free decarboxylative carbon-carbon bond formation: Greener synthesis of 3, 3-disubstituted oxindoles

(2017) Jasneet Kaur et al.   TETRAHEDRON

Synthesis of dispirocyclohexadiene bisoxindole from Morita-Baylis-Hillman carbonate of isatin

(2017) Beom Kyu Min et al.   TETRAHEDRON LETTERS

Part I: Diastereoselective Reactions Involving β-Mono- and β,β′-Disubstituted Alkylidene Oxindoles: Pondering Alkene Geometry

(2017) Madhu Ganesh et al.   Asian Journal of Organic Chemistry

I2/O2-Enabled N–S Bond Formation to Access Functionalized 1,2,3-Thiadiazoles

(2016) Wei Fan et al.   ORGANIC LETTERS

Synthesis of 6-Substituted 6H-Indolo[2,3-b]quinolines from Isoindigos

(2016) Ling Fan et al.   ORGANIC LETTERS

Lewis Base and Brønsted Base Dual-Catalyzed Formal [4+3] Cyclo­addition Reaction: Synthesis of Aza-Spirocycloheptane Oxindole

(2016) Peng-Fei Xu et al.   SYNLETT

Stereoselective construction of Bi-spirooxindole frameworks via a Michael addition/cyclization and an unexpected redox/oxidative coupling/cyclization

(2016) Xiao-Qian Zhu et al.   TETRAHEDRON

Mild and efficient synthesis of isoindigo derivatives catalyzed by Lewis acid

(2016) Meilin Liu et al.   TETRAHEDRON LETTERS

Diastereoselective Synthesis of Six-Membered Carbocyclic Spirooxindolesvia6π-Electrocyclization of 3-Dienylidene-2- oxindoles

(2015) Ko Hoon Kim et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Construction of Spirooxindoles by Arylative Cyclization of 3-(γ,δ-Disubstituted)allylidene-2-Oxindoles

(2015) Ko Hoon Kim et al.   ADVANCED SYNTHESIS & CATALYSIS

Divergent Cyclization Reactions of Morita–Baylis–Hillman Carbonates of 2-Cyclohexenone and Isatylidene Malononitriles

(2015) Jing Peng et al.   ORGANIC LETTERS

[4 + 3] Cycloadditions with Bromo-Substituted Morita–Baylis–Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides

(2015) Gu Zhan et al.   ORGANIC LETTERS

Highly Diastereoselective Synthesis of Spirocyclopropane-oxindoles Using InCl3 as a Catalyst in Water

(2015) Sengodagounder Muthusamy et al.   SYNLETT

A One-Pot, Multicomponent Synthesis of 5′-Amino-2,2′-dioxospiro[indoline-3,3′-pyrrole]-4′-carbonitriles

(2015) Mehdi Adib et al.   SYNLETT

Bi(OTf)3-catalyzed C–H bond functionalization of azaarenes for the facile access to oxindoles featuring quaternary carbon centers

(2015) Beili Lu et al.   RSC Advances

Ordered short channel mesoporous silica modified with 1,3,5-triazine–piperazine as a versatile recyclable basic catalyst for cross-aldol, Knoevenagel and conjugate addition reactions with isatins

(2015) Naveen Gupta et al.   RSC Advances

Substituent-Controlled Selective Synthesis of Spirooxindoles and Oxazolyloxindoles via Two Tandem Reactions

(2015) Yun Liu et al.   Asian Journal of Organic Chemistry

Furan-Basedo-Quinodimethanes by Gold-Catalyzed Dehydrogenative Heterocyclization of 2-(1-Alkynyl)-2-alken-1-ones: A Modular Entry to 2,3-Furan-Fused Carbocycles

(2014) Liejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AlCl3-Promoted Selective Michael Addition with Allenoate and Methyleneindolinone: Synthesis of Spirocyclic Oxindole by Using Allenoate as a Four-Carbon Component Building Block

(2014) Shibo Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper(I)-Catalyzed Multicomponent Reaction Providing a New Access to Fully Substituted Thiophene Derivatives

(2014) Bo Jiang et al.   ORGANIC LETTERS

Studies Toward Communesin F: A Diels–Alder Approach

(2014) Jakob Danielsson et al.   ORGANIC LETTERS

Convenient Synthesis of Triphenylphosphanylidene Spiro[cyclopentane-1,3′-indolines] and Spiro[cyclopent[2]ene-1,3′-indolines] via Three-Component Reactions

(2014) Ying Han et al.   ORGANIC LETTERS

Indium Trichloride Catalysed Domino Reactions of Isatin: A Facile Access to the Synthesis of Spiro(indoline-3,4′-pyrano[2,3-c]pyrazol)-2-one Derivatives

(2014) Paramasivan Perumal et al.   SYNLETT

Efficient Catalyst-Free One-Pot Three-Component Synthesis of Novel Spiro­oxindole Derivatives, and Their Cytotoxic Activities

(2014) Jingchao Tao et al.   SYNTHESIS-STUTTGART

An efficient, three-component synthesis and molecular structure of derivatives of 2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide spirocombined with a 2-oxindole nucleus

(2014) Leonid A. Shemchuk et al.   TETRAHEDRON

Efficient construction of highly functionalized endo′-selective spiro[pyrrolidin-2,3′-oxindoles] via a regioselective 1,3-dipolar cycloaddition reaction between 3-amino oxindoles as azomethine ylide precursors and nitroalkenes

(2014) Hongbao Sun et al.   TETRAHEDRON LETTERS

Highly regio- and diastereoselective construction of spirocyclopenteneoxindole phosphonates through a phosphine-catalyzed [3 + 2] annulation reaction

(2014) Chengbin Yu et al.   RSC Advances

Phosphotungstic Acid as an Efficient Catalyst for Allylation of Isatins andN-tert-Butyloxycarbonylamido Sulfones Under Solvent-Free Conditions

(2014) Debashis Ghosh  et al.   Asian Journal of Organic Chemistry

Efficient Synthesis of Spiro[furan-3,3′-indoline] Derivatives via Reactions of Pyridinium Salts with Isatinylidene Acetoacetates

(2013) Zhenming Liu et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

(2013) Nadia G. Kandile et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Stereoselective Synthesis of Five-Membered Spirooxindoles through Tomita Zipper Cyclization

(2013) D. B. Ramachary et al.   ORGANIC LETTERS

Cufe2O4Nanoparticles: A Magnetically Retrievable Catalyst for Green Synthesis of Novel 2-(3-(Dicyanomethyl)-2-Oxoindolin-3-Ylthio)Acetic Acids

(2013) Ghazaleh Imani Shakibaei et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Recyclization in the Series of Spiro[indole-3,5′-pyrimido[4,5-b]quinoline]-2,2′,4′-triones Prepared by a Three-Component Reaction of Isatins with (Thio)barbituric Acids and Electron-Rich Anilines

(2013) Viktor Iaroshenko et al.   SYNTHESIS-STUTTGART

Baylis–Hillman carbonates in organic synthesis: a convenient one-pot strategy for nitrone–spiro-oxindole frameworks

(2013) Deevi Basavaiah et al.   TETRAHEDRON

A facile and efficient synthesis of 3-spirocyclopentene-2-oxindoles via palladium mediated vinylcyclopropane–cyclopentene rearrangement of oxindole derived vinylcyclopropanes

(2013) Kandapalam Arun Prasath Lingam et al.   TETRAHEDRON LETTERS

One pot four-component reaction for the efficient synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-3′-carboxylate derivatives

(2013) Suman Pal et al.   TETRAHEDRON LETTERS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Ultrasound-assisted Synthesis of Azlactone and its Reactions with Nucleophiles

(2012) Boris V. Paponov et al.   MENDELEEV COMMUNICATIONS

A Facile Method for the Synthesis of 3-(Aminomethylene)oxindoles from Isatylidene Malononitriles and α-Azido Ketones

(2012) Paramasivan Perumal et al.   SYNLETT

A Unique Approach to Catalyst-Free, One-Pot Synthesis of Spirooxindole-Pyrazolines

(2012) Abdolali Alizadeh et al.   SYNLETT

One-Pot, Pseudo Five-Component Synthesis of Spirooxindole Derivatives Containing Fused 1,4-Dihydropyridines in Water

(2012) Abdolali Alizadeh et al.   SYNTHESIS-STUTTGART

Phosphorus-containing Lewis base catalyzed highly regioselective cyclization of isatin derived electron-deficient alkenes with but-3-yn-2-one

(2012) Zhong Lian et al.   TETRAHEDRON

A novel organocatalytic multi-component reaction: an efficient synthesis of polysubstituted pyrano-fused spirooxindoles

(2012) Zeinab Noroozi Tisseh et al.   TETRAHEDRON LETTERS

NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives

(2012) Harshita Sachdeva et al.   Journal of Chemistry

Syntheses of Spirocyclic Oxindole-Butenolides by Using Three-Component Cycloadditions of Isocyanides, Allenoates, and Isatins

(2011) Jian Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Phosphine- and Nitrogen-Containing Lewis Base Catalyzed Highly Regioselective and Geometric Selective Cyclization of Isatin Derived Electron-Deficient Alkenes with Ethyl 2,3-Butadienoate

(2011) Xiu-Chun Zhang et al.   ORGANIC LETTERS

Highly Regio- and Diastereoselective Construction of Spirocyclopenteneoxindoles through Phosphine-Catalyzed [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates with Isatylidene Malononitriles

(2011) Hong-Ping Deng et al.   ORGANIC LETTERS

Phosphine-Catalyzed Cascade [3 + 2] Cyclization−Allylic Alkylation, [2 + 2 + 1] Annulation, and [3 + 2] Cyclization Reactions between Allylic Carbonates and Enones

(2011) Rong Zhou et al.   ORGANIC LETTERS

A [3 + 2] Dipolar Cycloaddition Route to 3-Hydroxy-3-alkyl Oxindoles: An Approach to Pyrrolidinoindoline Alkaloids

(2011) Anand Singh et al.   ORGANIC LETTERS

A novel MgI2 mediated unusual dimerization–spirocyclopropanation of bromo isomerised Morita–Baylis–Hillman adduct of isatin: a facile synthesis of 3-spirocyclopropane-2-oxindole derivatives

(2011) Kandapalam Arun Prasath Lingam et al.   TETRAHEDRON LETTERS

An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction

(2010) Kodirajan Selvakumar et al.   CHEMICAL COMMUNICATIONS

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

(2010) Richard N. Butler et al.   CHEMICAL REVIEWS

Indoloquinolines as Scaffolds for Drug Discovery

(2010) J. Lavrado et al.   CURRENT MEDICINAL CHEMISTRY

Simple Synthesis of Some 2-Substituted Melatonin Derivatives

(2010) Natalia Lozinskaya et al.   SYNTHESIS-STUTTGART

Synthesis of Novel Spiro Cyclic 2-Oxindole Derivatives of 6-Amino-4H-Pyridazine via [3+3] Atom Combination Utilizing Chitosan as a Catalyst

(2009) Ismail Abdelhamid   SYNLETT

DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+3] atom combination

(2009) Ismail A. Abdelhamid et al.   TETRAHEDRON

A Short and Efficient Synthesis of 3-Spiro-α-methylene-γ-butyrolactone Oxindolones from Isomerised Bromo Derivatives of Morita-Baylis-Hillman Adducts

(2008) Ponnusamy Shanmugam et al.   SYNLETT

Stereoselective synthesis of 3-spiro-α-methylene-γ-butyrolactone oxindoles from Morita–Baylis–Hillman adducts of isatin

(2008) Ponnusamy Shanmugam et al.   TETRAHEDRON

A novel reaction of 6-amino-uracils and isatins

(2008) Minoo Dabiri et al.   TETRAHEDRON

An InCl3 catalyzed facile one-pot synthesis of novel dispiro[cyclopent-3′-ene]bisoxindoles

(2008) Gnanamani Shanthi et al.   TETRAHEDRON LETTERS