期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 46, 期 7, 页码 1488-1494出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2017.1374283
关键词
Bauhinia variegata; anthocyanins; alpha-amylase; silver nanoparticles; antioxidant activity
资金
- Periyar University, Tamil Nadu, India
- Science and Engineering Research Board, India [PDF/2015/000252]
- Department of Science and Technology, India [IF140651]
Silver nanoparticles (AgNPs) were biosynthesized using Bauhinia variegata flower extract (BVFE). The BVF-AgNPs was found to be spherical shaped with the size of 5-15nm. The phytoconstituents analysis and FTIR spectrum indicated that bioactive compounds like, phenols, flavonoids, benzophenones, nitro compounds, aromatics and aliphatic amines from BVFE might absorb on the surface of BVF-AgNPs. The synthesized BVF-AgNPs showed potent antioxidant property and -amylase enzyme activity inhibition. The IC50 value of BVF-AgNPs was found to be 4.64 and 16.6 mu g/ml for DPPH and ferric reducing power assay, respectively. The IC50 value of BVF-AgNPs for -amylase inhibition was found to be 38 mu g/ml. The K-i value of BVF-AgNPs for -amylase inhibitory effect was found to be 21 mu g/ml with the non-competitive mode of inhibition. These results suggest that BVF-AgNPs might be an effective nano-drug to treat diabetic conditions.
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